Still Targeted
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The Ischemic Penumbra Still The Target For Stroke Therapies
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Author : Argye E. Hillis
language : en
Publisher: Frontiers Media SA
Release Date : 2015-07-23
The Ischemic Penumbra Still The Target For Stroke Therapies written by Argye E. Hillis and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-07-23 with Acute ischemic stroke categories.
The ischemic penumbra was initially defined by Symon, Lassen and colleagues in the 1970s as an area of brain tissue with inadequate blood flow to maintain electric activity of neurons but adequate blood flow to preserve the function of the ion channels. This area of tissue, receiving enough blood to survive but not enough to function, often surrounds or abuts the irreversibly damaged core in ischemic stroke. It was shown that if blood flow could be restored to this area of marginal perfusion, the tissue could survive and function again, and growth of the core could be prevented. Based on seminal PET studies, penumbra or "penumbral tissue" eventually took on a subtly different meaning - the area of brain that is destined to progress to infarct unless blood flow is restored within a particular time window. The penumbra thus became the target for all acute stroke interventions - to preserve viability of the tissue and restore function. New imaging techniques, including diffusion and perfusion MRI and CT perfusion, were developed to rapidly identify individuals with penumbra, who were thought to be the best candidates for aggressive interventions to restore blood flow, particularly beyond the licensed time-window for IV thrombolysis. However, most clinical trials have failed to establish the usefulness of identifying candidates for treatment in this way using pre-specified protocols and primary endpoints. These trials have used different and sometimes unvalidated thresholds of hypoperfusion as well as irreversible infarct and various definitions of significant penumbra (or mismatch between irreversible infarct and hypoperfused, but salvageable tissue), and reanalysis of their data using more refined image processing showed post-hoc positivity. They have also evaluated outcome in a variety of ways, with few studies measuring the direct effect of restoring blood flow on the function of the penumbral tissue. Therefore, important remaining questions include how to define, characterize, and image the penumbra in acute stroke to achieve the greatest reliability and validity for what we want to measure, and whether this concept, so defined, provides an optimal target for stroke therapy using state-of-the-art trial design.
Strategic Uses Of Alternative Media Just The Essentials
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Author : Robyn Blakemen
language : en
Publisher: Routledge
Release Date : 2014-12-18
Strategic Uses Of Alternative Media Just The Essentials written by Robyn Blakemen and has been published by Routledge this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-12-18 with Business & Economics categories.
Designed for students and practitioners in the fields of organizational behavior and human resource training and development, this book examines improving organizational communication. Terrence Gargiulo shows how the use of storytelling is the key to effective communication and learning.
Davidson S Principles And Practice Of Medicine E Book
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Author : Brian R. Walker
language : en
Publisher: Elsevier Health Sciences
Release Date : 2013-12-06
Davidson S Principles And Practice Of Medicine E Book written by Brian R. Walker and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-12-06 with Medical categories.
More than two million medical students, doctors and other health professionals from around the globe have owned a copy of Davidson’s Principles and Practice of Medicine since it was first published. Today’s readers rely on this beautifully illustrated text to provide up-to-date detail of contemporary medical practice, presented in a style that is concise and yet easy to read. Davidson’s provides the factual knowledge required to practise medicine, explaining it in the context of underlying principles, basic science and research evidence, and shows how to apply this knowledge to the management of patients who present with problems rather than specific diseases. The book has won numerous prizes including being highly commended in the British Medical Association book awards. Davidson’s global perspective is enhanced by the input of an international team of authors and a distinguished International Advisory Board from 17 countries. Building on the foundations laid down by its original editor, Davidson’s remains one of the world’s leading and most respected textbooks of medicine. The underlying principles of medicine are described concisely in the first part of the book, and the detailed practice of medicine within each sub-specialty is described in later system-based chapters. Most chapters begin with a two-page overview of the important elements of the clinical examination, including a manikin to illustrate the key steps in the examination of the relevant system. A practical, problem-based clinical approach is described in the ‘Presenting Problems’ sections, to complement the detailed descriptions of each disease. The text is extensively illustrated, with over 1000 diagrams, clinical photographs, and radiology and pathology images. 1350 text boxes present information in a way suitable for revision, including 150 clinical evidence boxes summarising the results of systematic reviews and randomised controlled trials and 65 ’In Old Age’ boxes highlighting important aspects of medical practice in the older population. A combined index and glossary of medical acronyms contains over 10 000 subject entries. The contents can also be searched comprehensively as part of the online access to the whole book on the StudentConsult platform. Access over 500 self-testing questions with answers linked to the book’s content for further reading. The text uses both SI and non-SI units to make it suitable for readers throughout the globe. A new chapter specifically on Stroke Disease recognises the emergence of Stroke Medicine as a distinct clinical and academic discipline. A rationalisation of the 1350 boxes used throughout the book gives a simpler and clearer presentation of the various categories. New ‘In Adolescence’ boxes recognise the fact that many chronic disorders begin in childhood and become the responsibility of physicians practising adult medicine. These boxes acknowledge the overlap ‘transitional’ phase and highlight the key points of importance when looking after young people. The regular introduction of new authors and editors maintains the freshness of each new edition. On this occasion Dr Ian Penman has joined the editorial team and 18 new authors bring new experience and ideas to the content and presentation of the textbook. An expanded International Advisory Board of 38 members includes new members from several different countries.
Ramblings Of A Targeted Individual
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Author : Sharon R. Poet
language : en
Publisher: CreateSpace
Release Date : 2014-10-06
Ramblings Of A Targeted Individual written by Sharon R. Poet and has been published by CreateSpace this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-10-06 with Biography & Autobiography categories.
A Targeted Individual's fight to expose criminal use of satellite surveillance systems, radio wave technologies and covert harassment programs. Find more on, http://www.sharonpoet-ti.blogspot.com and on http://www.targetedinamerica.com
A World Made For Money
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Author : Bret Wallach
language : en
Publisher: U of Nebraska Press
Release Date : 2015-05-01
A World Made For Money written by Bret Wallach and has been published by U of Nebraska Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-05-01 with Business & Economics categories.
A spirited and incisive survey of economic geography, A World Made for Money begins with the author stopped at a red light in Norman, Oklahoma. Observing the landscape of drugstores and banks, and for that matter the stoplight and roads themselves, Bret Wallach observes, “Everything I see has been built to make money” or, at the very least, to facilitate making money. This, he argues, is a global phenomenon that nonetheless has occurred only within the past hundred years or so. Although guidebooks and culture brokers often disparage these landscapes of commerce, Wallach—recipient of a MacArthur “genius grant”—argues that we would do well to pay them close attention. A World Made for Money provides a compelling, condensed tour of our world. From Silicon Valley to Sri Lanka, from post-Soviet Russia to post-apartheid South Africa, Wallach looks at how human beings are buying, manufacturing, working, growing and shipping food, and accessing the natural resources to fuel it all. These essential facets of daily life, propelled by the profit motive, represent a transnational force shaping our surroundings and environment in ways that may not always be beautiful (or even healthy) but that are fundamental to understanding how the world works in the twenty-first century. Wallach examines the relationship between acquisitiveness and landscape, reveals surprising contradictions and nuances, and provides fresh perspective on politically charged topics such as sprawl, deindustrialization, and agribusiness.
Human Computer Interaction Interact 2013
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Author : Paula Kotzé
language : en
Publisher: Springer
Release Date : 2013-07-30
Human Computer Interaction Interact 2013 written by Paula Kotzé and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-07-30 with Computers categories.
The four-volume set LNCS 8117-8120 constitutes the refereed proceedings of the 14th IFIP TC13 International Conference on Human-Computer Interaction, INTERACT 2013, held in Cape Town, South Africa, in September 2013. The 55 papers included in the second volume are organized in topical sections on E-input/output devices (e-readers, whiteboards), facilitating social behaviour and collaboration, gaze-enabled interaction design, gesture and tactile user interfaces, gesture-based user interface design and interaction, health/medical devices, humans and robots, human-work interaction design, interface layout and data entry, learning and knowledge-sharing, learning tools, learning contexts, managing the UX, mobile interaction design, and mobile phone applications.
Ramblings Of A Targeted Individual Sixth Edition
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Author : Sharon R. Poet
language : en
Publisher: Createspace Independent Pub
Release Date : 2014-11-04
Ramblings Of A Targeted Individual Sixth Edition written by Sharon R. Poet and has been published by Createspace Independent Pub this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-11-04 with Technology & Engineering categories.
A Targeted Individual's painful fight to expose criminal use of satellite surveillance systems and radio wave technologies as well as covert harassment programs. My work has become a fight to regain my freedom from covert targeting so that I can recover and do what I was born to be doing with my life. Please become aware and help bring an end to this crisis. www.targetedinamerica.com
Public Administration In Theory And Practice
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Author : Raymond W Cox III
language : en
Publisher: Routledge
Release Date : 2015-07-22
Public Administration In Theory And Practice written by Raymond W Cox III and has been published by Routledge this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-07-22 with Political Science categories.
Hailed for its timelessness and timeliness, Public Administration in Theory and Practice examines public administration from a normative perspective, and provides students with an understanding of the practice of public administration. Combining historical, contextual and theoretical perspectives, this text give students a truly comprehensive overview of the discipline and focuses on the practical implications of public administration theory. Features Normative perspective focuses on the practice of public administration and helps students understand what public administrators do. Historical, contextual and theoretical perspectives provide comprehensive coverage of the subject matter. A thematic overview reinforces the multiple conceptual frameworks or lens through which we see public administration. Students will learn to think through to practical and realistic solutions that acknowledge an historic precedence and theory. Emphasis on performance measures and assessments
Targeting The Third Reich
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Author : Robert S. Ehlers
language : en
Publisher:
Release Date : 2009
Targeting The Third Reich written by Robert S. Ehlers and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with History categories.
Argues that air intelligence played a crucial but largely overlooked role in the successful execution of the Allied bombing campaigns against the Third Reich, which in turn proved a decisive factor in both ending the war in Europe and ending it as soon as it did.
Strategic And Foreign Policy Implications Of Abm Systems March 6 11 13 21 26 28 1969
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Author : United States. Congress. Senate. Committee on Foreign Relations. Subcommittee on International Organization and Disarmament Affairs
language : en
Publisher:
Release Date : 1969
Strategic And Foreign Policy Implications Of Abm Systems March 6 11 13 21 26 28 1969 written by United States. Congress. Senate. Committee on Foreign Relations. Subcommittee on International Organization and Disarmament Affairs and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1969 with Air defenses categories.
Considers the national and international ramifications of U.S. ABM deployment, and its effects on SALT talks with the Soviet Union.