Sensory Hair Cells
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Sensory Hair Cell Death And Regeneration
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Author : Michael E. Smith
language : en
Publisher: Frontiers Media SA
Release Date : 2016-12-13
Sensory Hair Cell Death And Regeneration written by Michael E. Smith and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-12-13 with Neurosciences. Biological psychiatry. Neuropsychiatry categories.
Sensory hair cells are the specialized mechanosensory receptors found in vertebrate auditory, vestibular, and lateral line organs that transduce vibratory and acoustic stimuli into the sensations of hearing and balance. Hair cells can be damaged due to such factors as aging, ototoxic chemicals, acoustic trauma, infection, or genetic factors. Loss of these hair cells lead to deficits in hearing and balance, and in mammals, such deficits are permanent. In contrast, non-mammalian vertebrates exhibit the capability to regenerate missing hair cells. Researchers have been examining the process of hair cell death and regeneration in animal models in an attempt to find ways of either preventing hair cell loss or stimulating the production of new hair cells in mammals, with the ultimate goal of finding new therapeutics for human sensorineural hearing and balance deficits. This has led to a wide array of research on sensory hair cells- such as understanding the factors that cause hair cell loss and finding agents that protect them from damage, elucidating the cell signaling pathways activated during hair cell death, examining the genes and cellular pathways that are regulated during the process of hair cell death and regeneration, and characterizing the functional sensory loss and recovery following acoustic or ototoxic insults to the inner ear. This research has involved cell and developmental biologists, physiologists, geneticists, bioinformaticians, and otolaryngologists. In this Research Topic, we have collated reviews of the past progress of hair cell death and regeneration studies and original research articles advancing sensory hair cell death and regeneration research into the future.
Sensory Hair Cell Death And Regeneration
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Author :
language : en
Publisher:
Release Date : 2016
Sensory Hair Cell Death And Regeneration written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with categories.
Sensory hair cells are the specialized mechanosensory receptors found in vertebrate auditory, vestibular, and lateral line organs that transduce vibratory and acoustic stimuli into the sensations of hearing and balance. Hair cells can be damaged due to such factors as aging, ototoxic chemicals, acoustic trauma, infection, or genetic factors. Loss of these hair cells lead to deficits in hearing and balance, and in mammals, such deficits are permanent. In contrast, non-mammalian vertebrates exhibit the capability to regenerate missing hair cells. Researchers have been examining the process of hair cell death and regeneration in animal models in an attempt to find ways of either preventing hair cell loss or stimulating the production of new hair cells in mammals, with the ultimate goal of finding new therapeutics for human sensorineural hearing and balance deficits. This has led to a wide array of research on sensory hair cells- such as understanding the factors that cause hair cell loss and finding agents that protect them from damage, elucidating the cell signaling pathways activated during hair cell death, examining the genes and cellular pathways that are regulated during the process of hair cell death and regeneration, and characterizing the functional sensory loss and recovery following acoustic or ototoxic insults to the inner ear. This research has involved cell and developmental biologists, physiologists, geneticists, bioinformaticians, and otolaryngologists. In this Research Topic, we have collated reviews of the past progress of hair cell death and regeneration studies and original research articles advancing sensory hair cell death and regeneration research into the future.
Sensory Hair Cells
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Author : Georgiĭ Nikolaevich Akoev
language : en
Publisher:
Release Date : 1993
Sensory Hair Cells written by Georgiĭ Nikolaevich Akoev and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993 with Medical categories.
Hair Cell Regeneration Repair And Protection
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Author : Richard J. Salvi
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-03-15
Hair Cell Regeneration Repair And Protection written by Richard J. Salvi and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-03-15 with Science categories.
Not male pattern baldness, but the loss of sensory hair, is a very serious topic. Sensory hair cells convert sound and motion into our sense of hearing, movement, and head position. In mammals, the loss of hair cells is irreversible. Or is it? Hair cells in other vertebrates are capable of regenerating and recovering partial or complete function. This book provides a comprehensive survey of the regeneration of sensory hair cells.
Sensory Hair Cells
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Author : Georgij N. Akoev
language : en
Publisher: Springer
Release Date : 1993-07-27
Sensory Hair Cells written by Georgij N. Akoev and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993-07-27 with Medical categories.
The acousticolateral system plays an important role in the biological activity of vertebrates. It includes the organ of Corty, the vestibular and otolith apparatus, lateral-line organs and electroreceptors. Throughout the acousticolateral system, the sensory receptors are hair cells. Provided here is a comprehensive overview of current research on synaptic transmission in sensory hair cells. Morphological characteristics are presented and data on the properties and selectivity of various ionic channels are given. The mechanisms of neurotransmiter release from hair cells and the postsynaptic responses of afferent fibres are described and the role of excitatory amino acids is analyzed.
Biophysics Of Hair Cell Sensory Systems Proceedings Of The International Symposium
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Author : H Duifhuis
language : en
Publisher: World Scientific
Release Date : 1993-11-30
Biophysics Of Hair Cell Sensory Systems Proceedings Of The International Symposium written by H Duifhuis and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993-11-30 with categories.
The last decade revealed to auditory researchers that hair cells can not only detect and process mechanical energy, but are also able to produce it. Thanks to the active hair cell, ears can produce otoacoustic emissions. This book gives the newest insights into the biophysics and physiology of individual hair cells and integral hair cell systems such as the inner ear and the lateral line organ.
Differentiation Of Sensory Hair Cells In The Vertebrate Inner Ear
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Author : Pamela J. Lanford
language : en
Publisher:
Release Date : 1997
Differentiation Of Sensory Hair Cells In The Vertebrate Inner Ear written by Pamela J. Lanford and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with Hair cells categories.
On The Physiology Of The Sensory Hair Cells In The Lateral Line
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Author : Alfonsus Bernardus Antonius Kroese
language : en
Publisher:
Release Date : 19??
On The Physiology Of The Sensory Hair Cells In The Lateral Line written by Alfonsus Bernardus Antonius Kroese and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 19?? with categories.
Hair Cell Regeneration
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Author : Mark E. Warchol
language : en
Publisher: Springer Nature
Release Date : 2023-04-27
Hair Cell Regeneration written by Mark E. Warchol and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-04-27 with Medical categories.
This volume provides a detailed update on progress in the field of hair cell regeneration. This topic is of considerable interest to academicians, clinicians, and commercial entities, including students of auditory and vestibular neuroscience, audiologists, otologists, and industry, all of whom may have interest in hair cell regeneration as a potential future therapy for hearing and balance dysfunction. In 2008, Springer published a SHAR volume on this subject (Hair Cell Regeneration, Repair, and Protection, Editors Richard Salvi and Richard Fay). Since that time, there has been considerable advancement in this field.This book provides a historical perspective on the field, but the emphasis is on more "prospective" views of the various facets of regeneration research, in the hope that the volume will stimulate new projects and approaches, focusing on the limitations of current knowledge and describing promising strategies for future work. The book will include the following key features of hair cell regeneration: • Cellular and molecular control hair cell regeneration in non-mammalian species (in particular zebrafish and chickens) • Our current understanding of the capacity for hair cell replacement in mammals (rodents and humans). • Signals controlling pro-regenerative behaviors in supporting cells, the hair cell progenitors. • New techniques that have been applied to study the genetic and epigenetic regulation of hair cell regeneration in mammals and non-mammals. • Contributions of stem cells toward building new tools to explore how hair cell regeneration is controlled and toward developing cells and tissue for therapeutic transplantation. • Studies that have applied gene and drug therapy to promote regeneration in mammals.
Mechanisms Of High Sensitivity And Active Amplification In Sensory Hair Cells
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Author : Mahvand Khamesian
language : en
Publisher:
Release Date : 2018
Mechanisms Of High Sensitivity And Active Amplification In Sensory Hair Cells written by Mahvand Khamesian and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with Bullfrog categories.
Hair cells mediating the senses of hearing and balance rely on active mechanisms for amplification of mechanical signals. In amphibians, hair cells exhibit spontaneous self-sustained mechanical oscillations of their hair bundles. In addition to mechanical oscillations, it is known that the electrical resonance is responsible for frequency selectivity in some inner ear organs. Furthermore, hair cells may show spontaneous electrical oscillations of their membrane potentials. In this dissertation, we study these mechanisms using a computational modeling of the bullfrog sacculus, a well-studied preparation in sensory neuroscience. In vivo, hair bundles of the bullfrog sacculus are coupled by an overlying otolithic membrane across a significant fraction of epithelium. We develop a model for coupled hair bundles in which non-identical hair cells are distributed on a regular grid and coupled mechanically via elastic springs connected to the hair bundles.