Stress Inducible Cellular Responses
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Stress Inducible Cellular Responses
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Author : U. Feige
language : en
Publisher: Birkhäuser
Release Date : 2013-03-11
Stress Inducible Cellular Responses written by U. Feige and has been published by Birkhäuser this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-11 with Science categories.
This book will deal with heat shock proteins and more generally with stress-related inducible gene expression as a pleiotropic adaptive response to stress. It presents a textbook-like overview of the field not only to heat shock experts, but to physiologists, pharmacologists, physicians, neuropsychologists and others as well. It is intended to be a state-of-the-art and perspective book rather than an up-to-date presentation of recent data. It should provide a basis for new experimetal approaches to fields at the edge of the classical heat shock field. Drugs, UV irradiation and environmental toxics will be considered as important modulators of the stress response. Radical scavengers such as superoxide dismutases and inducible regulatory proteins of metallic ion status such as ferritin as well as immunophilins and protein disulfide isomerases will be considered within the frame of stress proteins. The potential practical applications of heat shock proteins in toxicology and medicine for the diagnosis, prognosis and eventually therapy of clinical conditions associated with an increased oxidative burden will be outlined. The role of heat shock proteins in the modulation of immune responses will also be included. The book considers heat shock from a broad perspective including fields for which heat-shock may become of importance in the very near future such as cellular responses to environmental stresses and complex stress responses under specific conditions. It was also felt timely to incorporate a whole section on medical and technological applications of stress proteins. The book will be invaluable for all those working on stress and is intended for every "stress laboratory" as a source of knowledge and perspectives.
Stress Response
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Author : Stephen M. Keyse
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-10-26
Stress Response written by Stephen M. Keyse and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-10-26 with Science categories.
Mammalian cells have evolved a complex multicomponent machinery that enables them to sense and respond to a wide variety of potentially toxic agents present in their environment. These stress responses are often associated with an increased cellular capacity to tolerate normally lethal levels of an insult. The realization that the mammalian stress response may be intimately linked with many human diseases, including rheumatoid arthritis, ischemia, fever, infection, and cancer, has led to an explosion of interest in this research area. Stress Response: Methods and Protocols brings together a diverse array of practical methodologies that may be employed to address various aspects of the response of mammalian cells to environmental stress. The p- tocols are carefully described by authors who have both devised and succe- fully employed them, and they represent a mixture not only of well-established techniques, but also new technologies at the leading edge of research. The areas covered include the detection and assay of stress-induced damage, the acti- tion of signal transduction pathways, stress-inducible gene expression, and stress protein function. Although no volume of this size can be comprehensive and the topics covered reflect a personal choice, it is hoped that it will prove of subst- tial interest and use to a wide range of research workers in the field.
The Role Of Stress
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Author : L. Zhou
language : en
Publisher:
Release Date : 1996
The Role Of Stress written by L. Zhou and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with categories.
Cellular Responses To Stress
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Author : Biochemical Society (Great Britain). Symposium
language : en
Publisher:
Release Date : 1999
Cellular Responses To Stress written by Biochemical Society (Great Britain). Symposium and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with Cell metabolism categories.
Cellular Response To Oxidative And Osmotic Stress
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Author :
language : en
Publisher:
Release Date : 2000
Cellular Response To Oxidative And Osmotic Stress written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with categories.
Cellular Stress Responses
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Author :
language : en
Publisher:
Release Date : 2010
Cellular Stress Responses written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with categories.
Exploring The Role Of Dicer In The Cellular Response To Mild 39 5 C Hyperthermia Stress
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Author : Anand Shankar Devasthanam Krupashankar
language : en
Publisher:
Release Date : 2017
Exploring The Role Of Dicer In The Cellular Response To Mild 39 5 C Hyperthermia Stress written by Anand Shankar Devasthanam Krupashankar and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with categories.
Thermotolerance is a biological phenomenon wherein mild hyperthermia experienced cells achieve a transient state of resistance to a subsequent heat shock insult. A thermotolerant phenotype is thought to be sustained largely via the heat shock response (HSR) and the endoplasmic reticulum (ER) stress response pathways. Our previous work suggests that mild hyperthermia stress at 39. 5C induces elevations in Dicer protein levels in various human and murine cell lines; however, the biological relevance of this finding is uncertain. Here we hypothesize that the thermotolerant phenotype is sustained, in significant part, by the elevated Dicer protein levels. To address this hypothesis, we also determined whether a causal link exists between mild hyperthermia-induced increases in Dicer protein levels and critical factors within the ER and HSR pathways. We find that elevated Dicer protein levels are associated with the activation of protein kinase R (PKR) and eukaryotic initiation factor 2 (eIF2) in thermotolerant cells. We also find that elevated Dicer protein levels in thermotolerant cells play a role in the pro-survival phenotype by differentially modulating ATF4 and CHOP protein levels. Further, we suggest a novel role for Dicer in the cellular stress response to mild hyperthermia that is likely distinct from its role in microRNA processing. Our studies show that Dicer is regulated at multiple levels during cell stress and that the heat-inducible chaperone HSP90 is involved in the posttranslational regulation of Dicer following mild hyperthermia conditions. Overall our work indicates that Dicer plays an important role in the ER stress network and as a result, provides a framework to better understand its role in the cellular response to mild hyperthermia, and potentially other stresses.
Expression Of Constitutive Hsc70 And Stress Inducible Hsp70 Mrna And Protein In The Rabbit Central Nervous System
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Author : Pasquale Manzerra
language : en
Publisher:
Release Date : 1997
Expression Of Constitutive Hsc70 And Stress Inducible Hsp70 Mrna And Protein In The Rabbit Central Nervous System written by Pasquale Manzerra and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with categories.
The induction of hsp70 has been established as a useful marker of cellular stress in the mammalian nervous system. In addition, studies have indicated a role for members of the hsp70 gene family in protecting cells from the lethal effects of heat and other stresses. In this thesis the stress response is examined in the rabbit nervous system following a physiologically relevant heat shock using hsc70 and hsp70-specific riboprobes and antibodies. A rapid and transient induction of hsp70 mRNA and protein was observed following hyperthermic stress. Tissue-specific differences in the magnitude of induction of hsp70 protein were observed. Induction was greatest in non-neural tissues compared to regions of the rabbit nervous system. In unstressed animals, abundant levels of hsc70 protein were detected in brain regions whereas lower levels were detected in non-neural tissues. In addition to hsc70, basal levels of inducible hsp70 isoforms were also observed in control animals. At the cellular level, distinct patterns of hsc70 and hsp70 expression were observed in the rabbit brain. In control animals, hsc70 mRNA and protein exhibited a neuronal pattern of expression. In response to hyperthermia, large neuronal cells (Purkinje neurons, deep cerebellar nuclei of the cerebellum and motor neurons of the spinal cord), which expressed high constitutive levels of hsc70, showed a dampened or delayed accumulation of hsp70 mRNA. Hsp70 protein was not detected in these neurons. Glial cells, which show little detectable levels of hsc70, demonstrate a robust induction of hsp70. To further evaluate the neuronal stress response, nuclear translocation of hsc70 and hsp70 protein was used as an additional indicator of cellular stress. Following a 2-3$\sp\circ$C increase in body temperature, non-neuronal cell types (ependymal cells and oligodendrocytes) exhibited features of a stress response. In contrast, several neuronal cell types (Purkinje, cortical, dentate granule and thalamic neurons) required an increased degree of hyperthermia (3.4 $\pm$.2$\sp\circ$C) before eliciting a feature of the stress response, namely nuclear translocation of hsc70 protein. Taken together, these results suggest that the neural heat shock response may occur in stages depending on the level of stress on individual cell populations and existing cellular levels of hsps.
Molecular Aspects Of The Stress Response Chaperones Membranes And Networks
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Author : Peter Csermely
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-08-09
Molecular Aspects Of The Stress Response Chaperones Membranes And Networks written by Peter Csermely and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-08-09 with Science categories.
This book makes a novel synthesis of the molecular aspects of the stress response and long term adaptation processes with the system biology approach of biological networks. Authored by an exciting mixture of top experts and young rising stars, it provides a comprehensive summary of the field and identifies future trends.
Autophagy Cancer Other Pathologies Inflammation Immunity Infection And Aging
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Author : M. A. Hayat
language : en
Publisher: Academic Press
Release Date : 2016-12-28
Autophagy Cancer Other Pathologies Inflammation Immunity Infection And Aging written by M. A. Hayat and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-12-28 with Medical categories.
Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging is an eleven volume series that discusses in detail all aspects of autophagy machinery in the context of health, cancer, and other pathologies. Autophagy maintains homeostasis during starvation or stress conditions by balancing the synthesis of cellular components and their deregulation by autophagy. This series discusses the characterization of autophagosome-enriched vaccines and its efficacy in cancer immunotherapy. Autophagy serves to maintain healthy cells, tissues, and organs, but also promotes cancer survival and growth of established tumors. Impaired or deregulated autophagy can also contribute to disease pathogenesis. Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and forward-thinking, these books offer a valuable guide to cellular processes while also inciting researchers to explore their potentially important connections. Presents the most advanced information regarding the role of the autophagic system in life and death Examines whether autophagy acts fundamentally as a cell survivor or cell death pathway or both Introduces new, more effective therapeutic strategies in the development of targeted drugs and programmed cell death, providing information that will aid in preventing detrimental inflammation Features recent advancements in the molecular mechanisms underlying a large number of genetic and epigenetic diseases and abnormalities, including atherosclerosis and CNS tumors, and their development and treatment Includes chapters authored by leaders in the field around the globe—the broadest, most expert coverage available