Telocytes
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Telocytes
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Author : Xiangdong Wang
language : en
Publisher: Springer
Release Date : 2016-10-31
Telocytes written by Xiangdong Wang and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-10-31 with Science categories.
This book elucidates the genetic, biological, morphological and functional aspects of telocytes. Telocytes are a recently defined type of interstitial (stromal) cells, with very long (tens to hundreds of micrometres) and very thin prolongations (mostly below the resolving power of light microscopy). The book describes the presence of telocytes in various organs and tissues, details their morphological characteristics, explores their genomic and proteomic profiles, puts forward preclinical evidence of their application, and discusses their potential in the context of clinical therapeutics. As such, it offers a valuable guide for biologists and clinicians alike. Dr. Xiangdong Wang is a distinguished Professor of Medicine. He is Director of the Shanghai Institute of Clinical Bioinformatics, Executive Director of the Clinical Science Institute at Fudan University Zhongshan Hospital, Shanghai, China; Dr. Dragos Cretoiu is an Associate Professor of Pathology at the Department of Cellular and Molecular Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest.
Telocytes
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Author : Sanda Maria Cretoiu
language : en
Publisher:
Release Date : 2019
Telocytes written by Sanda Maria Cretoiu and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with Science categories.
Telocytes (TCs) represent a new type of interstitial cells, and were discovered by Prof. Popescu and his collaborators from Bucharest in 2005, and described as Interstitial Cajal-Like Cells (ICLCs). In 2010, Prof. Popescu and Prof. Faussone-Pellegrini from Florence, based on their expertise in morphology, agreed that in fact ICLCs were a brand-new entity and they renamed them telocytes. TCs are characterized by specific veil- or ribbon-like extensions called telopodes. Telopodes aid TCs in forming homo- or hetero-cellular contacts; thus, assembling three-dimensional networks that organizes the stromal and the parenchymal components of the organs. TCs can transfer information to neighbor cells ensuring a short-distance communication, and remotely by the release a wide variety of extracellular vesicles: exosomes, ectosomes, and multivesicular bodies. Here, we reviewed the evolution of the interest regarding TCs in different organs, in normal and pathological conditions. The main focus was on the role of TCs in gastrointestinal tract, urinary bladder, reproductive tract, and heart. This chapter sums up information about the possibilities that TCs are capable to behave as sensors/mediators in nervous activity, to represent mesenchymal stem cell precursors in adulthood, and to control and determine the differentiation/maturation of other cell types either during development or in postnatal life.
Cardiac Telocytes
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Author : Dragos Cretoiu
language : en
Publisher: LAP Lambert Academic Publishing
Release Date : 2015-10-27
Cardiac Telocytes written by Dragos Cretoiu and has been published by LAP Lambert Academic Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-10-27 with categories.
Telocytes (TCs) are interstitial cells previously characterized by electron microscopy as cells with very long extensions (telopodes, Tps), present in numerous organs, including the heart interstitial space and cardiac stem cell niche. TCs have several particular morphological and phenotypical properties, as well as specific gene expression and proteomic profiles which define TCs as a distinct type of interstitial cells, different from fibroblasts. Given the fact that TCs interact through Tps with identical cells generating a network, as well as with other type of cells, including vascular and nervous cells, it has been proposed that TCs have a role in the fine-tuning of regulatory signals delivered through vascular, nervous and endocrine systems. TCs have been found within the stem cell niche of several organs. TCs release extracellular vesicles (EVs) in vivo and in vitro, suggesting that they may regulate the activity of other cells, including cardiac stem cells (CSCs), by vesicular paracrine signals. The most advanced morphological studies using focused ion beam scanning electron microscopy (FIB-SEM tomography) showed the 3D reconstruction of cardiac TCs.
The Role Of Telocytes In Teeth Development And Regeneration
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Author : Guillermo Villagomez Olea
language : en
Publisher:
Release Date : 2022
The Role Of Telocytes In Teeth Development And Regeneration written by Guillermo Villagomez Olea and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022 with categories.
Cardiac Telocytes Exist In The Adult Xenopus Tropicalis Heart
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Author : Luocheng Lv
language : en
Publisher:
Release Date : 2020
Cardiac Telocytes Exist In The Adult Xenopus Tropicalis Heart written by Luocheng Lv and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020 with categories.
Tissue Barriers In Disease Injury And Regeneration
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Author : Nikolai V. Gorbunov
language : en
Publisher: Elsevier
Release Date : 2021-06-23
Tissue Barriers In Disease Injury And Regeneration written by Nikolai V. Gorbunov and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-06-23 with Science categories.
Tissue Barriers in Disease, Injury and Regeneration focuses on the molecular and cellular fundamentals of homeostatic and defense responses of tissue barriers, covering the damaging impacts and exposure to pathogens and engineered nanomaterials. Sections emphasize the role of mesenchymal stoma, vascular, epithelial, telocyte, myofibroblast, lymphoid and reticuloendothelial cells, along with reactions that bridge the effects of ambient factors, medical treatments, drag delivery systems with alterations in barrier integrity, tissue/organ functions, and metabolic status. Other sections cover the role of progenitor cells of different origins in the remodeling and regeneration of tissue stroma, vasculature of blood-tissue barriers, and more. Includes special emphasis on the role of mesenchymal stoma, vascular, epithelial, telocyte, myofibroblast, lymphoid and reticuloendothelial cells in the development of reactions that bridge the effects of ambient factors, medical treatments, drag delivery systems with alterations in barrier integrity, tissue/organ functions, and in metabolic status Examines the role of progenitor cells of different origins in the remodeling and regeneration of tissue stroma, the vasculature of blood-tissue barriers, and mucosa and external epithelium
Sex Steroids
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Author : Scott M. Kahn
language : en
Publisher: IntechOpen
Release Date : 2012-01-27
Sex Steroids written by Scott M. Kahn and has been published by IntechOpen this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-01-27 with Medical categories.
This book, entitled "Sex Steroids", features a valuable collection of reviews and research articles written by experts in signal transduction, cellular biology, diseases and disorders. "Sex Steroids" is comprised of four sections, "The Biology of Sex Steroids", "Sex Steroids, Memory, and the Brain", "Sex Steroids and the Immune Response", and "Therapy"; individual chapters address a broad range of recognized and predicted functions and applications of sex steroids. "Sex Steroids" is intended to provide seasoned veterans as well as newcomers to this area of research with informative, resourceful, and provocative insights. Readers of "Sex Steroids" should emerge with an appreciation and understanding of the multitude and complexity of biologic processes attributed to these important hormones, and possible future directions of research in this fascinating and ever evolving field.
Tissue Barriers In Disease Injury And Regeneration
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Author : Nikolai V. Gorbunov
language : en
Publisher: Elsevier
Release Date : 2021-06-19
Tissue Barriers In Disease Injury And Regeneration written by Nikolai V. Gorbunov and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-06-19 with Science categories.
Tissue Barriers in Disease, Injury and Regeneration focuses on the molecular and cellular fundamentals of homeostatic and defense responses of tissue barriers, covering the damaging impacts and exposure to pathogens and engineered nanomaterials. Sections emphasize the role of mesenchymal stoma, vascular, epithelial, telocyte, myofibroblast, lymphoid and reticuloendothelial cells, along with reactions that bridge the effects of ambient factors, medical treatments, drag delivery systems with alterations in barrier integrity, tissue/organ functions, and metabolic status. Other sections cover the role of progenitor cells of different origins in the remodeling and regeneration of tissue stroma, vasculature of blood-tissue barriers, and more. Includes special emphasis on the role of mesenchymal stoma, vascular, epithelial, telocyte, myofibroblast, lymphoid and reticuloendothelial cells in the development of reactions that bridge the effects of ambient factors, medical treatments, drag delivery systems with alterations in barrier integrity, tissue/organ functions, and in metabolic status Examines the role of progenitor cells of different origins in the remodeling and regeneration of tissue stroma, the vasculature of blood-tissue barriers, and mucosa and external epithelium
Resident Stem Cells And Regenerative Therapy
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Author : Regina Coeli dos Santos Goldenberg
language : en
Publisher: Elsevier
Release Date : 2023-09-07
Resident Stem Cells And Regenerative Therapy written by Regina Coeli dos Santos Goldenberg and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-09-07 with Technology & Engineering categories.
Resident Stem Cells and Regenerative Therapy: Sources and Clinical Applications, Second Edition presents the main findings to date and the important factors to be considered when contemplating resident stem cells in regenerative therapies. Chapters on cardiac, brain, neural, liver, kidney, skeletal muscle, bone, pancreatic, skin and lung resident stem cells will assist in defining the level of success that has been achieved and the direction for the road ahead. With contributions from leading laboratories, open questions related to resident stem cells and regenerative therapies will also be presented for debate. In the last several decades, stem cells have greatly impacted the scientific and lay communities, providing huge advances in the treatment of devastating human diseases, including myocardial infarction, diabetes, muscular dystrophy, cystic fibrosis, cirrhosis, and osteoporosis. Alongside debates of induced pluripotent stem cells and embryonic stem cells has been the discovery of adult stem cells in many different tissues. While these organ resident or progenitor stem cells offer prospects to contribute to tissue regeneration, they also present challenges because of the complexity of organ structures. Highlights basic research in tissue specific stem cells, experiments with animal models, and clinical trials that are transforming the field of regeneration Provides a clear understanding of endogenous stem cells, their role in current regenerative therapies, and prospects for future research Reports on the main-stream clinical approaches and in vivo experiments published in primary literature to help categorizes the advances in various aspects of regenerative therapy and illustrate opportunities for clinical applications
Exosomes In Cardiovascular Diseases
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Author : Junjie Xiao
language : en
Publisher: Springer
Release Date : 2017-09-19
Exosomes In Cardiovascular Diseases written by Junjie Xiao and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-09-19 with Science categories.
The book provides and intensive overview on exosomes in cardiovascular diseases, its potential as biomarkers, as well as pathological and therapeutic effects. It firstly describes the general aspects of exosomes including the definition, formation and secretion of exosomes and highlight their roles as biomarkers and pathological and therapeutic effects in cardiovascular diseases as well. Secondly, basic aspects of exosomes including the purification methods of exosomes, exosomes content, and functional roles of the cardiovascular exosomes are summarized. Thirdly, exosomes as biomarkers of cardiovascular diseases are overviewed including their roles in diagnosis, prognosis and reaction to therapy. Fourthly, pathological effects of exosomes and therapeutic effects of exosomes are highlighted. Finally, future prospects of exosomes in cardiovascular research would be provided. This is an essential reference for researchers working in cell biology and regeneration, as well as clinicians such as cardiologist.