The Pathomechanics Of Tissue Injury And Disease And The Mechanophysiology Of Healing
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The Pathomechanics Of Tissue Injury And Disease And The Mechanophysiology Of Healing
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Author : Amit Gefen
language : en
Publisher:
Release Date : 2009-01-01
The Pathomechanics Of Tissue Injury And Disease And The Mechanophysiology Of Healing written by Amit Gefen and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-01-01 with Bones categories.
Over the last decade, it became clear that mechanical factors, such as deformations, forces and stiffness properties have critical influence on a wide spectrum of diseases. Traditionally, since the 1960's, mechanics has been associated mainly with orthopaedics, trauma and rehabilitation as well as with cardiovascular problems, and so, the work of biomechanists was mostly related to these areas. This led, for example, to good understanding of the loading conditions at which bone fractures occur, and how bone fractures can be healed more quickly if their mechanical environment is adequately controlled (e.g. via compression plate-screw systems). However, more recently, on the 1980's-1990's, it was discovered that mechanics has much more fundamental roles and effects on biological processes, as many cell types appeared to be responsive to mechanical stimuli. This boosted biomechanical research on the effects of mechanical factors at the microscopic scale of tissues, and the fields of mechanobiology and mechanotransduction emerged. Most recently, on the 2000's, there were studies, e.g. by Dr. Valerie Weaver and colleagues (as described in this book), reporting that at the cell scale, inadequate mechanical stimuli may even provoke cancer. Hence, the role of integration between mechanics, life sciences and medicine is growing rapidly, and becomes more important by the day. What allows this integration to expand so fast is the development of sophisticated bioengineering research and analysis tools. These include highly realistic computer simulations, small animal MRI, micro-sensors, bio-reactors and many other recent breakthroughs that allow precision measurements of the mechanical conditions that apply in tissues at different levels of architectural hierarchy, whereas at the same time, close monitoring of the biological responses to these mechanical conditions became possible. This exciting atmosphere is at the background of the present book, which contains perspectives from leading scientists worldwide on the role of mechanics in injury, disease and healing. The topics covered span from bone tumors to pressure ulcers and from osteoarthritis to breast cancer, which illustrates how mechanics is now identified as the common denominator in so many important chronic conditions, as opposed to just trauma. In view of the multi-disciplinary and diverse nature of this book, I expect it to be appealing to a broad readership, obviously including biomechanists but also medical doctors, physiologists, cell biologists, physiotherapists, nurses and all those who are interested in reading on the latest developments in our journey towards understanding the complex connections between mechanics and biology.
Journal Of Rehabilitation Research Development
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Author :
language : en
Publisher:
Release Date : 2010
Journal Of Rehabilitation Research Development written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Disabled veterans categories.
Journal Of Rehabilitation Research And Development
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Author :
language : en
Publisher:
Release Date : 2010
Journal Of Rehabilitation Research And Development written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Disabled veterans categories.
Neural Tissue Biomechanics
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Author : Lynne E. Bilston
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-07-23
Neural Tissue Biomechanics written by Lynne E. Bilston and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-07-23 with Technology & Engineering categories.
Damage to the central nervous system resulting from pathological mechanical loading can occur as a result of trauma or disease. Such injuries lead to significant disability and mortality. The peripheral nervous system, while also subject to injury from trauma and disease, also transduces physiological loading to give rise to sensation, and mechanotransduction is also thought to play a role in neural development and growth. This book gives a complete and quantitative description of the fundamental mechanical properties of neural tissues, and their responses to both physiological and pathological loading. This book reviews the methods used to characterize the nonlinear viscoelastic properties of central and peripheral neural tissues, and the mathematical and sophisticated computational models used to describe this behaviour. Mechanisms and models of neural injury from both trauma and disease are reviewed from the molecular to macroscopic scale. The book provides a comprehensive picture of the mechanical and biological response of neural tissues to the full spectrum of mechanical loading to which they are exposed. This book provides a comprehensive reference for professionals involved in pre prevention of injury to the nervous system, whether this arises from trauma or disease.
Military Injury Biomechanics
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Author : Melanie Franklyn
language : en
Publisher: CRC Press
Release Date : 2017-06-12
Military Injury Biomechanics written by Melanie Franklyn and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-06-12 with Medical categories.
Military Injury Biomechanics: The Cause and Prevention of Impact Injuries is a reference manual where information and data from a large number of sources, focussing on injuries related to military events, has been critically reviewed and discussed. The book covers the cause and prevention of impact injuries to all the major body regions, while topics such as the historical background of military impact biomechanics, the history and use of anthropomorphic test devices for military applications and the medical management of injuries are also discussed. An international team of experts have been brought together to examine and review the topics. The book is intended for researchers, postgraduate students and others working or studying defence and impact injuries.
Bioengineering Research Of Chronic Wounds
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Author : Amit Gefen
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-11-18
Bioengineering Research Of Chronic Wounds written by Amit Gefen and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-11-18 with Technology & Engineering categories.
Pressure-related chronic wounds are an important health concern that affects millions of patients and accumulates billions in annual costs. These wounds may occur when soft tissues are mechanically compressed between bony prominences and a supporting surface. This book gives a complete and quantitative explanation of the mechanobiology which causes chronic wounds. The reviews give an overall picture on all length scales of the phenomenon, starting from musculoskeletal biomechanics to the modeling of soft tissues and their interaction with bones. At the microscopic levels, it thoroughly reviews experiments and modeling of cellular forces and molecular processes that occur during injury and healing, including the integrity of living cells subjected to sustained mechanical forces and deformations. The results allow a complete picture of the tolerance of human tissues to sustained loads, and an understanding of the risk for onset of chronic wounds. Hence, this book is also valuable for all professionals involved in the prevention and treatment of chronic wounds.
The Mechanobiology And Mechanophysiology Of Military Related Injuries
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Author : Amit Gefen
language : en
Publisher: Springer
Release Date : 2016-03-31
The Mechanobiology And Mechanophysiology Of Military Related Injuries written by Amit Gefen and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-03-31 with Technology & Engineering categories.
This book provides a state-of-the-art update, as well as perspectives on future directions of research and clinical applications in the implementation of biomechanical and biophysical experimental, theoretical and computational models which are relevant to military medicine. Such experimental and modeling efforts are helpful, on the one hand, in understanding the aetiology, pathophysiology and dynamics of injury development and on the other hand in guiding the development of better equipment and protective gear or devices that should ultimately reduce the prevalence and incidence of injuries or lessen their hazardous effects. The book is useful for military-oriented biomedical engineers and medical physicists, as well as for military physiologists and other medical specialists who are interested in the science and technology implemented in modern investigations of military related injuries.
Biological Mechanisms Of Tooth Movement
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Author : Vinod Krishnan
language : en
Publisher: John Wiley & Sons
Release Date : 2021-05-24
Biological Mechanisms Of Tooth Movement written by Vinod Krishnan and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-05-24 with Medical categories.
Biological Mechanisms of Tooth Movement This new edition continues to be an authoritative reference to the scientific foundations underpinning clinical orthodontics The newly and thoroughly revised Third Edition of Biological Mechanisms of Tooth Movement delivers a comprehensive reference for orthodontic trainees and specialists. It is fully updated to include new chapters on personalized orthodontics as well as the inflammatory process occurring in the dental and paradental tissues. It is heavily illustrated throughout, making it easier for readers to understand and retain the information discussed within. The topics covered range from bone biology, the effects of mechanical loading on tissues and cells, genetics, tissue remodeling, and the effects of diet, drugs, and systemic diseases. The Third Edition of Biological Mechanisms of Tooth Movement features seven sections that cover subjects such as: The development of biological concepts in orthodontics, including the cellular and molecular biology behind orthodontic tooth movement Mechanics meets biology, including the effects of mechanical loading on hard and soft tissues and cells, and biological reactions to temporary anchorage devices Inflammation and orthodontics, including markers for tissue remodeling in the gingival crevicular fluid and saliva Personalized diagnosis and treatment based on genomic criteria, including the genetic influences on orthodontic tooth movement Rapid orthodontics, including methods to accelerate or decelerate orthodontic tooth movement Perfect for residents and PhD students of orthodontic and periodontal programs, Biological Mechanisms of Tooth Movement is also useful to academics, clinicians, bone biologists, and researchers with an interest in the mechanics and biology of tooth movement.
Patient Specific Modeling In Tomorrow S Medicine
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Author : Amit Gefen
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-01-05
Patient Specific Modeling In Tomorrow S Medicine written by Amit Gefen and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-01-05 with Technology & Engineering categories.
This book reviews the frontier of research and clinical applications of Patient Specific Modeling, and provides a state-of-the-art update as well as perspectives on future directions in this exciting field. The book is useful for medical physicists, biomedical engineers and other engineers who are interested in the science and technology aspects of Patient Specific Modeling, as well as for radiologists and other medical specialists who wish to be updated about the state of implementation.
Reducing The Burden Of Injury
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Author : Committee on Injury Prevention and Control
language : en
Publisher: National Academies Press
Release Date : 1999-01-04
Reducing The Burden Of Injury written by Committee on Injury Prevention and Control and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-01-04 with Medical categories.
Injuries are the leading cause of death and disability among people under age 35 in the United States. Despite great strides in injury prevention over the decades, injuries result in 150,000 deaths, 2.6 million hospitalizations, and 36 million visits to the emergency room each year. Reducing the Burden of Injury describes the cost and magnitude of the injury problem in America and looks critically at the current response by the public and private sectors, including: Data and surveillance needs. Research priorities. Trauma care systems development. Infrastructure support, including training for injury professionals. Firearm safety. Coordination among federal agencies. The authors define the field of injury and establish boundaries for the field regarding intentional injuries. This book highlights the crosscutting nature of the injury field, identifies opportunities to leverage resources and expertise of the numerous parties involved, and discusses issues regarding leadership at the federal level.