Segredos De Um Rep Rter

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Translational Medicine

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Author : Joy A. Cavagnaro
language : en
Publisher: CRC Press
Release Date : 2021-11-26

Translational Medicine written by Joy A. Cavagnaro and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-26 with Medical categories.

Translational Medicine: Optimizing Preclinical Safety Evaluation of Biopharmaceuticals provides scientists responsible for the translation of novel biopharmaceuticals into clinical trials with a better understanding of how to navigate the obstacles that keep innovative medical research discoveries from becoming new therapies or even making it to clinical trials. The book includes sections on protein-based therapeutics, modified proteins, oligonucleotide-based therapies, monoclonal antibodies, antibody–drug conjugates, gene and cell-based therapies, gene-modified cell-based therapies, combination products, and therapeutic vaccines. Best practices are defined for efficient discovery research to facilitate a science-based, efficient, and predictive preclinical development program to ensure clinical efficacy and safety. Key Features: Defines best practices for leveraging of discovery research to facilitate a development program Includes general principles, animal models, biomarkers, preclinical toxicology testing paradigms, and practical applications Discusses rare diseases Discusses "What-Why-When-How" highlighting different considerations based upon product attributes. Includes special considerations for rare diseases About the Editors Joy A. Cavagnaro is an internationally recognized expert in preclinical development and regulatory strategy with an emphasis on genetic medicines.. Her 40-year career spans academia, government (FDA), and the CRO and biotech industries. She was awarded the 2019 Arnold J Lehman Award from the Society of Toxicology for introducing the concept of science-based, case-by-case approach to preclinical safety evaluation, which became the foundation of ICH S6. She currently serves on scientific advisory boards for advocacy groups and companies and consults and lectures in the area of preclinical development of novel therapies. Mary Ellen Cosenza is a regulatory toxicology consultant with over 30 years of senior leadership experience in the biopharmaceutical industry in the U.S., Europe, and emerging markets. She has held leadership position in both the American College of Toxicology (ACT) and the International Union of Toxicology (IUTOX) and is also an adjunct assistant professor at the University of Southern California where she teaches graduate-level courses in toxicology and regulation of biologics.

Reptile Biodiversity

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Author : Roy W. McDiarmid
language : en
Publisher: Univ of California Press
Release Date : 2012-01-10

Reptile Biodiversity written by Roy W. McDiarmid and has been published by Univ of California Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-01-10 with Nature categories.

“Authoritative and comprehensive—provides an up-to-date description of the tool box of methods for inventorying and monitoring the diverse spectrum of reptiles. All biodiversity scientists will want to have it during project planning and as study progresses. A must for field biologists, conservation planners, and biodiversity managers.”—Jay M. Savage, San Diego State University “Kudos to the editors and contributors to this book. From the perspective of a non-ecologist such as myself, who only occasionally needs to intensively sample a particular site or habitat, the quality and clarity of this book has been well worth the wait.”—Jack W. Sites, Jr.

Stand Up Comedy

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Author : Judy Carter
language : en
Publisher: Dell
Release Date : 2010-03-03

Stand Up Comedy written by Judy Carter and has been published by Dell this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-03-03 with Performing Arts categories.

If you think you’re funny, buy this book! Whether you dream of becoming a star . . . A better public speaker . . . A more effective communicator . . . A funnier, happier human being . . . You can learn to leave ‘em laughing! David Letterman learned to do it. Jay Leno learned to do it. Roseanne Barr learned to do it. So can you! Now successful stand-up comic Judy Carter—who went from teaching high school to performing in Las Vegas, Atlantic City, Lake Tahoe, and on over 45 major TV shows—gives you the same hands-on, step-by-step instruction she’s taught to students in her comedy workshops. She shows you how to do it: create an act, perform it, make money with it, or apply it to everyday life. Discover: • The formulas for creating comedy material • How to find your own style • The three steps to putting your act together • Rehearsal do’s and don’ts • What to do if you bomb • Ways to punch up your everyday life with humor

Peace And War

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Author : Raymond Aron
language : en
Publisher: Transaction Publishers
Release Date : 2003

Peace And War written by Raymond Aron and has been published by Transaction Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with Political Science categories.

Peace and War by Raymond Aron is one of the greatest books ever written on international relations. Aron's starting point is the state of nature that exists between nations, a condition that differs essentially from the civil state that holds within political communities. Ever keeping this brute fact about the life of nations in mind and ranging widely over political history and many disciplines, Aron develops the essential analytical tools to enable us to think clearly about the stakes and possibilities of international relations. In his first section, “Theory,” Aron shows that, while international relations can be mapped, and probabilities discerned, no closed, global “science” of international relations is anything more than a mirage. In the second part, “Sociology,” Aron studies the many ways various subpolitical forces influence foreign policy. He emphasizes that no rigorous determinism is at work: politics—and thus the need for prudent statesmanship—are inescapable in international relations. In part three, “History,” Aron offers a magisterial survey of the twentieth century. He looks at key developments that have had an impact on foreign policy and the emergence of what he calls “universal history,” which brings far-flung peoples into regular contact for the first time. In a final section, “Praxeology,” Aron articulates a normative theory of international relations that rejects both the bleak vision of the Machiavellians, who hold that any means are legitimate, and the naiveté of the idealists, who think foreign policy can be overcome. This new edition of Peace and War includes an informative introduction by Daniel J. Mahoney and Brian C. Anderson, situating Aron's thought in a new post-Cold War context, and evaluating his contribution to the study of politics and international relations.

Asylums

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Author : Erving Goffman
language : en
Publisher: Routledge
Release Date : 2017-09-08

Asylums written by Erving Goffman and has been published by Routledge this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-09-08 with Social Science categories.

A total institution is defined by Goffman as a place of residence and work where a large number of like-situated, individuals, cut off from the wider society for an appreciable period of time, together lead an enclosed, formally administered round of life. Prisons serve as a clear example, providing we appreciate that what is prison-like about prisons is found in institutions whose members have broken no laws. This volume deals with total institutions in general and, mental hospitals, in particular. The main focus is, on the world of the inmate, not the world of the staff. A chief concern is to develop a sociological version of the structure of the self. Each of the essays in this book were intended to focus on the same issue--the inmate's situation in an institutional context. Each chapter approaches the central issue from a different vantage point, each introduction drawing upon a different source in sociology and having little direct relation to the other chapters. This method of presenting material may be irksome, but it allows the reader to pursue the main theme of each paper analytically and comparatively past the point that would be allowable in chapters of an integrated book. If sociological concepts are to be treated with affection, each must be traced back to where it best applies, followed from there wherever it seems to lead, and pressed to disclose the rest of its family.

Big Farms Make Big Flu

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Author : Rob Wallace
language : en
Publisher: NYU Press
Release Date : 2016-06-30

Big Farms Make Big Flu written by Rob Wallace and has been published by NYU Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-06-30 with Social Science categories.

The first collection to explore infectious disease, agriculture, economics, and the nature of science together Thanks to breakthroughs in production and food science, agribusiness has been able to devise new ways to grow more food and get it more places more quickly. There is no shortage of news items on hundreds of thousands of hybrid poultry—each animal genetically identical to the next—packed together in megabarns, grown out in a matter of months, then slaughtered, processed and shipped to the other side of the globe. Less well known are the deadly pathogens mutating in, and emerging out of, these specialized agro-environments. In fact, many of the most dangerous new diseases in humans can be traced back to such food systems, among them Campylobacter, Nipah virus, Q fever, hepatitis E, and a variety of novel influenza variants. Agribusiness has known for decades that packing thousands of birds or livestock together results in a monoculture that selects for such disease. But market economics doesn't punish the companies for growing Big Flu—it punishes animals, the environment, consumers, and contract farmers. Alongside growing profits, diseases are permitted to emerge, evolve, and spread with little check. “That is,” writes evolutionary biologist Rob Wallace, “it pays to produce a pathogen that could kill a billion people.” In Big Farms Make Big Flu, a collection of dispatches by turns harrowing and thought-provoking, Wallace tracks the ways influenza and other pathogens emerge from an agriculture controlled by multinational corporations. Wallace details, with a precise and radical wit, the latest in the science of agricultural epidemiology, while at the same time juxtaposing ghastly phenomena such as attempts at producing featherless chickens, microbial time travel, and neoliberal Ebola. Wallace also offers sensible alternatives to lethal agribusiness. Some, such as farming cooperatives, integrated pathogen management, and mixed crop-livestock systems, are already in practice off the agribusiness grid. While many books cover facets of food or outbreaks, Wallace's collection appears the first to explore infectious disease, agriculture, economics and the nature of science together. Big Farms Make Big Flu integrates the political economies of disease and science to derive a new understanding of the evolution of infections. Highly capitalized agriculture may be farming pathogens as much as chickens or corn.

The Lacanian Subject

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Author : Bruce Fink
language : en
Publisher: Princeton University Press
Release Date : 1995

The Lacanian Subject written by Bruce Fink and has been published by Princeton University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995 with Literary Criticism categories.

Lacanian psychoanalyst Bruce Fink lucidly guides readers through the labyrinth of Lacanian theory to provide the most penetrating view of Lacan's work to date. Revealing in-depth knowledge of Lacan's theoretical and clinical work, Fink shines a light on Lacan's controversial notions about the Other, object a, the unconscious as structured like a language, alienation and separation, the paternal metaphor, jouissance, and sexual difference.

Design

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Author : Bernhard E. Bürdek
language : de
Publisher: Birkhäuser
Release Date : 2015-08-31

Design written by Bernhard E. Bürdek and has been published by Birkhäuser this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-08-31 with Architecture categories.

For students of design, professional product designers, and anyone interested in design equally indispensable: the fully revised and updated edition of the reference work on product design. The book traces the history of product design and its current developments, and presents the most important principles of design theory and methodology, looking in particular at the communicative function of products and highlighting aspects such as corporate and service design, design management, strategic design, interface/interaction design and human design.. From the content: Design and history: The Bauhaus; The Ulm School of Design; The Example of Braun; The Art of Design Design and Globalization Design and Methodology: Epistemological Methods in Design Design and Theory: Aspects of the Disciplinary Design Theory Design and its Context: From Corporate Design to Service Design Product Language and Product Semiotics Architecture and Design Design and Society Design and Technological Progress

Preclinical Safety Evaluation Of Biopharmaceuticals

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Author : Joy A. Cavagnaro
language : en
Publisher: John Wiley & Sons
Release Date : 2013-03-07

Preclinical Safety Evaluation Of Biopharmaceuticals written by Joy A. Cavagnaro and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-07 with Medical categories.

"The goal is to provide a comprehensive reference book for the preclinicaldiscovery and development scientist whose responsibilities span target identification, lead candidate selection, pharmacokinetics, pharmacology, and toxicology, and for regulatory scientists whose responsibilities include the evaluation of novel therapies." —From the Afterword by Anthony D. Dayan Proper preclinical safety evaluation can improve the predictive value, lessen the time and cost of launching new biopharmaceuticals, and speed potentially lifesaving drugs to market. This guide covers topics ranging from lead candidate selection to establishing proof of concept and toxicity testing to the selection of the first human doses. With chapters contributed by experts in their specific areas, Preclinical Safety Evaluation of Biopharmaceuticals: A Science-Based Approach to Facilitating Clinical Trials: Includes an overview of biopharmaceuticals with information on regulation and methods of production Discusses the principles of ICH S6 and their implementation in the U.S., Europe, and Japan Covers current practices in preclinical development and includes a comparison of safety assessments for small molecules with those for biopharmaceuticals Addresses all aspects of the preclinical evaluation process, including: the selection of relevant species; safety/toxicity endpoints; specific considerations based upon class; and practical considerations in the design, implementation, and analysis of biopharmaceuticals Covers transitioning from preclinical development to clinical trials This is a hands-on, straightforward reference for professionals involved in preclinical drug development, including scientists, toxicologists, project managers, consultants, and regulatory personnel.

A History Of Ancient Philosophy Iv

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Author : Giovanni Reale
language : en
Publisher: State University of New York Press
Release Date : 1989-12-21

A History Of Ancient Philosophy Iv written by Giovanni Reale and has been published by State University of New York Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1989-12-21 with Philosophy categories.

This book covers the first 500 years of the common era. These years witnessed the revivals of Aristotelianism, Epicureanism, Pyrrhonism, Cynicism, and Pythagoreanism; but by far the most important movement was the revival of Platonism under Plotinus. Here, the historical context of Plotinus is provided including the currents of thought that preceded him and opened the path for him. The presuppositions of the Enneads are made explicit and the thought of Plotinus is reconstructed. The author reorients the expositions of Middle Platonism and neo-Pythagoreanism. He provides a full exposition of Hermeticism and the doctrines of the Chaldean Oracles. He also defends the notion that Philo of Alexandria nourished a Jewish philosophy, not an eclectic mixture.