Studying The Evolution Of Emerging Viruses Using Genome Wide Analysis
DOWNLOAD
Download Studying The Evolution Of Emerging Viruses Using Genome Wide Analysis PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Studying The Evolution Of Emerging Viruses Using Genome Wide Analysis book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page
Studying The Evolution Of Emerging Viruses Using Genome Wide Analysis
DOWNLOAD
Author : Lulan Wang
language : en
Publisher:
Release Date : 2019
Studying The Evolution Of Emerging Viruses Using Genome Wide Analysis written by Lulan Wang and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with categories.
In arms-race between the human host and viral pathogens, the favor often belongs to the pathogens. I have investigated emerging viruses by using meta-genomic data and system-wide mutagenesis of Zika and Influenza virus. Initially isolated from the Zika forest at Uganda in 1947. Zika virus (ZIKV) has been spreading in Africa, Asia and Asian-Pacific islands. It is not until late 2015 that Zika virus has emerged as a virus with significant public health impact, with rapidly accumulating evidence of a causal relationship with fetal neurologic birth defects. First reported from Northeast of Brazil in May 2015, followed by Colombia and Suriname in October 2015. Over the next couple of years, the virus has spread over 130 countries and infected tens of millions of people globally. It has been hypothesized that the virus may have recently evolved to become more neurotropic, to exhibit increased replicative capacity, and/or to become more transmissible to humans, but causal support for these possibilities is outstanding. To gain a better understanding of the molecular evolution of the virus, we have developed a novel genetic footprint method, as well as targeted structural modeling, on all known full-length ZIKV available to date. We were able to classify the ZIKV strains into ten groups and trace the spread and evolution of ZIKV in different parts of Brazil and other countries. Our analysis further pointed to the possibility that different groups of ZIKV may trigger different levels of host immune responses and cause distinct levels of pathogenesis. Vaccination is one of the greatest accomplishments in modern medicine and has effectively eradicated several life-threatening viruses in the past. A vaccine is essentially the injection of an attenuated pathogen, allowing the immune system to recognize and generate protective antibodies, which could serve future protection when re-exposed to the same pathogen. Over the years, the development of vaccine has followed an empirical paradigm, which has been successful for a few viruses, but not others. We began to recognize that viruses have developed their own complex strategies to combat vaccine-induced immune recognition. Viruses like influenza and HIV have developed powerful mutational strategies, that requires rational vaccine-design strategies to reduce or eradicate. Influenza A virus is a major public health problem, infecting as many as 500 million people a year worldwide. Unfortunately, the current vaccines are highly inefficient in its cross-protection. It is urgent that we uncover new strategies for generating a universal vaccine. Here we combined high-coverage and unbiased transposon mutagenesis of influenza virus with a rapid high-throughput screening for attenuation to generate W7-791, a live attenuated mutant virus strain. W7-791 produced only a transient asymptomatic infection in adult and neonatal mice even at doses 100-fold higher than the LD50 of the parent strain. A single administration of W7-791 conferred full protection to mice against lethal challenge with H1N1, H3N2, and H5N1 strains, and improved viral clearance in ferrets. Furthermore, W7-791-immunized mice conferred heterologous protection, indicating a role for T cell-mediated immunity.
Origin And Evolution Of Viruses
DOWNLOAD
Author : Esteban Domingo
language : en
Publisher: Elsevier
Release Date : 2008-06-23
Origin And Evolution Of Viruses written by Esteban Domingo and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-06-23 with Science categories.
New viral diseases are emerging continuously. Viruses adapt to new environments at astounding rates. Genetic variability of viruses jeopardizes vaccine efficacy. For many viruses mutants resistant to antiviral agents or host immune responses arise readily, for example, with HIV and influenza. These variations are all of utmost importance for human and animal health as they have prevented us from controlling these epidemic pathogens. This book focuses on the mechanisms that viruses use to evolve, survive and cause disease in their hosts. Covering human, animal, plant and bacterial viruses, it provides both the basic foundations for the evolutionary dynamics of viruses and specific examples of emerging diseases. NEW - methods to establish relationships among viruses and the mechanisms that affect virus evolution UNIQUE - combines theoretical concepts in evolution with detailed analyses of the evolution of important virus groups SPECIFIC - Bacterial, plant, animal and human viruses are compared regarding their interation with their hosts
Current Research Topics In Plant Virology
DOWNLOAD
Author : Aiming Wang
language : en
Publisher: Springer
Release Date : 2016-07-07
Current Research Topics In Plant Virology written by Aiming Wang and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-07-07 with Science categories.
Topics covered in this book include RNA silencing and its suppression in plant virus infection, virus replication mechanisms, the association of cellular membranes with virus replication and movement, plant genetic resistance to viruses, viral cell-to-cell spread, long distance movement in plants, virus induced ER stress, virus diversity and evolution, virus-vector interactions, cross protection, geminiviruses, negative strand RNA viruses, viroids, and the diagnosis of plant viral diseases using next generation sequencing. This book was anticipated to help plant pathologists, scholars, professors, teachers and advanced students in the field with a comprehensive state-of-the-art knowledge of the subject.
Plant Virus Evolution
DOWNLOAD
Author : Marilyn J. Roossinck
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-23
Plant Virus Evolution written by Marilyn J. Roossinck and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-23 with Science categories.
This book provides a comprehensive look at the field of plant virus evolution. It is the first book ever published on the topic. Individual chapters, written by experts in the field, cover plant virus ecology, emerging viruses, plant viruses that integrate into the host genome, population biology, evolutionary mechanisms and appropriate methods for analysis. It covers RNA viruses, DNA viruses, pararetroviruses and viroids, and presents a number of thought-provoking ideas.
Genomics Of Disease
DOWNLOAD
Author : J.P. Gustafson
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-12
Genomics Of Disease written by J.P. Gustafson and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-12 with Medical categories.
This title develops from the 24th Stadler symposium. It explores the general theme "GENOME EXPLOITATION: Data Mining the Genomes". The idea behind the theme is to discuss and illustrate how scientists are going to characterize and make use of the massive amount of information being accumulated about plant and animal genomes. The book presents a state-of-the-art picture on mining the Genome databases. Its chapters are authored by key stars in the field.
Genetics And Evolution Of Infectious Diseases
DOWNLOAD
Author : Michel Tibayrenc
language : en
Publisher: Elsevier
Release Date : 2010-12-17
Genetics And Evolution Of Infectious Diseases written by Michel Tibayrenc and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-12-17 with Medical categories.
Genetics and Evolution of Infectious Diseases is at the crossroads between two major scientific fields of the 21st century: evolutionary biology and infectious diseases. The genomic revolution has upset modern biology and has revolutionized our approach to ancient disciplines such as evolutionary studies. In particular, this revolution is profoundly changing our view on genetically driven human phenotypic diversity, and this is especially true in disease genetic susceptibility. Infectious diseases are indisputably the major challenge of medicine. When looking globally, they are the number one killer of humans and therefore the main selective pressure exerted on our species. Even in industrial countries, infectious diseases are now far less under control than 20 years ago. The first part of this book covers the main features and applications of modern technologies in the study of infectious diseases. The second part provides detailed information on a number of the key infectious diseases such as malaria, SARS, avian flu, HIV, tuberculosis, nosocomial infections and a few other pathogens that will be taken as examples to illustrate the power of modern technologies and the value of evolutionary approaches. Takes an integrated approach to infectious diseases Includes contributions from leading authorities Provides the latest developments in the field
Next Generation Sequencing
DOWNLOAD
Author : Jerzy Kulski
language : en
Publisher: BoD – Books on Demand
Release Date : 2016-01-14
Next Generation Sequencing written by Jerzy Kulski and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-01-14 with Medical categories.
Next generation sequencing (NGS) has surpassed the traditional Sanger sequencing method to become the main choice for large-scale, genome-wide sequencing studies with ultra-high-throughput production and a huge reduction in costs. The NGS technologies have had enormous impact on the studies of structural and functional genomics in all the life sciences. In this book, Next Generation Sequencing Advances, Applications and Challenges, the sixteen chapters written by experts cover various aspects of NGS including genomics, transcriptomics and methylomics, the sequencing platforms, and the bioinformatics challenges in processing and analysing huge amounts of sequencing data. Following an overview of the evolution of NGS in the brave new world of omics, the book examines the advances and challenges of NGS applications in basic and applied research on microorganisms, agricultural plants and humans. This book is of value to all who are interested in DNA sequencing and bioinformatics across all fields of the life sciences.
Sequence Evolution Function
DOWNLOAD
Author : Eugene V. Koonin
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-06-29
Sequence Evolution Function written by Eugene V. Koonin and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-29 with Science categories.
Sequence - Evolution - Function is an introduction to the computational approaches that play a critical role in the emerging new branch of biology known as functional genomics. The book provides the reader with an understanding of the principles and approaches of functional genomics and of the potential and limitations of computational and experimental approaches to genome analysis. Sequence - Evolution - Function should help bridge the "digital divide" between biologists and computer scientists, allowing biologists to better grasp the peculiarities of the emerging field of Genome Biology and to learn how to benefit from the enormous amount of sequence data available in the public databases. The book is non-technical with respect to the computer methods for genome analysis and discusses these methods from the user's viewpoint, without addressing mathematical and algorithmic details. Prior practical familiarity with the basic methods for sequence analysis is a major advantage, but a reader without such experience will be able to use the book as an introduction to these methods. This book is perfect for introductory level courses in computational methods for comparative and functional genomics.
The Adaptive Seascape
DOWNLOAD
Author : David J. Merrell
language : en
Publisher: U of Minnesota Press
Release Date : 1994
The Adaptive Seascape written by David J. Merrell and has been published by U of Minnesota Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994 with Science categories.
Based on observational and experimental data, in natural populations of plants and animals studied in the field and in the laboratory, this perspective unravels the hidden and often poorly founded assumptions underlying some of the more troublesome controversies in evolutionary biology today
Viruses
DOWNLOAD
Author : Paula Tennant
language : en
Publisher: Academic Press
Release Date : 2018-03-12
Viruses written by Paula Tennant and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-03-12 with Science categories.
Viruses: Molecular Biology, Host Interactions, and Applications to Biotechnology provides an up-to-date introduction to human, animal and plant viruses within the context of recent advances in high-throughput sequencing that have demonstrated that viruses are vastly greater and more diverse than previously recognized. It covers discoveries such as the Mimivirus and its virophage which have stimulated new discussions on the definition of viruses, their place in the current view, and their inherent and derived ‘interactomics’ as defined by the molecules and the processes by which virus gene products interact with themselves and their host’s cellular gene products. Further, the book includes perspectives on basic aspects of virology, including the structure of viruses, the organization of their genomes, and basic strategies in replication and expression, emphasizing the diversity and versatility of viruses, how they cause disease and how their hosts react to such disease, and exploring developments in the field of host-microbe interactions in recent years. The book is likely to appeal, and be useful, to a wide audience that includes students, academics and researchers studying the molecular biology and applications of viruses Provides key insights into recent technological advances, including high-throughput sequencing Presents viruses not only as formidable foes, but also as entities that can be beneficial to their hosts and humankind that are helping to shape the tree of life Features exposition on the diversity and versatility of viruses, how they cause disease, and an exploration of virus-host interactions