Steroid Receptors In Breast Cancer
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Steroid Receptors In Breast Cancer
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Author :
language : en
Publisher:
Release Date : 1983
Steroid Receptors In Breast Cancer written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1983 with Breast categories.
Clinical Interest Of Steroid Hormone Receptors In Breast Cancer
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Author : G. Leclercq
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Clinical Interest Of Steroid Hormone Receptors In Breast Cancer written by G. Leclercq and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Several papers dealing with the clinical relevance of steroid hormone receptors in breast cancer have already been published. However, no publication has overviewed studies currently being conducted in Europe, nor is there a register of the european centers performing receptor assays. It has been our purpose to fill these gaps. A large majority of authors who we contacted kindly agreed to con tribute to our book. Papers were grouped into six main parts according to their contents. The abundance of clinical data relevant to receptor assays led us to add critical summaries to help the reader to form his own opinions on the subject. We would like to thank Drs. R. J. B. King, G. Contesso, L. Santi, and E. Engelsman, who helped us in this regard. We hope that this book will enable the reader to become acquainted with the present state of European steroid hormone receptor studies devoted to breast cancer treatment. We also hope that it will promote cooperation between European oncologists involved in this field of research.
Immunocytochemistry For Steroid Receptors
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Author : Louis P. Pertschuk
language : en
Publisher: CRC Press
Release Date : 1990-08-15
Immunocytochemistry For Steroid Receptors written by Louis P. Pertschuk and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1990-08-15 with Medical categories.
A comprehensive review of the literature on steroid hormone receptor immuncytochemistry. It includes the development of the first monoclonal antireceptor antibody and initial procedures designed to localize steroid receptors in situ up to the present. The step-by-step instructions provide easy reading of topics such as tissue handling, processing, and interpretation. This text places particular emphasis on the studies of human material-especially mammary carcinoma. It presents specific details with chapters on estrogen and progesterone receptors in breast malignancies and benign breast disease. Each section of this outstanding book contains comprehensive photomicrographs that illustrate the most salient features discussed. Detailed graphs pertaining to theoretical particulars concerning technology and the relationship between image analysis and endocrine response are also included. This monograph is an excellent resource for all researchers concerned with hormone-dependent tissues, pathologists who have an interest in working with novel techniques for localizing steroid hormone receptors, and oncologists who must use assay results in the treatment of breast cancer.
Advances In Rapid Sex Steroid Action
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Author : Gabriella Castoria
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-12-15
Advances In Rapid Sex Steroid Action written by Gabriella Castoria and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-12-15 with Medical categories.
Breast and prostate cancers are both hormone-dependent, at least in some stages of their progression. Hormonal manipulation represents an important therapeutic approach. Although most of breast and prostate cancers initially respond to hormone therapy, most tumors reinitiate to growth. Finally, hormone-resistant and metastatic breast and prostate cancers may develop. Thus, the challenge is the dissection of mechanisms by which steroid receptor signaling pathways continue to influence cell growth and invasiveness. Compelling evidence indicates that steroid hormones elicit non-genomic responses in extra-nuclear compartment of target cells. In this cellular location, steroid-coupled receptors rapidly recruit signaling effectors or scaffold proteins and activate multiple pathways leading to proliferation, survival, migration and invasiveness. The immediate challenge is the dissection of key events regulating the steroid response of target tissues to prevent progression and improve treatment of breast and prostate cancers.
The Role Of Steroid Receptor Coactivator 1 In Breast Cancer
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Author :
language : en
Publisher:
Release Date : 1999
The Role Of Steroid Receptor Coactivator 1 In Breast Cancer written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with categories.
The steroid hormones estrogen and progesterone and their intracellular receptors have been Implicated in the development and progression of primary epithelial breast cancer. Regulation of gene expression by hormone-bound steroid receptors Is mediated by members of the steroid receptor coactivator (SRC) family. The purpose of this study was to examine the role of SRC-1 in the regulation of gene expression by steroid receptors. In breast cancer SRC-1 was found to exist in a multifactor complex which was stably associated with liganded progesterone receptor, implicating an active SRC-1 complex as a primary target of liganded PR in breast cancer cells. In an effort to further define the role of SRC-1 in breast cancer, we characterized a member of the active SRC-1 complex, SRA (steroid receptor RNA coactivator), which was shown to function as an RNA. Significantly, SRA Is a limiting factor required for efficient transcriptional activation by steroid hormone receptors in breast cancer cells.
Steriod Receptors In Breast Cancer
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Author :
language : en
Publisher:
Release Date : 1979
Steriod Receptors In Breast Cancer written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1979 with Breast categories.
Steroid Receptors In Health And Disease
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Author : Virinder Moudgil
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-09
Steroid Receptors In Health And Disease written by Virinder Moudgil and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-09 with Medical categories.
During the last two decades, progress in steroid hormone research has resulted in the development of new approaches to contraception as well as diagnosis and treatment of endocrine disorders and cancers. Although significant advances have been made in the purification, characterization, immunochemistry and molecular biology of steroid receptors, the precise molecular mechanism of steroid hormone action has remained obscure. This book captures the detailed presentations made at the first conference on Steroid Receptors in Health and Disease held at Meadow Brook Hall, Oakland University in the fall of 1987. The purpose of this international con ference was to facilitate scientific exchange toward a better understand ing of the mode of action of steroid hormones. The scientific sessions consisted of poster presentations and state-of-the-art lectures, the latter of which make up this volume. The first chapter is meant to provide the reader with a more general background of the topics covered in the book, as well as to discuss certain theme-related issues that are either not yet well-established or accepted or are in the stage of infancy. It is hoped that this volume will serve as a useful treatise for students and investigators interested in basic and clinical aspects of biological regulation by steroid hormones. A task of this magnitude could not have been undertaken without the encouragement, advice and continued generous assistance of the members of the scientific committee. I am gratefully indebted to Drs.
Differential Regulation Of Steroid Receptors In Breast Cancer By The Rho Gef Vav3
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Author : Jessica Anne McCarrick
language : en
Publisher:
Release Date : 2008
Differential Regulation Of Steroid Receptors In Breast Cancer By The Rho Gef Vav3 written by Jessica Anne McCarrick and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with categories.
Recently reported data demonstrate that Vav3, a Rho Guanine Nucleotide Exchange Factor (Rho GEF) is overexpressed in breast tumors, coexpressed with ER, necessary for proliferation in breast cancer cells, and predictive of response to neoadjuvant endocrine therapies in patients with ER+ tumors. Such data beg the question as to what roles Vav3 plays in modulation of steroid receptor activity in breast cancer and in resistance to current hormonal therapies. Using reporter assays, I provide novel evidence that Vav3 potentiates Estrogen Receptor activity and represses Androgen Receptor activity in breast cancer cells. Vav3 potentiates ligand-dependent estrogen receptor activity in the MCF-7. A truncated, constitutively active form of Vav3, caVav3 potentiates ligand dependent ER activity in both MCF-7 and T47D. Vav3 activates Rho GTPases through its GEF domain. ER potentiation by caVav3 is dependent upon GEF activity. A caVav3 mutant with defective GEF function represses basal and ligand-mediated ER activity in T47D. Although other studies have shown that Vav3 could activate various Rho GTPases, only constitutively active Rac1 mutants potentiated ER activity in both cell lines. Contrastingly, reporter assays were used to show that caVav3 inhibits ligand-mediated AR activity in the AR+ T47D cell line by both R1881 and DHT stimulation. caVav3-mediated repression of AR activity is GEF-dependent, as caVav3 GEF mutants potentiate AR activity. Constitutively active forms of Rho GTPases were found to repress AR activity to different extents, but R1881-mediated AR activity was only significantly repressed by caCdc42. My studies of the effect of androgens on AR protein by western blot show that androgens downregulate AR protein in the highly Vav3 positive T47D cell line. Previous studies have demonstrated that androgens stabilize AR protein in MCF-7, and I now provide evidence that overexpression of Vav3 or caVav3 reverses hormone-mediated AR protein stabilization in MCF-7. These data are especially relevant given recently published data that decreased AR protein levels contributed to failure of response to MPA in patients with metastatic breast cancer. Further breast cancer studies may prove Vav3 to be a potential drug target in hormone dependent, hormone independent, and metastatic disease.
Localization Of Putative Steroid Receptors
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Author : Pertschuk
language : en
Publisher: CRC Press
Release Date : 2018-02-01
Localization Of Putative Steroid Receptors written by Pertschuk and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-02-01 with Medical categories.
These volumes represent the "state-of-the-art" in morphological methods for detection of steroid receptors. Some physician authors have applied many of the new methodologies in clinical research projects deisgned to improve medical practice, and these attempts have been placed in Volume II. The Background and recent advances presented here are intended to stimulate further experimentation and new innovations, and spur clinical trials by all investigators with an interest in steroid hormones, cell biology, and clinical oncology.
Steroid Receptors And The Management Of Cancer
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Author :
language : en
Publisher:
Release Date : 1979
Steroid Receptors And The Management Of Cancer written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1979 with Cancer categories.