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The Dna Replication Machinery As Therapeutic Targets


The Dna Replication Machinery As Therapeutic Targets
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The Dna Replication Machinery As Therapeutic Targets


The Dna Replication Machinery As Therapeutic Targets
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Author : Andrew F. Gardner
language : en
Publisher: Frontiers Media SA
Release Date : 2019-09-19

The Dna Replication Machinery As Therapeutic Targets written by Andrew F. Gardner and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-09-19 with categories.


In all organisms, the DNA replication machinery is responsible for accurate and efficient duplication of the chromosome. Inhibitors of replication proteins are commonly used in anti-cancer and anti-viral therapies. This eBook on “The DNA Replication Machinery as Therapeutic Targets” examines the normal functions of replication proteins as well as strategies to target each step during the replication process including DNA unwinding, DNA synthesis, and DNA damage bypass and repair. Articles discuss current strategies to develop drugs targeting DNA replication proteins as well as future outlooks and needs.



Human Papilloma Viruses


Human Papilloma Viruses
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Author : D.J. McCance
language : en
Publisher: Gulf Professional Publishing
Release Date : 2002-09-13

Human Papilloma Viruses written by D.J. McCance and has been published by Gulf Professional Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-09-13 with Medical categories.


This book describes up-to-date information on the pathogenesis and molecular biology of human papillomaviruses and describes the mechanistic role of the viruses in epithelial cancers. Included in the book are chapters on the epidemiology of human papillomaviruses, the factors that control replication and transcription and the viral proteins, which are involved in modulating the biology of the host cell leading to cancer. Details of the immune response to the viruses and potential vaccine strategies are discussed.



Emerging Therapeutic Targets Potential Diagnostic Or Prognostic Markers For Colorectal Cancer


Emerging Therapeutic Targets Potential Diagnostic Or Prognostic Markers For Colorectal Cancer
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Author : Muzafar Ahmad Macha
language : en
Publisher: Frontiers Media SA
Release Date : 2023-06-09

Emerging Therapeutic Targets Potential Diagnostic Or Prognostic Markers For Colorectal Cancer written by Muzafar Ahmad Macha and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-06-09 with Medical categories.




Improving The Therapeutic Ratio In Head And Neck Cancer


Improving The Therapeutic Ratio In Head And Neck Cancer
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Author :
language : en
Publisher: Academic Press
Release Date : 2019-10-04

Improving The Therapeutic Ratio In Head And Neck Cancer written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-10-04 with Science categories.


Improving the Therapeutic Ratio in Head and Neck Cancer provides a complete review of current approaches to modulating therapeutic sensitivity in head and neck cancer. It presents a broad background of current approaches and by highlighting the potential for clinical translational, introduces a roadmap for how to move promising preclinical findings into the clinic. The book discusses topics such as immunotherapy and molecularly targeted therapies in head and neck cancer, PI3k/mTOR pathway, autophagy inhibition to sensitize HNC to radiation and chemotherapy, TAM and Eph/Ephrin family proteins and metabolic reprogramming to modulate therapeutic sensitivity. Additionally, it details approaches to improve the response to immunotherapy, and Chk1/2 inhibition in radiation and cetuximab resistance. This book is a valuable source to head and neck cancer researchers and advanced students, and to those studying specific approaches in other model systems and disease sites. Provides key scientific background for clinicians when developing novel clinical trials and important examples for basic scientists of the types of work required to move a concept from the lab to the clinic Presents consistent pathway diagrams in each chapter, thus making it easier to understand complicated pathways Includes chapter summaries of the critical next steps needed to move studies from their current state into practice changing clinical data



Development And Prevention Of Behaviour Problems


Development And Prevention Of Behaviour Problems
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Author : Richard E. Tremblay
language : en
Publisher: Psychology Press
Release Date : 2010-02-25

Development And Prevention Of Behaviour Problems written by Richard E. Tremblay and has been published by Psychology Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-02-25 with Psychology categories.


This book brings together world leading researchers from diverse fields to explore the potential causes of the development of behaviour problems. The book presents theories that hope to influence public health, education and social policy in the prevention of the costly social troubles that behaviour problems can cause. Featuring contributions from researchers whose backgrounds range from the social and behavioural sciences to economics, the varied chapters assesses the potential role of gene–environment interactions, biological factors and gender differences in the development of behaviour problems. The book includes a review of studies that attempt to understand why antisocial behaviour is concentrated within families, and concludes with three chapters that link developmental research directly with policy issues. It provides a framework for students, scientists, educators and care givers to understand where frontier research on behaviour problems is going and how it can be applied in the social, educational and health services. This collection will interest all students of psychology and the behavioural sciences as well as those with an interest in public policy, sociology, abnormal psychology, psychopathology and personality disorders.



Apoptotic Pathways As Targets For Novel Therapies In Cancer And Other Diseases


Apoptotic Pathways As Targets For Novel Therapies In Cancer And Other Diseases
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Author : Marek Los
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-06-20

Apoptotic Pathways As Targets For Novel Therapies In Cancer And Other Diseases written by Marek Los and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-06-20 with Medical categories.


As our understanding of apoptotic pathway expands, we are coming to realize the great potential of utilizing this pathway to treat diseases such as cancer. The book attempts to review, summarize, and speculate on the apoptotic pathways, how are they regulated and how targeted therapies are being used to treat a wide variety of diseases. Special emphasis is placed on cancer since new treatments either being developed or currently in the clinical setting are showing great promise to increase survival rates for cancer patients. Chapters will address the biology behind regulating the apoptotic pathways and what goes wrong in disease states whereas other chapters will concentrate on new therapies targeting apoptotic pathways. The reader by the end of the book should have greater insight into the understanding and utilization of apoptotic pathways to fight diseases such as cancer.



Checkpoint Controls And Targets In Cancer Therapy


Checkpoint Controls And Targets In Cancer Therapy
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Author : Zahid H. Siddik
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-03-12

Checkpoint Controls And Targets In Cancer Therapy written by Zahid H. Siddik and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-03-12 with Medical categories.


Much work over the last two decades has firmly established that loss of cell cycle checkpoint regulation, and resultant unabated cellular proliferation, is an inherent characteristic of cancer. This loss may occur through aberration in any single component involved in signal transduction pathways that orchestrate checkpoint regulation, which may manifest through either a failure to activate the checkpoint or a failure to respond to the activated checkpoint. In normal cells, checkpoint pathways are activated when genetic or cellular homeostasis is compromised, and signals are then transduced to re-stabilize homeostasis, and, failing this, to activate the apoptotic machinery to induce a cellular suicidal response. This implies that both survival and cell death pathways are induced following checkpoint activation, and that the final decision is dependant on the net result of integrating the two sets of signals. It is intriguing that checkpoint pathways are also critical in cancer therapy to provide an apoptotic stimulus when cellular damage induced by the therapeutic agent is detected by the sensor system. Therefore, it is not surprising that failure in pro-survival checkpoint response will render tumor cells hypersensitive to cytotoxics and, conversely, failure in pro-apoptotic checkpoint response will induce genetic instability and/or therapeutic resistance. Understanding the intricacies of checkpoint response is, therefore, central to the design of therapeutic regimen that will enhance antitumor effects. Although early versions of this design entail combination of cytotoxic agents with cell cycle or checkpoint inhibitors, a greater understanding of the concepts could make such combinations clinically more effective. The contributions in this book will consolidate the current state of knowledge on checkpoint responses that may lay the foundation for hypothesis-driven rational approaches in advancing the management of cancer. The immediate attraction of the book to the scientific community is that it represents a timely opportunity to build upon existing concepts of checkpoints to expand our understanding of the inner workings of the critical checkpoint machinery. The present understanding has provided ample appreciation that response to checkpoint activation is manifested through coordinated inhibition of cyclin-dependent kinase (CDK) complexes in G1, S and/or the G2 phase in order to arrest the cell cycle. Kinase inhibition can occur through several mechanisms, including inhibitory phosphorylation of CDK, destruction of the cognate cyclins, and recruitment of CDK inhibitors from the INK and WAF1/CIP1 families. However, the wealth of information from recent discoveries needs to be examined critically to consolidate our conceptual knowledge of checkpoints. At the same time, there is acute awareness in the diversity of checkpoint response between cytotoxic agents, and this serves as a reminder of the magnitude of complexity that is inherent in checkpoint regulation. This volume is intended to bring the cancer research community closer toward an improved understanding of this regulation, how checkpoint abnormalities can impact negatively on cancer therapy, and emerging strategies to target checkpoint response as a therapeutic end-point.



Genome Duplication


Genome Duplication
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Author : Melvin DePamphilis
language : en
Publisher: Garland Science
Release Date : 2010-10-06

Genome Duplication written by Melvin DePamphilis and has been published by Garland Science this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-10-06 with Science categories.


Genome Duplication provides a comprehensive and readable overview of the underlying principles that govern genome duplication in all forms of life, from the simplest cell to the most complex multicellular organism. Using examples from the three domains of life - bacteria, archaea, and eukarya - Genome Duplication shows how all living organisms store their genome as DNA and how they all use the same evolutionary-conserved mechanism to duplicate it: semi-conservative DNA replication by the replication fork. The text shows how the replication fork determines where organisms begin genome duplication, how they produce a complete copy of their genome each time a cell divides, and how they link genome duplication to cell division. Genome Duplication explains how mistakes in genome duplication are associated with genetic disorders and cancer, and how understanding genome duplication, its regulation, and how the mechanisms differ between different forms of life, is critical to the understanding and treatment of human disease.



Biochemical And Molecular Pharmacology In Drug Discovery


Biochemical And Molecular Pharmacology In Drug Discovery
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Author : Mithun Rudrapal
language : en
Publisher: Elsevier
Release Date : 2024-06-28

Biochemical And Molecular Pharmacology In Drug Discovery written by Mithun Rudrapal and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-06-28 with Medical categories.


Biochemical and Molecular Pharmacology in Drug Discovery comprises fundamental biochemical and molecular aspects of drug discovery and basic understanding of modern drug discovery approaches along with certain key topics related to molecular pharmacology of drugs and therapeutics. Molecular pharmacology has gained significant momentum among researchers, scientists, and academicians because of its increasing interest in drug discovery research across the globe. Molecular pharmacology involves a fundamental understanding of drug actions at the molecular level with the help of several tools and techniques of biochemical and molecular biology. It explains the phenomena of drug-target interactions considering different biochemical systems and cellular strategies. With the advent of technologies, current advances and research trends move toward molecular and/or target-based drug design and discovery. Through this book, readers will be able to gain skills and knowledge with a thorough understanding of the subject of biochemical and molecular pharmacology, in a comprehensive and systematic manner with special reference to recent advances in drug discovery research. Highlights the fundamentals of biochemical and molecular aspects, with reference to drug discovery research Depicts modern drug discovery approaches such as reverse pharmacology, drug repositioning, and CADD in the context of current research updates Summarizes recent developments in the molecular pharmacology of novel drugs/ therapeutic molecules



Pharmacologic Analysis Of Drug Receptor Interaction


Pharmacologic Analysis Of Drug Receptor Interaction
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Author : Terrence P. Kenakin
language : en
Publisher: Lippincott Williams & Wilkins
Release Date : 1997

Pharmacologic Analysis Of Drug Receptor Interaction written by Terrence P. Kenakin and has been published by Lippincott Williams & Wilkins this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with Medical categories.


The thoroughly revised, updated Third Edition of this highly acclaimed text reflects the past four years' groundbreaking developments in receptor pharmacology, particularly the use of human recombinant receptor systems in drug design and development. Whereas prior editions focused on the correspondence of animal to human receptor systems, this new edition examines drug effects on human receptors obtained by recombinant technology, as well as on physiological natural receptor systems in animals. Two new chapters explain how to produce and use human recombinant receptor systems and discuss the interpretation of data from human recombinant receptor studies. Other chapters describe the use of receptor studies to measure and characterize the biological actions of drugs.