Studies Toward The Total Synthesis Of Maoecrystal V
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Total Synthesis Of Maoecrystal V
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Author : Jianxian Gong
language : en
Publisher: Springer
Release Date : 2014-07-08
Total Synthesis Of Maoecrystal V written by Jianxian Gong and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-07-08 with Science categories.
In this thesis, the author describes the total synthesis of natural product Maoecrystal V in detail. In the first part of the thesis, the author introduces the research background and reviews the research progress in total synthesis of Maoecrystal V. In the second part, the author develops a novel and concise approach for the stereo selective construction of the tetracyclic model system of Maoecrystal V. The model system is accomplished in 8 steps with 20% yield. In the third part, the author describes the first successful total synthesis of Maoecrystal V and investigates four strategies for constructing the key tetrahydrofuran oxa-bridge skeleton. The total synthesis starts from a known compound and is accomplished in 17 steps with 1.2% yield. The successful total synthesis of Maoecrystal V will contribute to the development of efficient synthetic strategies for natural products and other compounds with complex structures.
Studies Toward The Total Synthesis Of Maoecrystal V
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Author : Paul John Krawczuk
language : en
Publisher:
Release Date : 2011
Studies Toward The Total Synthesis Of Maoecrystal V written by Paul John Krawczuk and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with Diterpenes categories.
In 2004, Li and coworkers reported the isolation of the complex diterpenoid maoecrystal V, from the leaves of the Chinese medicinal herb Isodon eriocalyx, whose structure was verified by x-ray crystallographic analysis. It possesses a unique architecture, with five highly congested rings and seven stereocenters, two of which are adjacent all carbon quaternary centers located in its interior. In addition to the complex structure of this natural product, it also has promising biological activity, showing selective cytotoxicity towards the HeLa tumor cell line at low concentration (IC50 =40 nM), and low toxicity towards other cell lines tested. For these reasons maoecrystal V has attracted significant attention from the synthetic community. Herein we report on many of the strategies that we have pursued towards the total synthesis. One of these strategies culminated in the stereoselective synthesis of the complete carbon skeleton of the natural product. The hallmarks of this strategy are the arylation of a substituted cyclohexane ring, followed by an oxidative dearomatization, and finally by an intramolecular Diels-Alder reaction in order to construct the [2.2.2]bicyclooctane moiety.
Studies In Natural Product Synthesis
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Author : Irina Albrecht
language : en
Publisher:
Release Date : 2020
Studies In Natural Product Synthesis written by Irina Albrecht and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020 with categories.
Total Synthesis Of Maoecrystal V
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Author : Jianxian Gong
language : en
Publisher:
Release Date : 2014-03-31
Total Synthesis Of Maoecrystal V written by Jianxian Gong and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-03-31 with categories.
Total Synthesis Of Maoecrystal V
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Author : Feng Peng
language : en
Publisher:
Release Date : 2012
Total Synthesis Of Maoecrystal V written by Feng Peng and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with categories.
This thesis describes in detail our journey toward Maoecrystal V, a potential anti-cancer diterpenoid. Maoecrsytal V was isolated in 2004 from a Chinese herbal medicine. It has a highly congested structure, in which there are three continuous quaternary carbon center embedded within a rigid pentacyclic scaffold. The first chapter of this thesis covers the isolation, bioactivity, and synthetic efforts from other groups. The second chapter discusses our first generation strategy toward Maoecrystal V. During our early studies, we successfully found the conditions for the key intramolecular Diels-Alder reaction. We also identified that the facial selectivity of this Diels-Alder reaction is a big challenge for our synthesis plan. The third chapter describes our solution to the core structure of Maoecrystal V. The exploration resulted in the discovery of a novel exo-glycal epoxide rearrangement. The last chapter describes the total synthesis of Maoecrystal V. The difficulties we met and our solution is discussed.
Total Synthesis Of Cylindricines A And B
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Author : Julie Elizabeth Fields
language : en
Publisher:
Release Date : 1999
Total Synthesis Of Cylindricines A And B written by Julie Elizabeth Fields and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with categories.
Studies Towards The Total Synthesis Of Fr182877
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Author : Frederick Woolf Goldberg
language : en
Publisher:
Release Date : 2004
Studies Towards The Total Synthesis Of Fr182877 written by Frederick Woolf Goldberg and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with categories.
Studies Towards The Total Synthesis Of Manzamine A
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Author : Karel Marie Josef Brands
language : nl
Publisher:
Release Date : 1990
Studies Towards The Total Synthesis Of Manzamine A written by Karel Marie Josef Brands and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1990 with categories.
Studies Towards The Total Synthesis Of Manzamine A
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Author : Karel M. Brands
language : en
Publisher:
Release Date : 1990
Studies Towards The Total Synthesis Of Manzamine A written by Karel M. Brands and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1990 with categories.
The Total Synthesis Of Waihoensene And Studies Toward The Syntheses Of Vallesamidine And Lyconadin C
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Author : Lisa-Catherine Rosenbaum
language : en
Publisher:
Release Date : 2022
The Total Synthesis Of Waihoensene And Studies Toward The Syntheses Of Vallesamidine And Lyconadin C written by Lisa-Catherine Rosenbaum and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022 with categories.