Redox And Cancer Part A
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Redox And Cancer Part A
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Author :
language : en
Publisher: Academic Press
Release Date : 2014-06-25
Redox And Cancer Part A written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-06-25 with Medical categories.
Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics — Volume 122 explores subjects related to redox, including: redox homeostasis in epithelial-derived cancers; reactive oxygen species in normal and tumor stem cells; and gamma-glutamyl transpeptidase and redox regulation. Provides information on cancer research Outstanding and original reviews Suitable for researchers and students
Redox And Metabolic Circuits In Cancer
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Author : Salvatore Rizza
language : en
Publisher: Frontiers Media SA
Release Date : 2018-12-21
Redox And Metabolic Circuits In Cancer written by Salvatore Rizza and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-12-21 with categories.
Living cells require a constant supply of energy for the orchestration of a variety of biological processes in fluctuating environmental conditions. In heterotrophic organisms, energy mainly derives from the oxidation of carbohydrates and lipids, whose chemical bonds breakdown allows electrons to generate ATP and to provide reducing equivalents needed to restore the antioxidant systems and prevent from damage induced by reactive oxygen and nitric oxide (NO)-derived species (ROS and RNS). Studies of the last two decades have highlighted that cancer cells reprogram the metabolic circuitries in order to sustain their high growth rate, invade other tissues, and escape death. Therefore, this broad metabolic reorganization is mandatory for neoplastic growth, allowing the generation of adequate amounts of ATP and metabolites, as well as the optimization of redox homeostasis in the changeable environmental conditions of the tumor mass. Among these, ROS, as well as NO and RNS, which are produced at high extent in the tumor microenvironment or intracellularly, have been demonstrated acting as positive modulators of cell growth and frequently associated with malignant phenotype. Metabolic changes are also emerging as primary drivers of neoplastic onset and growth, and alterations of mitochondrial metabolism and homeostasis are emerging as pivotal in driving tumorigenesis. Targeting the metabolic rewiring, as well as affecting the balance between production and scavenging of ROS and NO-derived species, which underpin cancer growth, opens the possibility of finding selective and effective anti-neoplastic approaches, and new compounds affecting metabolic and/or redox adaptation of cancer cells are emerging as promising chemotherapeutic tools. In this Research Topic we have elaborated on all these aspects and provided our contribution to this increasingly growing field of research with new results, opinions and general overviews about the extraordinary plasticity of cancer cells to change metabolism and redox homeostasis in order to overcome the adverse conditions and sustain their “individualistic” behavior under a teleonomic viewpoint.
Redox Regulation And Therapeutic Approaches In Cancer
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Author : Mohinder Pal Bansal
language : en
Publisher: Springer Nature
Release Date :
Redox Regulation And Therapeutic Approaches In Cancer written by Mohinder Pal Bansal and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.
Redox Active Therapeutics
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Author : Ines Batinić-Haberle
language : en
Publisher: Springer
Release Date : 2016-10-13
Redox Active Therapeutics written by Ines Batinić-Haberle and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-10-13 with Science categories.
This essential volume comprehensively discusses redox-active therapeutics, focusing particularly on their molecular design, mechanistic, pharmacological and medicinal aspects. The first section of the book describes the basic aspects of the chemistry and biology of redox-active drugs and includes a brief overview of the redox-based pathways involved in cancer and the medical aspects of redox-active drugs, assuming little in the way of prior knowledge. Subsequent sections and chapters describe more specialized aspects of central nervous system injuries, neurodegenerative diseases, pain, radiation injury and radioprotection (such as of brain, lungs, head and neck and erectile function) and neglected diseases (e.g., leishmaniasis). It encompasses several major classes of redox-active experimental therapeutics, which include porphyrins, salens, nitrones, and most notably metal-containing (e.g., Mn, Fe, Cu, Zn, Sb) drugs as either single compounds or formulations with nanomaterials and quantum dots. Numerous illustrations, tables and figures enhance and complement the text; extensive references to relevant literature are also included. Redox-Active Therapeutics is an invaluable addition to Springer’s Oxidative Stress in Applied Basic Research and Clinical Practice series. It is essential reading for researchers, clinicians and graduate students interested in understanding and exploring the Redoxome—the organism redox network—as an emerging frontier in drug design, redox biology and medicine.
Targeting Redox Regulation And Autophagy Systems For Cancer Therapy
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Author : Junmin Zhang
language : en
Publisher: Frontiers Media SA
Release Date : 2023-03-03
Targeting Redox Regulation And Autophagy Systems For Cancer Therapy written by Junmin Zhang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-03-03 with Medical categories.
Oxidative Stress In Cancer Aids And Neurodegenerative Diseases
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Author : Luc Montagnier
language : en
Publisher: CRC Press
Release Date : 1997-10-06
Oxidative Stress In Cancer Aids And Neurodegenerative Diseases written by Luc Montagnier and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-10-06 with Medical categories.
Based on a conference on Oxidative Stress and Redox Regulation, held at the Pasteur Institute, Paris, this work examines fundamental, chemical, biological and medical studies of free radicals on different targets and the consequences of their reactivity. It covers the chemistry and biochemistry of free radicals, free radicals as second messengers that group the activation of transcription factors and enzymes, the importance of the antioxidant system in cell metabolism regulation, and the role of free radicals and antioxidants in disease management. The editors of this work are three of the most respected pioneers in the field. Dr. Montagnier is credited as the discoverer of HIV.
Redox Regulation Of Differentiation And De Differentiation
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Author : Carsten Berndt
language : en
Publisher: CRC Press
Release Date : 2021-08-26
Redox Regulation Of Differentiation And De Differentiation written by Carsten Berndt and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-08-26 with Science categories.
Cell differentiation and the development of multicellular organisms are processes of self-assembly, controlled and driven by signaling molecules and cascades including redox regulation. These reactions may have provided the energy for the first metabolic steps in the evolution of life. Today, redox modifications are established as important regulatory events in cellular functions including differentiation and development. Redox modifications of single cysteines regulate differentiation of stem cells, formation of functioning organs, and de-differentiation such as formation of cancer cells. Current cancer therapy is based on redox events as well and regeneration often reactivates developmental pathways. Understanding differentiation and de-differentiation on a molecular level is therefore a prerequisite for the continuing development of new medical therapies. This book summarizes the roles of redox regulation in development by bringing together different concepts and comparing similarities and differences between various cell types and species. An international team of contributors presents several new aspects of redox-regulated differentiation and de-differentiation, including aspects of redox medicine. Key Features Provides the first summary on this important topic Reviews redox-dependent development of model organisms and single organs Highlights the redox-regulated pathways important for differentiation processes Illustrates the potential of redox medicine Combines state-of-the-art knowledge in differentiation/development, aging/longevity, and repair/regeneration Written by leading experts in the field Related Titles Ayyanathan, K., ed. Cancer Cell Signaling: Targeting Signaling Pathways Toward Therapeutic Approaches to Cancer (ISBN 978-1-77188-067-1) Clarke, M. & J. Frampton. Stem Cells: Biology and Application (ISBN 9780-8153-4511-4) Lim, W. & B. Mayer. Cell Signaling: Principles and Mechanisms (ISBN 978-0-8153-4244-1) Wong, E., ed. Autophagy and Signaling (ISBN 978-0-367-65772-7)
Redox And Cancer
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Author : Danyelle M. Townsend
language : en
Publisher:
Release Date : 2014
Redox And Cancer written by Danyelle M. Townsend and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with categories.
Oxidative Stress Mechanisms And Their Modulation
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Author : Mohinder Bansal
language : en
Publisher: Springer
Release Date : 2014-10-17
Oxidative Stress Mechanisms And Their Modulation written by Mohinder Bansal and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-10-17 with Science categories.
Research over the years has demonstrated that free radicals mediated oxidative stress lies at the helm of almost all patho-physiological phenomena. These findings emphasize on the need to understand the underlying molecular mechanism(s) and their critical role in the pathogenesis. This book aims to focus on these areas to provide readers a comprehensive outlook about the major redox sensitive pathways and networks involved in various disease conditions. In the first chapter of the book, basic information about the oxidative stress, its generation, its biomarkers and its role in body are discussed. In the next three chapters, the role of oxidative stress in various pathologies ranging from neurological disorders, to cardiovascular diseases, cancers, metabolic diseases and ageing have been described. Chapter 5 cumulatively describes the most important molecular signaling pathways that are affected by reactive oxygen species (ROS). These are the mechanisms which are common denominators in various pathological states. In the next part of the book, various antioxidant strategies to target and mitigate ROS have been discussed with details on the mechanisms. Selenium, being the research focus and interest of the authors for years, the role of selenium as an antioxidant as part of selenoproteins has been included in the book. Finally, the book culminates with authors’ perspective on the future of the redox biology field. Throughout the book, efforts have been made to use simplified language and suitable figures for ease to understand the contents. Although the authors have tried to touch on all the different aspects of oxidative stress in detail, the fact that it is a continuously growing field with updates coming every day, there might be some areas which might not be described in depth. This book is designed for students, young scientists to get acquainted with the redox biology. Overall, this book is a reference to understand the redox regulation of cellular signaling pathways involved in pathogenesis.
Oxidative Stress In Cancer Aids And Neurodegenerative Diseases
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Author : Luc Montagnier
language : en
Publisher: CRC Press
Release Date : 1997-10-06
Oxidative Stress In Cancer Aids And Neurodegenerative Diseases written by Luc Montagnier and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-10-06 with Medical categories.
Based on a conference on Oxidative Stress and Redox Regulation, held at the Pasteur Institute, Paris, this work examines fundamental, chemical, biological and medical studies of free radicals on different targets and the consequences of their reactivity. It covers the chemistry and biochemistry of free radicals, free radicals as second messengers that group the activation of transcription factors and enzymes, the importance of the antioxidant system in cell metabolism regulation, and the role of free radicals and antioxidants in disease management. The editors of this work are three of the most respected pioneers in the field. Dr. Montagnier is credited as the discoverer of HIV.