Tempo Voc Sabe Administrar
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Translational Medicine
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Author : Joy A. Cavagnaro
language : en
Publisher: CRC Press
Release Date : 2021-11-26
Translational Medicine written by Joy A. Cavagnaro and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-26 with Medical categories.
Translational Medicine: Optimizing Preclinical Safety Evaluation of Biopharmaceuticals provides scientists responsible for the translation of novel biopharmaceuticals into clinical trials with a better understanding of how to navigate the obstacles that keep innovative medical research discoveries from becoming new therapies or even making it to clinical trials. The book includes sections on protein-based therapeutics, modified proteins, oligonucleotide-based therapies, monoclonal antibodies, antibody–drug conjugates, gene and cell-based therapies, gene-modified cell-based therapies, combination products, and therapeutic vaccines. Best practices are defined for efficient discovery research to facilitate a science-based, efficient, and predictive preclinical development program to ensure clinical efficacy and safety. Key Features: Defines best practices for leveraging of discovery research to facilitate a development program Includes general principles, animal models, biomarkers, preclinical toxicology testing paradigms, and practical applications Discusses rare diseases Discusses "What-Why-When-How" highlighting different considerations based upon product attributes. Includes special considerations for rare diseases About the Editors Joy A. Cavagnaro is an internationally recognized expert in preclinical development and regulatory strategy with an emphasis on genetic medicines.. Her 40-year career spans academia, government (FDA), and the CRO and biotech industries. She was awarded the 2019 Arnold J Lehman Award from the Society of Toxicology for introducing the concept of science-based, case-by-case approach to preclinical safety evaluation, which became the foundation of ICH S6. She currently serves on scientific advisory boards for advocacy groups and companies and consults and lectures in the area of preclinical development of novel therapies. Mary Ellen Cosenza is a regulatory toxicology consultant with over 30 years of senior leadership experience in the biopharmaceutical industry in the U.S., Europe, and emerging markets. She has held leadership position in both the American College of Toxicology (ACT) and the International Union of Toxicology (IUTOX) and is also an adjunct assistant professor at the University of Southern California where she teaches graduate-level courses in toxicology and regulation of biologics.
Sapiens
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Author : Yuval Noah Harari
language : en
Publisher: Random House
Release Date : 2014-09-04
Sapiens written by Yuval Noah Harari and has been published by Random House this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-09-04 with History categories.
'Interesting and provocative... It gives you a sense of how briefly we've been on this Earth' Barack Obama What makes us brilliant? What makes us deadly? What makes us Sapiens? One of the world's preeminent historians and thinkers, Yuval Noah Harari challenges everything we know about being human. Earth is 4.5 billion years old. In just a fraction of that time, one species among countless others has conquered it: us. In this bold and provocative book, Yuval Noah Harari explores who we are, how we got here and where we're going. **ONE OF THE GUARDIAN'S 100 BEST BOOKS OF THE 21st CENTURY** PRAISE FOR SAPIENS: 'Jaw-dropping from the first word to the last... It may be the best book I've ever read' Chris Evans 'Startling... It changes the way you look at the world' Simon Mayo 'I would recommend Sapiens to anyone who's interested in the history and future of our species' Bill Gates
Managing Your Time
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Author : Iain Maitland
language : en
Publisher: CIPD Publishing
Release Date : 1999
Managing Your Time written by Iain Maitland and has been published by CIPD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with Business & Economics categories.
This guide to managing your time in the workplace includes coverage of: getting it right first time; delegating successfully; recognising time-wasting activities and people; tackling paperwork efficiently; organising work practices; making the best use of travel time; running better meetings; and handling interruptions and the unwanted telephone call.
You Are God S Best
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Author : T. L. Osborn
language : en
Publisher: Destiny Image Publishers
Release Date : 2003-01-01
You Are God S Best written by T. L. Osborn and has been published by Destiny Image Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-01-01 with Religion categories.
During over a half century of teaching the Gospel to millions of people, face to face, in nations worldwide, Dr. T.L. Osborn and his associate minister and wife, Dr. Daisy Wasburn Osborn (now deceased), discovered seven basic, vital secrets or principles concerning God's BEST in life. The fundamentals have been tested and proven in the living arena of human experience all over the world. The Osborns have taught them to Buddhists, Muslims, Shintoists, Hundus, animists, fetish worshippers, Christians, and atheists - to people of most of the major cultures and religions of the free world. This Classic on Human Value is an inspiring guide to the discovery of self-dignity in God's redemptive plan. The energizing power of these vital truths is life-changing. You Are God's Best will free you from the demeaning influence programmed into you by negative religious tradition, and will open the door to new hope and to a new lifestyle with God as your best friend.
Managing Your Emotions
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Author : Joyce Meyer
language : en
Publisher: FaithWords
Release Date : 2008-11-16
Managing Your Emotions written by Joyce Meyer and has been published by FaithWords this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-11-16 with Religion categories.
God Gave You Emotions on Purpose! Our emotions play a vital role in living happy, healthy, successful lives. All emotions, from love and joy to anger and fear, have an important part to play in understanding ourselves and others. They help us discover the wonders of this life as well as warn us when we are in danger. But this diversity of feelings is meant to complement our life, not determine it! In this life-transforming book, Joyce Meyer reveals powerful truths from God's Word that will help you learn to manage all of your emotions in the right direction. Through hilarious illustrations and real-life applications, Joyce delivers the keys to keeping your emotions in the proper place while allowing the Spirit of God to lead and direct you. Dynamic scriptural insights are included on topics such as: * How not to be led by feelings * Codependency * Forgiveness * Mood swings * Healing for damaged emotions * Depression * And much more! Don't allow your feelings to determine your destiny! Instead, manage your emotions to complement and enhance your attitude for a joyful, victorious life!
Finishing Well
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Author : Bob Buford
language : en
Publisher: HarperChristian + ORM
Release Date : 2011-04-05
Finishing Well written by Bob Buford and has been published by HarperChristian + ORM this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-04-05 with Self-Help categories.
Author Bob Buford called them "code breakers." They are people age 40 and older who have pioneered the art of finishing well in these modern times, and who can teach us to do the same, starting today. Buford sought out 60 of these trailblazers--including Peter Drucker, Roger Staubach, Jim Collins, Ken Blanchard, and Dallas Willard--and has recorded their lively conversations in these pages so that they can serve as "mentors in print" for all of us. "Twenty years from now," Buford writes, "the rules for this second adulthood as a productive season of life may be better known. But for now, we're out across the frontier breaking new ground." Buford gives you a chance to sit at the feet of these pioneers and learn the art of finishing well so you can shift into a far more fulfilling life now, no matter your age, and pursue a lasting significance that will be a legacy for future generations.
Nursing Interventions Classification Nic
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Author : Gloria M. Bulechek, PhD, RN, FAAN
language : en
Publisher: Elsevier Health Sciences
Release Date : 2012-11-01
Nursing Interventions Classification Nic written by Gloria M. Bulechek, PhD, RN, FAAN and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-11-01 with Medical categories.
Covering the full range of nursing interventions, Nursing Interventions Classification (NIC), 6th Edition provides a research-based clinical tool to help in selecting appropriate interventions. It standardizes and defines the knowledge base for nursing practice while effectively communicating the nature of nursing. More than 550 nursing interventions are provided - including 23 NEW labels. As the only comprehensive taxonomy of nursing-sensitive interventions available, this book is ideal for practicing nurses, nursing students, nursing administrators, and faculty seeking to enhance nursing curricula and improve nursing care. More than 550 research-based nursing intervention labels with nearly 13,000 specific activities Definition, list of activities, publication facts line, and background readings provided for each intervention. NIC Interventions Linked to 2012-2014 NANDA-I Diagnoses promotes clinical decision-making. New! Two-color design provides easy readability. 554 research-based nursing intervention labels with nearly 13,000 specific activities. NEW! 23 additional interventions include: Central Venous Access Device Management, Commendation, Healing Touch, Dementia Management: Wandering, Life Skills Enhancement, Diet Staging: Weight Loss Surgery, Stem Cell Infusion and many more. NEW! 133 revised interventions are provided for 49 specialties, including five new specialty core interventions. NEW! Updated list of estimated time and educational level has been expanded to cover every intervention included in the text.
Social Enterprise
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Author : Janelle A. Kerlin
language : en
Publisher: UPNE
Release Date : 2009-11-15
Social Enterprise written by Janelle A. Kerlin and has been published by UPNE this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-11-15 with Business & Economics categories.
The first comparative look at how social enterprise is shaped by local conditions worldwide
Preclinical Safety Evaluation Of Biopharmaceuticals
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Author : Joy A. Cavagnaro
language : en
Publisher: John Wiley & Sons
Release Date : 2013-03-07
Preclinical Safety Evaluation Of Biopharmaceuticals written by Joy A. Cavagnaro and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-07 with Medical categories.
"The goal is to provide a comprehensive reference book for the preclinicaldiscovery and development scientist whose responsibilities span target identification, lead candidate selection, pharmacokinetics, pharmacology, and toxicology, and for regulatory scientists whose responsibilities include the evaluation of novel therapies." —From the Afterword by Anthony D. Dayan Proper preclinical safety evaluation can improve the predictive value, lessen the time and cost of launching new biopharmaceuticals, and speed potentially lifesaving drugs to market. This guide covers topics ranging from lead candidate selection to establishing proof of concept and toxicity testing to the selection of the first human doses. With chapters contributed by experts in their specific areas, Preclinical Safety Evaluation of Biopharmaceuticals: A Science-Based Approach to Facilitating Clinical Trials: Includes an overview of biopharmaceuticals with information on regulation and methods of production Discusses the principles of ICH S6 and their implementation in the U.S., Europe, and Japan Covers current practices in preclinical development and includes a comparison of safety assessments for small molecules with those for biopharmaceuticals Addresses all aspects of the preclinical evaluation process, including: the selection of relevant species; safety/toxicity endpoints; specific considerations based upon class; and practical considerations in the design, implementation, and analysis of biopharmaceuticals Covers transitioning from preclinical development to clinical trials This is a hands-on, straightforward reference for professionals involved in preclinical drug development, including scientists, toxicologists, project managers, consultants, and regulatory personnel.
The Heavier The Chains
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Author : M. E. Clayton
language : en
Publisher:
Release Date : 2019-09
The Heavier The Chains written by M. E. Clayton and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-09 with categories.
Kenzlee Mitchell's life went from mansions to suburbia, just like that. Determined to do her best to adjust, she accepts the changes and challenges. She just never expected Talon Draven.Talon Draven doesn't have time for distractions; he's got enough responsibilities to deal with. Determined to stay focused, he minds his own business and avoids drama. He just never expected Kenzlee Mitchell.