Regulatory Mechanisms Of The Heat Shock Response
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Regulatory Mechanisms Of The Heat Shock Response
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Author : Tianxin (Cynthia) Chen
language : en
Publisher:
Release Date : 2002
Regulatory Mechanisms Of The Heat Shock Response written by Tianxin (Cynthia) Chen and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Heat shock proteins categories.
Identifying Mechanisms Of Regulation And Signal Integration Of The Heat Shock Response
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Author : Brian Douglas Alford
language : en
Publisher:
Release Date : 2020
Identifying Mechanisms Of Regulation And Signal Integration Of The Heat Shock Response written by Brian Douglas Alford and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020 with categories.
The heat shock response (HSR) is the cell's primary response to cytosolic misfolded protein. It is conserved across eukaryotes and is essential for cell survival. How cells detect misfolded protein and modulate their HSR levels is a poorly understood process. Additionally, manipulation of HSR levels has shown significant promise in treating diseases including cancer and neurodegeneration. Many mechanisms have been proposed for how misfolded protein could alter HSR activity. However, these regulatory mechanisms often lack evidence for if or when they are ever employed. Thus, for most proteotoxic stress conditions, if one or more of these proposed mechanisms is used to activate the HSR or if HSR activation occurs through an entirely different mechanism remains unknown. In this dissertation, I describe our work to quantify the contributions of known HSR activation pathways and discover new pathways of activating the HSR. We developed a method to quantify the most prevalent model of HSR regulation: inhibition of the HSR by the Hsp90 chaperone. We found some stressors for which this model can explain much of the HSR activation, and others for which it contributed very little, suggesting alternative mechanisms of HSR activation. Additionally, I describe the development of ReporterSeq, a high throughput screen to identify genes which regulate a reporter gene's expression under multiple conditions in a time-resolved manner. Using ReporterSeq, we measured the effect of full genome knockdowns on HSR activation across 15 stress conditions. From these data, we identified new general and stress-specific genetic regulators of the HSR. Combined, these data give us a more complete idea of the regulatory mechanisms of the HSR and how they are integrated together.
Regulation Of Heat Shock Protein Responses
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Author : Alexzander A A Asea
language : en
Publisher: Springer
Release Date : 2018-05-01
Regulation Of Heat Shock Protein Responses written by Alexzander A A Asea and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-05-01 with Medical categories.
This books provides the most up-to-date reviews on current advances in our understanding of the regulation of heat shock protein responses. Key basic scientists and clinical research laboratories from major universities, academic medical centers and pharmaceutical companies around the world have contributed chapters that review present research activity and importantly project this field into the future. For easy readability, the book is sub divided into four sections, including, Section I - HSP and Stress Responses; Section II - Chaperone Functions of HSP; Section III - HSP in Human Diseases; Section IV - Prognosis & Diagnosis of HSP. The book is a must read for researchers involved in biomedical research, drug discovery and design to improve human health.
Heat Shock
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Author : Bruno Maresca
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Heat Shock written by Bruno Maresca and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
During the last years the heat shock response has been stu- died as a model system to analyze control mechanisms regula- ting the synthesis of heat shock proteins providing impor- tant general insight into the regulation of gene expression. But the major revelation, which has sparked interest from all quarters of biology, is the discovery that heat shock proteins play major roles in an extraordinary variety of normal cellular processes. They are the focus of investiga- tions in many areas of cell biology, including protein traf- ficking, signal transduction, DNS replication, transcrip- tion, protein synthesis, and in the assembly of di- verse protein structures. These aspects are thoroughly trea- ted in the book, as are the implications in immunology, in- fec- tious diseases, chronic degeneration, hyperthermia, and can- cer research.
Heat Shock Proteins And Stress
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Author : Alexzander A. A. Asea
language : en
Publisher: Springer
Release Date : 2018-10-24
Heat Shock Proteins And Stress written by Alexzander A. A. Asea and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-10-24 with Science categories.
The book Heat Shock Proteins and Stress provides the most comprehensive review on contemporary knowledge on the role of HSP in Stress. Using an integrative approach to understanding the regulation of HSP responses, the contributors provide a synopsis of novel mechanisms by which HSP responses are regulated under normal physiological and pathophysiological conditions. Key basic and clinical research laboratories from major universities and academic medical hospitals around the world contribute chapters that review present research activity and importantly project the field into the future. The book is a must read for researchers, postdoctoral fellows and graduate students in the fields of Translational Medicine, Clinical Psychologists, Human Physiology, Zoologists, Botanists, Biotechnology, Molecular Medicine, Infectious Diseases Experts and Pathologists.
Role And Regulatory Mechanisms Of Heat Shock Factor 2
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Author : Johanna Björk
language : en
Publisher:
Release Date : 2011
Role And Regulatory Mechanisms Of Heat Shock Factor 2 written by Johanna Björk and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with Heat categories.
Molecular Aspects Of The Stress Response Chaperones Membranes And Networks
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Author : Peter Csermely
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-08-09
Molecular Aspects Of The Stress Response Chaperones Membranes And Networks written by Peter Csermely and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-08-09 with Science categories.
This book makes a novel synthesis of the molecular aspects of the stress response and long term adaptation processes with the system biology approach of biological networks. Authored by an exciting mixture of top experts and young rising stars, it provides a comprehensive summary of the field and identifies future trends.
Heat Shock Proteins And Whole Body Adaptation To Extreme Environments
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Author : Michael B. Evgen'ev
language : en
Publisher: Springer
Release Date : 2014-10-24
Heat Shock Proteins And Whole Body Adaptation To Extreme Environments written by Michael B. Evgen'ev and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-10-24 with Medical categories.
For many years, the authors have investigated the adaptive role of heat shock proteins (HSPs) in different animals, including the representatives of homothermic and poikilothermic organisms that inhabit regions with contrasting thermal conditions. This book will summarize the data accumulated in the course of these studies and describe the general molecular mechanisms underlying the adaptation of various organisms to aggressive environments. We also concentrate on different evolutionary trends characteristic for HSP systems in the course of adaptation to fluctuating environmental conditions. In addition, we describe the peculiarities in the regulatory regions of heat shock genes necessary for fine tuning of these systems providing the adaptation to adverse conditions. Special emphasis is given to the role of mobile elements in the evolution and functioning of various groups of HSP genes. The book combines the results of field studies and laboratory analysis of stress genes systems.
Heat Shock Factor
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Author : Akira Nakai
language : en
Publisher: Springer
Release Date : 2016-01-06
Heat Shock Factor written by Akira Nakai and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-01-06 with Science categories.
This book presents a large amount of information related to the heat shock response and heat shock factor (HSF), describes core observations about molecular mechanisms and pathophysiological roles, and provides fundamental concepts on the basis of information from diverse aspects. This adaptive response to high temperature or protein misfolding is a fundamental mechanism to maintain the capacity of protein homeostasis, or proteostasis, and is evolutionally conserved among all living organisms, including bacteria and humans, on the earth. Furthermore, physiological and pathological roles of HSF have been extensively studied in fruit fly, worm, and mouse models. It has been revealed that HSF plays roles in development of the brain, reproductive and sensory organs, and in ageing, inflammation, and circadian rhythm. Analysis of the mechanisms have uncovered that HSF exerts a wide range of effects on gene expression and epigenetic status on the whole genome. Moreover, loss or gain of HSF function is also closely related to protein-misfolding diseases including neurodegenerative diseases, psychiatric diseases, heart diseases, and cancers. Therefore, HSF is now thought to be a promising therapeutic target for treatment of these refractory diseases. For undergraduate students, this is a highly understandable source of information on heart shock response and HSF, covering the basis of HSF biology, the physiological role of HSF, and disease associated with HSF function. This book not only serves as a guide to the heat shock response and HSF for students and young researchers in other fields, but also is a cornerstone for future work in the field related to the heat shock response and HSF.
Involvement Of A Redox Mechanism In The Transcriptional Regulation Of The Heat Shock Response In Human Cells
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Author : L. Eric Huang
language : en
Publisher:
Release Date : 1994
Involvement Of A Redox Mechanism In The Transcriptional Regulation Of The Heat Shock Response In Human Cells written by L. Eric Huang and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994 with categories.