Radical Sam Enzymes Involved In Tetrapyrrole Biosynthesis And Insertion
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Radical Sam Enzymes Involved In Tetrapyrrole Biosynthesis And Insertion
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Author : Gunhild Layer
language : en
Publisher:
Release Date : 2022
Radical Sam Enzymes Involved In Tetrapyrrole Biosynthesis And Insertion written by Gunhild Layer and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022 with categories.
Abstract: The anaerobic biosyntheses of heme, heme d1, and bacteriochlorophyll all require the action of radical SAM enzymes. During heme biosynthesis in some bacteria, coproporphyrinogen III dehydrogenase (CgdH) catalyzes the decarboxylation of two propionate side chains of coproporphyrinogen III to the corresponding vinyl groups of protoporphyrinogen IX. Its solved crystal structure was the first published structure for a radical SAM enzyme. In bacteria, heme is inserted into enzymes by the cytoplasmic heme chaperone HemW, a radical SAM enzyme structurally highly related to CgdH. In an alternative heme biosynthesis route found in archaea and sulfate-reducing bacteria, the two radical SAM enzymes AhbC and AhbD catalyze the removal of two acetate groups (AhbC) or the decarboxylation of two propionate side chains (AhbD). NirJ, a close homologue of AhbC, is required for propionate side chain removal during the formation of heme d1 in some denitrifying bacteria. Biosynthesis of the fifth ring (ring E) of all chlorophylls is based on an unusual six-electron oxidative cyclization step. The sophisticated conversion of Mg-protoporphyrin IX monomethylester to protochlorophyllide is facilitated by an oxygen-independent cyclase termed BchE, which is a cobalamin-dependent radical SAM enzyme. Most of the radical SAM enzymes involved in tetrapyrrole biosynthesis were recognized as such by Sofia et al. in 2001 ( Nucleic Acids Res. 2001, 29, 1097−1106) and were biochemically characterized thereafter. Although much has been achieved, the challenging tetrapyrrole substrates represent a limiting factor for enzyme/substrate cocrystallization and the ultimate elucidation of the corresponding enzyme mechanisms
Biological Inorganic Chemistry
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Author : Robert R. Crichton
language : en
Publisher: Elsevier
Release Date : 2007-12-11
Biological Inorganic Chemistry written by Robert R. Crichton and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-12-11 with Science categories.
The importance of metals in biology, the environment and medicine has become increasingly evident over the last twenty five years. The study of the multiple roles of metal ions in biological systems, the rapidly expanding interface between inorganic chemistry and biology constitutes the subject called Biological Inorganic Chemistry. The present text, written by a biochemist, with a long career experience in the field (particularly iron and copper) presents an introduction to this exciting and dynamic field. The book begins with introductory chapters, which together constitute an overview of the concepts, both chemical and biological, which are required to equip the reader for the detailed analysis which follows. Pathways of metal assimilation, storage and transport, as well as metal homeostasis are dealt with next. Thereafter, individual chapters discuss the roles of sodium and potassium, magnesium, calcium, zinc, iron, copper, nickel and cobalt, manganese, and finally molybdenum, vanadium, tungsten and chromium. The final three chapters provide a tantalising view of the roles of metals in brain function, biomineralization and a brief illustration of their importance in both medicine and the environment. Relaxed and agreeable writing style. The reader will not only fiind the book easy to read, the fascinating anecdotes and footnotes will give him pegs to hang important ideas on.Written by a biochemist. Will enable the reader to more readily grasp the biological and clinical relevance of the subject.Many colour illustrations. Enables easier visualization of molecular mechanismsWritten by a single author. Ensures homgeneity of style and effective cross referencing between chapters
Advances In Bacterial Respiratory Physiology
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Author :
language : en
Publisher: Academic Press
Release Date : 2012-10-04
Advances In Bacterial Respiratory Physiology written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-10-04 with Science categories.
Advances in Microbial Physiology is one of the most successful and prestigious series from Academic Press, an imprint of Elsevier. It publishes topical and important reviews, interpreting physiology to include all material that contributes to our understanding of how microorganisms and their component parts work. First published in 1967, it is now in its 61st volume. The Editors have always striven to interpret microbial physiology in the broadest context and have never restricted the contents to “traditional views of whole cell physiology. Now edited by Professor Robert Poole, University of Sheffield, Advances in Microbial Physiology continues to be an influential and very well reviewed series. Contributions from leading authorities Informs and updates on all the latest developments in the field
Encyclopedia Of Biological Chemistry
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Author :
language : en
Publisher: Academic Press
Release Date : 2013-01-08
Encyclopedia Of Biological Chemistry written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-01-08 with Science categories.
The 4-volume Encyclopedia of Biological Chemistry, Second Edition, represents the current state of a dynamic and crucial field of study. The Encyclopedia pulls together over 500 articles that help define and explore contemporary biochemistry, with content experts carefully chosen by the Editorial Board to assure both breadth and depth in its coverage. Editors-In-Chief William J. Lennarz and M. Daniel Lane have crafted a work that proceeds from the acknowledgement that understanding every living process-from physiology, to immunology, and genetics-is impossible without a grasp on the basic chemistry that provides its underpinning. Each article in the work provides an up-to-date snapshot of a given topic, written by experts, as well as suggestions for further readings for students and researcher wishing to go into greater depth. Available on-line via SciVerse ScienceDirect, the functionality of the Encyclopedia will provide easy linking to referenced articles, electronic searching, as well an online index and glossary to aid comprehension and searchability. This 4-volume set, thoroughly up-to-date and comprehensive, expertly captures this fast-moving field Curated by two esteemed editors-in-chief and an illustrious team of editors and contributors, representing the state of the field Suggestions for further readings offer researchers and students avenues for deeper exploration; a wide-ranging glossary aids comprehension
Biosynthesis Of Tetrapyrroles
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Author : P.M. Jordan
language : en
Publisher: Elsevier
Release Date : 1991-11-21
Biosynthesis Of Tetrapyrroles written by P.M. Jordan and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991-11-21 with Science categories.
The study of the structure and function of tetrapyrrolic compounds has excited the interests of organic chemists, biochemists, botanists and biologists for more than a hundred years. Scientific analysis began with the first descriptions of naturally occurring porphyrins, and progress was made towards understanding the structure of chlorophyll. This was followed by the use of newly available isotopes of carbon and nitrogen to investigate the formation of porphyrins in biological systems. Further discoveries led to the elucidation of the atoms in protoporphyrin IX, made possible by the application of physical methods, such as NMR spectroscopy and recombinant DNA technology. The present volume discusses many more exciting and unexpected developments which have been made in the field over the last ten to fifteen years. While not all questions have yet been answered, the forum is set for a great scope of further research in the study of tetrapyrroles. • Of interest to biochemists, organic chemists and plant scientists • The book focusses on the exciting and unexpected developments in the field of tetrapyrolles over the last ten years • It paves the way for future research in this area
The Porphyrin Handbook
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Author : Karl Kadish
language : en
Publisher: Elsevier
Release Date : 2012-12-02
The Porphyrin Handbook written by Karl Kadish and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-02 with Technology & Engineering categories.
The Porphyrin Handbook, Volume 12: The Iron and Cobalt Pigments: Biosynthesis, Structure, and Degradation provides information pertinent to every aspect of the chemistry, synthesis, spectroscopy, and structure of phthalocyanines. This book presents the biochemical and clinical aspects of genetically transmitted or drug-induced diseases associated with errors in heme metabolism. Organized into eight chapters, this volume begins with an overview of the comparison of regulatory principles in animal and plant tetrapyrrole biosynthesis. This text then examines the biology and medical implications of porphyrin systems. Other chapters consider the transformation of hemes into bile pigments, the organic synthesis of bilins, and the pathways of degradation of chlorophyll in senescent plants. This book discusses as well the biosynthesis of porphyrins, vitamin B12, and chlorophylls. The final chapter deals with genome sequencing projects that provide sources of genes encoding the enzymes needed for the synthesis of the intermediates. This book is a valuable resource for research scientists, engineers, and clinicians.
Pseudomonas
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Author : Juan-Luis Ramos
language : en
Publisher: Springer Science & Business Media
Release Date : 2004-06-17
Pseudomonas written by Juan-Luis Ramos and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-06-17 with Science categories.
Pseudomonas comprises three volumes covering the biology of pseudomonads in a wide context, including the niches they inhabit, the taxonomic relations among members of this group, the molecular biology of gene expression in different niches and under different environmental conditions, the analysis of virulence traits in plants, animals and human pathogens as well as the determinants that make some strains useful for biotechnological applications and promotion of plant growth. There has been growing interest in pseudomonads and a particular urge to understand the biology underlying the complex metabolism of these ubiquitous microbes. These bacteria are capable of colonizing a wide range of niches, including the soil, the plant rhizosphere and phylosphere, and animal tissues; more recently they have attracted attention because of their capacity to form biofilms, a characteristic with potentially important medical and environmental implications. The three volumes cover the following topics: - Taxonomy, - Genomics, - Life styles, - Cell Architecture, - Virulence, - Regulation, - Macromolecules, - Alternative Respiratory Substrates, - Catabolism and Biotransformations. Pseudomonas will be of use to all researchers working on these bacteria, particularly those studying microbiology, plant crops, pathogenesis, and chemical engineering. Advanced students in biology, medicine and agronomy will also find these three volumes a valuable reference during their studies.
Prokaryotic Metabolism And Physiology
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Author : Byung Hong Kim
language : en
Publisher: Cambridge University Press
Release Date : 2019-05-16
Prokaryotic Metabolism And Physiology written by Byung Hong Kim and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-05-16 with Medical categories.
Extensive and up-to-date review of key metabolic processes in bacteria and archaea and how metabolism is regulated under various conditions.
The Porphyrin Handbook The Iron And Cobalt Pigments Biosynthesis Structure And Degradation
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Author :
language : en
Publisher:
Release Date : 2000
The Porphyrin Handbook The Iron And Cobalt Pigments Biosynthesis Structure And Degradation written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with Porphyrins categories.
Natural Product Biosynthesis
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Author : Christopher T. Walsh
language : en
Publisher: Royal Society of Chemistry
Release Date : 2017-04-28
Natural Product Biosynthesis written by Christopher T. Walsh and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-04-28 with Science categories.
This textbook describes the types of natural products, the biosynthetic pathways that enable the production of these molecules, and an update on the discovery of novel products in the post-genomic era.