Synthesis Of Novel Polymeric Nanoparticles For Hydrophobic And Hydrophilic Drug Delivery
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Synthesis Of Novel Polymeric Nanoparticles For Hydrophobic And Hydrophilic Drug Delivery
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Author : Marta Sartor
language : en
Publisher:
Release Date : 2010
Synthesis Of Novel Polymeric Nanoparticles For Hydrophobic And Hydrophilic Drug Delivery written by Marta Sartor and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with categories.
Modern medicine has achieved extraordinary results with the use of nanotechnologies. The combination of the two disciplines created the modern field of nanomedicine, in which drug delivery is one of the most prominent branches. Several aspects are involved in drug delivery; this work will focus on the drug delivery vehicle. In particular three aspects will be investigated: building material, internal structure and material compatibility. In a first project DNA was proposed as an innovative building material. DNA nanoparticles were made from self-folding of long concatameric repeats of a single strand sequence. Nanoparticles with different sequences created a library that was bio- panned against dendritic cells (DC). Particles from the enriched library were sequenced and individually tested for affinity towards DC. The use of DNA as building material offers several advantages. For instance DNA binding drugs (such as Doxorubicin) can be easily incorporated, and immunostimulatory sequences (such as GpC) and any other encoding sequence can be integrated within the concatamers. In addition, any other molecule or small particle of interest can be conjugated to a short complementary sequence and hybridized on the outer layer of the DNA nanoparticle. DNA nanoparticles' payloads are limited to hydrophilic drugs. In addition to an hydrophobic payload, some therapies require a high loading and steady release. To achieve such results a gradient structure was created within the core of a polymeric nanoparticle. Physical and chemical gradient were considered. A chemical gradient was created by combining a low molecular weigh polycaprolactone (PCL) to a higher molecular weigh poly(lactic-co-glycolic acid) (PLGA). PCL and PLGA have different degradation rate and hydrophobicity. The particles created by combining the two polymers showed properties (such as loading) dependent on the two polymers' proportion into the composition. The chemical gradient nanoparticles are characterized by high loading and steady release of hydrophobic drugs. A new technique was examined to encapsulate hydrophilic oligonucleotides into hydrophobic nanoparticles. PMAL-C8, a zwitterionic polymer, interacts with oligonucleotides of different length and improves their loading into the hydrophobic core. The nanoparticles created were successfully used in transfection experiments, showing the bioavailability of the loaded oligonucleotides.
Polymer Nanoparticles For Nanomedicines
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Author : Christine Vauthier
language : en
Publisher: Springer
Release Date : 2018-07-12
Polymer Nanoparticles For Nanomedicines written by Christine Vauthier and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-07-12 with Medical categories.
This volume serves as a valuable handbook for the development of nanomedicines made of polymer nanoparticles because it provides researchers, students, and entrepreneurs with all the material necessary to begin their own projects in this field. Readers will find protocols to prepare polymer nanoparticles using different methods, since these are based on the variety of experiences that experts encounter in the field. In addition, complex topics such as, the optimal characterization of polymer nanoparticles is discussed, as well as practical guidelines on how to formulate polymer nanoparticles into nanomedicines, and how to modify the properties of nanoparticles to give them the different functionalities required to become an efficient nanomedicine for different clinical applications. The book also discusses the translation of technology from research to practice, considering aspects related to industrialization of preparation and aspects of regulatory and clinical development.
Synthesis Of Polymeric Nanoparticles For The Controlled Release Of Hydrophobic And Hydrophillic Theraputic Compounds
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Author : Jiang Xu
language : en
Publisher:
Release Date : 2016
Synthesis Of Polymeric Nanoparticles For The Controlled Release Of Hydrophobic And Hydrophillic Theraputic Compounds written by Jiang Xu and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with categories.
Polymeric nanoparticle (NP) drug carriers present a promising technology for controlled release since they are capable of improving the encapsulation efficiency and stability of the drugs inside the NPs and also able to provide effective drug levels over a longer period of time, compared to traditional therapy. However, before the NP drug delivery technology becomes a reality, important parameters of NPs like size, drug loading ability and sustained release kinetics must be well investigated and optimized in order to minimize the adverse effects of chemotherapeutic compounds and prolong the drug releasing profile in a controlled manner. In order to accomplish this objective, this thesis proposed two novel methods for synthesis of NPs as drug delivery carriers, with assistance from bulk and microfluidic technologies, for hydrophobic and hydrophilic drugs, individually. For encapsulation of hydrophobic drugs, a modified flow focusing method was developed on a glass capillary microfluidic platform. Unlike conventional microfluidic flow focusing using two miscible phases, an insoluble component (DCM) was introduced into the dispersed phase to form a partially water-miscible precursor, and a transformation phenomenon of “jet-micro droplets--nanoparticles” was firstly observed instead of the “jet-micro droplets” or “jet-nanoparticles” from traditional flow focusing. Using Doxorubicin as a drug model, size-tunable Doxorubicin-PLGA NPs (80~170 nm) were synthesized by adjusting the flow rates, polymer concentration and the volume fraction of DCM in dispersed phase with an excellent monodispersity (PDI=0.1~0.2) which was superior to those from conventional flow focusing. We also found that drug loading content increased when volume ratio of DCM/DMSO in dispersed phase increased, with a considerable mass loading ratio up to 26.3%. In addition, Doxorubicin-PLGA NPs synthesized with DCM/DMSO precursor exhibited a slower drug release profile than those synthesized with pure DMSO precursor. This modified flow focusing method can also be extended to encapsulate inorganic compounds, such as iron oxide (Fe2O3) for a combination of chemotherapy and thermo-therapy, and showed a better loading ability of Fe2O3 than conventional research using pure DMSO. This method successfully combined the advantages from previous classical drug encapsulation techniques: small particle size, ease to operation-like nanoprecipitation; monodispersity, high drug encapsulation efficiency-like emulsion-based methods, provided us a promising tool for preparing nanoparticle carriers for multiple drug loading of both organic drugs and inorganic compounds For encapsulation and release of hydrophilic drugs, a modified bulk drop-wise nanoprecipiation method was designed by separating drug and polymer into aqueous and DMSO phases, respectively. In this case, we successfully solved the problem of the poor solubility of hydrophilic drug in organic solvents, for which reason the traditional nanoprecipitation method was limited to the application of hydrophilic drug encapsulation. Monodisperse ciprofloxacin-loaded PLA (poly (D,L-lactide))-Dextran and PLGA-PEG (poly (lactide-co-glycolide)-block-poly (ethylene glycol)) NPs were prepared of a tunable size range (80~200 nm). The drug loading ability, up to 18.6% (w/w), was found having an excellent linear correlation with the original feed of the ciprofloxacin drug, which indicated that drug content encapsulated by the NPs could be precisely controlled and an in-vitro sustained release was achieved up to 95.4% in 6 days. This thesis demonstrated the design and mechanism of different drug encapsulation and release systems; and synthesis, characterization, and optimization of drug-loaded polymeric nanoparticles. Our novel drug delivery systems significantly improved the encapsulation efficiency of various therapeutic compounds and exhibited a sustained-release profile. These nano-drug-delivery systems exploited intrinsic properties of NPs for controlled release, and will not only benefit the field of nanobiomedicine, but also could be further applied to food, flavor, fragrance and cosmetics industry.
Polymers At Nanoscale In 2 Volumes
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Author : Jie He
language : en
Publisher: World Scientific
Release Date : 2023-11-03
Polymers At Nanoscale In 2 Volumes written by Jie He and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-11-03 with Science categories.
Making polymers into nanoparticles as an essential step in polymer solution processing is of key importance for many applications of polymers. This book seeks to uncover the basics and recent advances in polymer nanoparticles, including polymer synthesis, self-assembly, properties, and applications. It encompasses the various preparation methods of polymer nanoparticles, broadly ranged from single chain collapse to polymerization methods and solution self-assembly. It showcases a wide range of advanced applications of polymer nanoparticles in several fields that include pharmaceutics (drug and nucleotide delivery), biomedicals (bioimaging, diagnosis, and therapeutics), energy (batteries and solar cells) and environmental (catalysis and water purification).This book is enriched with a comprehensive range of content, incorporating synthesis, properties and applications in polymeric nanoparticles that will serve as a suitable beginner guide and survey book in polymer nanomaterials, as well as a useful tool for graduate students, scientists and practitioners in related fields or industries such as chemistry, materials science and engineering, nanomaterials, energy storage and conversion devices, and biomedicine.
Block Co Polymeric Nanocarriers Design Concept And Therapeutic Applications
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Author : Neeraj Mishra
language : en
Publisher: Springer Nature
Release Date : 2023-11-29
Block Co Polymeric Nanocarriers Design Concept And Therapeutic Applications written by Neeraj Mishra and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-11-29 with Medical categories.
This book focuses on current advancements in the field of block copolymers and covers design, concept, and various therapeutic applications in the drug delivery. It also reviews the use of block copolymers in drug delivery applications from the development of sustained release products to smart polymeric delivery systems such as stimuli-responsive polymeric systems, for example, thermosensitive, redox-sensitive, photo-sensitive, and enzyme-sensitive. The book further discusses the nano assemblies from amphiphilic block copolymers as nanomedicine platforms for diagnosis and therapy due to their relatively small size, high drug loading capacity, controlled drug release, in vivo stability, and prolonged blood circulation. The chapters also review the various patents and ongoing clinical trials on the applications, covering several important new concepts and findings in the field of block copolymers. The book is aimed at researchers, academicians, and industrial scientists involved in the development of drug-delivery systems based on polymers.
Nanotechnology And Drug Delivery Volume One
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Author : José L. Arias
language : en
Publisher: CRC Press
Release Date : 2014-08-04
Nanotechnology And Drug Delivery Volume One written by José L. Arias and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-08-04 with Medical categories.
Pharmacotherapy is often limited by the inefficient activity and severe toxicity of drug molecules. Nanotechnology offers a revolutionary and definitive approach for the efficient delivery of drug molecules to non-healthy tissues and cells. This first volume of a series of two volumes analyzes the basics in the development of drug-loaded nanoplatfo
Nanotechnology And Drug Delivery Volume One
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Author : José L. Arias
language : en
Publisher: CRC Press
Release Date : 2014-08-04
Nanotechnology And Drug Delivery Volume One written by José L. Arias and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-08-04 with Medical categories.
Pharmacotherapy is often limited by the inefficient activity and severe toxicity of drug molecules. Nanotechnology offers a revolutionary and definitive approach for the efficient delivery of drug molecules to non-healthy tissues and cells. This first volume of a series of two volumes analyzes the basics in the development of drug-loaded nanoplatforms, the so-called nanomedicines. Special attention is given to physicochemical engineering, pharmacokinetics, biocompatibility and biodegradability, representative nanoplatforms (based on lipids, polymers, cyclodextrins, metals, carbon, silica, iron oxides, etc.), and advanced nano-engineering strategies for passive, ligand-mediated, and/or stimuli-sensitive drug delivery and release.
Polymer And Polymer Hybrid Nanoparticles
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Author : Stanislav Rangelov
language : en
Publisher: CRC Press
Release Date : 2013-08-28
Polymer And Polymer Hybrid Nanoparticles written by Stanislav Rangelov and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-08-28 with Science categories.
Polymeric and hybrid nanoparticles have received increased scientific interest in terms of basic research as well as commercial applications, promising a variety of uses for nanostructures in fields including bionanotechnology and medicine. Condensing the relevant research into a comprehensive reference, Polymer and Polymer-Hybrid Nanoparticles: Fr
Functional Hydrogels In Drug Delivery
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Author : Umile Gianfranco Spizzirri
language : en
Publisher: CRC Press
Release Date : 2017-08-10
Functional Hydrogels In Drug Delivery written by Umile Gianfranco Spizzirri and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-08-10 with Medical categories.
The book deals with the synthesis and characterization of hydrogels specifically used as drug delivery systems. Each chapter includes the most recent updates about the different starting materials employed and the improvement of their physicochemical and biological properties to synthetize high performing carriers for specific uses.
Nanotechnology In Drug Delivery
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Author : Saurabh Bhatia
language : en
Publisher: CRC Press
Release Date : 2017-03-03
Nanotechnology In Drug Delivery written by Saurabh Bhatia and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-03-03 with Medical categories.
This important new book provides the fundamental understanding of the peptide and protein drug delivery systems with a special focus on their nanotechnology applications. Addressing an increasing interest in peptide and protein drug delivery systems in both academic and industrial circles worldwide, this book fills the need for a comprehensive review and assessment of conventional and nonconventional routes of administration.