Quantitative Aspects Of Chemical Pharmacology

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Quantitative Aspects Of Chemical Pharmacology

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Author : R.B. Barlow
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06

Quantitative Aspects Of Chemical Pharmacology written by R.B. Barlow and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.

This book gathers together chemical ideas which are important for understanding how drugs act and how new drugs may be developed. Students meet some of these ideas in courses in chemistry, biochemistry and pharmacology but in my experience they find it difficult to put together information often acquired in different years and from different departments; they need it set out in a book. I believe also that it helps if they can see how these ideas may be applied to numerical problems so I have included examples (with answers), many of which are taken from research work. These should therefore provide a chance for the student both to test his or her own understanding and to see the sort of results which form the bricks of which any experimental science is made. In all the problems the arithmetic takes less than ten minutes with a small calculator which has exponential functions and logarithms.

Quantitative Aspects Of Chemical Pharmacology

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Author : Richard Bawden Barlow
language : en
Publisher: Springer
Release Date : 1980

Quantitative Aspects Of Chemical Pharmacology written by Richard Bawden Barlow and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1980 with Chemistry, Analytic categories.

Quantitative Aspects Of Risk Assessment In Chemical Carcinogenesis

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Author : J. Clemmesen
language : en
Publisher: Springer
Release Date : 1980

Quantitative Aspects Of Risk Assessment In Chemical Carcinogenesis written by J. Clemmesen and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1980 with Medical categories.

Quantitative Calculations In Pharmaceutical Practice And Research

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Author : Themistoklēs P. Chatzēiōannou
language : en
Publisher: VCH Publishers
Release Date : 1993

Quantitative Calculations In Pharmaceutical Practice And Research written by Themistoklēs P. Chatzēiōannou and has been published by VCH Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993 with Medical categories.

This practical handbook aims at familiarizing students and scientists with the most common calculations encountered in the pharmaceutical sciences. It consolidates theoretical knowledge by applying it to the solution of real problems. Each chapter provides a short introduction of the relevant theory and includes equations to aid the comprehension of the theoretical principle. The text includes 220 solved examples and 250 problems and answers. Annotation copyright by Book News, Inc., Portland, OR

Chemical Structure Biological Activity Relationships Quantitative Approaches

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Author : F. Darvas
language : en
Publisher: Elsevier
Release Date : 2013-10-22

Chemical Structure Biological Activity Relationships Quantitative Approaches written by F. Darvas and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10-22 with Medical categories.

Chemical Structure-Biological Activity Relationships: Quantitative Approaches, Volume III, documents the proceedings of the 3rd Congress of the Hungarian Pharmacological Society held in Budapest, 1979. This volume focuses on the methodological aspects of QSAR. It also aims to inform the reader about the QSAR research conducted in East-European countries. This volume contains 38 presentations organized into six sections. Several lecturers deal with ""real prediction"" cases, i.e. activity estimation prior to the synthesis of the compounds. A particularly abundant section is devoted to the question of how the receptor models can be built up by means of QSAR calculations. Other sections present mathematical models and algorithms which could be applied to improve further the effectiveness of QSAR calculations. As another unique feature, a separate section treats the quantitative aspects of peptide structure-activity relationships—a field seemingly backward despite its evident importance. Hydrophobicity and its influence on biological potency along with the relationship of steric properties and biological activity are also discussed.

Quantitative Structure Activity Relationships Of Drugs

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Author : John Topliss
language : en
Publisher: Elsevier
Release Date : 2012-12-02

Quantitative Structure Activity Relationships Of Drugs written by John Topliss and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-02 with Medical categories.

Medicinal Chemistry, Volume 19: Quantitative Structure-Activity Relationships of Drugs is a critical review of the applications of various quantitative structure-activity relationship (QSAR) methodologies in different drug therapeutic areas and discusses the results in terms of their contribution to medicinal chemistry. After briefly describing the developments in QSAR research, this 12-chapter volume goes on discussing the contributions of QSAR methodology in elucidating drug action and rational development of drugs against bacterial, fungal, viral, and other parasitic infections of man. Other chapters explore the mode of action and QSAR of antitumor, cardiovascular, antiallergic, antiulcer, antiarthritic, and nonsteroidal antiinflammatory drugs (NSAID) agents. The discussion then shifts to the pharmacologic effects and QSAR analysis of central nervous system agents, steroids, and other hormones. A chapter examines the major chemicals affecting insects and mites, with particular emphasis on the parameters of binding correlation and reactivity for insect and mite enzymes. The concluding chapters cover the limitations of the QSAR approach in the quantitative treatment of drug absorption, distribution, and metabolism. This volume is of great value to medicinal chemists, scientists, and researchers.

Collected Papers

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Author : Bertram Kostant
language : en
Publisher: Springer
Release Date : 2022-11-15

Collected Papers written by Bertram Kostant and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-11-15 with Mathematics categories.

For more than five decades Bertram Kostant has been one of the major architects of modern Lie theory. Virtually all his papers are pioneering with deep consequences, many giving rise to whole new fields of activities. His interests span a tremendous range of Lie theory, from differential geometry to representation theory, abstract algebra, and mathematical physics. It is striking to note that Lie theory (and symmetry in general) now occupies an ever increasing larger role in mathematics than it did in the fifties. Now in the sixth decade of his career, he continues to produce results of astonishing beauty and significance for which he is invited to lecture all over the world. This is the second volume (1965-1975) of a five-volume set of Bertram Kostant's collected papers. A distinguished feature of this second volume is Kostant's commentaries and summaries of his papers in his own words.

Quantitative Structure Activity Relationships In Drug Design Predictive Toxicology And Risk Assessment

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Author : Roy, Kunal
language : en
Publisher: IGI Global
Release Date : 2015-02-28

Quantitative Structure Activity Relationships In Drug Design Predictive Toxicology And Risk Assessment written by Roy, Kunal and has been published by IGI Global this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-02-28 with Technology & Engineering categories.

Quantitative structure-activity relationships (QSARs) represent predictive models derived from the application of statistical tools correlating biological activity or other properties of chemicals with descriptors representative of molecular structure and/or property. Quantitative Structure-Activity Relationships in Drug Design, Predictive Toxicology, and Risk Assessment discusses recent advancements in the field of QSARs with special reference to their application in drug development, predictive toxicology, and chemical risk analysis. Focusing on emerging research in the field, this book is an ideal reference source for industry professionals, students, and academicians in the fields of medicinal chemistry and toxicology.

Basic Pharmacology

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Author : Maria A. Hernandez, Ph.D.
language : en
Publisher: CRC Press
Release Date : 2017-07-12

Basic Pharmacology written by Maria A. Hernandez, Ph.D. and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-07-12 with Medical categories.

Intended for use in an introductory pharmacology course, Basic Pharmacology: Understanding Drug Actions and Reactions provides an in-depth discussion of how to apply the chemical and molecular pharmacology concepts, a discussion students need for more advanced study. The textbook introduces the principles of chemistry and biology necessary to understand drug interactions at the cellular level. The authors highlight chemical and physical properties of drugs, drug absorption and distribution, drug interactions with cellular receptors, and drug metabolism and elimination. The book begins with a review of chemical principles as they apply to drug molecules, focusing mainly on those for commonly prescribed drugs. The authors use drug structures to illustrate the chemical concepts learned in general and organic chemistry courses. They cover the dynamics of receptors in mediating the pharmacological effects of drugs. They clarify theories, drawn from the scientific literature, which explain drug-receptor interactions and the quantitative relationship between drug binding and its effects at the cellular level. The authors’ extensive use of drug structures for teaching chemical and molecular pharmacology principles, and their emphasis on the relevance of these principles in future professional life makes this book unique. It provides the framework for better understanding of advanced pharmacology and therapeutics topics. Blending medicinal chemistry and pharmacodynamics aspects, this textbook clearly elucidates the essential concepts that form the cornerstone for further work in pharmacology.

Drug Design Strategies

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Author : David J. Livingstone
language : en
Publisher: Royal Society of Chemistry
Release Date : 2012

Drug Design Strategies written by David J. Livingstone and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Medical categories.

This book brings together drug design practitioners, all leaders in their field, who are actively advancing the field of quantitative methods to guide drug discovery, from structure-based design to empirical statistical models - from rule-based approaches to toxicology to the fields of bioinformatics and systems biology. The aim of the book is to show how various facets of the drug discovery process can be addressed in a quantitative fashion (ie: numerical analysis to enable robust predictions to be made). Each chapter includes a brief review of the topic showing the historical development of.