The Cytotoxic T Cell Response To Flavivirus Infection
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The Cytotoxic T Cell Response To Flavivirus Infection
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Author : Matthias Regner
language : en
Publisher:
Release Date : 2000
The Cytotoxic T Cell Response To Flavivirus Infection written by Matthias Regner and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with Flaviviruses categories.
The Flaviviruses Pathogenesis And Immunity
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Author :
language : en
Publisher: Elsevier
Release Date : 2003-12-18
The Flaviviruses Pathogenesis And Immunity written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-12-18 with Medical categories.
Over 50% of known flaviviruses have been associated with human disease. The Flavivirus genus constitutes some of the most serious human pathogens including Japanese encephalitis, dengue and yellow fever. Flaviviruses are known for their complex life cycles and epidemic spread, and are considered a globally-emergent viral threat.Pathogenesis and Immunity, the second volume of The Flaviviruses, examines the processes by which the flaviviruses cause disease, the different cytopathic effects and the associated immunopathological responses produced in their hosts. * Comprehensive approach to the scientific disciplines needed to unravle the complexities of virus-host interactions.* New, detailed information on the pathogenesis and immunology of the Flavivirus family.* Descibes the technologies that have contributed to our current knowledge about the Flaviviruses.* Identifies the major problems faced in attempting to further understand the virus-host interactions that result in disease.* An exhaustive compendium of current and past knowledge on the Flavivirus family
Viruses And The Cellular Immune Response
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Author : D. Brian Thomas
language : en
Publisher: CRC Press
Release Date : 1993-06-23
Viruses And The Cellular Immune Response written by D. Brian Thomas and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993-06-23 with Medical categories.
Presents a comprehensive review of cell-mediated immunity to viral infection, highlighting aspects relevant to HIV research. Opening chapters discuss antigen processing and presentation, and lymphokine function. Subsequent chapters consider immune responses to individual viruses including: HIV, visn
An Analysis Of The Cytotoxic T Cell Response To Flaviviruses Using Kunjin Vaccinia Virus Recombinants
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Author : Ann Bernice Hill
language : en
Publisher:
Release Date : 1990
An Analysis Of The Cytotoxic T Cell Response To Flaviviruses Using Kunjin Vaccinia Virus Recombinants written by Ann Bernice Hill and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1990 with Flaviviruses categories.
Cytotoxic T Lymphocytes In Human Viral And Malaria Infections
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Author : Michael B.A. Oldstone
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-11
Cytotoxic T Lymphocytes In Human Viral And Malaria Infections written by Michael B.A. Oldstone and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-11 with Medical categories.
Cytotoxic T lymphocytes (CTL) control several viral infections in animals based on deletion and reconstitution experiments with CTL clones and use of CD8 genetically deficient (knock-out) mice. In this volume, data for the role that CTL play in human infectious diseases is presented. As such, this represents the first volume in which such information from several different viral and protozoan infections is brought together.
Composition And Efficacy Of Cytotoxic T Cell Responses Determine Virus Elimination And Immunopathology After Virus Infections
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Author :
language : en
Publisher:
Release Date : 2010
Composition And Efficacy Of Cytotoxic T Cell Responses Determine Virus Elimination And Immunopathology After Virus Infections written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with categories.
This study addresses different aspects of antiviral CD8+ T cell-mediated immunopathology using two mouse models of human diseases. After pulmonary infection with respiratory syncytial virus (RSV), disease is mainly mediated by cytotoxic T cells (CTL). We used MHC congenic mice to address the question to what extent the MHC-determined CD8+ T cell response contributes to the different outcomes after RSV infection of BALB/c (H-2d) and C57BL/6 (H-2b) mice. The two investigated MHC alleles had no impact on virus elimination, but influenced weight loss and pulmonary inflammation. The overall magnitude of the virus-specific CTL response was similar. However, the H-2d restricted CTL response was less diverse and of lower avidity, thereby probably contributing to delayed elimination of stimulating APCs followed by prolonged CTL activation and cytokine-mediated immunopathology. The concept of CTL-mediated disease due to prolonged antigen stimulation is well illustrated in another disease called hemophagocytic lymphohistiocytosis (HLH). This disease is due to defects in cytotoxicity and can be modelled by LCMV infection of perforin-deficient mice. In this study, we analyzed two mouse models of partially impaired cytotoxicity. LCMV infection of pearl mice (a mouse model for Hermansky-Pudlak syndrome type II - HPSII) induced a transient HLH, which was related to a delayed virus control. In addition, pearl CTLs showed a proliferation defect indicating that defective APCs also contributed to the phenotype. Since the only human HPSII patient who developed lethal HLH also had a RAB27A mutation, we also analyzed pearl mice heterozygous for a Rab27a mutation. This did not aggravate the cytotoxicity defect or the disease phenotype, suggesting that in that patient, HPSII was sufficient for the disease. LCMV infection of beige and souris mice (mouse models for Chèdiak-Higashi syndrome with different mutations in the Lyst gene) was used to investigate the impact of viral, T cell and host.
Dengue Virus Specific T Cell Immunity
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Author : Laura Rivino
language : en
Publisher:
Release Date : 2020
Dengue Virus Specific T Cell Immunity written by Laura Rivino and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020 with categories.
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
The Togaviridae And Flaviviridae
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Author : Sondra Schlesinger
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-09
The Togaviridae And Flaviviridae written by Sondra Schlesinger and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-09 with Medical categories.
The publication of this volume of The Viruses entitled The Togaviridae and Flaviviridae comes at an appropriate time. The structure and rep lication strategies of these viruses are now known to be sufficiently di verse to warrant the removal of flaviviruses from the Togaviridae family and establish them as an independent family. Flaviviridae have a special place in the history of virology. The prototype virus-yellow fever virus was the first virus to be identified as the cause of a human disease. Some of the history of this discovery is described in Chapter 1 of this volume; in Chapter 10 the complete sequence of the RNA genome of the virus is presented. This sequence not only defines the primary structure of the viral proteins, it also clarifies the mechanism of translation of the fla vivirus genome. Knowledge of the sequence of the structural proteins of these viruses represents an important step in the potential goal of using purified flavivirus glycoproteins as vaccines. Many of the chapters in this volume focus on the structure and replication of the Togaviridae. These viruses have provided valuable models for studies in cell biology, partic ularly with regard to the cotranslational and posttranslational steps re quired for the synthesis and localization of membrane glycoproteins. Fur thermore, Togaviridae have been pivotal in our growing understanding of how enveloped viruses enter and exit from cells. The broad outlines of the structure and gene expression of Togavir idae and Flaviviridae are known, but important questions remain.
Dengue And Zika Control And Antiviral Treatment Strategies
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Author : Rolf Hilgenfeld
language : en
Publisher: Springer
Release Date : 2018-05-29
Dengue And Zika Control And Antiviral Treatment Strategies written by Rolf Hilgenfeld and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-05-29 with Medical categories.
This contributed volume contains 25 chapters from leading international scientists working on dengue and Zika viruses, who came together in Praia do Tofo in Mozambique to discuss the latest developments in the fields of epidemiology, pathogenesis, structural virology, immunology, antiviral drug discovery and development, vaccine efficacy, and mosquito control programs. The meeting venue offered an opportunity to discuss current research on these flaviviruses in an idyllic setting, and also to develop first-hand appreciation of the issues in infectious diseases facing developing countries and of the research gaps in Africa. For readers, who should include basic and clinical researchers in the field and public health professionals, the chapters are organized to provide a comprehensive overview of the various topics in current dengue and Zika virus research. A unique feature of the proceedings of this meeting is the inclusion of the discussions that took place following presentations. These have been transcribed and appended to the end of the relevant chapters, and they form the “salt in the soup” of this book.
Innate Immunity In Health And Disease
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Author : Shailendra K. Saxena
language : en
Publisher: BoD – Books on Demand
Release Date : 2021-08-25
Innate Immunity In Health And Disease written by Shailendra K. Saxena and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-08-25 with Medical categories.
The book focuses on various aspects and properties of innate immunity, whose deep understanding is integral for safeguarding the human race from further loss of resources and economies due to innate immune response-mediated diseases. Throughout this book, we examine the individual mechanisms by which the innate immune response acts to protect the host from pathogenic infectious agents and other non-communicable diseases. Written by experts in the field, the volume discusses the significance of macrophages in infectious disease, tumor metabolism, and muscular disorders. Chapters cover such topics as the fate of differentiated macrophages and the molecular pathways that are important for the pathologic role of macrophages.