Ssri

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Selective Serotonin Reuptake Inhibitors Ssris

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Author : S. Clare Stanford
language : en
Publisher: Landes Bioscience
Release Date : 1999

Selective Serotonin Reuptake Inhibitors Ssris written by S. Clare Stanford and has been published by Landes Bioscience this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with Medical categories.

Details advantages and disadvantages of SSRIs. Starts with a personal memoir of the discovery of the first SSRI, then looks at SSRIs from the clinical point of view. Later chapters concentrate on preclinical material. A final chapter makes pharmacological and clinical comparisons between the tricycl

Selective Serotonin Reuptake Inhibitors Ssris For Major Depression

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Author : Devidas Menon
language : en
Publisher:
Release Date : 1997

Selective Serotonin Reuptake Inhibitors Ssris For Major Depression written by Devidas Menon and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with Antidepressants categories.

Recent years have witnessed large increase in expenditures on antidepressants. This has coincided with the introduction and the widespread use of a new class of antidepressants, the selective serotonin reuptake inhibitors (SSRIs). SSRIs are substantially more expensive than the older tricyclic antidepressants (TCAs), but have a different adverse effect profile and are better tolerated. This study examines the cost-effectiveness of this new class of antidepressants as compared to TCAs in the outpatient treatment of depression. A decision model is built in order to compare three different strategies. The first strategy consists of an SSRI followed by a TCA in case of failure, the second strategy consists of a TCA followed by an SSRI in case of failure, and the third strategy consists of TCA only. The model indicates that the success rate of a short term treatment with an SSRI is higher than one with a TCA, but is also more expensive. However, as maintenance therapy is initiated, and the switch of medications is allowed for those who drop out of treatment, the cumulative success rate of SSRI first strategy becomes very similar to that of the TCA first strategy, but the cost of the SSRI first strategy increases over time. In comparison, when estimates of drop-out rates taken from studies conducted in naturalistic environments are substituted for clinical trial rates, this additional cost becomes increasingly small. If quality of life is considered, the SSRI first strategy offers improved quality of life over the TCA first strategy. In other words, an SSRI first-line strategy is dominant over a TCA only strategy, and an SSRI first-line strategy compared to a SSRI second-line strategy produces QALYs at an acceptable cost by current standards.

Ssris In Depression And Anxiety

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Author : Stuart A. Montgomery
language : en
Publisher:
Release Date : 1998-10-15

Ssris In Depression And Anxiety written by Stuart A. Montgomery and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998-10-15 with Medical categories.

Perspectives in Psychiatry Volume 7 SSRIs in Depression and Anxiety Edited by Stuart A. Montgomery Imperial College, London, UK and Johan A. den Boer Groningen University, The Netherlands The therapeutic profile of SSRIs, shown to work in the treatment of depression, has now been expanded to treat anxiety. Written to fill the current research gap and reflect a topical subject of growing importance, this timely volume explains the origins of anxiety, its biological basis, how it relates to depression and various anxiety disorders and phobias. The book also describes the biological and clinical effects of SSRIs on such conditions, providing readers with an international perspective and up-to-date source of information from experts in this field. This highly topical book discusses: The epidemiology of depression and anxiety disorders; the biological aspects of anxiety disorders and depression; comorbidity of depression and anxiety disorders; the utility of SSRIs in anxious depression; SSRIs in the treatment of panic disorder; SSRIs in social phobia with or without major depression; SSRIs in obsessive-compulsive disorder; serotonin and serotonergic drugs in post-traumatic stress disorder.

Selective Serotonin Reuptake Inhibitors Advances In Research And Application 2011 Edition

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Author :
language : en
Publisher: ScholarlyEditions
Release Date : 2012-01-09

Selective Serotonin Reuptake Inhibitors Advances In Research And Application 2011 Edition written by and has been published by ScholarlyEditions this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-01-09 with Medical categories.

Selective Serotonin Reuptake Inhibitors: Advances in Research and Application: 2011 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Selective Serotonin Reuptake Inhibitors in a concise format. The editors have built Selective Serotonin Reuptake Inhibitors: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Selective Serotonin Reuptake Inhibitors in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Selective Serotonin Reuptake Inhibitors: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Living With Prozac And Other Selective Serotonin Reuptake Inhibitors Ssris Personal Accounts Of Life On Antidepressants

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Author : Debra Elfenbein
language : en
Publisher: Harper San Francisco
Release Date : 1995

Living With Prozac And Other Selective Serotonin Reuptake Inhibitors Ssris Personal Accounts Of Life On Antidepressants written by Debra Elfenbein and has been published by Harper San Francisco this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995 with Medical categories.

Used by more than 11 million people worldwide, Prozac's healing powers have been widely acclaimed. For those who are presently taking Prozac or who are considering it, this invaluable resource presents actual testimonies by patients who speak out about the benefits of this life-changing drug.

The Marketization Of Depression

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Author : Janet C. Currie
language : en
Publisher:
Release Date : 2005

The Marketization Of Depression written by Janet C. Currie and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with Antidepressants categories.

Let Them Eat Prozac

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Author : David Healy
language : en
Publisher: NYU Press
Release Date : 2006-10

Let Them Eat Prozac written by David Healy and has been published by NYU Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-10 with Medical categories.

A psychiatrist provides an insider account on the controversial use of selective serotonin reuptake inhibitors (SSRIs) Prozac. Paxil. Zoloft. Turn on your television and you are likely to see a commercial for one of the many selective serotonin reuptake inhibitors (SSRIs) on the market. We hear a lot about them, but do we really understand how these drugs work and what risks are involved for anyone who uses them? Let Them Eat Prozac explores the history of SSRIs—from their early development to their latest marketing campaigns—and the controversies that surround them. Initially, they seemed like wonder drugs for those with mild to moderate depression. When Prozac was released in the late 1980s, David Healy was among the psychiatrists who prescribed it. But he soon observed that some of these patients became agitated and even attempted suicide. Could the new wonder drug actually be making patients worse? Healy draws on his own research and expertise to demonstrate the potential hazards associated with these drugs. He intersperses case histories with insider accounts of the research leading to the development and approval of SSRIs as a treatment for depression. Let Them Eat Prozac clearly demonstrates that the problems go much deeper than a side-effect of a particular drug. The pharmaceutical industry would like us to believe that SSRIs can safely treat depression, anxiety, and a host of other mental problems. But, as Let Them Eat Prozac reveals, this “cure” may be worse than the disease.

Paradoxical Effects Of Ssri Antidepressants When Treating Mood Dysregulation In Borderline Personality Disorder

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Author : Carlo Lazzari
language : en
Publisher:
Release Date : 2017

Paradoxical Effects Of Ssri Antidepressants When Treating Mood Dysregulation In Borderline Personality Disorder written by Carlo Lazzari and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with categories.

OBJECTIVEAntidepressants of the SSRI (Serotonin System Reuptake Inhibitors) are frequently prescribed in primary and secondary care to address depression. SSRI antidepressants are also frequently prescribed in patients with a borderline personality disorder (BPD) to address low mood. However, the author of the current research found paradoxical effects in the combination SSRI-BPD. There is current concern about the increase of suicidality and deliberate self harm in patients under SSRI. Authors suggest attention when SSRI are prescribed to children and adolescents as SSRI can trigger suicidal ideation and aggression [1-3]. However, evidence to show increased deliberate self harm in patients on SSRI is contradictory in several studies due to confounding variables [4].METHODSThe aim of psychiatric teams in primary and secondary care is to stabilize the presentation and to reduce deliberate self-harm and suicidal ideation in patients with BPD. Patients with BPD have mood dysregulation with dysthymia or cyclothymia. The BPD patientsu2019 narratives used for the study provided some evidence or paradoxical effects when SSRI antidepressants are used to address mood dysregulation in BPD. RESULTSPatients with BPD treated with SSRI antidepressants are at high risk of presenting with dose-related behavioral symptoms of serotonin activation including increased impulsivity, increased suicidal ideation and acts, increased violence towards others, increased deliberate self-harm, and increased agitation. Therefore, the paradoxical effect of SSRI is not age related in this group of patients.CONCLUSIONSThe use of SSRI antidepressants in BPD should receive a warning when used in BPD while the use of more sedative mood stabilizers should be considered instead.REFERENCES[1] Nischal A, Tripathi A, Nischal A, Trivedi JK. Suicide and Antidepressants: What Current Evidence Indicates. Mens Sana Monogr 2012; 10: 33-44.[2] Sharma T, Guski LS,Freund N, Gu00f8tzsche PC, Suicidality and aggression during antidepressant treatment: systematic review and meta-analyses based on clinical study reports. BMJ 2016;352:i65http://dx.doi.org/10.1136/bmj.i65[3] National Health Service. Antidepressants and suicide risk. 2009 (online) Available at: https://www.nhs.uk/news/mental-health/antidepressants-and-suicide-risk/[4] Didham RC, Connell DW, Blair HJ, Reith DM, Br J Clin Pharmacol. 2005 Nov; 60(5): 519u2013525. doi:10.1111/j.1365-2125.2005.02480.x.

Ssri Vs Maoi

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Author : Mick Hardman
language : en
Publisher:
Release Date : 2007

Ssri Vs Maoi written by Mick Hardman and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with Antidepressants categories.

This research project explains the chemical, physiological, and selling differences between monoamine oxidase inhibitors (MAOI) and selective serotonin reuptake inhibitors (SSRI). The chemical and cellular comparisons between these two antidepressants have different and similar effects in the human body. This project further explains about the marketing and advertising differences between these two antidepressants and the common side effects of SSRI and MAOI antidepressants.

Fluoxetine

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Author : Graziano Pinna
language : en
Publisher:
Release Date : 2015-04-01

Fluoxetine written by Graziano Pinna and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-04-01 with categories.

Fluoxetine, best known by the trade name Prozac®, unlike other psychotropic drugs whose effects were serendipitously stumbled upon, was the first developed for a precise mechanism of action, that is, the ability to selectively inhibit serotonin reuptake, based upon the theory that increasing the availability of serotonin would treat major depression. Once approved by the FDA in 1987, fluoxetine quickly became the most prescribed psychotropic drug worldwide and its success in improving mood disorders has triggered the development of a large number of congener molecules, commonly known as SSRIs after their purported mechanism of action. However, a quarter of a century after its development, the idea that fluoxetine asserts its positive behavioral effect through inhibition of serotonergic reuptake is not firmly established. This book reviews several preclinical and clinical reports suggesting that the pharmacological effects of fluoxetine may be mediated by means other than the regulation of serotonin, including the regulation of gene expression, modifying epigenetic mechanisms as well as modifying microRNAs. One of the most prominent mechanisms for the therapeutic relevance of fluoxetine relates to influencing neuroplasticity by enhancing neurotropic factors, including BDNF signaling and altering adult neurogenesis. The ability of fluoxetine to rapidly increase neurosteroid levels accounts for the fast anxiolytic effects of this drug. Fluoxetine action at sigma-1 receptor or modulating glutamatergic neurotransmission as well as the combination of fluoxetine with other psychotropic drugs is discussed in relation to its therapeutic effects. While fluoxetine was primarily prescribed as an antidepressant, this drug currently represents a treatment of choice for a broad spectrum of psychiatric disorders, including post-traumatic stress disorder and a range of anxiety disorders. This drug even possesses analgesic actions and is a valuable therapy for stroke. This book also highlights emerging evidence on the gender-specific effects of fluoxetine, its potential adverse features, including its addiction liability in combination with psychostimulants, and the impact of perinatal fluoxetine exposure.