The Role Of Microrna 340 In The Development And Progression Of Melanoma
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The Role Of Microrna 340 In The Development And Progression Of Melanoma
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Author : Ashley M. Poenitzsch Strong
language : en
Publisher:
Release Date : 2015
The Role Of Microrna 340 In The Development And Progression Of Melanoma written by Ashley M. Poenitzsch Strong and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with categories.
Melanoma is responsible for only 4% of skin cancer diagnoses, however 80% of skin cancer deaths are attributed to melanoma annually [1]. microRNA (miRNA)-dependent regulation of gene expression is increasingly linked to development and progression of melanoma. However, the mechanisms underlying the regulation of a gene network by individual miRNAs remain uncharacterized. Elucidating the roles gene regulatory networks play in cellular biology is critical for understanding diseases and developing treatment options. Understanding how miRNAs function remains to be fully determined. To this end, a pathway-specific miRNA function model is explored to further conceptualize miRNA regulatory networks. In this regulatory paradigm, the focus is centered around the simultaneous miRNA-dependent regulation of multiple components from numerous pathways, highlighting the complex effects miRNAs impart on cellular biology and function. A key hypothesis for this project was miR-340 functions as a tumor suppressor in melanoma by inhibiting key oncogenic pathways through its pleiotropic effects on multiple components of these networks. The results discussed here demonstrate miR-340 inhibits the tumorigenic phenotype in melanoma cells. Data presented also establish miR-340 regulates RAS-RAF-Mitogen Activated Protein Kinase (MAPK) signaling by modulating the expression of multiple components of this pathway, highlighting a pathway-specific miRNA regulatory role. microRNA IFAST (miFAST, pronounced “my-fast”), a novel efficient method for the characterization of miRNA direct target networks is presented. Data from miFAST experiments demonstrate several mRNAs, most from the RAS-RAF-MAPK pathway, are directly targeted by miR-340. Given the importance of MAPK signaling in melanoma, these results provide further insight into the pathogenesis of this cancer. Overall, the data discussed here characterized and established a novel gene regulatory paradigm for miR-340 in melanoma, e.g. a pathway-specific miRNA targetome.
Research On Melanoma
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Author : Mandi Murph
language : en
Publisher: BoD – Books on Demand
Release Date : 2011-09-12
Research On Melanoma written by Mandi Murph and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-09-12 with Medical categories.
The book Research on Melanoma: A Glimpse into Current Directions and Future Trends, is divided into sections to represent the most cutting-edge topics in melanoma from around the world. The emerging epigenetics of disease, novel therapeutics under development and the molecular signaling aberrations are explained in detail. Since there are a number of areas in which unknowns exist surrounding the complex development of melanoma and its response to therapy, this book illuminates and comprehensively discusses such aspects. It is relevant for teaching the novice researcher who wants to initiate projects in melanoma and the more senior researcher seeking to polish their existing knowledge in this area. Many chapters include visuals and illustrations designed to easily guide the reader through the ideas presented.
Melanoma Development
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Author : Anja K. Bosserhoff
language : en
Publisher: Springer
Release Date : 2017-01-20
Melanoma Development written by Anja K. Bosserhoff and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-01-20 with Medical categories.
This book focuses on malignant melanoma, discussing the current state of scientific knowledge and providing insights into the underlying basic mechanisms, the molecular changes, genetics and genomics. Human Melanoma is a dangerous type of skin cancer affecting an increasing population, and a better understanding of its development will help in finding sophisticated targeted therapies. The second revised edition features the latest research findings and offers updates on the latest advances and potential novel melanoma therapies. It is a valuable resource for researchers and clinicians working in the fields of melanoma, cancer research and therapy as well as dermatology.
Micrornas In Cancer
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Author : Cesar Lopez-Camarillo
language : en
Publisher: CRC Press
Release Date : 2013-02-22
Micrornas In Cancer written by Cesar Lopez-Camarillo and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-02-22 with Medical categories.
MicroRNA (miRNA) biology is a cutting-edge topic in basic as well as biomedical research. This is a specialized book focusing on the current understanding of the role of miRNAs in the development, progression, invasion, and metastasis of diverse types of cancer. It also reviews their potential for applications in cancer diagnosis, prognosis, and th
Exosomes Stem Cells And Microrna
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Author : Karl L. Mettinger
language : en
Publisher: Springer
Release Date : 2018-05-12
Exosomes Stem Cells And Microrna written by Karl L. Mettinger and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-05-12 with Science categories.
This volume provides insight into the pivotal roles of stem cells, exosomes and other microvesicles in biofunction and molecular mechanisms and their therapeutic potential in translational nanomedicine. It further highlights evidence from recent studies as to how stem cell derived exosomes and microRNAs may restore and maintain tissue homeostasis, enable cells to recover critical cellular functions and begin repair regeneration. These early studies in animal models of aging also show evidence of improved immune, cardiovascular and cognitive functions as well as improved health span and life span. The use of exosomes from body fluids to define specific biomarkers for various tumors may also clear the path to patient-targeted treatments by developing exosome-derived microRNA based cancer therapeutics. It is essential reading for graduate students, research fellow and biomedical researchers in academia or the pharmaceutical or biotech industries.
Microrna In Cancer
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Author : Suresh Alahari
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-08-01
Microrna In Cancer written by Suresh Alahari and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-08-01 with Medical categories.
The field of microRNA biology is really emerging in the last couple of years. Several investigators highlighted the importance of miRNAs in cancer. Although there is so much literature on microRNAs exist, a comprehensive book is still not available. Thus this book will be a great use to the scientists in the field of cancer biology. In addition, this book will be a good source of information for undergraduate, graduate students who want to develop their research careers in cancer biology.
Melanoma Development
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Author : Anja Bosserhoff
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-06-24
Melanoma Development written by Anja Bosserhoff and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-06-24 with Medical categories.
The book provides comprehensive insights into molecular changes in malignant melanoma. The general mechanisms of melanoma growth and development are described, as well as new research findings. Our current knowledge on the molecules involved in cell transformation and tumor progression will soon lead to sophisticated, targeted therapies. Recent studies with targeted b-RAF inhibitors have given us grounds to hope that these therapies will be successful. Melanoma Development- Molecular Biology, Genetics and Clinical Application aims to contribute to this knowledge. Summarizing the newest data and presenting upcoming research areas in the field, the book will be of great interest to basic researchers and physicians working in the important fields of melanoma, cancer research, therapy and dermatology.
Rna Nanotechnology
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Author : Bin Wang
language : en
Publisher: CRC Press
Release Date : 2014-04-02
Rna Nanotechnology written by Bin Wang and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-04-02 with Medical categories.
In the past few decades there has been incredible growth in "bionano"-related research, which has been accompanied by numerous publications in this field. Although various compilations address topics related to deoxyribonucleic acid (DNA) and protein, there are few books that focus on determining the structure of ribonucleic acid (RNA) and using RNA as building blocks to construct nanoarchitectures for biomedical and healthcare applications. RNA Nanotechnology is a comprehensive volume that details both the traditional approaches and the latest developments in the field of RNA-related technology. This book targets a wide audience: a broad introduction provides a solid academic background for students, researchers, and scientists who are unfamiliar with the subject, while the in-depth descriptions and discussions are useful for advanced professionals. The book opens with reviews on the basic aspects of RNA biology, computational approaches for predicting RNA structures, and traditional and emerging experimental approaches for probing RNA structures. This section is followed by explorations of the latest research and discoveries in RNA nanotechnology, including the design and construction of RNA-based nanostructures. The final segment of the book includes descriptions and discussions of the potential biological and therapeutic applications of small RNA molecules, such as small/short interfering RNAs (siRNAs), microRNAs (miRNAs), RNA aptamers, and ribozymes.
Microrna As Biomarkers In Cancer Diagnostics And Therapy
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Author : Lorenzo F. Sempere
language : en
Publisher: MDPI
Release Date : 2019-07-30
Microrna As Biomarkers In Cancer Diagnostics And Therapy written by Lorenzo F. Sempere and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-07-30 with Science categories.
This book is a printed edition of the Special Issue MicroRNA as Biomarkers in Cancer Diagnostics and Therapy that was published in IJMS
Regulation Of Micrornas
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Author : Helge Großhans
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-12-10
Regulation Of Micrornas written by Helge Großhans and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-12-10 with Science categories.
Given this pervasiveness and importance of miRNA-mediated gene regulation, it should come as little surprise that miRNAs themselves are also highly regulated. However, the recent explosion of knowledge on this topic has been remarkable, providing a primary motivation for publication of this book. As miRNAs are transcribed by RNA polymerase II, the enzyme that also generates mRNAs, it was perhaps not unexpected that miRNA transcription would be subject to regulation, and we have willfully mitted this aspect from this monograph. However, what has been unexpected is the extent of post-transcriptional regulation of miRNAs that is illustrated in this book.