Recent Progresses Of Non Coding Rnas In Biological And Medical Research 2nd Edition
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Recent Progresses Of Non Coding Rnas In Biological And Medical Research 2nd Edition
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Author : Yun Zheng
language : en
Publisher: Frontiers Media SA
Release Date : 2020-11-04
Recent Progresses Of Non Coding Rnas In Biological And Medical Research 2nd Edition written by Yun Zheng and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-11-04 with Science categories.
Publisher’s note: In this 2nd edition, the following article has been updated: Xun Y, Tang Y, Hu L, Xiao H, Long S, Gong M, Wei C, Wei K and Xiang S (2019) Purification and Identification of miRNA Target Sites in Genome Using DNA Affinity Precipitation. Front. Genet. 10:778. doi: 10.3389/fgene.2019.00778
Computational Biology Of Non Coding Rna
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Author : Xin Lai
language : en
Publisher: Springer Nature
Release Date : 2024-12-19
Computational Biology Of Non Coding Rna written by Xin Lai and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-12-19 with Science categories.
This second edition details a collection of state-of-art methods including identification of novel ncRNAs and their targets, functional annotation and disease association in different biological contexts. Chapters guide readers through an overview of disease-specific ncRNAs, computational methods and workflows for ncRNA discovery, annotation based on high-throughput sequencing data, bioinformatics tools and databases for ncRNA analyses, network-based methods, and kinetic modelling of ncRNA-mediated gene regulation. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Computational Biology of Non-Coding RNA: Methods and Protocols, Second Edition aims to ensure successful results in the further study of this vital field.
Advances In Molecular Biology Knowledge Of Rectal Cancer And Forthcoming Role Of Liquid Biopsy
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Author : Letizia Gnetti
language : en
Publisher: Frontiers Media SA
Release Date : 2024-11-06
Advances In Molecular Biology Knowledge Of Rectal Cancer And Forthcoming Role Of Liquid Biopsy written by Letizia Gnetti and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-11-06 with Medical categories.
The treatment algorithm of locally advanced rectal cancer has been changing in the last years and a multidisciplinary approach is required to select effective and personalized treatment. Nowadays, total neoadjuvant treatment is an established validated strategy for high-risk rectal cancer patients as it showed and has shown increased complete response rate representing a new standard of care. Therefore, the selection of predictive molecular markers is, even more, an essential and pursued medical needs goal. Moreover, regarding the early stage of disease, one major question pertains to the risk of recurrence and minimal residual disease: when is staging based on pathologic features adequate for a shared therapeutic decision? This is one of the main issues concerning future advances.
The Long And Short Non Coding Rnas In Cancer Biology
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Author : Erwei Song
language : en
Publisher: Springer
Release Date : 2016-07-04
The Long And Short Non Coding Rnas In Cancer Biology written by Erwei Song and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-07-04 with Medical categories.
The book conveys a comprehensive knowledge of long and short ncRNAs in cancer regulation and their potentials as diagnostic biomarkers and therapeutic targets. Topics covered include the molecular mechanisms of various classes of ncRNAs (with emphasis on long non-coding RNAs and microRNAs) in cancer, the functional roles of ncRNAs in regulating different cancer hallmarks (including proliferation, apoptosis, stem-cell properties, epithelial-mesenchymal transition, metabolism, angiogenesis, tumor-host interactions and therapeutic resistance), the role of ncRNAs in regulating cancer signaling circuitry programs (highlighting their involvement in c-myc, p53 and NFkB signaling), a systemic summary of clinical and preclinical studies that evaluate the potential of ncRNA signatures for cancer diagnosis and prognosis and strategies to delivery short ncRNAs as therapeutic molecules for cancer treatment. This book may serve as a comprehensive resource for researchers, graduate students and oncologists in ncRNA and cancer research and help drug development by identifying ncRNA targets.
Ago Driven Non Coding Rnas
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Author : Bibekanand Mallick
language : en
Publisher: Academic Press
Release Date : 2019-01-20
Ago Driven Non Coding Rnas written by Bibekanand Mallick and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-01-20 with Science categories.
The 'RNA world' hypothesis that proposed RNA molecules as the first form of genetic material was put forwarded in the late 1980s but got impetus only recently when high-throughput sequencing technologies began unearthing new types of non-coding RNA (ncRNA) transcripts in higher eukaryotes. Till then, research on ncRNAs were primarily confined to transfer RNAs and, ribosomal RNAs, which act as the messengers of the protein synthesis and allow translation of genetic information encoded by DNA into proteins. In recent years, the integration of high-throughput genomic technologies with molecular biology and omics sciences have revolutionized the fields of ncRNA research by identifying the hidden treasures of several new types of ncRNAs encoded in the genomes of several organisms and decrypting their versatile roles in gene expression and epigenetics. Among these, two small endogenous ncRNAs, namely microRNAs (miRNAs) and piwi-interacting RNAs (piRNAs) that drive argonaute (AGO) family of proteins namely Ago and Piwi respectively and silence the expression of genes have geared up molecular and disease biology research in recent years. Both miRNAs and piRNAs are expressed in higher eukaryotes, including human and act as cellular rheostats by regulating the expression of significant fraction of genes encoded in the genomes. The aberrant expressions of these small ncRNAs within the cells cause various abnormalities and diseases including cancer. Manipulating their aberrant expression or function can serve as potential novel diagnostic/prognostic biomarkers and bring in new therapeutic strategies for multiple human diseases. This can be further translated from bench-side to clinic for improving human health. This book captures the essence of the pioneering work of some of the world's leading researchers showcasing the scientific excitements surrounding the evolving regulatory roles of miRNAs and piRNAs highlighting their potential towards the diagnosis and therapeutics of various diseases. The book is geared towards scientists, students, and will particularly appeal to active investigators in RNA biology, molecular biology, cancer research as well as clinicians and will provide them a comprehensive view of recent discoveries and research progresses to utilize miRNAs, piRNAs and their interacting proteins, Ago and Piwi for diagnosis, prognosis and therapeutics of diseases. - Provides a unified cutting-edge resource for both miRNAs and piRNAs, two promising AGO-clade small ncRNAs, their functions and potential applications - Showcase high-throughput technologies and other approaches for discovery of these small ncRNAs and their targets - Unveils the diverse molecular mechanisms by which miRNAs and piRNAs regulate gene expression in animal cells - Showcase recent discoveries on involvement of Argonaute and Piwi proteins in different biological processes and diseases as well as their possible use in diagnosis - Report breakthroughs in the use of small ncRNAs for diagnosis and personalized therapy
Fasciolosis 2nd Edition
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Author : John P. Dalton
language : en
Publisher: CABI
Release Date : 2021-12-14
Fasciolosis 2nd Edition written by John P. Dalton and has been published by CABI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-12-14 with Medical categories.
Fasciolosis is a major global infection of livestock causing both huge losses to the agricultural community and affecting human health as a food-borne disease. Fully updated throughout, this new edition continues to cover the life cycle, biology, and development of the parasite; clinical pathology, immunology, diagnosis and vaccine development; and emergence, cause and mechanisms of drug resistance. It reviews the temperate liver fluke Fasciola hepatica, together with molecular, biochemical, control, and epidemiologial aspects of the tropical liver fluke F. gigantica. Many fundamental advances have taken place in the last two decades, but of particular importance has been the mapping of the draft genome of Fasciola. In addition, comprehensive advances in transcriptomics, proteomics and glycomics have been made, and the book therefore pays particular attention to these developments with the addition of brand-new chapters. Also covering the impact these parasites have had on the global human population, their distribution and their ecology, this book provides a comprehensive and accessible resource for scientists, researchers and students of medical and veterinary parasitology.
Advances In Cancer Stem Cell Biology
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Author : Hans-Juergen Schulten
language : en
Publisher: Frontiers Media SA
Release Date : 2021-05-24
Advances In Cancer Stem Cell Biology written by Hans-Juergen Schulten and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-05-24 with Science categories.
Advances In The Research Of Diabetic Retinopathy
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Author : Michele Lanza
language : en
Publisher: Frontiers Media SA
Release Date : 2022-11-28
Advances In The Research Of Diabetic Retinopathy written by Michele Lanza and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-11-28 with Medical categories.
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Muscle Cells
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Author : Mani T. Valarmathi
language : en
Publisher: BoD – Books on Demand
Release Date : 2020-01-22
Muscle Cells written by Mani T. Valarmathi and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-01-22 with Science categories.
The three different types of muscle tissue found in the animal kingdom are cardiac, skeletal, and smooth. The muscle cells are not only complex but also fascinating. In recent years there has been substantial advances in our understanding of muscle cell biology, especially in areas of molecular anatomy, basic physiology, understanding disease mechanisms, and therapeutic targets. Consequently, this book mainly focuses not only on the biology of myocytes, but also on all-encompassing disciplines pertaining to muscle tissue, such as fundamental physiology, molecular mechanisms of diseases, muscle regeneration, etc. for all three types of muscle, namely, skeletal, cardiac, and smooth muscle. As a result, the goal of this book is to consolidate the recent advances in the area of muscle biology/diseases/regeneration covering a broad range of interrelated topics in a timely fashion and to disseminate that knowledge in a lucid way to a greater scientific audience. This book will prove highly useful for students, researchers, and clinicians in muscle cell biology, exercise physiology/science, stem cell biology, developmental biology, cancer biology, pathology, oncology, as well as tissue engineering and regenerative medicine. This quick reference will benefit anyone desiring a thorough knowledge pertaining to recent advances in muscle biology in the context of health and disease.
The Pathogenic Yersiniae Advances In The Understanding Of Physiology And Virulence Volume Ii
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Author : Matthew S Francis
language : en
Publisher: Frontiers Media SA
Release Date : 2019-10-09
The Pathogenic Yersiniae Advances In The Understanding Of Physiology And Virulence Volume Ii written by Matthew S Francis and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-10-09 with categories.
Pathogenic Yersinia consist of the prominent human pathogens Y. pestis, Y. enterocolitica, and Y. pseudotuberculosis, the fish pathogen Y. ruckeri, as well as a number of insect pathogens. Facilitated by the ease of in vitro culturing, genetic tractability, and availability of relevant infection models, studies of pathogenic Yersinia have revealed a great deal about physiological processes at the molecular level that contribute to pathogen adaptation to the ever changing environments both inside and outside of the host. Comprehensive genome sequencing analyses has further benefitted understanding of this bacterial pathogen evolution. Critically, many of these detailed molecular studies also identified potential targets for the design and development of anti-bacterial therapeutic drugs that could help to fight the ever-increasing problem of resistance to conventional antibiotics. New developments in several of these areas are highlighted in this edition of the Research Topic “The Pathogenic Yersiniae – Advances in the Understanding of Physiology and Virulence, Second Edition”.