Stem Cell Genetic Fidelity
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Stem Cell Genetic Fidelity
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Author : James L Sherley
language : en
Publisher: Frontiers Media SA
Release Date : 2015-07-03
Stem Cell Genetic Fidelity written by James L Sherley and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-07-03 with Genetics categories.
The vision of this Frontiers in Oncology Research Topic on “Stem Cell Genetic Fidelity” had the goal of steeping a diverse range of research perspectives to a first comprehensive synthesis of thought on the questions of how tissue stem cells manage gene mutation rate and the significance of that management in mammalian evolution and biology, in particular as it relates to tissue cell renewal, carcinogenesis, and aging. The primary focus was determinants of mutation rate in distributed stem cells (DSCs), which encompass all naturally occurring stem cells at all stages of mammalian development. In particular, contributions were sought that considered a broad range of aspects of the immortal DNA strand hypothesis for DSC genetic fidelity. Though proposed in 1975, only in the last decade has this landmark concept in tissue cell biology emerged as a central discussion in DSC research with increasing scrutiny and discussion by an increasing number of laboratories of diverse research perspectives and experimental approaches. With this hypothesis presenting a formidable technical challenge for experimental investigation, as would be expected, both supportive and unsupportive reports have been lining up. In the case of supportive studies, neither the range of applicable tissues nor the responsible molecular mechanisms are known; and the essential genomic process, non-random DNA template strand inheritance by asymmetrically self-renewing DSCs, has been suggested to potentially have other cellular roles besides reducing mutation rate. A major aspiration of this Research Topic was to create the first comprehensive, critical synthesis of current insights and viewpoints on the impact of the immortal DNA strand hypothesis in the history of DSC mutation research. A wide range of article types was considered including historical perspectives, critical reviews, critical commentaries, new hypotheses, new research perspectives, technical advances, and original research reports. Although treatments of the immortal DNA strand hypothesis were the major focus, the desired synthesis required integration of related ideas on mechanisms of DSC mutagenesis and its impact in the evolution of mammals, the emergence of cancers, and stem cell aging. As such, investigators focused on issues in e.g., germ stem cell mutagenesis, effects of environmental mutagens on DSC mutation rate, DSC mutation and tissue aging, determinations of types of mutations in DSCs, and the role of DSC mutation in cancer initiation were invited. Similarly, although the specific goal of the Research Topic was to enlighten DSC genetic fidelity in humans and other mammalians, informing contributions based on studies in other model organisms were also welcomed. To achieve even better representation of current experience, advances, and ideas in this field of investigation, these early contributors were encouraged to extend the opportunity to others who shared their interest in advancing our understanding of the mutability of DSCs and its significance in human biology.
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Author :
language : en
Publisher:
Release Date : 1957
written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1957 with categories.
Genome Editing And Engineering
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Author : Krishnarao Appasani
language : en
Publisher: Cambridge University Press
Release Date : 2018-08-23
Genome Editing And Engineering written by Krishnarao Appasani and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-08-23 with Science categories.
A complete guide to endonuclease-based genomic engineering, from basic science to application in disease biology and clinical treatment.
Human Stem Cell Toxicology
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Author : James L Sherley
language : en
Publisher: Royal Society of Chemistry
Release Date : 2016
Human Stem Cell Toxicology written by James L Sherley and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with Medical categories.
Toxicity against tissue stem cells (TSCs) is a major problem in drug development and environmental health science. Despite their essential function in all human cellular tissues, the nature of tissue stem cells is not fully understood. The small fraction of stem cells in tissues and the lack of specific biomarkers for their quantification present a formidable challenge to developing tools for their study and assays that can identify stem cell-toxic agents. Human Stem Cell Toxicology reveals TSC toxicity as a biomedical reality that is now well under siege by newly emerging ideas and technologies, despite these challenges. Chapters consider stem cell toxicity by environmental agents, pharmaceutical drug candidates, and marketed therapeutic medicines with adverse side effects. New insights to cellular, molecular, biochemical and chemical mechanisms of human tissue stem cell toxicity are brought together. Experimental and theoretical treatments are of specific topics, including approaches to monitoring TSC function, newly discovered TSC types and TSC toxicity resistance mechanisms are covered by expert authors. This book informs and champions the continued development of innovative technologies to predict the TSC toxicity of compounds before their use, whether in patients or the environment, by addressing emerging new cell-based approaches and concepts for technical innovation. This publication will be a useful reference for postgraduate students and researchers working in toxicology, pharmaceutical science, tissue cell biology and stem cell biology.
Perinatal Stem Cells
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Author : Curtis L. Cetrulo
language : en
Publisher: John Wiley & Sons
Release Date : 2010-01-05
Perinatal Stem Cells written by Curtis L. Cetrulo and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-01-05 with Science categories.
Discover how perinatal stem cells may prove to be a more powerful therapeutic tool than embryonic stem cells Normally discarded as medical waste, perinatal stem cells are an incredible source of stem cells and are gaining phenomenal research attention for their potential to become a more powerful alternative to the controversial embryonic stem cells. In response to this growing field, this book provides a thorough tutorial on the current state of the art in perinatal stem cells. Presented by a panel of authorities whose expertise reaches from research to hematology to tissue engineering and beyond, this important volume covers all of the sources of stem cells found throughout pregnancy, revealing the underlying biology and potential therapeutic uses of each: Post-gestational maternal peripheral blood Umbilical cord blood Wharton's jelly Amniotic fluid Amnion lining the amniotic cavity Umbilical vein Chorionic mesenchymal stromal cells Multi-potent cells Placenta stem cells This book is a bountiful source for researchers, graduate students, cell biologists, gene therapists, obstetricians and gynecologists, and professionals engaged in regenerative medicine and developmental biology.
Human Embryonic Stem Cells
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Author : Arlene Chiu
language : en
Publisher: Springer Science & Business Media
Release Date : 2003-08
Human Embryonic Stem Cells written by Arlene Chiu and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-08 with Science categories.
A discussion of all the key issues in the use of human pluripotent stem cells for treating degenerative diseases or for replacing tissues lost from trauma. On the practical side, the topics range from the problems of deriving human embryonic stem cells and driving their differentiation along specific lineages, regulating their development into mature cells, and bringing stem cell therapy to clinical trials. Regulatory issues are addressed in discussions of the ethical debate surrounding the derivation of human embryonic stem cells and the current policies governing their use in the United States and abroad, including the rules and conditions regulating federal funding and questions of intellectual property.
Stem Cells Handbook
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Author : Stewart Sell
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-08-16
Stem Cells Handbook written by Stewart Sell and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-08-16 with Science categories.
This book discusses critical areas of progress in stem cell research, including the most recent research and applications of pluripotent embryonic cells, induced pluripotent cells, oligopotent tissue stem cells and cancer stem cells. The text covers basic knowledge of stem cell biology, stem cell ethics, development of techniques for applying stem cell therapy, the technology of obtaining appropriate cells for transplantation as well as the role of stem cells in cancer and how therapy may be directed to cancer stem cells. This new volume is essential reading for all scientists currently in the field or allied research areas, and those for those graduate students who envision a career in stem cells.
Current Topics In Developmental Biology
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Author :
language : en
Publisher: Elsevier
Release Date : 2006-06-16
Current Topics In Developmental Biology written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-06-16 with Science categories.
Current Topics in Developmental Biology provides a comprehensive survey of the major topics in the field of developmental biology. The volumes are valuable to researchers in animal and plant development, as well as to students and professionals who want an introduction to cellular and molecular mechanisms of development. The series has recently passed its 30-year mark, making it the longest-running forum for contemporary issues in developmental biology. Includes 20 color figures Latest volume in series, with eight reviews in more than 250 pages Topics covered include bone remodeling, ex vivo adult stem cell expansion, calcium sensing receptors and more
Nuclear Reprogramming
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Author : Kejin Hu
language : en
Publisher:
Release Date : 2021
Nuclear Reprogramming written by Kejin Hu and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021 with Cell nuclei categories.
This volume provides basic and advanced protocols on somatic cell nuclear transfer, induced pluripotent stem cells, and direct reprogramming of somatic cells into different functional cells. Chapters guide readers through methods on standardized procedures for characterization of induced pluripotent stem cells, as well as those for preparation of materials required for induction of pluripotent stem cells. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Nuclear Reprogramming: Methods and Protocols aims to ensure successful results in the further study of this vital field. .
Endometriosis
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Author : Juan A Garcia-Velasco
language : en
Publisher: Boydell & Brewer Ltd
Release Date : 2010-09-17
Endometriosis written by Juan A Garcia-Velasco and has been published by Boydell & Brewer Ltd this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-09-17 with Medical categories.
Endometriosis is a condition that effects 10% to 15% of women of reproductive age and in its more advanced stages it may be an indicator of infertility. This unique book reviews the whole topic of Endometriosis starting from a review of the epidemiological evidence through the sociology of the disease to diagnosis, medical and surgical treatments, management and a discussion of new medical options and future trends in the disease area. It covers pathogenesis, current and future diagnostic methods, therapeutic alternatives; and discusses fertility preservation, cancer possibilities, and quality of life in patients. The book also examines new medical treatments for the condition including Statins, Aromatase Inhibitors and Antiagiogenic Agents and reviews new delivery technologies for classical drugs and provides a synopsis of the new drug pipeline for the condition.