Repositioning Reference
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Drug Repositioning
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Author : Michael J. Barratt
language : en
Publisher: John Wiley & Sons
Release Date : 2012-05-29
Drug Repositioning written by Michael J. Barratt and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-05-29 with Medical categories.
The how's and why's of successful drug repositioning Drug repositioning, also known as drug reprofiling or repurposing, has become an increasingly important part of the drug development process. This book examines the business, technical, scientific, and operational challenges and opportunities that drug repositioning offers. Readers will learn how to perform the latest experimental and computational methods that support drug repositioning, and detailed case studies throughout the book demonstrate how these methods fit within the context of a comprehensive drug repositioning strategy. Drug Repositioning is divided into three parts: Part 1, Drug Repositioning: Business Case, Strategies, and Operational Considerations, examines the medical and commercial drivers underpinning the quest to reposition existing drugs, guiding readers through the key strategic, technical, operational, and regulatory decisions needed for successful drug repositioning programs. Part 2, Application of Technology Platforms to Uncover New Indications and Repurpose Existing Drugs, sets forth computational-based strategies, tools, and databases that have been designed for repositioning studies, screening approaches, including combinations of existing drugs, and a look at the development of chemically modified analogs of approved agents. Part 3, Academic and Non-Profit Initiatives & the Role of Alliances in the Drug Repositioning Industry, explores current investigations for repositioning drugs to treat rare and neglected diseases, which are frequently overlooked by for-profit pharmaceutical companies due to their lack of commercial return. The book's appendix provides valuable resources for drug repositioning researchers, including information on drug repositioning and reformulation companies, databases, government resources and organizations, regulatory agencies, and drug repositioning initiatives from academia and non-profits. With this book as their guide, students and pharmaceutical researchers can learn how to use drug repositioning techniques to extend the lifespan and applications of existing drugs as well as maximize the return on investment in drug research and development.
Optimizing Liner Shipping Fleet Repositioning Plans
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Author : Kevin Tierney
language : en
Publisher: Springer
Release Date : 2015-06-16
Optimizing Liner Shipping Fleet Repositioning Plans written by Kevin Tierney and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-06-16 with Business & Economics categories.
This monograph addresses several critical problems to the operations of shipping lines and ports, and provides algorithms and mathematical models for use by shipping lines and port authorities for decision support. One of these problems is the repositioning of container ships in a liner shipping network in order to adjust the network to seasonal shifts in demand or changes in the world economy. We provide the first problem description and mathematical model of repositioning and define the liner shipping fleet repositioning problem (LSFRP). The LSFRP is characterized by chains of interacting activities with a multi-commodity flow over paths defined by the activities chosen. We first model the problem without cargo flows with a variety of well-known optimization techniques, as well as using a novel method called linear temporal optimization planning that combines linear programming with partial-order planning in a branch-and-bound framework. We then model the LSFRP with cargo flows, using several different mathematical models as well as two heuristic approaches. We evaluate our techniques on a real-world dataset that includes a scenario from our industrial collaborator. We show that our approaches scale to the size of problems faced by industry, and are also able to improve the profit on the reference scenario by over US$14 million.
Official Gazette Of The United States Patent And Trademark Office
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Author : United States. Patent and Trademark Office
language : en
Publisher:
Release Date : 1996
Official Gazette Of The United States Patent And Trademark Office written by United States. Patent and Trademark Office and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with Patents categories.
Reference And Information Services
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Author : Melissa A. Wong
language : en
Publisher: Bloomsbury Publishing USA
Release Date : 2020-05-04
Reference And Information Services written by Melissa A. Wong and has been published by Bloomsbury Publishing USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-05-04 with Language Arts & Disciplines categories.
This revised and updated sixth edition of Reference and Information Services continues the book's rich tradition, covering all phases of reference and information services with less emphasis on print and more emphasis on strategies and scenarios. Reference and Information Services is the go-to textbook for MSLIS and i-School courses on reference services and related topics. It is also a helpful handbook for practitioners. Authors include LIS faculty and professionals who have relevant degrees in their areas and who have published extensively on their topics. The first half of the book provides an overview of reference services and techniques for service provision, including the reference interview, ethics, instruction, reader's advisory, and services to diverse populations including children. This part of the book establishes a foundation of knowledge on reference service and frames each topic with ethical and social justice perspectives. The second part of the book offers an overview of the information life cycle and dissemination of information, followed by an in-depth examination of information sources by type—including dictionaries, encyclopedias, indexes, and abstracts—as well as by broad subject areas including government, statistics and data, health, and legal information. This second section introduces the tools and resources that reference professionals use to provide the services described in the first half of the text.
Distributed Large Scale Dimensional Metrology
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Author : Fiorenzo Franceschini
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-06-06
Distributed Large Scale Dimensional Metrology written by Fiorenzo Franceschini and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-06-06 with Technology & Engineering categories.
The field of large-scale dimensional metrology (LSM) deals with objects that have linear dimensions ranging from tens to hundreds of meters. It has recently attracted a great deal of interest in many areas of production, including the automotive, railway, and shipbuilding sectors. Distributed Large-Scale Dimensional Metrology introduces a new paradigm in this field that reverses the classical metrological approach: measuring systems that are portable and can be easily moved around the location of the measured object, which is preferable to moving the object itself. Distributed Large-Scale Dimensional Metrology combines the concepts of distributed systems and large scale metrology at the application level. It focuses on the latest insights and challenges of this new generation of systems from the perspective of the designers and developers. The main topics are: coverage of measuring area, sensors calibration, on-line diagnostics, probe management, and analysis of metrological performance. The general descriptions of each topic are further enriched by specific examples concerning the use of commercially available systems or the development of new prototypes. This will be particularly useful for professional practitioners such as quality engineers, manufacturing and development engineers, and procurement specialists, but Distributed Large-Scale Dimensional Metrology also has a wealth of information for interested academics.
Envisioning The Future Of Reference
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Author : Diane Zabel
language : en
Publisher: Bloomsbury Publishing USA
Release Date : 2020-02-25
Envisioning The Future Of Reference written by Diane Zabel and has been published by Bloomsbury Publishing USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-02-25 with Reference categories.
Offering a broad overview of consequential changes in the landscape of reference services, this guide also provides practical guidance on how to meet the new challenges they present. For the past decade, librarians have been lamenting the demise of reference services. Encouraging recent research shows that reference librarians are actually in more demand than ever; however, nearly everything about reference has changed—from technologies, tools, and techniques to models of service. What are these changes, and how can the profession respond to and prepare for shifting priorities and user needs? In this volume, business librarians Diane Zabel and Lauren Reiter bring together a host of experts to answer these timely questions. Topics range from the education and training of professionals to meeting the needs and wants of employers. Covered are trends in chat reference, research consultations, do-it-yourself reference, tracking trends with user populations, assessment, and data-driven decisions about reference services. Grounded in the principle that, regardless of the evolutions in service, the user remains at the center of reference, this guide offers readers an exciting look at the future of this important public service.
Introducing Research Methodology
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Author : Uwe Flick
language : en
Publisher: SAGE Publications Limited
Release Date : 2025-02-22
Introducing Research Methodology written by Uwe Flick and has been published by SAGE Publications Limited this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-02-22 with Medical categories.
An encyclopedic introduction to research, showing students how to approach each stage of their research project and develop the skills needed to apply methodological concepts.
A Retrospective Comparison Of Two Techniques For Repositioning The Maxilla During Lefort I Surgery
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Author : Richard A. Stanchina
language : en
Publisher:
Release Date : 1990
A Retrospective Comparison Of Two Techniques For Repositioning The Maxilla During Lefort I Surgery written by Richard A. Stanchina and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1990 with Maxilla categories.
Official Gazette Of The United States Patent And Trademark Office
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Author :
language : en
Publisher:
Release Date : 2002
Official Gazette Of The United States Patent And Trademark Office written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Patents categories.
Manufacturing Driving Circular Economy
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Author : Holger Kohl
language : en
Publisher: Springer Nature
Release Date : 2023-05-27
Manufacturing Driving Circular Economy written by Holger Kohl and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-05-27 with Technology & Engineering categories.
This is an open access book. It gathers the proceedings of the 18th Global Conference on Sustainable Manufacturing, held on October 5-7, 2022, as a hybrid event, in/from Berlin, Germany. With a focus on manufacturing advances and practices driving the circular economy, the chapters selected for this book report on sustainable manufacturing technologies for the mobility, energy and construction sector, and for machines and equipments, covering applications of artificial intelligence and industry 4.0. Moreover, they discuss energy-efficient process, waste reuse, and CO2 neutral production, giving a special emphasis to developing sustainable manufacturing in emerging countries. This book offers extensive and timely information for both researchers and professionals in the field of manufacturing and business development.