The Genetics Of Osteoporosis And Metabolic Bone Disease
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The Genetics Of Osteoporosis And Metabolic Bone Disease
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Author : Michael J. Econs
language : en
Publisher: Springer Science & Business Media
Release Date : 2000-05-12
The Genetics Of Osteoporosis And Metabolic Bone Disease written by Michael J. Econs and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-05-12 with Medical categories.
The explosive growth in the field of molecular biology over the last two decades has started to make a great impact on clinical medicine. Genes have been cloned for diseases that were poorly understood only a decade ago. Additionally, investigators are increasingly aware that there are strong genetic components to complex disorders, such as osteoporosis, that are not classically thought of as genetic disorders. New insights into the pathogenesis of metabolic bone diseases have been obtained from investigations into the molecular biology of these diseases and new therapies will become available based on these new insights. In The Genefies of Osteoporosis and Metabolie Bane Disease, I have assembled an internationally renowned group of experts to write the various chapters. Each of the authors is an expert in his/her field who is currently performing research on the content of their chapter and have made important contributions to the understanding of the clinical fea tures and pathophysiology of metabolic bone disease and genetics. The first part of The Genefies of Osteoporosis and Metabolie Bane Disease addresses issues related to genetic contributions to the development of osteoporosis and the many factors that must be considered when searching for genesthat predispose to osteoporosis. The second sec tion addresses recent advances in the clinical and molecular biological aspects of inherited metabolic bone disorders. The last section reviews the latest techniques for finding genes that predispose to metabolic bone diseases.
The Genetics Of Osteoporosis And Metabolic Bone Disease
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Author : Michael J. Econs
language : en
Publisher:
Release Date : 2014-01-15
The Genetics Of Osteoporosis And Metabolic Bone Disease written by Michael J. Econs and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-01-15 with categories.
Genetics Of Bone Biology And Skeletal Disease
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Author : Rajesh V. Thakker
language : en
Publisher: Academic Press
Release Date : 2017-10-31
Genetics Of Bone Biology And Skeletal Disease written by Rajesh V. Thakker and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-10-31 with Medical categories.
Genetics of Bone Biology and Skeletal Disease, Second Edition, is aimed at students of bone biology and genetics and includes general introductory chapters on bone biology and genetics. More specific disease orientated chapters comprehensively summarize the clinical, genetic, molecular, animal model, molecular pathology, diagnostic, counseling, and treatment aspects of each disorder. The book is organized into five sections that each emphasize a particular theme, general background to bone biology, general background to genetics and epigenetics, disorders of bone and joint, parathyroid and related disorders, and vitamin D and renal disorders. The first section is specifically devoted to providing an overview of bone biology and structure, joint and cartilage biology, principles of endocrine regulation of bone, and the role of neuronal regulation and energy homeostasis. The second section reviews the principles and progress of medical genetics and epigenetics related to bone disease, including genome-wide association studies (GWAS), genomic profiling, copy number variation, prospects of gene therapy, pharmacogenomics, genetic testing and counseling, as well as the generation and utilizing of mouse models. The third section details advances in the genetics and molecular biology of bone and joint diseases, both monogenic and polygenic, as well as skeletal dysplasias, and rarer bone disorders. The fourth section highlights the central role of the parathyroids in calcium and skeletal homeostasis by reviewing the molecular genetics of: hyperparathyroidism, hypoparathyrodism, endocrine neoplasias, and disorders of the PTH and calcium-sensing receptors. The fifth section details molecular and cellular advances across associated renal disorders such as vitamin D and rickets. Identifies and analyzes the genetic basis of bone disorders in humans and demonstrates the utility of mouse models in furthering the knowledge of mechanisms and evaluation of treatments Demonstrates how the interactions between bone and joint biology, physiology, and genetics have greatly enhanced the understanding of normal bone function as well as the molecular pathogenesis of metabolic bone disorders Summarizes the clinical, genetic, molecular, animal model, molecular pathology, diagnostic, counseling, and treatment aspects of each disorder
Osteoporosis Genetics Prevention And Treatment
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Author : John S. Adams
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Osteoporosis Genetics Prevention And Treatment written by John S. Adams and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Modern society is altering the lifestyle and longevity of its members much more quickly than evolutionary adaptation to these changes can take place. The problem of calcium deficiency in the population is compounded by the growing percentage of aged individuals with relatively fragile, less massive skeletons. Current-day civilizations are much more effective in prolonging human life in a state of relative debility than even a few decades ago. This reality is unlikely to change and mandates that we develop strategies to prevent aging-related diseases like osteoporosis before they become manifest. Osteoporosis: Genetics, Prevention and Treatment places emphasis on the (1) genetic predisposition, (2) early recognition and (3) prevention of osteoporosis. The intent is not to move the practitioner's attention away from intervention therapy of osteoporosis, but rather to expand their view of this disease as one beginning at birth and one in which susceptibility is manifest at the conclusion of adolescence, not at menopause. The book concludes with an informed view of the future in terms of the recognition, prevention and management of osteoporosis.
Primer On The Metabolic Bone Diseases And Disorders Of Mineral Metabolism
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Author : Juliet E. Compston
language : en
Publisher: John Wiley & Sons
Release Date : 2009-12-22
Primer On The Metabolic Bone Diseases And Disorders Of Mineral Metabolism written by Juliet E. Compston and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-12-22 with Science categories.
EDITOR-IN-CHIEF: Clifford J. Rosen, M.D., Maine Medical Center Research Institute, Scarborough, Maine SENIOR ASSOCIATE EDITORS: Juliet E. Compston, M.D., FRCP, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom Jane B. Lian, Ph.D., University of Massachusetts Medical School, Worcester, Massachusetts This comprehensive yet concise handbook is an indispensable reference for the many clinicians who see patients with disorders of bone formation, metabolic bone diseases, or disorders of stone formation. It is also a crucial tool for researchers, students, and all other professionals working in the bone field. In a format designed for quick reference, it provides complete information on the symptoms, pathophysiology, diagnosis, and treatment of all common and rare bone and mineral disorders. New in this edition: detailed coverage of osteonecrosis of the jaw, more in-depth coverage of cancer and bone including new approaches to pathogenesis, diagnosis, and treatment; new approaches to anabolic therapy of osteoporosis; the latest research on Vitamin D; expanded coverage of international topics; more on the genetics of bone mass; and newer imaging techniques for the skeleton. In addition, this edition features a free, online-only appendix of medicines used to treat bone disorders and their availability around the world.
Calcium And Bone Disorders In Children And Adolescents
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Author : J. Allgrove
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2015-06-11
Calcium And Bone Disorders In Children And Adolescents written by J. Allgrove and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-06-11 with Medical categories.
There has been a rapid expansion of knowledge in the field of paediatric calcium and bone disorders over the past twenty years. Advances have been made in the underlying genetic basis for many conditions in conjunction with progress in bone density and geometry imaging and the development of new treatment options. The 2nd revised edition of ‘Calcium and Bone Disorders in Children and Adolescents’ presents up-to-date information on many aspects included in the 1st edition such as the physiology, pathology, diagnosis and management of numerous conditions including a chapter of case histories illustrating clinical aspects. New chapters on skeletal dysplasias, the genetics of osteoporosis, radiological imaging of bone and a practical approach to a child with recurrent fractures are included. Providing a comprehensive update, this book is a useful clinical resource for paediatricians and specialists in endocrinology, metabolic bone disease, nephrology, rheumatology, radiology, orthopaedics and clinical genetics who may be faced with a child with a calcium and/or bone disorder.
Pocket Reference To Osteoporosis
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Author : Serge Livio Ferrari
language : en
Publisher: Springer
Release Date : 2018-12-28
Pocket Reference To Osteoporosis written by Serge Livio Ferrari and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-12-28 with Medical categories.
This book responds to the daily needs of all clinicians treating patients with osteoporosis and provides a key reference guide for any challenges that arise in clinical practice. This book also covers the genetics of the disease, clinical presentation, diagnosis, and current and upcoming treatment recommendations in accordance with the latest international guidelines. Osteoporosis is a disease in which the density and quality of bone are greatly reduced, and as bones become more porous and fragile the risk of fracture increases greatly. It is one of the most common metabolic bone diseases globally with one in three women and one in five men at risk of an osteoporotic fracture, and can result in devastating physical, psychosocial, and economic consequences. However, in spite of this osteoporosis can often be overlooked and undertreated, thus there is a real need to raise awareness of this disease.
Primer On The Metabolic Bone Diseases And Disorders Of Mineral Metabolism
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Author : Asbmr
language : en
Publisher: Rittenhouse Book Distributors
Release Date : 2006
Primer On The Metabolic Bone Diseases And Disorders Of Mineral Metabolism written by Asbmr and has been published by Rittenhouse Book Distributors this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with Medical categories.
Prelude To Calculus
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Author : Warren L. Ruud
language : en
Publisher: Pws Publishing Company
Release Date : 1993
Prelude To Calculus written by Warren L. Ruud and has been published by Pws Publishing Company this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993 with Mathematics categories.
Bone disorders are common and represent a major burden on health economic costs. Our understanding of bone development has had tremendous advances in the last ten year due primarily to focusing on genetics. For example, osteoporosis and related fractures are the leading cause of hospital admission in women over the age of 50 years, and >80% of adults over 55 years of age will suffer from osteoarthritis. Treatments of some metabolic disorders have been greatly improved by an increased understanding of bone biology which has been facilitated by advances in unravelling the genetics underlying bone disorders. These interactions between bone biology / physiology and genetics have also greatly enhanced the understanding of normal bone function as well as the molecular pathogenesis of metabolic bone disorders. The purpose of this book is to identify and analyse the genetic basis of bone disorders in humans and to demonstrate the utility of mouse models in furthering the knowledge of mechanisms and evaluations of treatments. The book is aimed at all students of bone biology and genetics and with this in mind it includes general introductory chapters on genetics and bone biology; and more specific disease orientated chapters, which comprehensively summarize the clinical, genetic, molecular genetic, animal model, functional and molecular pathology, diagnostic, counselling and treatment aspects of each disorder. Saves academic, medical, and pharma researchers time in quickly accessing the very latest details on a broad range of genetic bone issues, as opposed to searching through thousands of journal articles. Provides a common language for bone biologists and geneticists to discuss the development of bone cells and genetics and their interactions in the development of disease Researchers in all areas bone biology and genetics will gain insight into how clinical observations and practices can feed back into the research cycle and will, therefore, be able to develop more targeted genomic and proteomic assays For those clinical researchers who are also MDs, correct diagnosis (and therefore correct treatment) of bone diseases depends on a strong understanding of the molecular basis for the disease.
Metabolic Bone Disease And Clinically Related Disorders
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Author : Louis V. Avioli
language : en
Publisher: Academic Press
Release Date : 1997-10-08
Metabolic Bone Disease And Clinically Related Disorders written by Louis V. Avioli and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-10-08 with Science categories.
Metabolic Bone Disease, Third Edition is the new, expanded edition of the classic text, featuring the latest advancements and research information in this fast-moving field. The Third Edition includes the most up-to-date information on molecular mechanisms, basic biology, pathophysiology, and diagnosis and management strategies of metabolic bone disease. Edited by "fathers of the field" An expanded version of a classic AP text Complete coverage of a fast-growing field