Radiolabeled Monoclonal Antibodies
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Radiolabeled Monoclonal Antibodies For Imaging And Therapy
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Author : Suresh C. Srivastava
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-14
Radiolabeled Monoclonal Antibodies For Imaging And Therapy written by Suresh C. Srivastava and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-14 with Medical categories.
The advent of hybridoma technology leading to the successful produc tion of monoclonal antibodies against a variety of tumor-associated antigens has, during the last decade, provided a very powerful tool for research and clinical investigations. These highly specific reagents have essentially replaced the polysera of the earlier days. The successful demonstration of the many wide ranging capabilities of the monoclonal antibody technique has already begun to exert an enormous impact on diverse areas of research in basic science and medicine. In particular, the potential of monoclonal antibodies to serve as carriers for selective targeting of radionuclides to tumors for diagnosis or therapy, has stimulated an intense surge of research interest and even revived hopes of realizing Ehrlich's concept of the "magic bullet". Indeed, the technology appears to be on the threshold of a revolution in diagnosing and treating malignant disease. Much work remains to be done, however, and even though the progress has been impressive, results to date have shown only moderate success. There is no question that the limited success we have achieved thus far is merely a prelude to the many more exciting developments yet to come.
Cancer Imaging With Radiolabeled Antibodies
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Author : David M. Goldenberg
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Cancer Imaging With Radiolabeled Antibodies written by David M. Goldenberg and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Where do you begin to look for a recent, authoritative article on the diagnosis or management of a particular malignancy? The few general oncology text books are generally out of date. Single papers in specialized journals are informative but seldom comprehensive; these are more often preliminary reports on a very limited number of patients. Certain general journals frequently publish good in-depth reviews of cancer topics, and published symposium lectures are often the best overviews available. Unfortunately, these reviews and supplements appear sporadically, and the reader can never be sure when a topic of special interest will be covered. Cancer Treatment and Research is a series of authoritative volumes that aim to meet this need. It is an attempt to establish a critical mass of oncology literature covering virtually all oncology topics, revised frequently to keep the coverage up to date, and easily available on a single library shelf or by a single personal subscription. We have approached the problem in the following fashion: first, by dividing the oncology literature into specific subdivisions such as lung cancer, genitourinary cancer, pediatric oncology, etc.; and second, by asking eminent authorities in each of these areas to edit a volume on the specific topic on an annual or biannual basis. Each topic and tumor type is covered in a volume appearing frequently and predictably, discussing current diagnosis, staging, markers, all forms of treatment modalities, basic biology, and more.
Radiolabeled Monoclonal Antibodies For Imaging And Therapy
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Author :
language : en
Publisher:
Release Date : 1986
Radiolabeled Monoclonal Antibodies For Imaging And Therapy written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1986 with categories.
This meeting focused on areas of research on radiolabeled monoclonal antibodies. Topics covered included the production, purification, and fragmentation of monoclonal antibodies and immunochemistry of hybridomas; the production and the chemistry of radionuclides; the radiohalogenation and radiometal labeling techniques; the in-vivo pharmacokinetics of radiolabeled antibodies; the considerations of immunoreactivity of radiolabeled preparations; the instrumentation and imaging techniques as applied to radioimmunodetection; the radiation dosimetry in diagnostic and therapeutic use of labeled antibodies; the radioimmunoscintigraphy and radioimmunotherapy studies; and perspectives and directions for future research. Tutorial as well as scientific lectures describing the latest research data on the above topics were presented. Three workshop panels were convened on ''Methods for Determining Immunoreactivity of Radiolabeled Monoclonal Antibodies - Problems and Pitfalls, '' Radiobiological and Dosimetric Considerations for Immunotherapy with Labeled Antibodies, '' and ''The Human Anti-Mouse Antibody Response in Patients.''
Recent Developments In Monoclonal Antibody Radiolabeling Techniques
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Author :
language : en
Publisher:
Release Date : 1989
Recent Developments In Monoclonal Antibody Radiolabeling Techniques written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1989 with categories.
Monoclonal antibodies (MAbs) have shown the potential to serve as selective carriers of radionuclides to specific in vivo antigens. Accordingly, there has been an intense surge of research activity in an effort to develop and evaluate MAb-based radiopharmaceuticals for tumor imaging (radioimmunoscintigraphy) and therapy (radioimmunotherapy), as well as for diagnosing nonmalignant diseases. A number of problems have recently been identified, related to the MAbs themselves and to radiolabeling techniques, that comprise both the selectivity and the specificity of the in vivo distribution of radiolabeled MAbs. This paper will address some of these issues and primarily discuss recent developments in the techniques for radiolabeling monoclonal antibodies that may help resolve problems related to the poor in vivo stability of the radiolabel and may thus produce improved biodistribution. Even though many issues are identical with therapeutic radionuclides, the discussion will focus mainly on radioimmunoscintigraphic labels. 78 refs., 6 tabs.
Systemic Radiotherapy With Monoclonal Antibodies
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Author : Marie-Luise Sautter-Bihl
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Systemic Radiotherapy With Monoclonal Antibodies written by Marie-Luise Sautter-Bihl and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Almost a century ago Paul Ehrlich introduced the "magic bullet" concept of targeting therapeutic agents to specific tissues in order to reduce systemic toxicity. Due to the advances in hybridoma technology in the 1980s, monoclonal antibodies (MAbs) with their exquisite affinity to tumor antigens have become powerful tools in the treatment of cancer, especially when linked to therapeutic agents such as radionuclides, drugs, toxins, or enzymes. It can now be expected that such agents will lead to new cancer treatments with high therapeutic success rates. However, there are major problems in developing this therapeutic concept to a routine treatment modality. This is partly due to factors such as heterogenous distribution of tumor antigens, insufficient blood supply of tumors, high interstitial pressure, and the large interstitial space that antibodies have to traverse. This book is focused on the development in radio immunotherapy (RIT) using radio labeled monoclonal antibodies as tumoritoxic agents. This area of research has attracted the interest of clinicians and scientists from many different disciplines. It is now clear that the full potential of RIT can only be realized through the concerted efforts of laboratory scientists (molecular biologists, cell physiologists, chemists, radiation physicists, and biologists) and cancer clinicians in nuclear medicine, radiooncology, and internal oncology.
Radiolabeled Monoclonal Antibodies
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Author : American Chemical Society
language : en
Publisher:
Release Date : 1986
Radiolabeled Monoclonal Antibodies written by American Chemical Society and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1986 with categories.
Radiolabeled Monoclonal Antibodies
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Author : Suresh C. Srivastava
language : en
Publisher:
Release Date : 1986
Radiolabeled Monoclonal Antibodies written by Suresh C. Srivastava and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1986 with categories.
Radiolabeled Monoclonal Antibodies
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Author : Kristina Norrgren
language : en
Publisher:
Release Date : 1993
Radiolabeled Monoclonal Antibodies written by Kristina Norrgren and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993 with categories.
Internal Radiation Dosimetry For Clinical Testing Of Radiolabeled Monoclonal Antibodies
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Author :
language : en
Publisher:
Release Date : 1990
Internal Radiation Dosimetry For Clinical Testing Of Radiolabeled Monoclonal Antibodies written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1990 with categories.
In gauging the efficacy of radiolabeled monoclonal antibodies in cancer treatment, it is important to know the amount of radiation energy absorbed by tumors and normal tissue per unit administered activity. This paper describes methods for estimating absorbed doses to human tumors and normal tissues, including intraperitoneal tissue surfaces, red marrow, and the intestinal tract from incorporated radionuclides. These methods use the Medical Internal Radiation Dose (MIRD) scheme; however, they also incorporate enhancements designed to solve specific dosimetry problems encountered during clinical studies, such as patient-specific organ masses obtained from computerized tomography (CT) volumetrics, estimates of the dose to tumor masses within normal organs, and multicellular dosimetry for studying dose inhomogeneities in solid tumors. Realistic estimates of absorbed dose are provided within the short time requirements of physicians so that decisions can be made with regard to patient treatment and procurement of radiolabeled antibodies. Some areas in which further research could improve dose assessment are also discussed. 16 refs., 3 figs.
Cancer Therapy With Radiolabeled Antibodies
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Author : David M. Goldenberg
language : en
Publisher: CRC Press
Release Date : 2018-01-18
Cancer Therapy With Radiolabeled Antibodies written by David M. Goldenberg and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-01-18 with Law categories.
Cancer Therapy with Radiolabeled Antibodies explores the most current experimental and clinical advances in the newly emerging field of cancer radioimmunotherapy (RAIT). Providing a multidisciplinary and international context, some of the world's leading experts examine the problems and prospects of RAIT from radiation, immunological, chemical, physical, physiological, and clinical perspectives with both overviews and original research. Discussions cover the up-to-date clinical results in the RAIT of ovarian, breast, colorectal, and brain cancers, as well as the current status of RAIT in the management of B cell lymphomas. Radiobiology, dosimetry, radiochemistry, targeting biology in experimental models, clinical experiences in hematopoietic and solid tumors, and new approaches to improve cancer radioimmunotherapy are also discussed. In addition, new dosimetry concepts, new labeling methods, new concepts of antibody pharmacokinetics, and new methods to enhance selective cancer radioimmunotherapy are included.