Quantification Of Immunological Memory
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Quantification Of Immunological Memory
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Author : Antonella Prisco
language : en
Publisher: Frontiers Media SA
Release Date : 2023-07-06
Quantification Of Immunological Memory written by Antonella Prisco and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-07-06 with Medical categories.
Immunological Memory
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Author : David Gray
language : en
Publisher:
Release Date : 2004
Immunological Memory written by David Gray and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with categories.
Immunological Memory
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Author :
language : en
Publisher:
Release Date : 2004
Immunological Memory written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with categories.
Role Of Tcr Affinity In Function Proliferation Memory Generation And Exhaustion During Human Viral Infection
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Author : Chad Manjeot Williams
language : en
Publisher:
Release Date : 2018
Role Of Tcr Affinity In Function Proliferation Memory Generation And Exhaustion During Human Viral Infection written by Chad Manjeot Williams and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with categories.
TCR affinity is a strong predictor of T cell function, proliferation, exhaustion, and generation of immune memory. 2D TCR affinity quantification is derived from direct antigen interaction on the T cell itself, making it a more physiologically relevant form of TCR affinity information. 2D TCR affinity demonstrated a 1000-fold affinity range within in vitro cultured Naïve Hepatitis C Virus (HCV) specific CD8+ T cells from HCV negative individuals. 2D affinity predicted T cell function better than other affinity measurement techniques, and identified TCRs capable of a CD8 independent functional response. High affinity HCV TCRs were more sensitive to low concentrations of antigen presentation giving these TCRs a greater capacity for immune surveillance during infection. However, the interrogation of the role TCR affinity plays in the immune response of CD8+ T cells during an ongoing viral infection has yet to be realized. With the advent of high throughput TCR affinity quantification techniques like in situ TCR affinity and sequence test (iTAST), it is now possible for rapid ex vivo isolation and TCR affinity quantification of antigen specific T cells responding to an ongoing viral infection. iTAST was used to isolate naïve, effector, and memory subsets of Cytomegalovirus (CMV) specific CD8+ T cells in the blood and spleen of CMV infected individuals. 2D TCR affinity of naïve cells had 1000-fold affinity range, yet effector and memory subsets were highly enriched for cells expressing medium affinity TCRs in comparison to either high or low affinity counterparts. This was corroborated by TCR sequencing analysis of the same populations for which 2D TCR affinity distributions were characterized. Surprisingly, the functional response of medium affinity TCRs, despite more reliance on CD8, was similar to that of TCRs with an order of magnitude higher TCR affinity, and seemed to be linked to intrinsic differences in inhibitory marker regulation and expression of PD-1, Tim-3, and LAG-3. Additionally, medium affinity CMV TCRs gave CD8+ T cells a proliferative advantage during in vitro culture conditions. In summary, TCR affinity influences CD8+ T cell function, proliferation, and exhaustion thus helping maintain immunological memory within an ongoing human viral infection
Persistent Viral Infections
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Author : R. Ahmed
language : en
Publisher: Wiley-Blackwell
Release Date : 1999
Persistent Viral Infections written by R. Ahmed and has been published by Wiley-Blackwell this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with Medical categories.
Persistent Viral Infections Edited by Rafi Ahmed Emory Vaccine Center, Atlanta, USA and Irvin S. Y. Chen UCLA School of Medicine, Los Angeles, USA During the past decade much of our attention has focused on diseases associated with viral persistence. Major breakthroughs in immunology, and the advent of molecular approaches to study pathogenesis have increased our understanding of the complex virus-host interactions that occur during viral persistence. Persistent Viral Infections focuses on: * The pathogenesis and immunology of chronic infections * Animal models that provide, or have the potential to provide, major insights This volume will be essential reading for virologists, immunologists, oncologists and neurologists.
A Historical Perspective On Evidence Based Immunology
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Author : Edward J. Moticka
language : en
Publisher: Newnes
Release Date : 2015-11-25
A Historical Perspective On Evidence Based Immunology written by Edward J. Moticka and has been published by Newnes this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-11-25 with Medical categories.
A Historical Perspective on Evidence-Based Immunology focuses on the results of hypothesis-driven, controlled scientific experiments that have led to the current understanding of immunological principles. The text helps beginning students in biomedical disciplines understand the basis of immunologic knowledge, while also helping more advanced students gain further insights. The book serves as a crucial reference for researchers studying the evolution of ideas and scientific methods, including fundamental insights on immunologic tolerance, interactions of lymphocytes with antigen TCR and BCR, the generation of diversity and mechanism of tolerance of T cells and B cells, the first cytokines, the concept of autoimmunity, the identification of NK cells as a unique cell type, the structure of antibody molecules and identification of Fab and Fc regions, and dendritic cells. Provides a complete review of the hypothesis-driven, controlled scientific experiments that have led to our current understanding of immunological principles Explains the types of experiments that were performed and how the interpretation of the experiments altered the understanding of immunology Presents concepts such as the division of lymphocytes into functionally different populations in their historical context Includes fundamental insights on immunologic tolerance, interactions of lymphocytes with antigen TCR and BCR, and the generation of diversity and mechanism of tolerance of T and B cells
The Science And Applications Of Synthetic And Systems Biology
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Author : Institute of Medicine
language : en
Publisher: National Academies Press
Release Date : 2011-12-30
The Science And Applications Of Synthetic And Systems Biology written by Institute of Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-12-30 with Science categories.
Many potential applications of synthetic and systems biology are relevant to the challenges associated with the detection, surveillance, and responses to emerging and re-emerging infectious diseases. On March 14 and 15, 2011, the Institute of Medicine's (IOM's) Forum on Microbial Threats convened a public workshop in Washington, DC, to explore the current state of the science of synthetic biology, including its dependency on systems biology; discussed the different approaches that scientists are taking to engineer, or reengineer, biological systems; and discussed how the tools and approaches of synthetic and systems biology were being applied to mitigate the risks associated with emerging infectious diseases. The Science and Applications of Synthetic and Systems Biology is organized into sections as a topic-by-topic distillation of the presentations and discussions that took place at the workshop. Its purpose is to present information from relevant experience, to delineate a range of pivotal issues and their respective challenges, and to offer differing perspectives on the topic as discussed and described by the workshop participants. This report also includes a collection of individually authored papers and commentary.
Immune Responses To Persistent Or Recurrent Antigens Implications For Immunological Memory And Immunotherapy
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Author : Alejandra Pera
language : en
Publisher: Frontiers Media SA
Release Date : 2021-04-22
Immune Responses To Persistent Or Recurrent Antigens Implications For Immunological Memory And Immunotherapy written by Alejandra Pera and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-04-22 with Medical categories.
Janeway S Immunobiology
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Author : Kenneth Murphy
language : en
Publisher: Garland Science
Release Date : 2010-06-22
Janeway S Immunobiology written by Kenneth Murphy and has been published by Garland Science this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-06-22 with Medical categories.
The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
A Year In Review Discussions In Immunological Memory
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Author : Scott N. Mueller
language : en
Publisher: Frontiers Media SA
Release Date : 2022-11-30
A Year In Review Discussions In Immunological Memory written by Scott N. Mueller and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-11-30 with Medical categories.
