Stereoselective Synthesis Of Functionalized Quaternary Stereocenters Naturally Occurring Tetronic Acids And R R L Factor
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Stereoselective Synthesis Of Functionalized Quaternary Stereocenters Naturally Occurring Tetronic Acids And R R L Factor
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Author : Amarender Manchoju
language : en
Publisher:
Release Date : 2018
Stereoselective Synthesis Of Functionalized Quaternary Stereocenters Naturally Occurring Tetronic Acids And R R L Factor written by Amarender Manchoju and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with categories.
Studies On The Stereoselective Synthesis Of Functionalized Quaternary Stereocenters And E 3 Arylmethylidene 5 Alkyl Aryl 2 3h Furanones
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Author : Gopinathan Muthusamy
language : en
Publisher:
Release Date : 2019
Studies On The Stereoselective Synthesis Of Functionalized Quaternary Stereocenters And E 3 Arylmethylidene 5 Alkyl Aryl 2 3h Furanones written by Gopinathan Muthusamy and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with categories.
An enantioselective synthesis of isolated acyclic quaternary stereocenters was achieved using metal-catalyzed Gosteli-Claisen rearrangements of allyl vinyl ethers. A concise synthesis of 2-t-butoxycarbonyl allyl vinyl ethers by regioselective Petasis methylenation and stereoselective Suzuki-Miyaura cross-coupling reactions of iodoallyl t-butyl oxalates was developed. Ethers with a terminally unsubstituted vinyl group and a terminally disubstituted allyl portion are readily accessible by this method. In addition to the metal-catalyzed Gosteli-Claisen rearrangements, organocatalytic variant of the Gosteli-Claisen rearrangement was investigated. A modular synthesis of several new, chiral cyclic phosphoramide-based, thioureas, formamidines and thiosemicarbazides was developed and these phosphoramides were examined for their ability to catalyze the Gosteli-Claisen rearrangement of a selected allyl vinyl ether. A variety of E-3-(arylidene)-5-(alkyl/aryl)-2(3H)-furanones were synthesized by employing regioselctive addition of -aryl acrylic acids with iodoacetylenes and subsequent intramolecular Heck reaction of Z-acyloxy iodo alkenes. The approach was applied in a formal synthesis of the naturally occurring kinase inhibitor BE-23372M.
Quaternary Stereocenters
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Author : Jens Christoffers
language : en
Publisher: Wiley-VCH
Release Date : 2006-05-12
Quaternary Stereocenters written by Jens Christoffers and has been published by Wiley-VCH this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-05-12 with Science categories.
Filling the gap in the literature, this book presents everything there is to know about this topic. By comprehensively covering the quaternary stereocenters found in a range of important and useful molecules in pharmaceutical and medicinal applications, as well as in thousands of natural products, the book provides the know-how chemists need to synthesize challenging molecules with numerous applications. A must for organic chemists in academia, the pharmaceutical industry and medicine. From the Contents: Important Natural Products Important Pharmaceuticals and Intermediates Aldol Reactions Michael Reactions and Conjugate Additions Cycloaddition Reactions Rearrangement Reactions Alkylation of Ketones and Imines Asymmetric Allylic Alkylation Asymmetric Cross Coupling and Heck Reactions Phase Transfer Catalysis Enzymatic Methods Radical Reactions