Single Nucleotide Polymorphisms
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Single Nucleotide Polymorphisms
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Author : Zuben E. Sauna
language : en
Publisher: Springer Nature
Release Date : 2022-08-08
Single Nucleotide Polymorphisms written by Zuben E. Sauna and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-08-08 with Medical categories.
This book explores the importance of Single Nucleotide Polymorphisms (SNPs) in biomedical research. As SNP technologies have evolved from labor intensive, expensive, time-consuming processes to relatively inexpensive methods, SNP discovery has exploded. In terms of human biology, this research, particularly since the completion of the Human Genome Project, has provided a detailed understanding of evolutionary forces that have generated SNPs. It also has shown how SNPs shape human variation. The ability to inexpensively generate and analyze vast amounts of genetic data is poised to transform our understanding of human evolution and biology. “Single Nucleotide Polymorphisms” covers a broad survey of SNPs and their classification into synonymous and non-synonymous; the role of SNPs in human disease; case studies providing specific examples of synonymous and non-synonymous SNPs associated with human diseases or affecting therapeutic interventions; mechanisms by which synonymous mutations affect protein levels or protein folding which affect human physiology and response to therapy; and the role of SNPs in personalized medicine. Understanding what SNPs are, how they have been shaped is necessary for an increasingly expanding audience. This research will revolutionize the future of medicine. Chapter 4 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com. SNPs Ability to Influence Disease Risk: Breaking the Silence on Synonymous Mutations in Cancer" is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Single Nucleotide Polymorphisms
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Author : Pui-Yan Kwok
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-04
Single Nucleotide Polymorphisms written by Pui-Yan Kwok and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-04 with Medical categories.
A comprehensive collection of readily reproducible techniques for the difficult process of single nucleotide polymorphisms (SNP) discovery and genotyping. These cutting-edge protocols for mutation/SNP detection utilize denaturing high-performance liquid chromatography (dHPLC), single-strand conformation polymorphism (SSCP), conformation-sensitive gel electrophoresis (CSGE), chemical cleavage, and direct sequencing. Equally powerful and up-to-date methods are given for genotyping SNPs, including molecular beacons, the Taqman assay, single-base extension approaches, pyrosequencing, ligation, the Invader assay, and primer extension with mass spectrometry detection.
Single Nucleotide Polymorphisms
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Author : Anton A. Komar
language : en
Publisher: Humana Press
Release Date : 2012-02-25
Single Nucleotide Polymorphisms written by Anton A. Komar and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-02-25 with Medical categories.
In recent years, single nucleotide polymorphisms have received increased and special attention in a rapidly developing field of personalized medicine and drug treatment. Comprising more than eighty percent of all known polymorphisms, single nucleotide polymorphisms (SNPs) are primarily responsible for phenotypic differences between individuals, and have been suggested to affect the development of diseases in humans and the response to drug treatment and environmental stress. In Single Nucleotide Polymorphisms: Methods and Protocols, Second Edition, expert researchers explore the latest advances in this area, highlighting the substantial progress that has been made in SNP genotyping, examining recent developments in high-throughput genotyping approaches, and exploring our new understanding of the impact of SNPs on gene function. Chapters address the impact of SNPs on phenotype, examine SNP databases, look at methods that have been applied for SNP bioinformatics discovery and analysis, and discuss advanced experimental approaches used for SNP detection. Composed in the highly successful Methods in Molecular BiologyTM series format, each chapter contains a brief introduction, step-by-step methods, a list of necessary materials, and a Notes section which shares tips on troubleshooting and avoiding known pitfalls. Current and innovative, Single Nucleotide Polymorphisms: Methods and Protocols, Second Edition is an essential guidebook for individual researchers as well as institutions and companies working in the field.
Global Views Of Human Genetic Variation
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Author : Coleman A. Mosley
language : en
Publisher:
Release Date : 2006
Global Views Of Human Genetic Variation written by Coleman A. Mosley and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with categories.
Single Nucleotide Polymorphisms
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Author : Lovina I. Iyandu Udoh
language : en
Publisher:
Release Date : 2020
Single Nucleotide Polymorphisms written by Lovina I. Iyandu Udoh and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020 with Electronic books categories.
Single nucleotide polymorphism (SNP) represent a change in a single nucleotide within the genome. This can alter the phenotype of an individual within the same species if it occurs in a coding region of the gene. The change in nucleotide can produce desirable characteristic in plants and can become an object for selection. New SNPs have been discovered and subsequently converted to molecular markers using various non-gel based and next generation sequencing platforms. Considering that SNP markers are based on target genes, its abundance in the genome, high automation and multiplexability, has made it a marker of choice and an effective tool for screening plant germplasm for desirable traits. This chapter considers SNP as molecular marker, their discovery and different SNP genotyping methods was documented. A few case studies of SNP as allele specific markers and their association with traits of interest was considered. Thus, highlighting their efficacy as useful tool for marker assisted selection and plant germplasms screening.
Single Nucleotide Polymorphisms Snps In Plant Genetics And Breeding
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Author : Hande Morgil
language : en
Publisher:
Release Date : 2019
Single Nucleotide Polymorphisms Snps In Plant Genetics And Breeding written by Hande Morgil and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with Science categories.
Recent advances in genome technology revealed various single nucleotide polymorphisms (SNPs), the most common form of DNA sequence variation between alleles, in several plant species. The discovery and application of SNPs increased our knowledge about genetic diversity and a better understanding on crop improvement. Natural breeding process which takes an agelong time during collecting, cultivating, and domestication has been accelerated by detecting dozens of SNPs on various species using advanced biotechnological techniques such as next-generation sequencing. This will result in the improvement of economically important traits. Therefore, we would like to focus on the discovery, current technologies, and applications of SNPs in breeding. The chapter covers the following topics: (1) introduction, (2) application of SNPs, (3) techniques to detect SNPs, (4) importance of SNPs for crop improvement, and (5) conclusion.
Single Nucleotide Polymorphism Analysis By Matrix Assisted Laser Desorption Ionization Time Of Flight Mass Spectrometry
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Author : Zhengdong Fei
language : en
Publisher:
Release Date : 1999
Single Nucleotide Polymorphism Analysis By Matrix Assisted Laser Desorption Ionization Time Of Flight Mass Spectrometry written by Zhengdong Fei and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with categories.
Single Nucleotide Polymorphisms Snps
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Author : Yousin Suh
language : en
Publisher:
Release Date : 2005
Single Nucleotide Polymorphisms Snps written by Yousin Suh and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with categories.
Association Mapping In Plants
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Author : Nnadozie C. Oraguzie
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-01-06
Association Mapping In Plants written by Nnadozie C. Oraguzie and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-01-06 with Science categories.
This book provides both basic and advanced understanding of association mapping and an awareness of population genomics tools to facilitate mapping and identification of the underlying causes of quantitative trait variation in plants. It acts as a useful review of the marker technology, the statistical methodology, and the progress to date. It also offers guides to the use of single nucleotide polymorphisms (SNPs) in association studies.
Identification Of Gene Specific Single Nucleotide Polymorphisms Within The Canine Genome And Their Use To Determine Nucleotide Diversity And Inbreeding Coefficients Within The Canine Genome
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Author : James A. Brouillette
language : en
Publisher:
Release Date : 2010
Identification Of Gene Specific Single Nucleotide Polymorphisms Within The Canine Genome And Their Use To Determine Nucleotide Diversity And Inbreeding Coefficients Within The Canine Genome written by James A. Brouillette and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Dogs categories.