Serotonin Molecular Biology Receptors And Functional Effects
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Serotonin Molecular Biology Receptors And Functional Effects
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Author : FOZARD
language : en
Publisher: Birkhäuser
Release Date : 2012-12-06
Serotonin Molecular Biology Receptors And Functional Effects written by FOZARD and has been published by Birkhäuser this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
The Second IUPHAR Satellite Meeting on Serotonin was held under the auspices of the Serotonin Club in Basel, Switzerland in July 1990. The scope was wide, ranging from molecular biology through in vitro and in vivo pharmacology to new drug tools and their clinical signifi cance. There were three invited review lectures, by J. M. Palacios, D. I. Wallis and A. Kaumann, and S. Peroutka gave the first Serotonin Club Irvine H. Page Lecture. The rest of the oral programme was put together by the Scientific Organizing Committee based on volunteered research contributions. The invited review lecturers, the platform speak ers and selected poster contributors were invited to write up their contributions for inclusion in this volume. Most complied and this book is the result of their efforts. When instructing the authors prior to the meeting, we emphasized that selected new data should be put in the context of the literature findings. In this way we hoped to achieve topicality yet preserve the review perspective which facilitates its appreciation by the non-special ist. It was truly a pleasure to read the interesting papers which resulted and to prepare them for publication. We believe they convey to a remarkable degree the spirit of what was generally felt to be a highly stimulating exchange of information on matters serotonergic which took place in Basel last July.
Serotonin Molecular Biology Receptors And Functional Effects
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Author : FOZARD
language : en
Publisher: Birkhäuser
Release Date : 1991-08-01
Serotonin Molecular Biology Receptors And Functional Effects written by FOZARD and has been published by Birkhäuser this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991-08-01 with Science categories.
The Second IUPHAR Satellite Meeting on Serotonin was held under the auspices of the Serotonin Club in Basel, Switzerland in July 1990. The scope was wide, ranging from molecular biology through in vitro and in vivo pharmacology to new drug tools and their clinical signifi cance. There were three invited review lectures, by J. M. Palacios, D. I. Wallis and A. Kaumann, and S. Peroutka gave the first Serotonin Club Irvine H. Page Lecture. The rest of the oral programme was put together by the Scientific Organizing Committee based on volunteered research contributions. The invited review lecturers, the platform speak ers and selected poster contributors were invited to write up their contributions for inclusion in this volume. Most complied and this book is the result of their efforts. When instructing the authors prior to the meeting, we emphasized that selected new data should be put in the context of the literature findings. In this way we hoped to achieve topicality yet preserve the review perspective which facilitates its appreciation by the non-special ist. It was truly a pleasure to read the interesting papers which resulted and to prepare them for publication. We believe they convey to a remarkable degree the spirit of what was generally felt to be a highly stimulating exchange of information on matters serotonergic which took place in Basel last July.
Serotonin Receptors And Their Ligands
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Author : B. Olivier
language : en
Publisher: Elsevier
Release Date : 1997-07-10
Serotonin Receptors And Their Ligands written by B. Olivier and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-07-10 with Science categories.
An international group of authors have produced an overview of the progress made in the medicinal chemistry of compounds (selectively) acting at serotonin receptors or serotonin transporters either as agonists, partial agonists or antagonists. Structure - affinity relationships and structure - activity relationships of agonists, partial agonists, and antagonists of 5-HT receptors and uptake sites, are discussed. Structure, sequence homology and the effect of site-directed mutations of 5-HT receptors and the reuptake site on the binding of ligands show the tremendous impact of molecular biology on medicinal chemistry research. Also discussed is the pharmacology and (potential) clinical applications of ligands for the 5-HT receptors and the reuptake site. By developing elegant techniques of cloning and expression of serotonin receptor subtypes, their mutants and chimeras, a unique opportunity was offered to study the binding mode of serotoninergic ligands to their receptors and transporters. The distribution, structure and homologies of serotonin receptor subtypes and the structure of the serotonin transporter are also taken into account. The (potential) therapeutic applications of ligands of the different subtypes are described. Altogether an excellent addition to the Pharmacochemical Library series.
The Serotonin Receptors
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Author : Bryan L. Roth
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-08-17
The Serotonin Receptors written by Bryan L. Roth and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-08-17 with Medical categories.
A comprehensive, state-of-the-art review of our current understanding of the molecular and structural biology of 5-HT receptors and their potential use for drug discovery. The authors describe the anatomical, cellular, and subcellular distribution of 5-HT receptors and demonstrate a powerful approach to elucidating their physiological role using knockout mice in which the 5-HT receptors were deleted. They also review our understanding of the physiological role(s) of 5-HT receptors based mainly on studies performed in genetically engineered mice. Highlights include discussions of the behavioral phenotypes of 5-HT receptor knockout animals, the molecular biology and pharmacology of 5-HT receptors, and insights into the complexity of 5-HT receptor signal transduction.
Serotonin
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Author : Paul M. Vanhoutte
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Serotonin written by Paul M. Vanhoutte and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
This volume contains the Proceedings of the invited lectures of the Second International Sym posium on SEROTONIN from Cell Biology to Pharmacology and Therapeutics held in Houston, Texas September 15-18, 1992. The meeting was held under the co-sponsorship of the Serotonin Club, the Giovanni Lorenzini Medical Foundation, and the Fondazione Giovanni Lorenzini. This volume discusses the major exploration in knowledge that has occurred recently of the complex role that 5- hydroxytryptamine (serotonin) plays in health and disease. In par ticular, these Proceedings highlight major breakthroughs in molecular biology and classification of receptor subtypes that are responsible for the many actions of the monoamine. The ever increasing importance of serotonin in central regulation, whether autonomic or behavioral is represented by a large number of chapters prepared by world experts. Additionally, the role of serotonin in peripheral organs is also discussed. Hence, this volume provides the reader with a unique, up-to-date review of this exciting and novel area of science. These Proceedings obviously are of great interest, not only to the researchers directly engaged in the quest for the understanding and unraveling of the actions of the interactions with serotonin as a major neurohumoral mediator, but also to all scholars and clinicians who wish to acquire a better understanding of the functioning of the brain and of peripheral organs. Since this volume was constructed as a compilation of invited lectures, the scientific content and the opinions expressed in the chapters are the sole responsibility of the authors.
Serotonin And Sleep Molecular Functional And Clinical Aspects
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Author : Jaime M. Monti
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-03-04
Serotonin And Sleep Molecular Functional And Clinical Aspects written by Jaime M. Monti and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-03-04 with Medical categories.
This book focuses on the neuropsychopharmacology of serotonin and its role in sleep and wakefulness, presenting neurochemical, electrophysiological, and neuropharmacological approaches to understand the mechanisms of serotonin and related substances. Covering core and contemporary topics in the area, this volume is valuable for all researchers interested in interdisciplinary studies concerning drugs affecting the central nervous system.
Serotonin Receptors In Neurobiology
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Author : Amitabha Chattopadhyay
language : en
Publisher: CRC Press
Release Date : 2007-05-17
Serotonin Receptors In Neurobiology written by Amitabha Chattopadhyay and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-05-17 with Medical categories.
A number of developments spanning a multitude of techniques makes this an exciting time for research in serotonin receptors. A comprehensive review of the subject from a multidisciplinary perspective, Serotonin Receptors in Neurobiology is among the first books to include information on serotonin receptor knockout studies. With contributions from l
Advances In Serotonin Receptor Research
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Author : Graeme R. Martin
language : en
Publisher:
Release Date : 1998
Advances In Serotonin Receptor Research written by Graeme R. Martin and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with Medical categories.
This volume addresses a number of key issues concerning receptor function and control. Special attention is paid to the physiological relevance of information obtained from recombinant receptor-transducer systems, especially in terms of constitutive receptor activity and receptor-transducer pleiotropism. The book also covers genetic basis of disease diagnosis and treatment, the molecular basis of drug-and-receptor trafficking, the importance of receptor-receptor interactions in cell conditioning and the utility of mutagenesis studies and transgenics in drug discovery. This volume should provide insights into novel approaches to serotonin receptor-targeted therapeutics.
Serotonin Neurotransmitter And Hormone Of Brain Bowels And Blood
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Author : Kaneez Fatima-Shad
language : en
Publisher: BoD – Books on Demand
Release Date : 2024-06-19
Serotonin Neurotransmitter And Hormone Of Brain Bowels And Blood written by Kaneez Fatima-Shad and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-06-19 with Medical categories.
Serotonin is an amazing neurotransmitter and hormone that is not only responsible for mood regulation but also plays an important role in regulating various aspects of human physiology and directly affecting human health. Serotonin is key to providing nutrition and oxygen from head to toe through vasoconstriction and hemostasis. The chapters in this book describe in detail not only how the serotonin receptor network interacts with each other but also their role in various pathologies. Disorders of serotonin could be related to structural and/or functional damage to the blood, brain, and bowel. Early identification of these conditions could benefit many diseases such as atherosclerosis, stroke, depression, and irritable bowel syndrome. The effects of serotonin abnormalities extend beyond one’s intellectual capacity. These effects can be felt at any time, from embryonic life to old age. In this book, you will not only find the role of other hormones such as insulin on serotonin but will also learn how serotonin plays an essential role in both plants and animals.
Serotonin
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Author : Bernard Haber
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Serotonin written by Bernard Haber and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
The vast growth of knowledge in recent years concerning the functional role of serotonergic systems in central nervous system function prompted the organization of the symposium. The organiz ing committees felt at the onset that the field of serotonin research had grown so rapidly that it would be impossible to cover every aspect of it in individual symposia. Thus it was felt that certain areas of research had to be omitted due to time constraints, and we extend an apology to the researchers in areas not included in these proceedings. Rather it was hoped to provide a balance overview of the field, starting with the anatomy of serotonergic systems and proceeding to the level of the serotonergic receptors at the cell membrane, and then inside the neuron to discuss the regulation of serotonin bisynthesis and integration within indole mine systems. The functional aspects of serotonergic transmission focused on the emerging role of this amine in the processing of nociceptive information, singly or in tandem with other neurotran smitters or neuromodulators. A separate symposium dealt with a variety of animal models suitable for the analysis of the role of serotonin in behavior, and finally led to the evaluation of serotonin metabolism in the study of abnormal human behavior. The editors would like to dedicate these proceedings on /Serotonin - Current Aspects of Neurochemistry and Function/ to two pioneers in this field, Dr. Irving Page and Dr. Maurice Rapport.