The Hpv Vaccine On Trial
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The Hpv Vaccine On Trial
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Author : Mary Holland
language : en
Publisher: Simon and Schuster
Release Date : 2018-09-25
The Hpv Vaccine On Trial written by Mary Holland and has been published by Simon and Schuster this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-09-25 with Medical categories.
A Groundbreaking Guide to the HPV Vaccine and the Science, Safety, and Business Behind It Cancer strikes fear in people’s hearts around globe. So the appearance of a vaccine to prevent cancer–as we are assured the human papillomavirus (HPV) vaccine will–seemed like a game-changer. Since 2006, over eighty countries have approved the vaccine, with glowing endorsements from the world’s foremost medical authorities. Bringing in over $2.5 billion in annual sales, the HPV vaccine is a pharmaceutical juggernaut. Yet scandal now engulfs it worldwide. The HPV Vaccine on Trial is a shocking tale, chronicling the global efforts to sell and compel this alleged miracle. The book opens with the vaccine’s invention, winds through its regulatory labyrinths, details the crushing denial and dismissal of reported harms and deaths, and uncovers the enormous profits pharma and inventors have reaped. Authors Holland, Mack Rosenberg, and Iorio drill down into the clinical trial data, government approvals, advertising, and personal accounts of egregious injuries that have followed in countries as far-flung as Japan, Australia, Colombia, India, Ireland, the U.K. and Denmark. The authors have written an unprecedented exposé about this vaunted vaccine. Written in plain language, the book is for everyone concerned – parents, patients, doctors, nurses, scientists, healthcare organizations, government officials, and schools. Ultimately, this book is not just about the HPV vaccine, but about how industry, government, and medical authorities may be putting the world’s children in harm’s way.
Primary End Points For Prophylactic Hpv Vaccine Trials
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Author : IARC HPV Working Group
language : en
Publisher:
Release Date : 2014
Primary End Points For Prophylactic Hpv Vaccine Trials written by IARC HPV Working Group and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with categories.
The potential of the current licensed preventive virus-like particle (VLP) human papillomavirus (HPV) vaccines to have a major public health impact is leading to additional clinical trials. The goals of such trials may include reducing the number of doses of a current vaccine, evaluating a vaccine similar to a licensed vaccine, increasing the valency of a licensed vaccine by including VLPs for additional HPV types, or evaluating alternative prophylactic vaccines that also use a viral capsid protein or polypeptide to induce neutralizing antibodies. The Working Group at the IARC/United States National Cancer Institute (NCI) Expert Meeting of September 2013 primarily reviewed the evidence as to whether it might be appropriate to use a virological end-point, rather than a disease end-point such as cervical intraepithelial neoplasia of grade 2 or worse (CIN2+), as the primary end-point for some future clinical efficacy trials, and the circumstances under which immunobridging trials might be sufficient for licensure. Virological end-points could accelerate vaccine evaluation and licensure. Several factors make virological end-points attractive when they represent valid surrogates for clinical premalignant disease end-points. They are more reproducible as end-points than disease end-points, they are the most definitive end-points when there is co-infection by more than one HPV type, and there are substantially more cases of infection by a given HPV type than cases of such disease. In the clinical trials that have been completed, efficacy against persistent infection has been found to be as stringent an outcome as CIN2+. Immunobridging trials have been used to extend the use of currently licensed vaccines to adolescents, an age group not evaluated in the efficacy trials. In these trials, the induction of non-inferior serum antibody titres after the same vaccine dosage schedule as in the efficacy trials has been used as the measure. Based on a review of the scientific evidence, for most situations, such as infection of the cervix or anus of young adults (e.g. individuals aged 16-26 years), the Working Group recommended that persistent HPV infection of 6 months or longer be used as an appropriate end-point when protection is being evaluated, with reduction in disease being verified by post-licensure monitoring. If vulvar/vaginal protection is to be evaluated in a trial, it is recommended to use HPV 16/18-positive high-grade vulvar intraepithelial neoplasia/vaginal intraepithelial neoplasia (VIN/VAIN) as a disease end-point, as there is relatively little experience in using persistent HPV infection as a surrogate end-point for vulvar and vaginal disease. A persistent infection end-point could be considered at these two sites if subsequent studies validated the ability to detect persistent infection at these sites. A persistent HPV 16/18 infection end-point is recommended for evaluating oral/oropharyngeal infection because an oral/oropharyngeal disease end-point comparable to those associated with anogenital infection is not feasible with current technology. After a vaccine has been shown to be effective in one population group (e.g. individuals aged 16-26 years), immunobridging is sufficient for extending licensure to other population groups (e.g. individuals aged
Canadian Immunization Guide
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Author : Canada. Comité consultatif national de l'immunisation
language : en
Publisher:
Release Date : 2006
Canadian Immunization Guide written by Canada. Comité consultatif national de l'immunisation and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with Immunization categories.
The seventh edition of the Canadian Immunization Guide was developed by the National Advisory Committee on Immunization (NACI), with the support ofthe Immunization and Respiratory Infections Division, Public Health Agency of Canada, to provide updated information and recommendations on the use of vaccines in Canada. The Public Health Agency of Canada conducted a survey in 2004, which confi rmed that the Canadian Immunization Guide is a very useful and reliable resource of information on immunization.
The Vaccine Friendly Plan
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Author : Paul Thomas, M.D.
language : en
Publisher: Ballantine Books
Release Date : 2016-08-23
The Vaccine Friendly Plan written by Paul Thomas, M.D. and has been published by Ballantine Books this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-08-23 with Medical categories.
An accessible and reassuring guide to childhood health and immunity from a pediatrician who’s both knowledgeable about the latest scientific research and respectful of a family’s risk factors, health history, and concerns In The Vaccine-Friendly Plan, Paul Thomas, M.D., presents his proven approach to building immunity: a new protocol that limits a child’s exposure to aluminum, mercury, and other neurotoxins while building overall good health. Based on the results from his pediatric practice of more than eleven thousand children, as well as data from other credible and scientifically minded medical doctors, Dr. Paul’s vaccine-friendly protocol gives readers • recommendations for a healthy pregnancy and childbirth • vital information about what to expect at every well child visit from birth through adolescence • a slower, evidence-based vaccine schedule that calls for only one aluminum-containing shot at a time • important questions to ask about your child’s first few weeks, first years, and beyond • advice about how to talk to health care providers when you have concerns • the risks associated with opting out of vaccinations • a practical approach to common illnesses throughout the school years • simple tips and tricks for healthy eating and toxin-free living at any age The Vaccine-Friendly Plan presents a new standard for pediatric care, giving parents peace of mind in raising happy, healthy children. Praise for The Vaccine-Friendly Plan “Finally, a book about vaccines that respects parents! If you choose only one book to read on the topic, read The Vaccine-Friendly Plan. This impeccably researched, well-balanced book puts you in the driver’s seat and empowers you to make conscientious vaccine decisions for your family.”—Peggy O’Mara, editor and publisher, Mothering Magazine “Sure to appeal to readers of all kinds as a friendly, no-nonsense book that cuts through the rhetoric surrounding vaccines. It offers validation to those who avoid some or all, while offering those who do want to vaccinate help on how to do so safely. This is a great book for anyone with children in their lives.”—Natural Mother “A valuable, science-supported guide to optimizing your child’s health while you navigate through complex choices in a toxic, challenging world.”—Martha Herbert, M.D., Ph.D., Harvard Medical School “An impressively researched guide, this important book is essential reading for parents. With clear and practical advice for shielding children from harmful toxins, it will compel us all to think differently about how to protect health.”—Jay Gordon, M.D., FAAP “Rather than a one-size-fits-all vaccine strategy, the authors suggest thoughtful, individualized decisions based on research and collaboration between parents and clinicians—a plan to optimize a child’s immune system and minimize any risks.”—Elizabeth Mumper, M.D., founder and CEO, The Rimland Center for Integrative Pediatrics “This well-written and thought-provoking book will encourage parents to think through decisions—such as food choices and the timing of vaccines—that affect the well-being of their children. In a world where children’s immune systems are increasingly challenged, this is a timely addition to the literature.”—Harriet Lerner, Ph.D., bestselling author of The Dance of Anger and The Mother Dance
The Vaccine Book
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Author : Barry R. Bloom
language : en
Publisher: Academic Press
Release Date : 2016-06-23
The Vaccine Book written by Barry R. Bloom and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-06-23 with Medical categories.
The Vaccine Book, Second Edition provides comprehensive information on the current and future state of vaccines. It reveals the scientific opportunities and potential impact of vaccines, including economic and ethical challenges, problems encountered when producing vaccines, how clinical vaccine trials are designed, and how to introduce vaccines into widespread use. Although vaccines are now available for many diseases, there are still challenges ahead for major diseases, such as AIDS, tuberculosis, and malaria. This book is designed for students, researchers, public health officials, and all others interested in increasing their understanding of vaccines. It answers common questions regarding the use of vaccines in the context of a rapidly expanding anti-vaccine environment. This new edition is completely updated and revised with new and unique topics, including new vaccines, problems of declining immunization rates, trust in vaccines, the vaccine hesitancy, and the social value of vaccines for the community vs. the individual child’s risk. Provides insights into diseases that could be prevented, along with the challenges facing research scientists in the world of vaccines Gives new ideas about future vaccines and concepts Introduces new vaccines and concepts Gives ideas about challenges facing public and private industrial investors in the vaccine area Discusses the problem of declining immunization rates and vaccine hesitancy
Vaccine Epidemic
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Author : Louise Kuo Habakus
language : en
Publisher: Simon and Schuster
Release Date : 2011-02-09
Vaccine Epidemic written by Louise Kuo Habakus and has been published by Simon and Schuster this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-02-09 with Science categories.
Public health officials state that vaccines are safe and effective, but the truth is far more complicated. Vaccination is a serious medical intervention that always carries the potential to injure and cause death as well as to prevent disease. Coercive vaccination policies deprive people of free and informed consent—the hallmark of ethical medicine. Americans are increasingly concerned about vaccine safety and the right to make individual, informed choices together with their healthcare practitioners. Vaccine Epidemic focuses on the searing debate surrounding individual and parental vaccination choice in the United States. Habakus, Holland, and Rosenberg edit and introduce a diverse array of interrelated topics concerning the explosive vaccine controversy, including the ethics of vaccination mandates, corrupting conflicts of interest in the national vaccine program, and personal narratives of parents, children, and soldiers who have suffered vaccine injury. Newly updated with additional chapters focusing on institutional scientific misconduct, mandates for healthcare workers, concerns about HPV vaccine development, and the story behind the Supreme Court’s recent vaccine decision, Vaccine Epidemic remains the essential handbook for the vaccination choice movement and required reading for all people contemplating vaccination for themselves and their children.
Vaccines For The Prevention Of Cervical Cancer
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Author : Peter L. Stern
language : en
Publisher: Oxford University Press, USA
Release Date : 2008
Vaccines For The Prevention Of Cervical Cancer written by Peter L. Stern and has been published by Oxford University Press, USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with Medical categories.
Cervical cancer is the second most common form of cancer found in women, and it is responsible for more than a quarter of a million deaths worldwide each year. With approximately 70% of cervical cancers now known to be caused by two types of the human pailloma virus (HPV), there is great interest surrounding the approval of the first preventative vaccines for clinical use. Despite this excitement, many questions remain about how the new vaccines should best be implemented and how cervical cnancer screening will change following vaccination. Part of the Oxford Oncology Library series, this practical handbook provides an overview of the role of HPV in the pathology of cervical cancer and its current screening and management, the principles of immune control of HPV infection in cervical cancer, and the challenges of implementing HPV vaccines and future developments.
Gynaecological Cancers In Australia
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Author :
language : en
Publisher: AIHW
Release Date : 2012
Gynaecological Cancers In Australia written by and has been published by AIHW this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Cancer in women categories.
Correlates Of Hpv Vaccination And Association With Hpv 16 And Hpv 18 Dna Detection In Young Women
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Author : Molly A. Feder
language : en
Publisher:
Release Date : 2017
Correlates Of Hpv Vaccination And Association With Hpv 16 And Hpv 18 Dna Detection In Young Women written by Molly A. Feder and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with categories.
Background: Human Papillomavirus (HPV) infection, primarily with high-risk (HR) types 16 and 18, is responsible for causing 17,600 cancers in women and 9,300 cancers in men in the US each year. However, the availability of the HPV vaccination series has substantially reduced the prevalence of vaccine-type HPV. Methods: We employed a cross-sectional study design to assess factors associated with HPV vaccine uptake, the effectiveness of HPV vaccination outside of a vaccine efficacy trial, and patterns of HPV vaccination in 21-29 year old women who were eligible to receive catch-up vaccination. Data came from the HOPE (Home HPV or Pap Exam) study, a randomized controlled trial based at the University of Washington, and included self-reported demographic and HPV vaccination information and researcher-reported typing for 14 high-risk HPV types. We used multivariable logistic regression to obtain crude and adjusted prevalence odds ratios and 95% confidence intervals for our associations of interest. Results: Of 375 subjects, 228 (60.8%) reported receipt of at least one dose of HPV vaccine at study entry, and 16 subjects (4.3%) were infected with HPV 16 and/or 18. Individuals with higher levels of education were more than four times as likely to be vaccinated than those reporting high school education or less. Among vaccinated study participants, 56.5% received their first dose of the HPV vaccination after age 18 and 68.4% after first vaginal intercourse. Unvaccinated women were somewhat more likely to have detectable HPV 16 and/or 18 (OR=2.05, 95% CI: 0.75 - 5.64). Women aged 19-26 at first HPV vaccination dose were more likely to have HPV types 16 and/or 18 compared to women who were vaccinated earlier (OR=3.2, 95% CI: 0.35 - 29.2). Similarly, women who received their first vaccination dose after first vaginal intercourse were more likely to be HPV infected (OR=1.89, 95% CI: 0.22 - 16.2). Conclusion: Our study suggests that increased education, perhaps through targeted campaigns in less educated populations, may reduce disparities in HPV vaccination uptake and that the HPV vaccine is effective at preventing HR-HPV types 16 and 18 among women from 20 to 29 years old outside of vaccine efficacy trials. Generalizable research on patterns of HPV vaccination and vaccine efficacy among larger sample sizes of women in their twenties is needed.
Design And Analysis Of Vaccine Studies
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Author : M. Elizabeth Halloran
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-10-27
Design And Analysis Of Vaccine Studies written by M. Elizabeth Halloran and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-10-27 with Medical categories.
As well as being a reference for the design, analysis, and interpretation of vaccine studies, the text covers all design and analysis stages, from vaccine development to post-licensure surveillance, presenting likelihood, frequentists, and Bayesian approaches.