The Chemistry Of Imaging Probes
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The Chemistry Of Imaging Probes
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Author : Lorenzo Tei
language : en
Publisher: Frontiers Media SA
Release Date : 2018-10-19
The Chemistry Of Imaging Probes written by Lorenzo Tei and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-10-19 with categories.
Over the past decades, the field of molecular imaging has been rapidly growing involving multiple disciplines such as medicine, biology, chemistry, pharmacology and biomedical engineering. Any molecular imaging procedure requires an imaging probe that is an agent used to visualize, characterize and quantify biological processes in living systems. Such a probe typically consists of an agent that usually produces signal for imaging purpose, a targeting moiety, and a linker connecting the targeting moiety and the signaling agent. Many challenging problems of molecular imaging can be addressed by exploiting the great possibilities offered by modern synthetic organic and coordination chemistry and the powerful procedures provided by conjugation chemistry. Thus, chemistry plays a decisive role in the development of this cutting-edge methodology. Currently, the diagnostic imaging modalities include Magnetic Resonance Imaging (MRI), Computed Tomography (CT), Ultrasound (US), Nuclear Imaging (PET, SPECT), Optical Imaging (OI) and Photoacoustic Imaging (PAI). Each of these imaging modalities has its own advantages and disadvantages, and therefore, a multimodal approach combining two techniques is often adopted to generate complementary anatomical and functional information of the disease. The basis for designing imaging probes for a given application is dictated by the chosen imaging modality, which in turn is dependent upon the concentration and localization profile (vascular, extracellular matrix, cell membrane, intracellular, near or at the cell nucleus) of the target molecule. The development of high-affinity ligands and their conjugation to the targeting vector is also one of the key steps for pursuing efficient molecular imaging probes. Other excellent reviews, text and monographs describe the principles of biomedical imaging, focusing on molecular biology or on the physics behind the techniques. This Research Topic aims to show how chemistry can offer molecular imaging the opportunity to express all its potential.
The Chemistry Of Imaging Probes
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Author :
language : en
Publisher:
Release Date : 2018
The Chemistry Of Imaging Probes written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with categories.
Over the past decades, the field of molecular imaging has been rapidly growing involving multiple disciplines such as medicine, biology, chemistry, pharmacology and biomedical engineering. Any molecular imaging procedure requires an imaging probe that is an agent used to visualize, characterize and quantify biological processes in living systems. Such a probe typically consists of an agent that usually produces signal for imaging purpose, a targeting moiety, and a linker connecting the targeting moiety and the signaling agent. Many challenging problems of molecular imaging can be addressed by exploiting the great possibilities offered by modern synthetic organic and coordination chemistry and the powerful procedures provided by conjugation chemistry. Thus, chemistry plays a decisive role in the development of this cutting-edge methodology. Currently, the diagnostic imaging modalities include Magnetic Resonance Imaging (MRI), Computed Tomography (CT), Ultrasound (US), Nuclear Imaging (PET, SPECT), Optical Imaging (OI) and Photoacoustic Imaging (PAI). Each of these imaging modalities has its own advantages and disadvantages, and therefore, a multimodal approach combining two techniques is often adopted to generate complementary anatomical and functional information of the disease. The basis for designing imaging probes for a given application is dictated by the chosen imaging modality, which in turn is dependent upon the concentration and localization profile (vascular, extracellular matrix, cell membrane, intracellular, near or at the cell nucleus) of the target molecule. The development of high-affinity ligands and their conjugation to the targeting vector is also one of the key steps for pursuing efficient molecular imaging probes. Other excellent reviews, text and monographs describe the principles of biomedical imaging, focusing on molecular biology or on the physics behind the techniques. This Research Topic aims to show how chemistry can offer molecular imaging the opportunity to express all its potential.
The Chemistry Of Molecular Imaging
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Author : Nicholas Long
language : en
Publisher: John Wiley & Sons
Release Date : 2014-12-01
The Chemistry Of Molecular Imaging written by Nicholas Long and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-12-01 with Technology & Engineering categories.
Molecular imaging is primarily about the chemistry of novelbiological probes, yet the vast majority of practitioners are notchemists or biochemists. This is the first book, written from achemist's point of view, to address the nature of the chemicalinteraction between probe and environment to help elucidatebiochemical detail instead of bulk anatomy. Covers all of the fundamentals of modern imaging methodologies,including their techniques and application within medicine andindustry Focuses primarily on the chemistry of probes and imagingagents, and chemical methodology for labelling andbioconjugation First book to investigate the chemistry of molecularimaging Aimed at students as well as researchers involved in the areaof molecular imaging
Biomedical Imaging
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Author : Martin Braddock
language : en
Publisher: Royal Society of Chemistry
Release Date : 2012
Biomedical Imaging written by Martin Braddock and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Medical categories.
The focus of this new book is for medicinal chemists on the chemical agents that have been used, or might be required in the future, and the methods of synthesis for inserting the reporter groups. Medicinal chemists need to know the critical issues involved in using such chemical agents with regard to the biological applications - for instance - what properties are needed chemically and why? The topics covered in the book are: PET, SPECT, contrast agents, radioimaging/radionuclide conjugates, receptor mapping, small animal imaging (eg. WBAR - whole body autoradiography); photoinduced labelling, as well as chapters on the physical techniques used including: NMR, mass spectrometry and Xray. A key reference for academics, postgraduates, researchers, industrialists and professionals working in or joining this field.
The Chemistry Of Contrast Agents In Medical Magnetic Resonance Imaging
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Author : Andre S. Merbach
language : en
Publisher: John Wiley & Sons
Release Date : 2013-02-19
The Chemistry Of Contrast Agents In Medical Magnetic Resonance Imaging written by Andre S. Merbach and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-02-19 with Science categories.
Magnetic Resonance Imaging (MRI) is one of the most important tools in clinical diagnostics and biomedical research. The number of MRI scanners operating around the world is estimated to be approximately 20,000, and the development of contrast agents, currently used in about a third of the 50 million clinical MRI examinations performed every year, has largely contributed to this significant achievement. This completely revised and extended second edition: Includes new chapters on targeted, responsive, PARACEST and nanoparticle MRI contrast agents. Covers the basic chemistries, MR physics and the most important techniques used by chemists in the characterization of MRI agents from every angle from synthesis to safety considerations. Is written for all of those involved in the development and application of contrast agents in MRI. Presented in colour, it provides readers with true representation and easy interpretation of the images. A word from the Authors: Twelve years after the first edition published, we are convinced that the chemistry of MRI agents has a bright future. By assembling all important information on the design principles and functioning of magnetic resonance imaging probes, this book intends to be a useful tool for both experts and newcomers in the field. We hope that it helps inspire further work in order to create more efficient and specific imaging probes that will allow materializing the dream of seeing even deeper and better inside the living organisms. Reviews of the First Edition: "...attempts, for the first time, to review the whole spectrum of involved chemical disciplines in this technique..."—Journal of the American Chemical Society "...well balanced in its scope and attention to detail...a valuable addition to the library of MR scientists..."—NMR in Biomedicine
Fluorescence Spectroscopy Imaging And Probes
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Author : Ruud Kraayenhof
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Fluorescence Spectroscopy Imaging And Probes written by Ruud Kraayenhof and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
The increased use of fluorescence techniques is greatly enhanced by the improved instrumentation pioneered by inventive scientists and now made available commercially by several high-tech companies. Moreover, the design and development of many new molecular probes with higher selectivity for specific microenvironmental properties has stimulated many new researchers to employ fluorescence techniques for solving their problems. This topic book, the second in his series, reflects this exciting scientific progress and deals, among others, with new approaches and new probes in fluorescence spectroscopy, single molecule fluorescence, applications in biomembrane and enzyme studies and imaging of living cells.
Molecular Imaging Probes For Cancer Research
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Author : Xiaoyuan Chen
language : en
Publisher: World Scientific
Release Date : 2012
Molecular Imaging Probes For Cancer Research written by Xiaoyuan Chen and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Medical categories.
This review volume integrates the advances in cancer biology, molecular imaging techniques and imaging probes for visualization and quantitative measurement of anatomical, functional, and molecular profiles of cancer. The volume also presents a comprehensive summary of the state-of-the-art technology in molecular imaging probe design and applications in radionuclide (PET and SPECT), magnetic resonance (MR), optical (fluorescence, Raman, photoacoustic), ultrasound, CT, and multimodality imaging. Bringing together the fundamentals of molecular imaging, and the basic principles of each molecular imaging modality in this volume, readers' understanding in this field is further enhanced. With a strong emphasis on the chemistry of the design of appropriate molecular imaging probes for early cancer detection, therapy-response monitoring, and anti-cancer drug development, the process of translating novel cancer imaging probes from bench to bedside is extensively discussed.
The Chemistry Of Molecular Imaging
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Author : Nicholas J. Long
language : en
Publisher:
Release Date : 2015
The Chemistry Of Molecular Imaging written by Nicholas J. Long and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with HEALTH & FITNESS categories.
"Covering all the fundamentals of modern imaging methodologies, including their techniques and application within medicine and industry, The Chemistry of Molecular Engineering focuses primarily on the chemistry of probes and imaging agents, as well as chemical methodology for labelling and bioconjugation. Written by an interdisciplinary team of experts, this book investigates the chemistry of molecular imaging and helps to educate non-chemists already involved in the area of molecular imaging. It addresses all the major modalities and techniques, such as MRI, positron emission tomography, single photon emission computed tomography, ultrasound, and fluorescence/optical imaging"--
Imaging Probes Of Spectroscopy And Dynamics
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Author : [Anonymus AC05866671]
language : en
Publisher:
Release Date : 2006
Imaging Probes Of Spectroscopy And Dynamics written by [Anonymus AC05866671] and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with categories.
Advances In Functional Micro Nanoimaging Probes
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Author : Zhe Liu
language : en
Publisher: Springer
Release Date : 2018-09-01
Advances In Functional Micro Nanoimaging Probes written by Zhe Liu and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-09-01 with Technology & Engineering categories.
This book highlights the latest advances in functional micro/nano imaging probes and their applications for biomedical imaging and therapy. Given the rapid emergence of transdisciplinary research and applications in materials, chemical probes and translational medicine in recent years, scientists in these areas are expected to keep up to date on the latest technologies and advances to promote comprehensive innovations. Addressing this need, the book presents recently introduced features, emerging techniques, and new strategies, complemented by detailed illustrations. Covering the status quo and offering an outlook on the future, it benefits all readers with an interest in functional materials, especially micro/nano imaging materials for biomedical imaging applications, providing them with both vital updates and inspiration for their own research.