Systems Model Study Of Blood Glucose Homeostasis
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Systems Model Study Of Blood Glucose Homeostasis
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Author : Daniel Larue Cook
language : en
Publisher:
Release Date : 1970
Systems Model Study Of Blood Glucose Homeostasis written by Daniel Larue Cook and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1970 with Homeostasis categories.
System Model Study Of Blood Glucose Homeostasis
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Author : Joseph Tiran
language : en
Publisher:
Release Date : 1974
System Model Study Of Blood Glucose Homeostasis written by Joseph Tiran and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1974 with Blood categories.
Sensitivity Analysis In Systems Biology Modelling And Its Application To A Multi Scale Model Of Blood Glucose Homeostasis
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Author : T. Sumner
language : en
Publisher:
Release Date : 2010
Sensitivity Analysis In Systems Biology Modelling And Its Application To A Multi Scale Model Of Blood Glucose Homeostasis written by T. Sumner and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with categories.
Biological systems typically consist of large numbers of interacting components and involve processes at a variety of spatial, temporal and biological scales. Systems biology aims to understand such systems by integrating information from all functional levels into a single cohesive model. Mathematical and computational modelling is a key part of the systems biology approach and can be used to produce composite models which describe systems across multiple scales. One of the major diculties in constructing models of biological systems is the lack of precise parameter values which are often associated with a high degree of uncertainty. This uncertainty in parameter values can be incorporated into the modelling process using sensitivity analysis, the systematic investigation of the relationship between uncertain model inputs and the resulting variation in the model outputs. This thesis discusses the use of global sensitivity analysis in systems biology modelling and addresses two main problem areas: the application of sensitivity analysis to time dependent model outputs and the analysis of multi-scale models. An approach to the analysis of time dependent model outputs which makes use of principal component analysis to extract the key modes of variation from the data, is presented. The analysis of multi-scale models is addressed using group-based sensitivity analysis which enables the identication of the most important sub-processes in the model. Together these methods provide a new methodology for sensitivity analysis in multi-scale systems biology modelling. The methodology is applied to a composite model of blood glucose homeostasis that combines models of processes at the sub-cellular, cellular and organ level to describe the physiological system. The results of the analysis suggest three main points about the system: the mobilisation of calcium by glucagon plays a minor role in the regulation of glycogen metabolism; auto-regulation of hepatic glucose production by glucose is important in regulating blood glucose levels; time-delays between changes in blood glucose levels, the release of insulin by the pancreas and the eect of the hormone on hepatic glucose production are important in the possible onset of ultradian glucose oscillations. These results suggest possible directions for further study into the regulation of blood glucose.
Sensitivity Analysis In Systems Biology Modelling And Its Application To A Multi Scale Model Of Blood Glucose Homeostasis
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Author : Thomas Sumner
language : en
Publisher:
Release Date : 2010
Sensitivity Analysis In Systems Biology Modelling And Its Application To A Multi Scale Model Of Blood Glucose Homeostasis written by Thomas Sumner and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with categories.
Model Studies Of The Glucose Homeostatic System
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Author : David Paul Hudson
language : en
Publisher:
Release Date : 1969
Model Studies Of The Glucose Homeostatic System written by David Paul Hudson and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1969 with categories.
The Association Of Blood Glucose With The Daily Self Regulation Of Everyday Life Stress In Adolescents With Type 1 Diabetes
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Author : Laura Bethany Cohen
language : en
Publisher:
Release Date : 2023
The Association Of Blood Glucose With The Daily Self Regulation Of Everyday Life Stress In Adolescents With Type 1 Diabetes written by Laura Bethany Cohen and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023 with Blood glucose categories.
Adolescents with type 1 diabetes must learn to balance the complexities of managing a chronic disease with managing non-disease-related experiences in their daily life that also contribute to stress. For example, in addition to diabetes management, these adolescents must also balance ongoing demands from everyday life stressors including school, social interactions, and home and family life. However, it remains unclear if daily diabetes management might contribute to experiences of everyday life stress. The present study assessed the association between daily everyday life stress and blood glucose regulation in adolescents with type 1 diabetes using both linear and nonlinear models. Thirty-nine adolescents diagnosed with type 1 diabetes between the ages of 13-17 completed seven daily diary surveys. Data were analyzed using multilevel modeling, including both linear covariation and autoregressive dynamic systems approaches. Results found that everyday life stress represents a regulatory system (attractor state) at the daily level, but daily blood glucose regulation did not covary with everyday life stress in the linear model nor change the state of the regulatory system in the autoregressive systems model. Future studies should continue to explore the relationship between everyday life stress and blood glucose regulation using a dynamic systems framework with different methodological approaches to better capture within-day nuances in stress and glucose regulation in adolescents with type 1 diabetes.
Glucose Homeostatis And The Pathogenesis Of Diabetes Mellitus
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Author :
language : en
Publisher: Academic Press
Release Date : 2013-12-24
Glucose Homeostatis And The Pathogenesis Of Diabetes Mellitus written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-12-24 with Science categories.
Diabetes mellitus is a disease with tremendous health and economic burden. A better understanding of how normal glucose homeostasis is maintained and the pathogenesis is important to identify new ways for diabetes treatment. This book addresses multiple aspects of this area of research. Written by experts in the field Informs on important topics related to the regulation of glucose homeostasis and the pathogenesis of diabetes mellitus, a field of intense research interest
Principles Of Diabetes Mellitus
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Author : Leonid Poretsky
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-11
Principles Of Diabetes Mellitus written by Leonid Poretsky and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-11 with Medical categories.
Diabetes mellitus is a very common disease which affects approximately 150,000,000 worldwide. With its prevalence rising rapidly, diabetes continues to mystify and fascinate both practitioners and investigators by its elusive causes and multitude of This textbook is written for endocrinologists, specialists in other disciplines who treat diabetic patients, primary care physicians, housestaff and medical students. It covers, in a concise and clear manner, all aspects of the disease, from its pathogenesis on the molecular and cellular levels to its most modern therapy.
Hypoglycemia In Diabetes
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Author : Philip Cryer
language : en
Publisher: American Diabetes Association
Release Date : 2016-07-12
Hypoglycemia In Diabetes written by Philip Cryer and has been published by American Diabetes Association this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-07-12 with Medical categories.
Intended for diabetes researchers and medical professionals who work closely with patients with diabetes, this newly updated and expanded edition provides new perspectives and direct insight into the causes and consequences of this serious medical condition from one of the foremost experts in the field. Using the latest scientific and medical developments and trends, readers will learn how to identify, prevent, and treat this challenging phenomenon within the parameters of the diabetes care regimen.
Data Driven Modeling For Diabetes
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Author : Vasilis Marmarelis
language : en
Publisher: Springer Science & Business
Release Date : 2014-04-22
Data Driven Modeling For Diabetes written by Vasilis Marmarelis and has been published by Springer Science & Business this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-04-22 with Technology & Engineering categories.
This contributed volume presents computational models of diabetes that quantify the dynamic interrelationships among key physiological variables implicated in the underlying physiology under a variety of metabolic and behavioral conditions. These variables comprise for example blood glucose concentration and various hormones such as insulin, glucagon, epinephrine, norepinephrine as well as cortisol. The presented models provide a powerful diagnostic tool but may also enable treatment via long-term glucose regulation in diabetics through closed-look model-reference control using frequent insulin infusions, which are administered by implanted programmable micro-pumps. This research volume aims at presenting state-of-the-art research on this subject and demonstrating the potential applications of modeling to the diagnosis and treatment of diabetes. The target audience primarily comprises research and experts in the field but the book may also be beneficial for graduate students.