Searching For Longevity Determinants
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Searching For Longevity Determinants
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Author : Luisa Salaris
language : en
Publisher:
Release Date : 2010
Searching For Longevity Determinants written by Luisa Salaris and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Longevity categories.
Search For Genetic Determinants Of Aging And Longevity
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Author : Arie Budovsky
language : en
Publisher:
Release Date : 2009
Search For Genetic Determinants Of Aging And Longevity written by Arie Budovsky and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with Aging categories.
Searching For Longevity Determinants
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Author : Luisa Salaris
language : en
Publisher: Presses univ. de Louvain
Release Date : 2009
Searching For Longevity Determinants written by Luisa Salaris and has been published by Presses univ. de Louvain this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with Business & Economics categories.
The scientific debate on longevity and its determinants is lively and involves researchers from different some people live longer than others is not an easy task. Variables that are shown to be significant for longer survival in certain populations are not always relevant to individuals of other populations. Recently, researchers have identified in Sardinia the Blue Zone (BZ), thus denominated due to the significant number of cases of centenarians recorded as well as a low sex ratio value. A village located in this area was selected for the carrying out of a more detailed analysis at individual level and socio-demographic determinants of longevity were examined. A family reconstructed database was created using a multi-source approach. Historical data was therefore used to study today's population, establishing a unique bridge between historical demography and the current level of longevity. The study focused on survival of newborns in the selected village during a period of 50 years – from 1866 to 1915 – and also took into consideration information on related family members. Each individual included in the database was followed from birth to death, as he/she went through marriage and family formation. Complete survival of all newborns was observed until the present. Based on careful review of the existing literature, the empirical model considered factors such as sex differential, the contribution of familial transmission both in terms of genes, biological, and shared environment, and the role played by environment operationalised considering early-life conditions. Concepts were organized into a life-course approach for survival analysis. The analysis of the data enabled to the estimation of mortality trajectories, which in turn confirmed the exceptional longevity of the population understudy and in particular of males. The investigation of differential survival among members of the same community brought to light the relevance of certain familial variables on survival, which are not exclusively genetic. The results achieved open the way to further studies.
Genetic Determinants Of Human Longevity
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Author : Giuseppina Rose
language : en
Publisher: MDPI
Release Date : 2019-10-28
Genetic Determinants Of Human Longevity written by Giuseppina Rose and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-10-28 with Science categories.
In the last two decades, due to the continuous increase of lifespans in Western societies, and the consequent growing of the elderly population, have witnessed an increase in the number of studies on biological and molecular factors able to promote healthy aging and reach longevity. The study of the genetic component of human longevity demonstrated that it accounts for 25% of intra population phenotype variance. The efforts made to characterize the genetic determinants suggested that the maintenance of cellular integrity, inflammation, oxidative stress response, DNA repair, as well as the use of nutrients, represent the most important pathways correlated with a longer lifespan. However, although a plethora of variants were indicated to be associated with human longevity, only very few were successfully replicated in different populations, probably because of population specificity, missing heritability as well as a complex interaction among genetic factors with lifestyle and cultural factors, which modulate the individual chance of living longer. Thus, many challenges remain to be addressed in the search for the genetic components of human longevity. This Special Issue is aimed to unify the progress in the analysis of the genetic determinants of human longevity, to take stock of the situation and point to future directions of the field. We invite submissions for reviews, research articles, short-communications dealing with genetic association studies in human longevity, including all types of genetic variation, as well as the characterization of longevity-related genes.
Health And Inequality
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Author : Owen O'Donnell
language : en
Publisher: Emerald Group Publishing
Release Date : 2013-12-12
Health And Inequality written by Owen O'Donnell and has been published by Emerald Group Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-12-12 with Business & Economics categories.
This volume contains methodological and empirical research on the measurement and causes of health inequality from leading experts in health economics and economic inequality. It is essential reading for researchers working on health inequality and provides an immediate reconnaissance of the frontiers for those entering this exciting field.
Human Longevity The Major Determining Factors
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Author : Joseph A. Knight M.D.
language : en
Publisher: Author House
Release Date : 2010-12-09
Human Longevity The Major Determining Factors written by Joseph A. Knight M.D. and has been published by Author House this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-12-09 with Health & Fitness categories.
Two thousand years ago, the average life expectancy from birth to death of a Roman citizen, an individual better off than most people at that time, was about 22 years (wars, infectious diseases, trauma, etc.). This progressively increased to about 47 years in the U.S. and most European countries by 1900. Today, the average life expectancy in the U.S. is 78 years (women about five years more than men). However, unless the obesity pandemic is reversed and lifestyles improved, the average life expectancy will likely decrease significantly. conversely, if our lifestyles improve, the average life expectancy could reach 85 or more years. Growing older does not necessarily mean growing sicker. Thus, "don't just add years to your life, add life to your years" (Hans Selve). Indeed, of the 15 major causes of death in the U.S., 65-70% are lifestyle-related. In this book, the following documented topics that are associated with diseases and mortality are discussed in detail: theories of aging; diseases and mortality associated with obesity, physical inactivity and poor nutrition; psychological stress (anxiety, depression); addiction (alcohol, tobacco, drugs); violence (suicide, homicide); food-borne and infectious diseases (viral, bacterial, parasitic); and various other conditions (air pollution, asbestosis, trace metals).
Genetic Determinants Of Human Longevity
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Author : Serena Dato
language : en
Publisher:
Release Date : 2019
Genetic Determinants Of Human Longevity written by Serena Dato and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with Electronic books categories.
In the last two decades, due to the continuous increase of lifespans in Westernsocieties, and the consequent growing of the elderly population, have witnessedan increase in the number of studies on biological and molecular factors able topromote healthy aging and reach longevity. The study of the genetic componentof human longevity demonstrated that it accounts for 25% of intra populationphenotype variance. The efforts made to characterize the genetic determinantssuggested that the maintenance of cellular integrity, inflammation, oxidativestress response, DNA repair, as well as the use of nutrients, represent the mostimportant pathways correlated with a longer lifespan. However, although aplethora of variants were indicated to be associated with human longevity, onlyvery few were successfully replicated in different populations, probably becauseof population specificity, missing heritability as well as a complex interactionamong genetic factors with lifestyle and cultural factors, which modulate theindividual chance of living longer. Thus, many challenges remain to be addressedin the search for the genetic components of human longevity. This Special Issue isaimed to unify the progress in the analysis of the genetic determinants of humanlongevity, to take stock of the situation and point to future directions of the field.We invite submissions for reviews, research articles, short-communicationsdealing with genetic association studies in human longevity, including all types ofgenetic variation, as well as the characterization of longevity-related genes.
Longevity
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Author : James R. Carey
language : en
Publisher: Princeton University Press
Release Date : 2003-03-02
Longevity written by James R. Carey and has been published by Princeton University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-03-02 with Family & Relationships categories.
Despite our deep interest in mortality, little is known about why some individuals live to middle age and others to extreme old age. Life span, mortality, and aging present some of the most profound mysteries in biology. In Longevity, James Carey draws on unprecedented data to develop a biological and demographic framework for identifying the key factors that govern aging, life span, and mortality in humans and other animals. Carey presents the results of a monumental, twelve-year, National Institute on Aging-funded research project on the determinants of longevity using data from the life tables of five million Mediterranean fruit flies, the most comprehensive set of life table studies ever on the mortality dynamics of a single species. He interprets the fruit fly data within the context of human aging and the aging process in general to identify the determinants of mortality. Three key themes emerge: the absence of species-specific life span limits, the context-specific nature of the mortality rate, and biodemographic linkages between longevity and reproduction. A powerful foundation for the emerging field of biodemography and a rich framework for considering the future of human life span, Longevity will be an indispensable resource for readers from a range of fields including population biology, demography, gerontology, ecology, evolutionary biology, and medical research.
Ageing Health And Productivity
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Author : Pietro Garibaldi
language : en
Publisher: OUP Oxford
Release Date : 2010-11-26
Ageing Health And Productivity written by Pietro Garibaldi and has been published by OUP Oxford this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-11-26 with Business & Economics categories.
Increase in life expectancy is arguably the most remarkable by-product of modern economic growth. In the last 30 years we have gained roughly 2.5 years of longevity every decade, both in Europe and the United States. Successfully managing ageing and longevity over the next twenty years is one of the major structural challenges faced by policy makers in advanced economies, particularly in health spending, social security administration, and labour market institutions. This book looks closely into those challenges and identifies the fundamental issues at both the macroeconomic and microeconomic level. The first half of the book studies the macroeconomic relationships between health spending, technological progress in medical related sectors, economic growth, and welfare state reforms. In the popular press, longevity and population ageing are typically perceived as a tremendous burden. However, with a proper set of reforms, advanced economies have the option of transforming the enormous challenge posed by longevity into a long term opportunity to boost aggregate outcomes. The basic prerequisite of a healthy ageing scenario is a substantial structural reform in social security and in labour market institutions. The second part of the book looks closely into the microeconomic relationship between population ageing and productivity, both at the individual and at the firm level. There is surprisingly little research on such key questions. The book contributes to this debate in two ways. It presents a detailed analysis of the determinants of productivity, with a focus on both the long-run historical evolution and the cross sectional changes. It also uses econometric analysis to look into the determinants of the various dimensions of individual productivity. The volume concludes that the complex relationship between population ageing and longevity is not written in stone, and can be modified by properly designed choices.
Healthy Longevity In China
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Author : Yi Zeng
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-01-10
Healthy Longevity In China written by Yi Zeng and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-01-10 with Social Science categories.
Key research in the world’s largest aging population – in China – has fed into this important new work, which aims to answer questions critical to older people worldwide. These include: is the period of disability compressing or expanding with increasing life expectancy and what factors are associated with these trends in the recent decades? And is it possible to realize morbidity compression with a prolongation of the life span in the future? Essential reading for gerontologists.