Retinal Degeneration And Therapy Approaches
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Retinal Degeneration And Therapy Approaches
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Author : Nicolás Cuenca
language : en
Publisher: Frontiers Media SA
Release Date : 2022-04-18
Retinal Degeneration And Therapy Approaches written by Nicolás Cuenca and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-04-18 with Science categories.
Retinal Degenerative Diseases
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Author : Catherine Bowes Rickman
language : en
Publisher: Springer
Release Date : 2015-10-01
Retinal Degenerative Diseases written by Catherine Bowes Rickman and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-10-01 with Medical categories.
Contains the proceedings of the XVI International Symposium on Retinal Degeneration (RD2014), to be held July 13-18, 2014 at the Asilomar Conference Center in Pacific Grove, California. A majority of those who will speak and present posters at the meeting will contribute to this volume. The Symposium addresses the blinding diseases of inherited retinal degenerations, which have no effective treatments and age-related macular degeneration, which has no cures, despite the fact that it is an epidemic among the elderly, with 1 in 3-4 affected by the age of 75. The RD2014 Symposium will focus on the exciting new developments aimed at understanding these diseases and providing therapies for them. The volume will present representative state-of-the-art research in almost all areas of retinal degenerations, ranging from cytopathologic, physiologic, diagnostic and clinical aspects; animal models; mechanisms of cell death; molecular genetics; and developing potential therapeutic measures such as gene therapy and neuroprotective agents for potential pharmaceutical therapy; and several sight restoration approaches, including optogenetics. While advances in these areas of retinal degenerations will be included, several new topics either were in their infancy or did not exist at the time of the last RD Symposium, RD2012. These include many new developments in sight restoration using optogenetics, retinal or RPE cell transplantation, stem cell approaches and visual prosthetic devices. In addition, major advances will be presented in other basic mechanisms in age-related macular degeneration, several new aspects of gene and antioxidant therapy and revolutionary new imaging and functional testing that will have a huge impact on the diagnosis and following the course of retinal degenerations, as well as to provide new quantitative endpoints for clinical trials. The retina is an approachable part of the central nervous system (CNS), and there is a major interest in neuroprotective and gene therapy for CNS diseases and neurodegenerations, in general. It should be noted that with successful and exciting initial clinical trials in neuroprotective and gene therapy, including the restoration of sight in blind children, the retinal degeneration therapies are leading the way towards new therapeutic measures for neurodegenerations of the CNS. Many of the successes recently reported in these areas of retinal degeneration sprang from collaborations established at previous RD Symposia, and many of those will be reported at the RD2014 meeting and included.
Drug Delivery Challenges And Novel Therapeutic Approaches For Retinal Diseases
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Author : Christopher L. Cioffi
language : en
Publisher: Springer Nature
Release Date : 2020-09-23
Drug Delivery Challenges And Novel Therapeutic Approaches For Retinal Diseases written by Christopher L. Cioffi and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-09-23 with Science categories.
This book reviews the current state of ocular drug therapy and future therapeutic opportunities for a wide variety of conditions, including Age-related Macular Degeneration, Diabetic Retinopathy and Macular Edema, Glaucoma, and Inherited Retinal Diseases. Retinal diseases are major contributors to moderate or severe vision impairment in adults aged 50 years and older. The respective patient populations for many of these indications is expected to significantly increase as the world population continues to grow older. An improved understanding of the etiological underpinnings of ocular degenerative diseases over the past decade has significantly bolstered ophthalmic drug discovery. In this volume, contributions from leading experts explore the unique challenges faced for ocular drug discovery and delivery providing the reader with detailed information on ocular pharmacokinetics, in vitro, ex vivo and in vivo models for retinal disease pathology and emerging gene therapy treatments. The book is intended for all researchers and clinicians who wish to increase their knowledge on the latest findings in ocular drug therapy.
Cellular Therapies For Retinal Disease
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Author : Steven D. Schwartz
language : en
Publisher: Springer
Release Date : 2017-06-20
Cellular Therapies For Retinal Disease written by Steven D. Schwartz and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-06-20 with Science categories.
This book familiarizes the reader with the current landscape of cell-based therapies for the treatment of retinal disease, including diseases that affect the choriocapillaris, retinal pigment epithelium, photoreceptors, and retinal ganglion cells. Instead of utilizing a disease-centric approach to the topic, this book—edited by two world-renowned stem cell scientists—focuses on strategies for developing and transplanting the cells. This includes the creation of replacement cells, cell-based neuroprotection, and in vitro disease modeling and testing. The final chapters briefly review parallel approaches that do not directly utilize cellular transplantation. The use of cellular transplantation to treat retinal disease has recently become a viable and exciting therapeutic approach. The visibility of the retina and its laminar cellular architecture render it an ideal organ for the development of surgically delivered cellular therapies. Having an in-depth understanding of the current state of cell therapy for the eye is an essential first step toward utilizing similar approaches in other organs. Ophthalmologists, translational clinician-scientists, stem cell scientists, and researchers interested in eye disease will find Cellular Therapies for Retinal Disease: A Strategic Approach essential reading and it is also suitable for workshops or courses at the undergraduate or Ph.D. level.
Retinal Degeneration
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Author : John Neidhardt
language : en
Publisher:
Release Date : 2010
Retinal Degeneration written by John Neidhardt and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with categories.
Retinal Degeneration
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Author : Bernhard H.F. Weber
language : en
Publisher: Humana Press
Release Date : 2016-08-23
Retinal Degeneration written by Bernhard H.F. Weber and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-08-23 with Science categories.
Over the past decades, knowledge about the cellular and molecular basis underlying the visual process has remarkably increased. In Retinal Degeneration: Methods and Protocols, expert researchers in the field provide a guide of relevant and state-of-the-art methods for studying retinal homeostasis and disease. These include methods and techniques for addressing cell culture systems and animal models of disease, their generation, their phenotypic and molecular characterization as well as their use in therapeutic approaches to the retina. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Retinal Degeneration: Methods and Protocols aids scientists in continuing to study the cutting-edge techniques of retinal cell biology in health and disease.
Cell Based Therapy For Retinal Degenerative Disease
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Author : R.P. Casaroli-Marano
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2014-04-22
Cell Based Therapy For Retinal Degenerative Disease written by R.P. Casaroli-Marano and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-04-22 with Science categories.
In this volume, some of the leading authorities present their exploration of applications of stem cell therapy to the treatment of major causes of blindness, including degenerative diseases and glaucoma. The diagnostic approach to patients, general concepts of cell-based therapy, immunological considerations, approaches to cell delivery (including engineered scaffolds), combined cell and gene therapy, nanomedicine applications to cell therapy and regulatory issues pertaining to manufacture and production are all considered in detail. The book serves as an excellent introduction to a field that is now entering early-stage clinical trials and promises to operate at the leading edge of regenerative medicine. Retina specialists, general ophthalmologists as well as researchers will find here a wealth of information on the translational aspects of cell-based therapies. Further, business executives and students interested in understanding the potential applications of stem cell therapy to retinal degenerative disease and glaucoma will also find this book informative reading.
Age Related Macular Degeneration
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Author : Frank G. Holz
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-08-31
Age Related Macular Degeneration written by Frank G. Holz and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-08-31 with Medical categories.
Age-related macular degeneration is the most common cause for the loss of central vision beyond the age of 50 in industrial nations. Triplication of the number of affected patients is expected over the next 25 years. Especially over the last years the standard of knowledge regarding etiology, risk factors, diagnostics and therapy of this retina illness has substantially grown – this will be covered in this up-to-date multi-authored work. Apart from epidemiologically and genetically identified risk factors both the various pathophysiological aspects including the role of the complement system and clinical manifestations including OCT and angiographic characteristics are clearly represented. Furthermore, the different therapeutic approaches are presented and discussed, including proven procedures such as intravitreal anti-VEGF therapy and seeing-aid systems, in addition to the latest and upcoming methods in the area of pharmacology. The volume is well-illustrated and tables and summaries complete the presentation.
Cell Based Therapy For Degenerative Retinal Disease
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Author : Marco A. Zarbin
language : en
Publisher: Springer
Release Date : 2019-03-01
Cell Based Therapy For Degenerative Retinal Disease written by Marco A. Zarbin and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-03-01 with Science categories.
This book discusses why specific diseases are being targeted for cell-based retinal therapy, what evidence exists that justifies optimism for this approach, and what challenges must be managed in order to bring this technology from the laboratory into routine clinical practice. There are a number of unanswered questions (e.g., surgical approach to cell delivery, management of immune response, optimum cell type to transplant) that very likely are not going to be answered until human trials are undertaken, but there is a certain amount of “de-risking” that can be done with preclinical experimentation. This book is essential reading for scientists, clinicians, and advanced students in stem cell research, cell biology, and ophthalmology.
Retinal Degenerations
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Author : Matthew M. LaVail
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Retinal Degenerations written by Matthew M. LaVail and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
The topics in this volume explore the etiology, cellular mechanisms, epidemiology, genetics, models and potential therapeutic measures for the blinding diseases of retinitis pigmentosa and age-related macular degeneration. Special focus is highlighted in the areas of Mechanisms of Photoreceptor Degeneration and Cell Death (extremely important because very little is known how or why photoreceptors die in these diseases, despite an abundance of genetic information), Age-Related Macular Degeneration (with several novel approaches to its analysis), Usher Syndrome (the most severe form of retinitis pigmentosa, which includes an early or congenital loss of hearing along with blindness), and Gene Therapy. In addition, the section on Basic Science Related to Retinal Degeneration is particularly strong with several laboratories reporting on new discoveries in the area of outer segment phagocytosis, a key component of photoreceptor-retinal pigment epithelial cell interactions in normal and degenerating retinas.