Review Of Epa S Draft Supplemental Guidance For Assessing Cancer Susceptibility From Early Life Exposure To Carcinogens
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Review Of Epa S Draft Supplemental Guidance For Assessing Cancer Susceptibility From Early Life Exposure To Carcinogens
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Author : United States. Environmental Protection Agency. Science Advisory Board. Supplemental Guidance for Assessing Cancer Susceptibility Review Panel
language : en
Publisher:
Release Date : 2004
Review Of Epa S Draft Supplemental Guidance For Assessing Cancer Susceptibility From Early Life Exposure To Carcinogens written by United States. Environmental Protection Agency. Science Advisory Board. Supplemental Guidance for Assessing Cancer Susceptibility Review Panel and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Carcinogenesis categories.
Review Of Epa S Draft Supplemental Guidance For Assessing Cancer Susceptibility From Early Life Exposure To Carcinogens
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Author : U.S. Environmental Protection Agency
language : en
Publisher: BiblioGov
Release Date : 2013-10
Review Of Epa S Draft Supplemental Guidance For Assessing Cancer Susceptibility From Early Life Exposure To Carcinogens written by U.S. Environmental Protection Agency and has been published by BiblioGov this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10 with categories.
Supplemental Guidance For Assessing Susceptibility From Earlylife Exposure To Carcinogens
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Author :
language : en
Publisher: DIANE Publishing
Release Date : 2005
Supplemental Guidance For Assessing Susceptibility From Earlylife Exposure To Carcinogens written by and has been published by DIANE Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with Cancer categories.
Guidelines For Carcinogen Risk Assessment
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Author :
language : en
Publisher: DIANE Publishing
Release Date : 2005
Guidelines For Carcinogen Risk Assessment written by and has been published by DIANE Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with Cancer categories.
Supplemental Guidance For Assessing Susceptibility From Early Life Exposure To Carcinogens
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Author : Hugh A. Barton
language : en
Publisher:
Release Date : 2005
Supplemental Guidance For Assessing Susceptibility From Early Life Exposure To Carcinogens written by Hugh A. Barton and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with Carcinogens categories.
This document focuses on cancer risks from early-life exposure compared with those from exposures occurring later in life.
Framework For Determining A Mutagenic Mode Of Action For Carcinogenicity External Review Draft
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Author :
language : en
Publisher:
Release Date : 2011
Framework For Determining A Mutagenic Mode Of Action For Carcinogenicity External Review Draft written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with Cancer categories.
Review Of The Environmental Protection Agency S Draft Iris Assessment Of Tetrachloroethylene
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Author : National Research Council
language : en
Publisher: National Academies Press
Release Date : 2010-04-18
Review Of The Environmental Protection Agency S Draft Iris Assessment Of Tetrachloroethylene written by National Research Council and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-04-18 with Nature categories.
Tetrachloroethylene is a volatile, chlorinated organic hydrocarbon that is widely used as a solvent in the dry-cleaning and textile-processing industries and as an agent for degreasing metal parts. It is an environmental contaminant that has been detected in the air, groundwater, surface waters, and soil. In June 2008, the U.S. Environmental Protection Agency released its draft Toxicological Review of Tetrachloroethylene (Perchloroethylene) (CAS No. 127-18-4) in Support of Summary Information on the Integrated Risk Information System (IRIS). The draft IRIS assessment provides quantitative estimates of cancer and noncancer effects of exposure to tetrachloreothylene, which will be used to establish airquality and water-quality standards to protect public health and to set cleanup standards for hazardous waste sites. At the request of EPA, the National Research Council conducted an independent scientific review of the draft IRIS assessment of tetrachloroethylene from toxicologic, epidemiologic, and human clinical perspectives. The resulting book evaluates the adequacy of the EPA assessment, the data and methods used for deriving the noncancer values for inhalation and oral exposures and the oral and inhalation cancer unit risks posed by tetrachloroethylene; evaluates whether the key studies underlying the draft IRIS assessment are of requisite quality, reliability, and relevance to support the derivation of the reference values and cancer risks; evaluates whether the uncertainties in EPA's risk assessment were adequately described and, where possible, quantified; and identifies research that could reduce the uncertainty in the current understanding of human health effects associated with tetrachloroethylene exposure.
Review Of The Environmental Protection Agency S Draft Iris Assessment Of Formaldehyde
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Author : National Research Council
language : en
Publisher: National Academies Press
Release Date : 2011-05-31
Review Of The Environmental Protection Agency S Draft Iris Assessment Of Formaldehyde written by National Research Council and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-05-31 with Science categories.
Formaldehyde is ubiquitous in indoor and outdoor air, and everyone is exposed to formaldehyde at some concentration daily. Formaldehyde is used to produce a wide array of products, particularly building materials; it is emitted from many sources, including power plants, cars, gas and wood stoves, and cigarettes; it is a natural product in come foods; and it is naturally present in the human body as a metabolic intermediate. Much research has been conducted on the health effects of exposure to formaldehyde, including effects on the upper airway, where formaldehyde is deposited when inhaled, and effects on tissues distant from the site of initial contact. The U.S. Environmental Protection Agency (EPA) released noncancer and cancer assessments of formaldehyde for its Intergated Risk Information System (IRIS) in 1990 and 1991, respectively. The agency began reassessing formaldehyde in 1998 and released a draft IRIS assessment in June 2010. Given the complexity of the issues and the knowledge that the assessment will be used as the basis of regulatory decisions, EPA asked the National Research Council (NRC) to conduct an independent scientific review of the draft IRIS assessment. In this report, the Committee to Review EPA's Draft IRIS Assessment of Formaldehyde first addresses some general issues associated with the draft IRIS assessment. The committee next focuses on questions concerning specific aspects of the draft assessment, including derivation of the reference concentrations and the cancer unit risk estimates for formaldehyde. The committee closes with recommendations for improving the IRIS assessment of formaldehyde and provides some general comments on the IRIS development process.
Review Of The Environmental Protection Agency S Draft Iris Assessment Of Tetrachloroethylene
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Author : National Research Council
language : en
Publisher: National Academies Press
Release Date : 2010-03-18
Review Of The Environmental Protection Agency S Draft Iris Assessment Of Tetrachloroethylene written by National Research Council and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-03-18 with Nature categories.
Tetrachloroethylene is a volatile, chlorinated organic hydrocarbon that is widely used as a solvent in the dry-cleaning and textile-processing industries and as an agent for degreasing metal parts. It is an environmental contaminant that has been detected in the air, groundwater, surface waters, and soil. In June 2008, the U.S. Environmental Protection Agency released its draft Toxicological Review of Tetrachloroethylene (Perchloroethylene) (CAS No. 127-18-4) in Support of Summary Information on the Integrated Risk Information System (IRIS). The draft IRIS assessment provides quantitative estimates of cancer and noncancer effects of exposure to tetrachloreothylene, which will be used to establish airquality and water-quality standards to protect public health and to set cleanup standards for hazardous waste sites. At the request of EPA, the National Research Council conducted an independent scientific review of the draft IRIS assessment of tetrachloroethylene from toxicologic, epidemiologic, and human clinical perspectives. The resulting book evaluates the adequacy of the EPA assessment, the data and methods used for deriving the noncancer values for inhalation and oral exposures and the oral and inhalation cancer unit risks posed by tetrachloroethylene; evaluates whether the key studies underlying the draft IRIS assessment are of requisite quality, reliability, and relevance to support the derivation of the reference values and cancer risks; evaluates whether the uncertainties in EPA's risk assessment were adequately described and, where possible, quantified; and identifies research that could reduce the uncertainty in the current understanding of human health effects associated with tetrachloroethylene exposure.
Science And Decisions
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Author : National Research Council
language : en
Publisher: National Academies Press
Release Date : 2009-03-24
Science And Decisions written by National Research Council and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-03-24 with Political Science categories.
Risk assessment has become a dominant public policy tool for making choices, based on limited resources, to protect public health and the environment. It has been instrumental to the mission of the U.S. Environmental Protection Agency (EPA) as well as other federal agencies in evaluating public health concerns, informing regulatory and technological decisions, prioritizing research needs and funding, and in developing approaches for cost-benefit analysis. However, risk assessment is at a crossroads. Despite advances in the field, risk assessment faces a number of significant challenges including lengthy delays in making complex decisions; lack of data leading to significant uncertainty in risk assessments; and many chemicals in the marketplace that have not been evaluated and emerging agents requiring assessment. Science and Decisions makes practical scientific and technical recommendations to address these challenges. This book is a complement to the widely used 1983 National Academies book, Risk Assessment in the Federal Government (also known as the Red Book). The earlier book established a framework for the concepts and conduct of risk assessment that has been adopted by numerous expert committees, regulatory agencies, and public health institutions. The new book embeds these concepts within a broader framework for risk-based decision-making. Together, these are essential references for those working in the regulatory and public health fields.