Reactive Free Radicals
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Oxygen Free Radicals In Tissue Damage
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Author : TARR,M.
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-06-29
Oxygen Free Radicals In Tissue Damage written by TARR,M. and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-29 with Science categories.
Oxygen free radicals and other reactive oxygen species are being postulated as causal agents in an increasing number of pathological conditions. Indeed, some investigators are suggesting that highly destructive reactive oxygen species are the final common path lead ing to tissue damage following a wide variety of insults including trauma, hypoxia, ischemia, hyperoxia, radiation, some toxins, and even strenuous athletic pursuits. But, as Robert Floyd points out, "Proof of the importance of oxygen free radicals and the oxidative damage they initiate depend on unequivocal evidence for the pres ence of free radicals and a clear association of their formation with the induction of the dysfunction of pathological conditions. " Since such proof does not come easily, there have been and will continue to be many controversies regarding the role played by reactive oxygen species in tissue damage. There have been many recent reviews of the chemistry and pos sible role of reactive oxygen species in many types of organ dys functions, tissue damage, degenerative diseases, and aging. This book is not such a review. Rather it presents for a diverse audience of physical-organic chemists, biochemists, medical researchers, and other investigators of pathophysiology, discussions of a variety of is sues important for understanding reactive oxygen species and their role in tissue damage.
Free Radicals In Biology And Medicine
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Author : Barry Halliwell
language : en
Publisher: OUP Oxford
Release Date : 2015-08-21
Free Radicals In Biology And Medicine written by Barry Halliwell and has been published by OUP Oxford this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-08-21 with Science categories.
Free Radicals in Biology and Medicine has become a classic text in the field of free radical and antioxidant research. Now in its fifth edition, the book has been comprehensively rewritten and updated whilst maintaining the clarity of its predecessors. Two new chapters discuss 'in vivo' and 'dietary' antioxidants, the first emphasising the role of peroxiredoxins and integrated defence mechanisms which allow useful roles for ROS, and the second containing new information on the role of fruits, vegetables, and vitamins in health and disease. This new edition also contains expanded coverage of the mechanisms of oxidative damage to lipids, DNA, and proteins (and the repair of such damage), and the roles played by reactive species in signal transduction, cell survival, death, human reproduction, defence mechanisms of animals and plants against pathogens, and other important biological events. The methodologies available to measure reactive species and oxidative damage (and their potential pitfalls) have been fully updated, as have the topics of phagocyte ROS production, NADPH oxidase enzymes, and toxicology. There is a detailed and critical evaluation of the role of free radicals and other reactive species in human diseases, especially cancer, cardiovascular, chronic inflammatory and neurodegenerative diseases. New aspects of ageing are discussed in the context of the free radical theory of ageing. This book is recommended as a comprehensive introduction to the field for students, educators, clinicians, and researchers. It will also be an invaluable companion to all those interested in the role of free radicals in the life and biomedical sciences.
Reactive Free Radicals
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Author : J Hay
language : en
Publisher: Elsevier
Release Date : 2012-12-02
Reactive Free Radicals written by J Hay and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-02 with Science categories.
Reactive Free Radicals deals with the chemistry of reactive free radicals. The initial premise is that the reactivity of a free radical depends upon its shape and therefore upon the character of the orbital(s) containing the unpaired electron. Based on this premise, a possible explanation for some of the fascinating phenomena observed in a number of free radical reactions such as combustion and pyrolysis is offered. This book is comprised of five chapters and begins with a brief overview of the chemistry of free radicals, what they are and how they are formed, and their structure and reactivity. The emphasis is on those characteristics of free radicals attributable directly to the unpaired electron function. The reader is then introduced to the techniques used for the determination of the structure of free radicals, including electron spin resonance spectroscopy, nuclear magnetic resonance spectroscopy, and infrared spectroscopy. Subsequent chapters focus on bond dissociation energies and some of the complications arising from polar and non-polar effects in free radical reactions. This monograph should serve as a valuable reference for organic chemists as well as undergraduate and graduate students of organic chemistry.
Free Radicals And Oxidation Phenomena In Biological Systems
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Author : Roberfroid
language : en
Publisher: CRC Press
Release Date : 1994-12-14
Free Radicals And Oxidation Phenomena In Biological Systems written by Roberfroid and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994-12-14 with Medical categories.
This work offers an analysis of the biological processes mediated by free radicals, from a toxicological point of view, providing easy access to information in an integrated, coherent presentation. The chemistry and biochemistry of all principal types of radical are explained, and the multiple forms in whch radicals participate in living organisms are investigated.;This work should be of use to biochemists, pharmacologists, pharmaceutical researchers, food scientists and technologists, nutritionists, toxicologists, chemists, biologists and graduate students in these disciplines.
Free Radicals And Antioxidants
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Author : U Satyanarayana
language : en
Publisher: Elsevier Health Sciences
Release Date : 2014-11-07
Free Radicals And Antioxidants written by U Satyanarayana and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-11-07 with Medical categories.
Free radicals and antioxidants Free radicals and antioxidants
Techniques In Free Radical Research
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Author : A.T. Diplock
language : en
Publisher: Elsevier
Release Date : 1991-12-11
Techniques In Free Radical Research written by A.T. Diplock and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991-12-11 with Science categories.
Free radical species are generally short-lived due to their high reactivity and thus direct measurement and identification are often impossible. ESR is the only technique which has the potential for direct detection of radicals but in biological systems even these must be trapped by a spin-trapping agent. Thus most investigations involve recognition of indicators of the presence of radicals in vivo or "FOOTPRINTS" of radical-mediated damage. Techniques in Free Radical Research assembles and critically assesses the most relevant and reliable experimental approaches used towards the measurement of radicals and radical-mediated damage in chemical systems, in cells and in tissues under the following six headings: a) Footprints of DNA damage, b) Footprints of protein damage, c) Footprints of lipid peroxidation, d) Footprints of antioxidant consumption, e) Footprints via indirect radical assays, and f) Footprints via the availability of transition metal complexes.
Free Radicals In Medicine
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Author : Radu Olinescu
language : en
Publisher: Nova Publishers
Release Date : 2002
Free Radicals In Medicine written by Radu Olinescu and has been published by Nova Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Antioxidants categories.
The role of reactive oxygen species and other free radicals in normal and disease processes has become a major area of interest in the medical scientific community. In the past 30 years, this area of study has advanced from outright rejection, to general acceptance, to intense study. While there is still some dispute as to the exact role of these highly reactive molecules in pathology, it is clear that they are present in and influence many biological processes. This book provides an overview of the possible biological effects of reactive oxygen species and other free radicals with an emphasis on pathology. The various types of free radicals that may affect the body are discussed along with the potential sources of free radicals, both internal and external to the body. The extensive defenses the body raises against the effects of these molecules in the form of enzymatic and non-enzymatic antioxidants is reviewed. A variety of conditions in which free radicals have been proposed to play a role are discussed. These include the physiological effects of oxygen stress in aging, exercise, and pregnancy. Pathologic conditions discussed include cancer, liver cirrhosis, respiratory problems, and others.
Free Radicals And Their Biological Damage Role Of Antioxidants
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Author : Manas Pratim Boruah
language : en
Publisher: LAP Lambert Academic Publishing
Release Date : 2013
Free Radicals And Their Biological Damage Role Of Antioxidants written by Manas Pratim Boruah and has been published by LAP Lambert Academic Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with categories.
Oxidation is essential in many living organisms for the production of energy to fuel biological processes. During this process, small amounts of partially reduced reactive oxygen forms are produced as unavoidable by-products which are referred to as Reactive Oxygen Species. An imbalance between free radical-generating and radical scavenging systems results in Oxidative Stress. Reactive nitrogen species and other non reactive derivatives are also involved. These processes lead to tissue damage and contribute to the pathogenesis of many disorders like hypertension, cancer, diabetes, neurodegenerative disorders, ageing etc. Almost all organisms are well protected against free radical damage by the production of antioxidant enzymes such as superoxide dismutase (SOD) and catalase, or compounds such as ascorbic acid, tocopherols and glutathione Antioxidants can also be taken exogenously through the diet. The book entitled "Free Radicals and Their Biological Damage: Role of Antioxidants" provides an overview of the different free radicals known, the mechanism by which they cause damage and the protective role played by different antioxidants.
Reactive Free Radicals
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Author : John Munro Hay
language : en
Publisher:
Release Date : 1974
Reactive Free Radicals written by John Munro Hay and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1974 with categories.
Free Radicals From Basic Science To Medicine
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Author : POLI
language : en
Publisher: Birkhäuser
Release Date : 2013-03-11
Free Radicals From Basic Science To Medicine written by POLI and has been published by Birkhäuser this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-11 with Science categories.
Free radical-mediated reactions have been well known in chemistry and physical chemistry for many years. Applying this knowledge to living organisms, biochemists have shown that reactive free radicals are formed at many intracellular sites during normal metabolism, and they have started to suggest possible roles in various pathological processes and conditions, for example in radiation damage, in the metabolism of xenobiotics, in carcinogenesis and in metabolic disorders. At present, a large and relevant mass of experimental evidence supports the view that reactive free radicals are involved in the pathogenesis of several diseases and syndromes. This literature has captured the attention and interest of people involved in the biomedical field. Exciting developments in radical research are probable in the near future, establishing a greater interaction between basic science research and medicine. While the task of defining the involvement of free radicals in human pathology is difficult, it is nonetheless extremely important that such interaction be fulfilled as soon as possible. These were the considerations motivating us during the organization of the VI Biennial Meeting of the International Society for Free Radical Research held in Torino, Italy, in June 1992, and also during the preparation of this book. Experts in the various aspects of free radical research were invited to participate in the Torino Meeting and to contribute chapters for this volume.