Targeting Hypokinesia In Parkinson S Disease With Quantitative Measures And A Computational Model To Determine Its Severity Its Improvement From Therapy And Explore Underlying Pathophysiological Mechanisms
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Targeting Hypokinesia In Parkinson S Disease With Quantitative Measures And A Computational Model To Determine Its Severity Its Improvement From Therapy And Explore Underlying Pathophysiological Mechanisms
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Author : Mandy Miller Koop
language : en
Publisher: Stanford University
Release Date : 2011
Targeting Hypokinesia In Parkinson S Disease With Quantitative Measures And A Computational Model To Determine Its Severity Its Improvement From Therapy And Explore Underlying Pathophysiological Mechanisms written by Mandy Miller Koop and has been published by Stanford University this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with categories.
significant finger and limb hypokinesia of the patient group's more affected side when compared to the non-dominant side of 19 age-matched healthy adults (HAs) (p=0.001 and p
Targeting Hypokinesia In Parkinson S Disease With Quantitative Measures And A Computational Model To Determine Its Severity Its Improvement From Therapy And Explore Underlying Pathophysiological Mechanisms
DOWNLOAD
Author : Mandy Miller Koop
language : en
Publisher:
Release Date : 2011
Targeting Hypokinesia In Parkinson S Disease With Quantitative Measures And A Computational Model To Determine Its Severity Its Improvement From Therapy And Explore Underlying Pathophysiological Mechanisms written by Mandy Miller Koop and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with categories.
Hypokinesia is one of the most disabling movement abnormalities caused by Parkinson's disease (PD). It is a clinical term that refers to the general reduction of mobility experienced by people with Parkinson's disease (PWPD). Hypokinesia affects movements in three ways: 1) movements are slow 2) movements are performed with reduced amplitude compared to what is required for the task and 3) it takes longer for PWPD to initiate movements. All of these impairments affect the ability of PWPD to perform common daily activities and can cause feelings of frustration and anger that may lead to altered self esteem, depression, and a reduction in their quality of life. Although effective treatments do exist for well-selected patients, there are many avenues open for improving current treatments, identifying new treatments, and understanding mechanisms of hypokinesia that could potentially lead to more effective therapies and greatly impact the lives of PWPD. In this dissertation we sought to improve current treatments and provide opportunities for future treatments for hypokinesia by addressing three important clinical questions relating to hypokinesia. First, are there immediate improvements in hypokinesia from a surgical procedure called deep brain stimulation (DBS) that can be measured during surgery and used to help guide surgical decisions and optimize clinical outcomes? Second, can we determine what types of movements are affected by hypokinesia in early stage, untreated PD in order to provide an objective metric used to assess an emerging treatment for PD? Third, might perceptual deficits that are linked to sensory processing impairments play a role in the manifestation of hypokinesia? If so, targeting these deficits may provide new and better therapies. We addressed these questions by using the quantitative and computational techniques outlined in the next three paragraphs. A common treatment for advanced PD is a surgical procedure called DBS. The surgery is performed on awake patients, and it entails surgically implanting electrodes (leads) that provide chronic stimulation to the affected brain area that controls movement. Although the treatment is almost always effective, the degree of improvement in hypokinesia varies among patients. The accuracy of the placement of the DBS lead in the affected area is believed to have the most effect on the improvement of hypokinesia. We suggest that using quantitative measurements of hypokinesia to evaluate the efficacy of the location of the DBS lead in improving hypokinesia during the surgical procedure might therefore improve the overall clinical outcomes. The surgical team would then have objective, accurate measurements of the degree of improvement in hypokinesia during the surgery, when the lead's position in the brain could be modified to achieve optimal results. Therefore, we designed a prospective study to measure upper extremity hypokinesia using a quantitative measure of angular velocity. Analysis of 98 DBS procedures performed on 61 patients showed that on average there was an 81% improvement in quantitative measures of hypokinesia from implanting and activating the DBS lead (p
Occupational Therapy For People With Parkinson S Disease
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Author : Ana Aragon
language : en
Publisher:
Release Date : 2010
Occupational Therapy For People With Parkinson S Disease written by Ana Aragon and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Occupational therapy categories.
These practice guidelines draw upon the widest relevant knowledge and evidence available to describe and inform contemporary best practice occupational therapy for people with Parkinson's disease. They include practical examples of interventions to allow occupational therapists to apply new treatments to their practice.
Prodromal Parkinson S Disease
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Author : David Crosiers
language : en
Publisher: Frontiers Media SA
Release Date : 2021-02-17
Prodromal Parkinson S Disease written by David Crosiers and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-02-17 with Medical categories.
Rehabilitation In Movement Disorders
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Author : Robert Iansek
language : en
Publisher: Cambridge University Press
Release Date : 2013-05-23
Rehabilitation In Movement Disorders written by Robert Iansek and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-05-23 with Medical categories.
Provides a broad overview of current rehabilitation approaches, emphasizing the need for interdisciplinary management and focussing on deliverable outcomes.
The Dysarthrias
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Author : Malcolm Ray McNeil
language : en
Publisher:
Release Date : 1984
The Dysarthrias written by Malcolm Ray McNeil and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1984 with Medical categories.
Brain Repair After Stroke
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Author : Steven C. Cramer
language : en
Publisher: Cambridge University Press
Release Date : 2010-10-28
Brain Repair After Stroke written by Steven C. Cramer and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-10-28 with Medical categories.
Increasing evidence identifies the possibility of restoring function to the damaged brain via exogenous therapies. One major target for these advances is stroke, where most patients can be left with significant disability. Treatments have the potential to improve the victim's quality of life significantly and reduce the time and expense of rehabilitation. Brain Repair After Stroke reviews the biology of spontaneous brain repair after stroke in animal models and in humans. Detailed chapters cover the many forms of therapy being explored to promote brain repair and consider clinical trial issues in this context. This book provides a summary of the neurobiology of innate and treatment-induced repair mechanisms after hypoxia and reviews the state of the art for human therapeutics in relation to promoting behavioral recovery after stroke. Essential reading for stroke physicians, neurologists, rehabilitation physicians and neuropsychologists.
Principles And Practice Of Movement Disorders E Book
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Author : Joseph Jankovic
language : en
Publisher: Elsevier Health Sciences
Release Date : 2011-04-01
Principles And Practice Of Movement Disorders E Book written by Joseph Jankovic and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-04-01 with Medical categories.
Principles and Practice of Movement Disorders provides the complete, expert guidance you need to diagnose and manage these challenging conditions. Drs. Stanley Fahn, Joseph Jankovic and Mark Hallett explore all facets of these disorders, including the latest rating scales for clinical research, neurochemistry, clinical pharmacology, genetics, clinical trials, and experimental therapeutics. This edition features many new full-color images, additional coverage of pediatric disorders, updated Parkinson information, and many other valuable updates. An accompanying Expert Consult website makes the content fully searchable and contains several hundred video clips that illustrate the manifestations of all the movement disorders in the book along with their differential diagnoses. Get just the information you need for a clinical approach to diagnosis and management, with minimal emphasis on basic science. Find the answers you need quickly and easily thanks to a reader-friendly full-color format, with plentiful diagrams, photographs, and tables. Apply the latest advances to diagnosis and treatment of pediatric movement disorders, Parkinson disease, and much more. View the characteristic presentation of each disorder with a complete collection of professional-quality, narrated videos online. Better visualize every concept with new full-color illustrations throughout. Search the complete text online, follow links to PubMed abstracts, and download all of the illustrations, at www.expertconsult.com.
Movement Disorder Emergencies
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Author : Steven J. Frucht
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-10
Movement Disorder Emergencies written by Steven J. Frucht and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-10 with Medical categories.
Movement Disorder Emergencies: Diagnosis and Treatment provides a fresh and unique approach to what is already a high-profile subspecialty area in clinical neurology. The disorders covered in this volume are standard fare in the field but emphasize the urgencies and emergencies that can occur. One of the very attractive features of the field of movement disorders is that diagnosis is often based on unique visible and sometimes audible phenomenological symptoms and signs. Therefore, in this era of highly sophisticated laboratory and radiological diagnostic tools, the diagnosis of many movement disorders is still largely made in the clinic where pattern recognition is key. Crucial to astute clinical diagnosis is broad clinical experience. In short, you have to have seen one to recognize one! Patients with movement disorders nearly always present as outpatients but, as aptly recognized by Drs. Frucht and Fahn, this may include acute manifestations leading to emergency presentations, often in an emergency room setting, where they are very likely to be unrecognized and therefore poorly managed. The authors define an “emergency” movement disorder as one in which failure to promptly diagnose and treat may result in significant morbidity or mortality. However, they also stress the importance of certain “can’t miss” diagnoses such as Wilson’s disease, dopa-responsive dystonia, and Whipple’s disease in which delayed diagnosis in less emergent situations can lead to slowly evolving and often irreversible neurological damage with tragic consequences.
An Essay On The Shaking Palsy
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Author : James Parkinson
language : en
Publisher:
Release Date : 1817
An Essay On The Shaking Palsy written by James Parkinson and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1817 with Parkinson's disease categories.