Ras Signaling
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Ras Signaling
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Author : Lorenza Trabalzini
language : en
Publisher: Humana Press
Release Date : 2014-01-28
Ras Signaling written by Lorenza Trabalzini and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-01-28 with Science categories.
Featuring experimental approaches that shed light on the complexity of Ras GTPase biological functions, Ras Signaling: Methods and Protocols contains general overviews and detailed applications of both well-established and recently developed research techniques, including biochemical, biophysical, molecular biology, genetic and behavioral approaches, advanced high resolution fluorescence and electron microscopy imaging and “omics” technologies. Through this, the detailed volume provides information on expression, post-translational modifications, subcellular localization and dynamics, regulatory mechanisms of upstream and downstream signaling pathways and ultimately, biological activities and functions of Ras GTPases in different model systems, including high and low eukaryotic organisms. Written in the highly successful Methods in Molecular Biology series format, chapters include brief introductions, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and tips on troubleshooting and avoiding known pitfalls. Wide-ranging and authoritative, Ras Signaling: Methods and Protocols serves as an aid for investigators of different backgrounds and interests related to the multiple physiological and pathological functions of the large superfamily of Ras GTPases.
Ras Activity And Signaling
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Author : Ignacio Rubio
language : en
Publisher: Humana
Release Date : 2021-05-12
Ras Activity And Signaling written by Ignacio Rubio and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-05-12 with Science categories.
This volume compiles new experimental approaches and concepts focusing mostly, but not solely, on ways to manipulate and regulate Ras activity and its downstream signaling output. Chapters detail standard methodologies, biochemical methods, Ras processing trafficking and localization, Ras signaling and inhibition, and in vivo models for studying Ras function. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, application details for both the expert and non-expert reader, and tips on troubleshooting and avoiding known pitfalls. Authoritative and accessible, Ras Activity and Signaling: Methods and Protocols aims to provide support and guidance to lab workers in their work on Ras GTPases and in the design of new projects requiring novel methodologies.
Regulation Of The Ras Signalling Network
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Author : Hiroshi Maruta
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-07
Regulation Of The Ras Signalling Network written by Hiroshi Maruta and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-07 with Science categories.
This book, which was written by the current leaders in the field of Ras research, provides the readers with the most comprehensive and up-to-date view of the major oncogene Ras. This volume is valuable not only for university students in molecular biology, biochemistry or medicine, but also for senior scientists currently conducting cancer research.
Regulation Of Ras Trafficking And Ras Signaling
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Author : Claudia Figueroa
language : en
Publisher:
Release Date : 2003
Regulation Of Ras Trafficking And Ras Signaling written by Claudia Figueroa and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with categories.
Regulation Of The Ras Signaling Network
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Author : Hiroshi Maruta
language : en
Publisher: Chapman & Hall
Release Date : 1996-01-01
Regulation Of The Ras Signaling Network written by Hiroshi Maruta and has been published by Chapman & Hall this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-01-01 with Cellular signal transduction categories.
The Structural Basis Of Ras Signaling
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Author : Lan Huang
language : en
Publisher:
Release Date : 1997
The Structural Basis Of Ras Signaling written by Lan Huang and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with categories.
Ras Family Gtpases
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Author : Channing Der
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-04-29
Ras Family Gtpases written by Channing Der and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-04-29 with Medical categories.
Since 1982, Ras proteins have been the subject of intense research investigation by the biomedical research community. The wide interest in Ras has been stimulated for three key reasons. This book features chapters contributed by leading investigators in the field that highlight the current state-of-the art in Ras biochemistry, structure and biology. This book is an excellent reference for students in the biomedical sciences and for investigators in the field.
Role Of Ras Signaling In Hematological Malignancies And The Potential Role Of Inhibitors Of The Ras Signaling Cascade As Anti Cancer Agents
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Author : Michael Alexander Morgan
language : en
Publisher:
Release Date : 2003
Role Of Ras Signaling In Hematological Malignancies And The Potential Role Of Inhibitors Of The Ras Signaling Cascade As Anti Cancer Agents written by Michael Alexander Morgan and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with categories.
Ras And Cancer In The 21st Century
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Author : Linda VanAelst
language : en
Publisher: Perspectives Cshl
Release Date : 2018
Ras And Cancer In The 21st Century written by Linda VanAelst and has been published by Perspectives Cshl this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with Medical categories.
Ras proteins are key molecular switches in cell signaling pathways that, when activated, trigger cell growth and division. Mutations that produce abnormally active Ras proteins are common in human cancers, particularly those of the pancreas, lung, and colon. These cancers can be difficult to treat because Ras oncoproteins have long been considered 'undruggable.' Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine covers the recent progress that has been made in understanding Ras biology, how Ras activation leads to tumorigenesis, and ways in which oncogenic Ras signaling may be targeted therapeutically. The contributors review the biochemical characteristics of the different Ras isoforms (HRAS, KRAS, and NRAS), their main effectors and signaling pathways, and the mutations that lead to their constitutive activation. Recent work showing that some Ras oncoproteins may be effectively inhibited by small molecules is covered, as is work on alternative targets (e.g., enzymes that catalyze posttranslational modifications of Ras) and inhibitors (e.g., nucleic acids). The authors also discuss how organoids and mouse models are being used to study tumor progression and therapeutic efficacy. This volume is therefore essential reading for all cancer biologists, cell and molecular biologists, and pharmacologists concerned with understanding and treating Ras-driven cancers.
The Role Of Ras Signaling Associative Learning And Memory In Drosophila
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Author : Toshimasa Sakamoto
language : en
Publisher:
Release Date : 2004
The Role Of Ras Signaling Associative Learning And Memory In Drosophila written by Toshimasa Sakamoto and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with categories.
(Cont.) Here, I also present the results of characterization of a strong eye phenotype resulting from inhibition of Ras signaling. When a dominant-negative form of mammalian ras was expressed in the eye imaginal disc, flies developed eyes that are severely reduced in size. The phenotype was modified in a way sensitive to the level of Ras signaling. It was based on massive cell death resulting from inhibition of EGFR/Ras-dependent signaling pathways, including the MAPK and PI3-K pathways. Additional components such as Amnesiac and Rap appeared to modulate the signaling machinery associated with the phenotype. Oncogenic ras has been implicated in many types of tumors. This Ras-associated small eye phenotype may provide a new powerful tool to help develop therapeutic strategies for human cancers, as well as further understand the complexity of Ras signaling in basic biological events.