T G Mura

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Mutator

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Author : Nigel Stephen Walker
language : en
Publisher:
Release Date : 2000

Mutator written by Nigel Stephen Walker and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with categories.

Collected Papers

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Author : S. Yehara
language : en
Publisher:
Release Date : 1920

Collected Papers written by S. Yehara and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1920 with categories.

The Involvement Of Systemic Homeostasis In Tumour Biology

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Author : Wei-Lin Jin
language : en
Publisher: Frontiers Media SA
Release Date : 2023-10-13

The Involvement Of Systemic Homeostasis In Tumour Biology written by Wei-Lin Jin and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-10-13 with Science categories.

Systemic homeostatic mechanisms include several aspects, such as metabolic, neuroendocrine, immune, and physiological homeostasis. Irreversible damage or reversible imbalance of such homeostatic processes may initiate cancers by altering the regulation of the molecular machinery. Systemic homeostasis-related genes have been found to be intimately involved in oncological processes and in some instances have shown prognostic value. Thus, future gene targeting approaches for cancer should not only focus on classical cancer drivers but also address systemic homeostasis-related genetic mechanisms. Identification of systemic homeostasis-related genes with diagnostic, prognostic or therapeutic value can advance translational cancer research. Increasing numbers of research studies have reported systemic homeostasis-related genes’ relevance to various types of cancer. For example, cancer cells have been shown to activate a critical mechanism of oxygen homeostasis—hypoxia inducible factors (HIFs) family genes, in order to adapt to the tumor microenvironment and develop into a more aggressive phenotype. In addition, methylene tetrahydrofolate dehydrogenase (MTHFD) family genes are involved in mitochondrial one-carbon metabolism, which is essential for maintaining systemic metabolic homeostasis, and have recently been found overexpressed in many cancers and have been correlated to poor survival outcomes. The overexpression of transferrin family genes with iron transporting function has been linked with iron accumulation, which is a known initiating factor in cancer. Another example is Forkhead box O (FOXO) family genes, which serve as a critical regulator of immune homeostasis and can regulate cancer immunity by negatively regulating the expression of immunosuppressive gene-programmed death 1 ligand 1 (PD-L1).Apart from these examples, other systemic homeostatic mechanisms such as glucose homeostasis, energy homeostasis, lipid homeostasis, phosphate homeostasis, cholesterol homeostasis, and mineral homeostasis may also be implicated in cancer pathogenesis. Although accruing research is focused on describing systemic homeostatic mechanisms in cancer biology, several research questions remain unaddressed. The utilization of recent analytic tools and bioinformatics as systems biology approaches has the potential to address these research gaps. Therefore, in this special issue we will collect articles focusing on the application of bioinformatics and systems biology based investigations of systemic homeostatic mechanisms in malignant diseases. Both original research and review articles are welcomed, however publications based on the analysis on only one database will not be accepted (e.g. TCGA).

Genomics And Epigenomics Of Cancer Immunotherapy Challenges And Clinical Implications

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Author : Xiao-Jie Lu
language : en
Publisher: Frontiers Media SA
Release Date : 2021-08-10

Genomics And Epigenomics Of Cancer Immunotherapy Challenges And Clinical Implications written by Xiao-Jie Lu and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-08-10 with Medical categories.

Central Asiatic Journal

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Author :
language : en
Publisher:
Release Date : 1982

Central Asiatic Journal written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1982 with Asia, Central categories.

Histology Immunohistochemistry And In Situ Hybridisation Lab Protocols

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Author : Jenny Steel
language : en
Publisher: Lulu.com
Release Date : 2017-03-26

Histology Immunohistochemistry And In Situ Hybridisation Lab Protocols written by Jenny Steel and has been published by Lulu.com this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-03-26 with Science categories.

This book is designed to be a manual for laboratory use, based upon the author's own experience and successful published results. It is for the use of students and researchers.

Prognostic Factors In Non Small Cell Lung Cancer

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Author : Luciano Mutti
language : en
Publisher: Frontiers Media SA
Release Date : 2023-04-12

Prognostic Factors In Non Small Cell Lung Cancer written by Luciano Mutti and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-04-12 with Medical categories.

Rna Modification In Human Cancers Roles And Therapeutic Implications

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Author : You Zhou
language : en
Publisher: Frontiers Media SA
Release Date : 2022-04-26

Rna Modification In Human Cancers Roles And Therapeutic Implications written by You Zhou and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-04-26 with Science categories.

Post Transcriptional Gene Regulation In Human Disease

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Author : Buddhi Prakash Jain
language : en
Publisher: Academic Press
Release Date : 2022-08-12

Post Transcriptional Gene Regulation In Human Disease written by Buddhi Prakash Jain and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-08-12 with Medical categories.

Post-transcriptional Gene Regulation in Human Disease, a new volume in the Translational Epigenetics book series, offers a thorough overview and discussion of post-transcriptional genetic control mechanisms and their roles across various pathologies and human developmental outcomes, along with regulatory mechanisms targeted for therapeutic approaches. The book is broadly divided in two parts: early chapters describe the basics of post-transcriptional gene regulation, associated epigenetic mechanisms, the role of RNA binding proteins, the evolution of post-transcriptional gene regulation, and methods to study these mechanisms. The second half of the book includes deeper discussion of post-transcriptional gene regulation across specific diseases and therapeutics targets. Various post-transcriptional events, including alternative splicing and polyadenylation, mRNA stability, and miRNAs and their involvement in the disease progression, are examined in detail. Includes full-color imagery illustrating key concepts and post-transcriptional disease processes, as well as descriptions of methods for studying post-transcriptional gene regulation Presents fundamental knowledge, molecular and biochemical mechanisms, and recent findings in concise and easily understandable formats Features a summary and conclusion at the end of each chapter

Influence Of Potential Diagnostic Biomarkers In Lung Cancer

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Author : Paul Takam Kamga
language : en
Publisher: Frontiers Media SA
Release Date : 2023-07-31

Influence Of Potential Diagnostic Biomarkers In Lung Cancer written by Paul Takam Kamga and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-07-31 with Medical categories.