The Genetics Of Complex Thyroid Diseases
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The Genetics Of Complex Thyroid Diseases
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Author : T. Akamizu
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
The Genetics Of Complex Thyroid Diseases written by T. Akamizu and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
The rapid developments in molecular genetics have clarified many of the muta tions in monogenic thyroid diseases over the last two decades; now the target of molecular thyroid genetics has become the oligogenic thyroid diseases. These include the autoimmune thyroid diseases and familial thyroid cancers, both of which are much commoner than the monogenic diseases. However, the method ological approach to the genetics of these more complex diseases is still far from being well established. Although the discovery of susceptibility genes has been partially accomplished in complex diseases such as asthma, Crohn's dis ease, and types I and II diabetes mellitus, the elucidation of susceptibility genes in complex diseases remains a major challenge. This volume contains papers presented at the International Symposium on the Genetics of Complex Thyroid Diseases. This meeting was held in association with the International Thyroid Congress in Kyoto in October 2000 and sup ported in part by the Japan Intractable Diseases Research Foundation and Knoll Pharmaceuticals Inc. The symposium was the first international symposium con cerning the genetics of complex thyroid diseases and was restricted to the study of the autoimmune thyroid diseases and familial thyroid cancer. Twenty distin guished researchers from the United States, the United Kingdom, France, Ger many, Italy, and Japan were invited. Each presentation precipitated intense dis cussion and there was much consensus during the meeting. Nevertheless, this volume will leave the reader with a clear understanding of how little we still know.
Diagnostic Pathology And Molecular Genetics Of The Thyroid
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Author : Yuri E. Nikiforov
language : en
Publisher: Lippincott Williams & Wilkins
Release Date : 2012-04-20
Diagnostic Pathology And Molecular Genetics Of The Thyroid written by Yuri E. Nikiforov and has been published by Lippincott Williams & Wilkins this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-04-20 with Medical categories.
Diagnostic Pathology and Molecular Genetics of the Thyroid, Second Edition, offers a comprehensive overview of the diagnostic surgical pathology, cytopathology, immunohistochemistry and molecular genetics of the thyroid diseases, including neoplastic and non-neoplastic conditions. The book provides a detailed description of the surgical pathology of thyroid diseases side by side with major advances in immunohistochemistry and molecular genetics that can be used in evaluating thyroid tumors and non-neoplastic diseases.
Genetic Perspectives In Thyroid Cancer
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Author : Susana Nunes Silva
language : en
Publisher: MDPI
Release Date : 2021-04-21
Genetic Perspectives In Thyroid Cancer written by Susana Nunes Silva and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-04-21 with Medical categories.
Thyroid cancer is an uncommon type of cancer, but it is one of the most common endocrine malignancies. The etiology of thyroid cancer is multifactorial, and radiation is the best documented risk factor related to the disease. Further risk factors have been hypothesized; however, we have yet to gather a wide range of information that will help us better understand the genetic mechanisms of thyroid cancer. The influence of genetics in the clinic and in therapeutics has been improved based on retrospective and prospective studies published worldwide in the last few decades, but the development of high through-put approaches has also been crucial. The new advances in high through-put methodologies such as next generation sequencing will open the door to new genetic variants that will help to clarify genotype–phenotype correlations, new gene associations, new genetic targets useful as potential biomarkers, and so on. The new decade that is now beginning may provide new evidence for the disease. “Genetic Perspectives in Thyroid Cancer” is an issue that intends to cover several topics on thyroid cancer, aiming to reach new findings based on genetic evidence in thyroid cancer as expressed in case studies, molecular approaches, and hereditary evidences, clinical and therapeutic developments.
Thyroid Autoimmunity
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Author : A. Pinchera
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Thyroid Autoimmunity written by A. Pinchera and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
In 1956, three groups independently reported evidence that some thyroid disease appearing spontaneously in humans or experimentally induced in animals are related to autoimmune processes. The interval between these landmark discoveries and the present has witnessed a remarkable and continuing growth of both knowledge and concepts concerning the mechanisms of immune regulation, the pathogenesis of autoimmune thyroid diseases, and their clinical and laboratory manifestations. More importantly knowledge of thyroid autoimmunity has, in many respects, comprised the vanguard of an ever increasing appreciation and understanding of autoimmune diseases in general. On November 24-26 1986, an International Symposium on Thyroid Autoimmunity was held in Pisa. Its purpose was to commemorate the birth of thyroid autoimmunity as a scientific discipline, to summarize current knowledge and concepts in this area, and where possible, to anticipate areas of opportunity for the future - hence the theme of the Symposium, Memories and Perspectives. To open the meeting, the Magnifico Rettore (Chancellor) of the University of Pisa granted special Awards to Dr. Deborah Doniach, Dr. Ivan Roitt, and Dr. Noel R. Rose, who published the first fundamental studies in the field of thyroid autoimmunity, and to Dr. Duncan G. Adams, whose discovery of the long-acting thyroid stimulator (LATS) opened the door to our current understanding of the pathogenesis of Graves' disease. During the meeting thirty plenary lectures were presented.
Thyroid Diseases
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Author : Paolo Vitti
language : en
Publisher: Springer
Release Date : 2018-09-09
Thyroid Diseases written by Paolo Vitti and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-09-09 with Medical categories.
This book presents the latest advances in knowledge of the pathogenesis of thyroid diseases and describes the state of the art in their diagnosis and treatment, including newly emerging management approaches. After an opening section that addresses thyroid physiology and laboratory evaluation, each of the major thyroid diseases and their subtypes is discussed, covering goiter and thyroid nodule, thyroiditis, hypothyroidism, hyperthyroidism and thyrotoxicosis, and thyroid carcinoma. Other conditions that affect thyroid function or induce thyroid dysfunction are also considered, e.g., pregnancy, non-thyroidal disorders, and medication use. The book is designed to assist practitioners to achieve optimal outcomes in clinical routine by providing clear guidance on clinical examination, the use of diagnostic tests, first- and second-line therapies, and follow-up. Chapter have been written by recognized experts in the field.
Paediatric Thyroidology
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Author : G. Szinnai
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2014-09-15
Paediatric Thyroidology written by G. Szinnai and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-09-15 with Medical categories.
This book presents a comprehensive overview of pediatric thyroid diseases and thus provides a useful tool for clinical problem solving. Opinion leaders in the field present reviews on all relevant diseases of the hypothalamic-pituitary-thyroid axis. Sixteen chapters cover topics ranging from fetal thyroidology, congenital hypothyroidism, central hypothyroidism, inherited defects of thyroid hormone action, cell transport and metabolism to iodine deficiency, autoimmune thyroid disease and thyroid tumors. Written by clinicians, the chapters provide in-depth information and current guidelines for clinical problems encountered in pediatric thyroidology. As a unique feature, a case seminar collection for each chapter presents typical patient histories providing key learning points and key references for clinical problem solving in family medicine, pediatric endocrinology and medical genetics. Providing a succinct update on clinical pediatric thyroidology, this book is an essential tool for pediatric and adult endocrinologists, as well as for general practitioners, pediatricians and medical geneticists.
The Bethesda System For Reporting Thyroid Cytopathology
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Author : Syed Z. Ali
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-03-20
The Bethesda System For Reporting Thyroid Cytopathology written by Syed Z. Ali and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-03-20 with Medical categories.
This atlas is the offspring of the “The National Cancer Institute (NCI) Thyroid Fine Needle Aspiration (FNA) State of the Science Conference,” hosted by the NCI and organized by Dr. Andrea Abati. Preparations for the conference began 18 months earlier with the designation of a steering committee and the establishment of a dedicated, p- manent web site. The meeting took place on October 22 and 23, 2007 in Bethesda, Maryland and was co-moderated by Susan J. Mandel and Edmund S. Cibas. The discussions and conclusions regarding terminology and morphologic criteria 1, 2 from the meeting were summarized in publications by Baloch et al. and form the framework for this atlas. The atlas is organized by the general categories of “Nondiagnostic,” “Benign,” “Follicular Neoplasm/Suspicious for a Follicular Neoplasm”, “Suspicious for Malignancy,” and “Malignant,” and it includes the defi- tions and morphologic criteria of these categories as set forth by Baloch et al. The majority of the conference participants also agreed on a category of “undetermined significance,” which is incorporated in this atlas (Chap. 4). It is critical that the cytopathologist communicate thyroid FNA interpretations to the referring physician in terms that are succinct, unambiguous, and helpful clinically. We recognize that the terminology used here is a flexible framework that can be modified by individual laboratories to meet the needs of their providers and the patients they serve.
Diagnostic Criteria In Autoimmune Diseases
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Author : Yehuda Shoenfeld
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-06-08
Diagnostic Criteria In Autoimmune Diseases written by Yehuda Shoenfeld and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-06-08 with Medical categories.
According to the Autoimmune Diseases Coordinating Committee (ADCC), between 14.7 and 23.5 million people in the USA – up to eight percent of the population are affected by autoimmune disease. Autoimmune diseases are a family of more than 100 chronic, and often disabling, illnesses that develop when underlying defects in the immune system lead the body to attack its own organs, tissues, and cells. In Handbook of Autoimmune Disease, the editors have gathered in a comprehensive handbook a critical review, by renowned experts, of more than 100 autoimmune diseases, divided into two main groups, namely systemic and organ-specific autoimmune diseases. A contemporary overview of these conditions with special emphasis on diagnosis is presented. Each chapter contains the essential information required by attending physicians as well as bench scientists to understand the definition of a specific autoimmune disease, the diagnostic criteria, and the treatment.
Thyroid Scanning
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Author : Clyde M. Williams
language : en
Publisher:
Release Date : 1968
Thyroid Scanning written by Clyde M. Williams and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1968 with categories.
Goiter
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Author : N.K. Agrawal
language : en
Publisher: BoD – Books on Demand
Release Date : 2020-04-08
Goiter written by N.K. Agrawal and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-04-08 with Medical categories.
The thyroid gland is a commonly diseased endocrine organ of human body. The disorders affecting the thyroid gland are varied but are very much amenable to treatment. The enlargement of the thyroid is termed goiter. It can affect the whole gland or only part of it. The disease is perplexing but in-depth knowledge of the pathophysiology helps in elucidating causes and thereby treating the disease. In this book, the diffuse and nodular goiter has been addressed as well as the functional abnormalities of the gland and its implications on the body are discussed in various chapters. The relevant updated information is included. To address a few of these current issues and recent updated information, authors have put in a lot of effort to organize the book.