Targeted Radionuclide Tumor Therapy
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Targeted Radionuclide Tumor Therapy
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Author : Torgny Stigbrand
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-09-01
Targeted Radionuclide Tumor Therapy written by Torgny Stigbrand and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-09-01 with Medical categories.
The last three decades have provided opportunities to explore the potential of treating malignant diseases with antibodies or other targeting molecules labelled with nuclides. While considerable advances have been reported, there is still a signi- cant amount of work left to accomplish before our ambitions can be achieved. It now seems timely to review the accomplishments achieved to date and to clarify the challenges that remain. The choice of radionuclide, the conjugation p- cedure employed, and the selection of suitable targets were early issues that were faced by our field that still persist, however we can now tackle these obstacles with significantly better insight. The expanding array of new targeting molecules (recombinant antibodies, peptides and agents based upon alternate scaffolds) may increase the therapeutic efficacy or even modify the radiation sensitivity of the targeted tumor cell. The title of this book “Targeted Radionuclide Tumour Therapy – Biological Aspects” was selected to reinforce the concept that a major focus of this volume was devoted to understanding the biological effects of targeting and radiation. These important issues have not previously been the primary focus in this context. Furthermore, our rapidly expanding knowledge of different types of cell death and the increasingly likely existence of cancer stem cells suggests to us that even more efficient approaches in targeting might be possible in the future.
Targeted Radionuclide Therapy
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Author : Tod W. Speer
language : en
Publisher: Lippincott Williams & Wilkins
Release Date : 2012-03-28
Targeted Radionuclide Therapy written by Tod W. Speer and has been published by Lippincott Williams & Wilkins this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-03-28 with Medical categories.
Radioimmunotherapy, also known as systemic targeted radiation therapy, uses antibodies, antibody fragments, or compounds as carriers to guide radiation to the targets. It is a topic rapidly increasing in importance and success in treatment of cancer patients. This book represents a comprehensive amalgamation of the radiation physics, chemistry, radiobiology, tumor models, and clinical data for targeted radionuclide therapy. It outlines the current challenges and provides a glimpse at future directions. With significant advances in cell biology and molecular engineering, many targeting constructs are now available that will safely deliver these highly cytotoxic radionuclides in a targeted fashion. A companion website includes the full text and an image bank.
Development And Optimization Of Targeted Radionuclide Tumor Therapy Using Folate Based Radiopharmaceuticals
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Author : Josefine Astrid Reber
language : en
Publisher:
Release Date : 2013
Development And Optimization Of Targeted Radionuclide Tumor Therapy Using Folate Based Radiopharmaceuticals written by Josefine Astrid Reber and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with categories.
Nuclear Medicine Therapy
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Author : Cumali Aktolun
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-08-31
Nuclear Medicine Therapy written by Cumali Aktolun and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-08-31 with Medical categories.
Nuclear Medicine Therapy presents the state of the art in targeted radionuclide therapy, both in clinical practice and contemporary clinical investigation and trials. With contributions from an internationally-distinguished group of physicians and scientists, the book is devoted entirely to the use of nuclear medicine techniques and technology for therapy of malignant and benign diseases. Individual chapters cover the scientific principles and clinical applications of radionuclide therapy and the state of clinical trials of agents currently under investigation in the therapy of tumors involving virtually every organ system. Due to overlapping interest in techniques, indications, and clinical use, the development of radionuclide therapy attracts considerable input from other medical specialists whose collaboration is essential, including radiation and medical oncologists, hematologists, diagnostic radiologists, hepatologists, endocrinologists, and rheumatologists. And because radionuclide therapy is a rapidly evolving field of nuclear medicine, it is the aim of this volume to appeal to all specialists involved in targeted radionuclide therapy and to contribute to the standardization of the practice globally.
Therapeutic Nuclear Medicine
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Author : Richard P. Baum
language : en
Publisher: Springer
Release Date : 2014-08-16
Therapeutic Nuclear Medicine written by Richard P. Baum and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-08-16 with Medical categories.
The recent revolution in molecular biology offers exciting new opportunities for targeted radionuclide therapy. This up-to-date, comprehensive book, written by world-renowned experts, discusses the basic principles of radionuclide therapy, explores in detail the available treatments, explains the regulatory requirements, and examines likely future developments. The full range of clinical applications is considered, including thyroid cancer, hematological malignancies, brain tumors, liver cancer, bone and joint disease, and neuroendocrine tumors. The combination of theoretical background and practical information will provide the reader with all the knowledge required to administer radionuclide therapy safely and effectively in the individual patient. Careful attention is also paid to the role of the therapeutic nuclear physician in coordinating a diverse multidisciplinary team, which is central to the safe provision of treatment.
Radiopharmaceuticals For Therapy
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Author : F. F. (Russ) Knapp
language : en
Publisher: Springer
Release Date : 2016-01-20
Radiopharmaceuticals For Therapy written by F. F. (Russ) Knapp and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-01-20 with Medical categories.
This book provides detailed information on therapeutic radiopharmaceuticals and discusses emerging technologies which have potential for broad clinical implementation. Recent advances in molecular biology, radiopharmaceutical chemistry and radioisotope production have stimulated a new era for the use of radiopharmaceuticals for targeted radionuclide therapy (TRT). Emerging clinical trials include use of peptides and monoclonal antibodies radiolabeled with therapeutic radionuclides for cancer therapy. In addition, small molecules are used for the treatment of chronic diseases such as metastatic bone pain palliation and radiation synovectomy of inflammatory joints. In the interventional arena, therapy of primary and metastatic liver cancer and arterial restenosis following angioplasty of both the coronary and peripheral arteries are being explored. Reactor and accelerator production of therapeutic radioisotopes is also integrated into these discussions. The development and use of radiopharmaceutical targeting characteristics required for treatment of specific disease processes and how these are implemented for radiopharmaceutical design strategies are also described. Radiopharmaceuticals for Therapy will benefit audiences in nuclear medicine and radionuclide therapy and will thus prove an invaluable source of up-to-date information for students, radiopharmaceutical scientists and professionals working in the radiopharmacy and nuclear medicine specialties.
Radionuclide Therapy
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Author : Recep Bekiş
language : en
Publisher: Springer Nature
Release Date : 2022-08-01
Radionuclide Therapy written by Recep Bekiş and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-08-01 with Medical categories.
The main purpose of this book is to create a reference for the indications, contraindications, patient selection, treatment practice, treatment side effect management, and follow-up of radionuclide treatments. Besides standard methods such as surgery, chemotherapy, radiotherapy, and hormone therapy, newly developed biological treatments, targeted treatments, personalized treatments, external beam radiotherapy, and targeted radionuclide treatments have begun to take their place in professional practice. Nuclear medicine, in addition to its role as a tracer of cancer, also assumes the role of treating with radioactive molecules directed to the cancer it traces. These traceable next-generation radionuclide treatments, whose efficacy and reliability have been proven and where diagnosis, treatment, and follow-up are carried out together, are increasingly included in oncology practice together with the new developed radiopharmaceuticals, ensuring a high rate of damage to cancer cells while protecting the surrounding normal tissues. Molecular cancer treatment will become more effective with individualized next-generation traceable radionuclide treatments, which will be shaped by genetic studies in the future. Radionuclide treatments for many cancer types and benign diseases are presented by experienced nuclear medicine experts in the light of their own experience and case studies, while systemic treatments in common cancer types and side effect management of these treatments are summarized by medical oncologists. This book will be of interest to nuclear medicine physicians as well as oncologists.
Monte Carlo Modeling Of Targeted Radionuclide Therapy Of Micrometastases
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Author : Mario Enrique Alcocer Avila
language : en
Publisher:
Release Date : 2021
Monte Carlo Modeling Of Targeted Radionuclide Therapy Of Micrometastases written by Mario Enrique Alcocer Avila and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021 with categories.
Targeted radionuclide therapy (TRT) is a cancer treatment modality in which radioactive isotopes are coupled to tumor-specific carrier molecules for the selective irradiation of tumor cells. The aim of this thesis is to provide an accurate description of the pattern of energy deposit by some of the most promising Auger electron- and alpha particle-emitting radionuclides currently considered for TRT, by means of accurate Monte Carlo track structure (MCTS) simulations. As part of this doctoral work, the TILDA-V code was extended and improved to include the full slowing-down of alpha particles in water. Radiation transport and dosimetry studies were performed to validate as a whole the capabilities of the latest version of TILDA-V for simulating the interactions of protons, alpha particles and electrons with biological matter. The code was extensively benchmarked against other numerical tools and available experimental data with satisfactory results. The effect on the simulations of changing the description of the biological medium (water versus DNA) was analyzed in detail as well. Furthermore, the various radionuclides of interest were evaluated by computing the absorbed dose to isolated tumor cells and to a small cell cluster representing a micrometastasis.The results of the present work will be valuable to the community of nuclear medicine to understand the relative merits of various radionuclides and to guide the choice of the most adapted radionuclide to arm a targeting molecule, taking into account the clinical setting in oncology.
Locoregional Radionuclide Cancer Therapy
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Author : Franklin C.L. Wong
language : en
Publisher: Springer Nature
Release Date : 2020-12-08
Locoregional Radionuclide Cancer Therapy written by Franklin C.L. Wong and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-08 with Medical categories.
This book reviews locoregional radionuclide cancer therapies (LRCT). Proving an increasingly viable alternative to radiotherapy, radionuclide therapy includes a diversity of choices of well characterized biochemical and physiologic target molecules. The delivery and retention of radionuclides may be monitored by advanced imaging for exact tissue localization and for real-time dosimetry to enable personalized precision medicine. Radiopharmaceuticals in human cancer therapies are typically delivered in systemic routes but can also be designed for locoregional routes to harness pharmacokinetic advantages of higher payload and lower systemic toxicities. This book explores the latest advancements and clinical considerations of the locoregional approach. Throughout the chapters, the clinical and scientific bases of cancer treatment and the locoregional use of radionculides are explored. Mathematical models of radiation dosimetry of locoregional radionculdies on tissues are studied using common models for multiple commercially available radionuclides. Rodent and canine tumor models of LRCT are compared for selected radionuclides and radiopharmaceuticals. The practical aspects of radiopharmaceuticals production, marketing, transport, as well as radiation protection are reviewed. Finally, the combination of LRCT with immunotherapy and other cancer therapies and prospective future use of LRCT are discussed. This is a guide for practicing nuclear physicians, interventional radiologists, radiation oncologists, radiation scientists, veterinarians and oncologists to expand their knowledge base and to prepare for designing locoregional radionuclide cancer therapies in animals and in humans.
Advancements In Prostate Specific Membrane Antigen Targeted Radionuclide Therapy Through Dosimetry
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Author : Catherine Anne Louise Meyer
language : en
Publisher:
Release Date : 2022
Advancements In Prostate Specific Membrane Antigen Targeted Radionuclide Therapy Through Dosimetry written by Catherine Anne Louise Meyer and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022 with categories.
One promising treatment option for metastatic castration-resistant prostate cancer is systemic radionuclide therapy targeting prostate-specific membrane antigen (PSMA). PSMA is a highly overexpressed protein on prostate cancer cells, but has low expression in normal organ tissues. Small molecule inhibitors of PSMA specifically bind to PSMA and can therefore be labeled with imaging or therapeutic isotopes to deliver the radiation directly to the site of cancer cells. When labeled with a therapeutic isotope, such as a beta- or alpha-emitter, PSMA ligands acts as a delivery vector for a lethal payload of radiation to cancer cells. This therapy is known as radionuclide therapy (RNT). The most commonly used therapeutic isotope in PSMA-targeted RNT is lutetium-177 (177Lu). Treatment response rates to 177Lu-PSMA RNT vary widely across treatment studies and patient cohorts from 30 to 70%. However, actinium-225 (225Ac), an alpha particle emitter, has emerged as a promising alternative isotope with favorable therapeutic decay properties. Alpha particles are of interest in RNT due to higher energy deposition over a shorter tissue penetration range, ostensibly causing more dense ionizations and inducing more DNA damage as compared with beta particles. While fewer clinical studies have been conducted with 225Ac-PSMA RNT, the studies so far report impressive response rates, particularly in chemotherapy-naïve patients. Despite improved biochemical response in 225Ac-treated patients, this comes at the cost of higher-grade toxicities. Overall, PSMA RNT using either therapeutic isotope is not curative and even in those patients who do respond, the disease almost inevitably relapses. One possible explanation for treatment failure and disease relapse is that the tumor targets are not receiving a sufficiently high radiation dose necessary to kill the cancer cells. The current treatment paradigm is to treat with fixed activities for the same number of cycles at fixed intervals. However, treatment with a fixed activity neglects the fact that the mechanism of action of RNT is by radiation, and as such warrants radiation dose evaluation. To move away from a "one size fits all" approach to more individualized treatment, dosimetry can be used to devise safe therapeutic activities to deliver maximal tumor doses while delivering as low as achievable doses to non-target volumes. This dissertation addresses two overarching goals: i) to identify clinically relevant differences between 177Lu and 225Ac by incorporating dosimetry in translational RNT research, and ii) to evaluate the clinical dosimetry of imaging and therapy theranostic agents. The first specific aim uses various in vivo murine models of prostate cancer for the optimization of preclinical PSMA RNT exploring the effect of different therapeutic isotopes and targeting ligands relative to intervention time and lesion size. The second specific aim evaluates the clinical radiation dosimetry profile of two new imaging theranostic tracers. Finally, the third specific aim seeks to quantify the patient-specific absorbed doses in tumors and normal organs for therapeutic 177Lu and 225Ac PSMA RNT agents.
