Synthesis And Applications Of Dna And Rna

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Synthesis And Applications Of Dna And Rna

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Author : Saran Narang
language : en
Publisher: Elsevier
Release Date : 2012-12-02

Synthesis And Applications Of Dna And Rna written by Saran Narang and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-02 with Science categories.

Synthesis and Applications of DNA and RNA discusses the significant contributions in the development of synthetic routes to DNA and RNA. This book contains nine chapters that describe the complexities in the chemistry and biology of DNA and RNA. After briefly dealing with the various stages of development in the chemical synthesis of polynucleotides, this book goes on presenting the DNA synthesis on solid supports and through the phosphoramidite method on silica supports. The discussions then shift to the chemical-enzymatic synthesis of expressed genes; the biochemical aspects of chemical syntheses of oligoribonucleotides; and the methods of rapid DNA and RNA sequence analysis. A chapter specifically tackles the protocols of DNA synthesis using double-stranded plasmid DNA as a template. The final chapter deals with the use of oligonucleotides for the identification and isolation of specific gene sequences. This chapter also covers the use oligonucleotides in the detection of human genetic diseases. Biologists, geneticists, and researchers interested in DNA and RNA synthesis will find this work invaluable.

Oligonucleotide Synthesis

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Author : Piet Herdewijn
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-04

Oligonucleotide Synthesis written by Piet Herdewijn and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-04 with Medical categories.

A collection of powerful new techniques for oligonucleotide synthesis and for the use of modified oligonucleotides in biotechnology. Among the protocol highlights are a novel two-step process that yields a high purity, less costly, DNA, the synthesis of phosphorothioates using new sulfur transfer agents, the synthesis of LNA, peptide conjugation methods to improve cellular delivery and cell-specific targeting, and triple helix formation. The applications include using molecular beacons to monitor the PCR amplification process, nuclease footprinting to study the sequence-selective binding of small molecules of DNA, nucleic acid libraries, and the use of small interference RNA (siRNA) as an inhibitor of gene expression.

Small Molecule Dna And Rna Binders

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Author : Martine Demeunynck
language : en
Publisher: John Wiley & Sons
Release Date : 2006-03-06

Small Molecule Dna And Rna Binders written by Martine Demeunynck and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-03-06 with Science categories.

The development of molecules that selectively bind to nucleic acids has provided many details about DNA and RNA recognition. The range of such substances, such as metal complexes, peptides, oligonucleotides and a wide array of synthetic organic compounds, is as manifold as the functions of nucleic acids. Nucleic acid recognition sequences are often found in the major or minor groove of a double strand, while other typical interactions include intercalation between base pairs or the formation of triple or quadruple helices. One example of a binding mode that has recently been proposed is end stacking on such complex structures as the telomere tetraplex. In this comprehensive book, internationally recognized experts describe in detail the important aspects of nucleic acid binding, and in so doing present impressive approaches to drug design. Since typical substances may be created naturally or synthetically, emphasis is placed on natural products, chemical synthesis, the use of combinatorial libraries, and structural characterization. The whole is rounded off by contributions on molecular modeling, as well as investigations into the way in which any given drug interacts with its nucleic acid recognition site.

Small Molecule Dna And Rna Binders

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Author : Martine Demeunynck
language : en
Publisher:
Release Date : 2003

Small Molecule Dna And Rna Binders written by Martine Demeunynck and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with Binding Sites categories.

Control Of Macromolecular Synthesis

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Author : Ole Maaløe
language : en
Publisher:
Release Date : 1966

Control Of Macromolecular Synthesis written by Ole Maaløe and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1966 with Bacteria categories.

Dna And Rna Nanobiotechnologies In Medicine Diagnosis And Treatment Of Diseases

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Author : Volker A. Erdmann
language : en
Publisher: Springer
Release Date : 2013-06-26

Dna And Rna Nanobiotechnologies In Medicine Diagnosis And Treatment Of Diseases written by Volker A. Erdmann and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-26 with Science categories.

This book will provide latest insights in the functional potentials of ribonucleic acids in medine and the use of Spiegelmer and Spiegelzyme systems. It will also deal with a new type of delivery systems for cellular targeting.

Molecular Biology Of The Cell

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Author : Bruce Alberts
language : en
Publisher:
Release Date : 2002

Molecular Biology Of The Cell written by Bruce Alberts and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Cytology categories.

Oligonucleotide Synthesis

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Author : Piet Herdewijn
language : en
Publisher: Humana
Release Date : 2004-09-01

Oligonucleotide Synthesis written by Piet Herdewijn and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-09-01 with Medical categories.

A collection of powerful new techniques for oligonucleotide synthesis and for the use of modified oligonucleotides in biotechnology. Among the protocol highlights are a novel two-step process that yields a high purity, less costly, DNA, the synthesis of phosphorothioates using new sulfur transfer agents, the synthesis of LNA, peptide conjugation methods to improve cellular delivery and cell-specific targeting, and triple helix formation. The applications include using molecular beacons to monitor the PCR amplification process, nuclease footprinting to study the sequence-selective binding of small molecules of DNA, nucleic acid libraries, and the use of small interference RNA (siRNA) as an inhibitor of gene expression.

Origins Of The Earth Moon And Life

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Author : Akio Makishima
language : en
Publisher: Elsevier
Release Date : 2017-01-27

Origins Of The Earth Moon And Life written by Akio Makishima and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-01-27 with Science categories.

Origins of the Earth, Moon, and Life: An Interdisciplinary Approach presents state-of-the-art knowledge that is based on theories, experiments, observations, calculations, and analytical data from five astro-sciences, astronomy, astrobiology, astrogeology, astrophysics, and cosmochemistry. Beginning with the origin of elements, and moving on to cover the formation of the early Solar System, the giant impact model of the Earth and Moon, the oldest records of life, and the possibility of life on other planets in the Solar System, this interdisciplinary reference provides a complex understanding of the planets and the formation of life. Synthesizing concepts from all branches of astro-sciences into one, the book is a valuable reference for researchers in astrogeology, astrophysics, cosmochemistry, astrobiology, astronomy, and other space science fields, helping users better understand the intersection of these sciences. Includes extensive figures and tables to enhance key concepts Uses callout boxes throughout to provide context and deeper explanations Presents up-to-date information on the universe, stars, planets, moons, and life in the solar system Combines knowledge from the fields of astrogeology, astrophysics, cosmochemistry, astrobiology, and astronomy, helping readers understand the origins of the Earth, the moon, and life in our solar system

Nutritional Epigenomics

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Author :
language : en
Publisher: Academic Press
Release Date : 2019-07-20

Nutritional Epigenomics written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-07-20 with Medical categories.

Nutritional Epigenomics offers a comprehensive overview of nutritional epigenomics as a mode of study, along with nutrition’s role in the epigenomic regulation of disease, health and developmental processes. Here, an expert team of international contributors introduces readers to nutritional epigenomic regulators of gene expression, our diet’s role in epigenomic regulation of disease and disease inheritance, caloric restriction and exercise as they relate to recent epigenomic findings, and the influence of nutritional epigenomics over circadian rhythms, aging and longevity, and fetal health and development, among other processes. Disease specific chapters address metabolic disease (obesity and diabetes), cancer, and neurodegeneration, among other disorders. Diet-gut microbiome interactions in the epigenomic regulation of disease are also discussed, as is the role of micronutrients and milk miRNAs in epigenetic regulation. Finally, chapter authors examine ongoing discussions of race and ethnicity in the social-epigenomic regulation of health and disease. Empowers the reader to employ nutritional epigenomics approaches in their own research Discusses the latest topics in nutritional epigenomics in the regulation of aging, circadian rhythm, inheritance and fetal development, as well as metabolism and disease Offers a full grounding in epigenetic reprogramming and nutritional intervention in the treatment and prevention of disease, as informed by population-based studies