The Genetic Epidemiology And Omics Of Age Related Cataract
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The Genetic Epidemiology And Omics Of Age Related Cataract
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Author : Ekaterina Yonova-Doing
language : en
Publisher:
Release Date : 2018
The Genetic Epidemiology And Omics Of Age Related Cataract written by Ekaterina Yonova-Doing and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with categories.
The Genetic Epidemiology And Omics Of Age Related Cataract
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Author : Ekaterina Hristova Yonova
language : en
Publisher:
Release Date : 2018
The Genetic Epidemiology And Omics Of Age Related Cataract written by Ekaterina Hristova Yonova and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with categories.
Age-related cataract is the leading cause of blindness worldwide and a major public health problem. The two most common types of age-related cataract are nuclear and cortical cataract. Nuclear and cortical cataracts are complex diseases, meaning both genetic and environmental factors play a role in their pathogenesis. In addition, it is increasingly clear that pathogenesis of age-related cataracts is intertwined with systemic factors related to ageing. Holistic approaches taking into account the systemic nature of the cataract risk factors are needed. High-throughput technologies have enabled detailed studies of the molecular changes and biological pathways underlying a variety of complex traits but their use in age-related cataract research is long overdue. The current thesis describes the implementation of various "omics" platforms to answer questions related to genetic and environmental risks such as: 1) What are the genetic variants (both common and rare) that underlie the pathogenesis of the common forms of age-related cataract: nuclear and cortical cataract?; 2) Do nuclear and cortical share genetic risk factors?; 3) What are the effects of diet on cataract formation and progression and are these effects mediated through circulating metabolites or the gut microbiome? The work presented in this thesis resulted in, among others: the identification of six new genetic loci for age-related nuclear cataract; determining that dietary vitamin C protects not only against cataract formation but also against cataract progression; and suggesting that gut bacteria may play a role in the pathogenesis of cataract. Omics data can be useful for elucidating the biological pathways underling cataract. However, various factors that lead to reduction in power to identify effects, such as mismatches between dates of phenotyping and sample collection, may limit their potential.
Ophthalmic Epidemiology
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Author : Ching-Yu Cheng
language : en
Publisher: CRC Press
Release Date : 2022-05-25
Ophthalmic Epidemiology written by Ching-Yu Cheng and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-05-25 with Medical categories.
Ophthalmic Epidemiology: Current Concepts to Digital Strategies provides a comprehensive guide to graduate students, ophthalmologists, and researchers in ophthalmic epidemiology. It covers recently developed new methodologies, technologies and resources in ocular epidemiological research, such as telemedicine, disease registries, EMR, bio-banks and omics. This book also summarizes recent epidemiological findings and provides up-to-date data on ocular diseases. Furthermore, it introduces and discusses the uses of epidemiology in the evaluation of health services and population screening programs and reviews the application of epidemiology in intervention trials in the communities. Key Features Comprehensive guide to the epidemiology of common eye diseases. Provides updates on the prevalence and risk factors of eye diseases. Outlines how epidemiological techniques can be utilized to evaluate ophthalmic health services and programs.
Updates On Myopia
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Author : Tien Y Wong
language : en
Publisher:
Release Date : 2020-10-08
Updates On Myopia written by Tien Y Wong and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-10-08 with Medical categories.
This book is open access under a CC BY 4.0 license. This open access book discusses basic clinical concepts of myopia, prevention of progression and surgical treatments for myopia and pathological myopia. It also summarises the latest evidence and best practices for managing myopia, high myopia and its complications. Written by leading experts, the book addresses clinical diagnosis and interpretation of imaging modalities, and various complications of myopia such as glaucoma, choroidal neovascularization, retinal degeneration and cataracts. It is a valuable comprehensive resource for general and sub-specialist ophthalmologists as well as residents and ophthalmologists in training.; This work was published by Saint Philip Street Press pursuant to a Creative Commons license permitting commercial use. All rights not granted by the work's license are retained by the author or authors.
Pathologic Myopia
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Author : Richard F. Spaide
language : en
Publisher: Springer Nature
Release Date : 2021-07-28
Pathologic Myopia written by Richard F. Spaide and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-07-28 with Medical categories.
Pathologic Myopia is a major cause of severe vision loss worldwide. The mechanisms for vision loss include cataract, glaucoma, retinal detachment, and above all, myopic maculopathy within the posterior staphyloma. The first edition of Pathologic Myopia is one of the only current books to specifically address this disease and discusses recent developments in imaging technologies and various approaches to treatments, such as laser photocoagulation, photodynamic therapy, pharmaco-therapeutic injections in the vitreous, and surgery. This new edition is a timely update to the standard reference in the field, with new chapters on advanced refractive error correction, genetics, developing a classification system, and special surgical approaches for pathologic myopia. Complete with even more high-quality color images and informative tables, this book is written and edited by leaders in the field and is geared towards ophthalmologists, including residents and fellows in training, glaucoma and cataract specialists, and vitreoretinal macula experts.
Oxford Textbook Of Old Age Psychiatry
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Author : Tom Dening
language : en
Publisher: Oxford University Press, USA
Release Date : 2020-11-05
Oxford Textbook Of Old Age Psychiatry written by Tom Dening and has been published by Oxford University Press, USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-11-05 with Medical categories.
Part of the authoritative Oxford Textbooks in Psychiatry series, Oxford Textbook of Old Age Psychiatry, Third Edition has been thoroughly updated to reflect the developments in old age psychiatry since publication of the Second Edition in 2013, and remains an essential reference for anyone interested in the mental health care of older people.
Probabilistic Boolean Networks
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Author : Ilya Shmulevich
language : en
Publisher: SIAM
Release Date : 2010-01-21
Probabilistic Boolean Networks written by Ilya Shmulevich and has been published by SIAM this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-01-21 with Mathematics categories.
The first comprehensive treatment of probabilistic Boolean networks, unifying different strands of current research and addressing emerging issues.
Asia Pacific Glaucoma Guidelines
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Author : T. Aung
language : en
Publisher: Kugler Publications
Release Date : 2016-07-13
Asia Pacific Glaucoma Guidelines written by T. Aung and has been published by Kugler Publications this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-07-13 with Medical categories.
Advances In Vision Research Volume Ii
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Author : Gyan Prakash
language : en
Publisher: Springer
Release Date : 2018-11-03
Advances In Vision Research Volume Ii written by Gyan Prakash and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-11-03 with Medical categories.
This second volume continues with a focus on the state of the art in genetic eye research in Asia and the Pacific. Though there has been an explosion of information on genetic eye research in western countries, more than sixty percent of the human genes involved in eye diseases in the Asian and Pacific population remain unknown. However, new efforts and a new awareness have sparked important discussions on the subject, and new plans are being implemented to discover the genes responsible for many eye diseases in the population. The book reviews the latest findings; its content ranges from genetic aspects of human migration to DNA sequence analysis, genome-wide association analysis, and disease phenotypes. The efforts of the Asian Eye Genetic Consortium (AEGC) are also discussed. The book’s editors have been instrumental in developing strategies for discovering the new Asian genes involved in many eye diseases. All chapters were written by leading researchers working on Asian eye genetics from the fields of Human Genetics, Ophthalmology, Molecular Biology, Biochemistry, Sensory Sciences, and Clinical Research. Advances in Vision Research, Volume II will prove to be a major resource for all researchers, clinicians, clinical researchers, and allied eye health professionals with an interest in eye diseases among the Asian population.
Ocular Infections
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Author : Khalid F. Tabbara
language : en
Publisher: Springer
Release Date : 2014-12-04
Ocular Infections written by Khalid F. Tabbara and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-12-04 with Medical categories.
Ocular infections remain an important cause of ocular morbidity and loss of vision, yet many are preventable or curable. Early diagnosis and prompt treatment help in the control of such infectious disorders and the prevention of blindness. There are many infectious diseases of the eye and adnexa and knowledge of their diagnosis and management is essential to an optimal therapeutic outcome. This book provides the practitioner with the important information required to ensure appropriate diagnosis and management of ocular infectious diseases. Specific clinical signs and symptoms are outlined, and the role of specific diagnostic tests, including molecular biology techniques, is explained. All of the most common microorganisms are considered and current knowledge on the antimicrobial therapy of ocular infections is clearly summarized. Ocular Infections will be a great help to physicians as a guide to the care of patients with ocular infectious diseases.