The Hepatobiliary System
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The Biliary System
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Author : David Q.-H. Wang
language : en
Publisher: Biota Publishing
Release Date : 2016-12-15
The Biliary System written by David Q.-H. Wang and has been published by Biota Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-12-15 with Medical categories.
The liver is a vital organ involved in numerous metabolic processes such as cholesterol and bile acid metabolism, biliary lipid secretion, and bile formation. Cholesterol balance across the liver has a crucial effect on influencing plasma total and LDL cholesterol levels and biliary cholesterol concentrations. Cholesterol and bile acid biosyntheses are primarily modulated by negative feedback regulatory mechanisms through the sterol regulatory element-binding protein isoform 2 (SREBP-2) and the farnesoid X receptor (FXR) pathways, respectively. The conversion of cholesterol to bile acids in the liver can balance the fecal excretion of bile acids, which is an important route for the removal of cholesterol from the body. Bile formation begins in the bile canaliculi, and maintenance of the enterohepatic circulation of bile acids results in a continuous secretion of bile. Hepatic secretion of biliary lipids is determined mainly by a group of ATP-binding cassette (ABC) transporters that are located on the canalicular membrane of hepatocytes, which are regulated by various nuclear receptors. Bile acids promote bile flow by their osmotic effects. Also, they are essential for the intestinal absorption of cholesterol, fatty acids, and fat-soluble vitamins and play an important role in aiding the digestion of dietary fat. Bile acids function as signaling molecules and anti-inflammatory agents to regulate lipid, glucose, and energy metabolism by rapidly activating nuclear receptors and cell signaling pathways. This eBook summarizes the progress in the molecular and cellular mechanisms of cholesterol and bile acid metabolism and the physical-chemistry of biliary lipids, with emphasis on biliary lipid metabolism that is regulated by nuclear receptors in the hepatobiliary system.
The Hepatobiliary System
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Author : W. Taylor
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-06-29
The Hepatobiliary System written by W. Taylor and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-29 with Medical categories.
A volume on the biliary system appeared in 1965, based on a symposium of the NATO Advanced Institute held in September, 1963, in Newcastle upon Tyne in England. It soon became an authorita tive text on the problems of the biliary tract and, for instance, the discussion on the biliary secretion of organic anions, organic cations and inorganic ions were classic references. The worn pages of the volume in many libraries, including my own, bespeak its usefulness over ten long years. The initiative and energy of the Director of the first Institute have to be admired, even more so since he was able to assemble a Second Institute in Aalborg, Denmark, in 1975. His wisdom is reflected in the selection of the subjects discussed. The comparison between the two volumes tells something about the advancement in the time interval in knowledge about liver and biliary tract diseases, about the turnover of researchers interested in the liver and its diseases, and also about the present philosophy in biologic science. For this com parison, this volume is particularly suited because, in contrast to many other recent conferences, the more leisurely pace of the NATO Institutes permits more comprehensive but still scholarly reviews of the problems. The foreword of the first volume, written by my colleague, the late Harry Sobotka, expresses his, now dated, astonishment about the progress of knowledge of biology of the bile, so much less accessible to study than urine.
The Biliary System
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Author : David Q.-H. Wang
language : en
Publisher: Morgan & Claypool Publishers
Release Date : 2012
The Biliary System written by David Q.-H. Wang and has been published by Morgan & Claypool Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Science categories.
The exponential expansion of knowledge in the field of hepatobiliary diseases makes systematic revisions of current concepts almost mandatory nowadays. This eBook summarizes the progress in understanding the molecular mechanism of cholesterol and bile acid metabolism and the physical-chemistry of biliary lipids, with emphasis on biliary lipid metabolism that is regulated by nuclear receptors in the hepatobiliary system. By guiding the readers through the various aspects of anatomy, physiology, and biochemistry of all "players" involved in bile formation, this eBook is intended to be a compendium of recent progresses in understanding the molecular mechanisms of cholesterol and bile acid metabolism. Table of Contents: Introduction / Anatomy of the Liver, Biliary Tract, and Gallbladder / Physical Chemistry of Bile / Hepatic Cholesterol Metabolism / Physical Chemistry and Hepatic Metabolism of Bile Acids / The Enterohepatic Circulation of Bile Acids / Hepatic Secretion of Biliary Lipids and Bile Formation / Summary / Acknowledgments / References / Author Biographies
The Hepatobiliary System
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Author : W. Taylor
language : en
Publisher:
Release Date : 2014-01-15
The Hepatobiliary System written by W. Taylor and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-01-15 with categories.
The Hepatobiliary System
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Author :
language : en
Publisher:
Release Date : 1976
The Hepatobiliary System written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1976 with categories.
Biliary Tract Radiology
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Author : Plinio Rossi
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Biliary Tract Radiology written by Plinio Rossi and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
This book, edited by Prof. PLINIO ROSSI, an internationally well-known expert in biliary tract radiology, provides in 31 chapters a very comprehensive update on both diagnostic and therapeutic radiology of the biliary tract. First, a very complete and interesting overview of the normal morphology of the ana tomical area is presented by an anatomist, a radiologist, and a surgeon. This is followed by a discussion not only of the well-known and accepted imaging modalities, but also of the newer ones such as, magnetic resonance imaging and endoluminal and laparoscopic ultra sound. The book thus illustrates very nicely the diversity of diagnostic radiological tech niques that are currently available. Considerable technical progress and remarkable new insights in biliary tract radiology have been achieved in the field of the radiological interventional approach during recent years. Therefore, much emphasis has been placed in this book on the therapeutic possibili ties of the radiologist using the percutaneous minimally invasive approach for the treat ment of the various pathological conditions of the biliary tract. It is most impressive to note the substantial progress in terms of patient comfort achieved by using the percutaneous as compared to the surgical methods. These new methods also result in shorter hospitalization times and thereby help to reduce health care costs. This book provides the interested reader with a fascinating and very complete over view of these new procedures.
Nuclear Hepatology
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Author : Gerbail T. Krishnamurthy
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-06-23
Nuclear Hepatology written by Gerbail T. Krishnamurthy and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-06-23 with Medical categories.
Since the publication of the first edition of Nuclear Hepatology almost 10 years ago, new advances have taken place, both in our understanding of liver pathophysiology and various imaging modalities. A unique feature of imaging of physiology is that it enables quanti- cation. Since liver physiology is complex, quantification has been a challenge. Many p- lications in the past have often included quantification based on home-made software not available for others. Thus, the comparison of results from one center to another becomes difficult, if not impossible. The second edition of Nuclear Hepatology addresses these issues. Sophisticated software for liver and gallbladder function has been tested and va- dated through many of our previous publications. Now that software is FDA approved and available for others through a commercial company, it is hoped that future publications of imaging of liver and gallbladder physiology would routinely include quantification. Although the function of the hepatocyte is complex, it can be broadly divided into two main categories, substrate uptake at the basolateral border and intracellular transit prior to excretion into the canaliculi. The earliest manifestation of hepatocellular injury occurs in the form of prolongation of the intracellular transit time, which occurs long before the disruption of the basolateral border with subsequent rupture and death. The liver enzymes are released into circulation after the death of the hepatocyte.
Bile Acids And The Hepatobiliary System
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Author : G. Paumgartner
language : en
Publisher: Springer
Release Date : 1993-06-30
Bile Acids And The Hepatobiliary System written by G. Paumgartner and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993-06-30 with Medical categories.
Bile acids have recently found application in the treatment of hepatobiliary diseases. Chenodeoxycholic acid and ursodeoxycholic acid have proved to be effective agents for the dissolution of cholesterol gallstones, and ursodeoxycholic acid has been shown to have beneficial effects in patients with chronic cholestatic liver disease such as primary biliary cirrhosis or primary sclerosing cholangitis. The question of the long-term benefit for the patient remains open and the mechanism of action is still unclear. As a consequence, much basic and clinical research is being conducted on bile acid therapy. The XIIth International Bile Acid Meeting brought together researchers and clinicians from around the world, and was dedicated to basic and clinical aspects of the use of bile acids in the therapy of hepatobiliary disease.
Diseases Of The Liver Gall Bladder And Biliary System
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Author : Sir Holburt Jacob Waring
language : en
Publisher:
Release Date : 1897
Diseases Of The Liver Gall Bladder And Biliary System written by Sir Holburt Jacob Waring and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1897 with Bile ducts categories.
Diseases Of The Biliary Tract An Issue Of Surgical Clinics
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Author : J. Bart Rose
language : en
Publisher: Elsevier Health Sciences
Release Date : 2019-03-11
Diseases Of The Biliary Tract An Issue Of Surgical Clinics written by J. Bart Rose and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-03-11 with Medical categories.
This issue of Surgical Clinics of North America focuses on Diseases of the Biliary Tract, and is edited by Dr. J Bart Rose. Articles will include: Anatomy, Embryology, and Imaging of the Biliary Tract; Cholangitis: Causes, Diagnosis, and Management; Autoimmune Diseases of the Biliary Tract; Biliary Dyskinesia; Gallstone Disease: Cholecystitis, Mirizzi’s Syndrome, Bouveret Syndrome, Gallstone Ileus; Technical Aspects of CholecystectomyTechnical Aspects of Bile Duct Evaluation and Exploration; Iatrogenic Biliary Injuries: Identification, Classification, and Management; Premalignant lesions: IPNB, Choledochal Cysts, and Biliary Cystadenomas; Gallbladder Cancer; Ampullary Cancer; Endoscopic Management of Biliary Disorders: Diagnostic and Therapeutic; Role of Transplant in Biliary Disease; Bile Metabolism and Lithogenesis; Cholangiocarcinoma: Intra and Extrahepatic; and more!