The Pharmacogenetics Of Breast Cancer Treatment

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Pharmacogenetics Of Breast Cancer

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Author : Brian Leyland-Jones
language : en
Publisher: CRC Press
Release Date : 2020-04-27

Pharmacogenetics Of Breast Cancer written by Brian Leyland-Jones and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-04-27 with Medical categories.

Pharmacogenetics is becoming increasingly relevant in the diagnosis, treatment, and recovery of cancer patients. A major problem facing oncologists is the outstanding varied efficacy of treatment. Promising advances in pharmacogenetics have allowed the development of effective agents which will enable personalized cancer chemotherapy to become rout

The Pharmacogenetics Of Breast Cancer Treatment

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Author : J. E. Abraham
language : en
Publisher:
Release Date : 2011

The Pharmacogenetics Of Breast Cancer Treatment written by J. E. Abraham and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with categories.

Pharmacogenetics Making Cancer Treatment Safer And More Effective

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Author : William G. Newman
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-07-20

Pharmacogenetics Making Cancer Treatment Safer And More Effective written by William G. Newman and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-07-20 with Medical categories.

Chemotherapy has made a dramatic difference to improved survival in patients with cancer. However, not all patients respond and some experience serious side effects. "Pharmacogenetics: Making cancer treatment safer and more effective" is an up to date summary of the exciting new field of how genetic testing can tailor more effective prescription in oncology. It is targeted at oncologists and professionals involved in the treatment of patients with cancer. It provides a core background in genetics and pharmacological principles before providing chapters from acknowledged experts in the field on genetic tests in specific cancer types, including breast, bowel and lung cancer. Clinical cases are used to illustrate the practical application of this knowledge. Chapters on ethics, health economics and the industry aspects of pharmacogenetics set out the challenges and opportunities afforded by this new science.

Pharmacogenetics Of Cytochromes In Breast Cancer Treatment

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Author : Paola Biason
language : en
Publisher:
Release Date : 2008

Pharmacogenetics Of Cytochromes In Breast Cancer Treatment written by Paola Biason and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with categories.

Genomics And Pharmacogenomics In Anticancer Drug Development And Clinical Response

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Author : Federico Innocenti
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-10-30

Genomics And Pharmacogenomics In Anticancer Drug Development And Clinical Response written by Federico Innocenti and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-10-30 with Medical categories.

Genomics and Pharmacogenomics in Anticancer Drug Development and Clinical Response provides the most comprehensive body of knowledge available on the role of genetic and genomic variation in the individualization of drug therapies in cancer patients. As a consequence of the intrinsic chromosomal and genetic instability of the tumor genome, it is generally believed that tailoring of chemotherapy in cancer - tients might be achieved by molecular analysis of patient tumor DNA. In addition, to reduce the toxicity risk of patients, the tumor DNA information should be in- grated with the available data on polymorphic drug-metabolizing enzyme and tra- porter genes mediating the exposure of patients to active drugs and/or their active metabolites. The chapters of this book clearly show how DNA information from both the host (germline) and the tumor should be taken into account for rational selection of drug therapies in cancer patients, an aspect that received little attention, despite its importance. The availability of new molecular approaches to the selection of drug therapy is an emerging need, because the traditional approach based on the evaluation of patient and tumor characteristics is clearly far from optimal. Many treated patients do not experience signi?cant bene?ts from the treatment, while they often experience moderate to severe toxicities. In addition, the development and clinical use of novel molecularly targeted agents (alone or in combination with classical cytotoxic therapy) requires the und- standing of the molecular features of the tumors and the identi?cation of tumor markers of response.

Role Of Sulfation Pharmacogenetics In Breast Cancer Treatment With 2 Methoxyestradiol

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Author : Araba A. Adjei
language : en
Publisher:
Release Date : 2001

Role Of Sulfation Pharmacogenetics In Breast Cancer Treatment With 2 Methoxyestradiol written by Araba A. Adjei and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001 with categories.

2-ME2 is an endogenous estrogen metabolite that inhibits the proliferation of breast and other human cancer cell lines. 2-ME2 also has potent anti-angiogenic and anti-tubulin properties, and it may inhibit estrogen- induced carcinogenesis in the mammary gland. We set out to test the hypothesis that 2-ME2 might be a substrate for sulfate conjugation and, therefore, that individual variations in the sulfation of 2-ME2 might contribute to individual differences in its metabolism, pharmacokinetics and therapeutic efficacy. As a first step, we tested 2-ME2 as a substrate for 7 human sulfotransferase (SULT) isoforms -- as well as all of the common allozymes for SULT 1 Al and 1A2.

Pharmacogenetics And Individualized Therapy

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Author : Anke-Hilse Maitland-van der Zee
language : en
Publisher: John Wiley & Sons
Release Date : 2012-04-02

Pharmacogenetics And Individualized Therapy written by Anke-Hilse Maitland-van der Zee and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-04-02 with Medical categories.

This resource provides thorough coverage of pharmacogenetics and its impact on pharmaceuticals, therapeutics, and clinical practice. It opens with the basics of pharmacogenetics, including drug disposition and pharmacodynamics. The following section moves into specific disease areas, including cardiovascular, psychiatry, cancer, asthma/COPD, adverse drug reactions, transplantation, inflammatory bowel disease, and pain medication. Clinical practice and ethical issues make up the third section, with the fourth devoted to technologies like genotyping, genomics, and proteomics. In the fifth part, chapters discuss the impact of key regulatory issues on the pharmaceutical industry.

Molecular Targeted Therapy In Oncology Lessons From Pharmacogenetics And Pharmacoepigenetics

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Author : Saber Imani
language : en
Publisher: Frontiers Media SA
Release Date : 2022-04-06

Molecular Targeted Therapy In Oncology Lessons From Pharmacogenetics And Pharmacoepigenetics written by Saber Imani and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-04-06 with Science categories.

Pharmacogenetics And Pharmacogenomics In Latin America Ethnic Variability New Insights In Advances And Perspectives A Relivaf Cyted Initiative

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Author : Luis Abel Quiñones
language : en
Publisher: Frontiers Media SA
Release Date : 2022-02-17

Pharmacogenetics And Pharmacogenomics In Latin America Ethnic Variability New Insights In Advances And Perspectives A Relivaf Cyted Initiative written by Luis Abel Quiñones and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-02-17 with Science categories.

Innovative Endocrinology Of Cancer

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Author : Lev M. Berstein
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-12-04

Innovative Endocrinology Of Cancer written by Lev M. Berstein and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-12-04 with Medical categories.

This volume is devoted to new developments in a huge range of topics, such as the mechanisms of hormonal carcinogenesis, epidemiology and risk factors, hormone production by tumor tissue and antihormonal therapy of cancer and its prevention.