The Role Of Nitric Oxide In The Central Nervous System
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The Role Of Nitric Oxide In The Central Nervous System
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Author :
language : en
Publisher:
Release Date : 1996
The Role Of Nitric Oxide In The Central Nervous System written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with categories.
Role Of Nitric Oxide Synthase In The Function Of The Central Nervous System Under Normal And Infectious Conditions
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Author : Patricia Alves Reis
language : en
Publisher:
Release Date : 2017
Role Of Nitric Oxide Synthase In The Function Of The Central Nervous System Under Normal And Infectious Conditions written by Patricia Alves Reis and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with Science categories.
Nitric oxide (NO) was discovered as an endothelium-derived relaxing factor more than two decades ago. Since then, it has been shown to participate in many pathways. NO has been described as a key mediator of different pathways in the central nervous system (CNS) in both healthy and diseased processes. The three isoforms of nitric oxide synthase differ in their activity patterns and expression in different cells. Neuronal nitric oxide synthase (nNOS) is localized in synaptic spines, astrocytes, and the loose connective tissue surrounding blood vessels in the brain; eNOS is present in both cerebral vascular endothelial cells and motor neurons; and iNOS is induced in astrocytes and microglia under pathological conditions. During physiological processes, NO produced by eNOS/nNOS, respectively, controls blood flow activation, and act as a messenger during long-term potentiation (LTP). However, under pathological conditions, eNOS appears to be impaired, leading to a reduction in blood flow and, consequently, low oxygen/metabolites delivery, efflux of toxicological agents from the brain tissue and disturbance in the blood-brain barrier. The NO produced by iNOS in glial cells and nNOS, which triggers the NMDA-excitotoxic pathway, combines with superoxide anion and results in peroxynitrite synthesis, a potent free radical that contributes to tissue damage in the brain. Here, we intend to show the controversial role of the nitric oxide delivered by the three isoforms of the nitric oxide synthase in the CNS, assess its impact under healthy/pathological conditions and speculate on its possible sequela, particularly in long-term cognitive decline.
Nitric Oxide In The Nervous System
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Author :
language : en
Publisher: Elsevier
Release Date : 1995-04-07
Nitric Oxide In The Nervous System written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995-04-07 with Medical categories.
The gas nitric oxide (NO) has burst upon neuroscience only recently, and yet it has permeated into almost every avenue of current research. The unique properties of this novel messenger have revolutionized our way ofthinking about neurotransmission. These special properties have also lead neuroscientists to invoke NO to explain many previously unexplained phenomena in neurobiology. Fortunately, the development of numerous pharmacological agents is now allowing thesehypotheses to be tested.This volume will provide a synopsis of what is now known about NO. How and where NO is produced, how it acts at the molecular level to activate the synthesis of cGMP, and the possible targets of cGMP in the nervous system are reviewed. The roles of theNO/cGMP signal transduction pathway in the central and peripheral nervous systems, in glial cells, and in neuropathology are then explored. Together, these reviews will lead to further work explaining the varied functions of NO. Key Features* Describes how and why NO is produced in the nervous system* Examines all that is known of NOs role as a neurotransmitter* Explores cellular actions and physiological roles in the brain and peripheral nervous systemCovers NOs molecular synthesis to its role in neuropathology
The Role Of Nitric Oxide In The Central Nervous System
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Author : Hiroshi Kimura
language : en
Publisher:
Release Date : 1996
The Role Of Nitric Oxide In The Central Nervous System written by Hiroshi Kimura and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with categories.
The Role Of Nitric Oxide In Physiology And Pathophysiology
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Author : Hilary Koprowski
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
The Role Of Nitric Oxide In Physiology And Pathophysiology written by Hilary Koprowski and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
Nitric Oxide (NO) an endogenous free radical, has been shown recently to mediate several important biological effects. It plays a neuro-transmitter like role in vascular endothelium, a scond-messenger role in N-methyl-D-aspartate (NMDA) responsive neurons in the central nervous system (CNS), a neurotoxic role after its release from these neurons, and a cytotoxic role after its release by macrophages. This volume reviews among other topics the basic chemistry and physical properties of S-nitrosothiols (RS-NO) and their biochemical mechanisms of action, NO synthase isozymes, NO synthase structure, mechanisms of NO synthesis, regulation of NOS expression and posttranslational modification, and mechanisms involving NO of CNS's damage in virus infections.
Nitric Oxide In Health And Disease
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Author : Jill Lincoln
language : en
Publisher: Cambridge University Press
Release Date : 1997-08-28
Nitric Oxide In Health And Disease written by Jill Lincoln and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-08-28 with Medical categories.
Nitric oxide has a tantalizing role in health and disease: while many of its wide-ranging effects are well known, there remains much more to explore and to learn about the interactions of this fascinating molecule in physiological and pathophysiological processes. The volume reviews the myriad effects of nitric oxide as a chemical messenger in the central nervous system, peripheral nervous system, immune system and cardiovascular system. Furthermore, it provides a very practical introduction to the procedures and experimental protocols necessary to work with and study nitric oxide and its synthesizing enzyme, nitric oxide synthase, in the laboratory. In this respect the volume is unique, providing as it does a complete single-volume review of the role of nitric oxide in health and disease, and a very practical introduction to the methods and protocols involved in this intriguing and active area of biomedical research.
The Role Of Nitric Oxide In Neurotransmitter Release From The Rat Central Nervous System
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Author : Tracy Lorraine Stewart
language : en
Publisher:
Release Date : 1996
The Role Of Nitric Oxide In Neurotransmitter Release From The Rat Central Nervous System written by Tracy Lorraine Stewart and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with categories.
Nitric Oxide Synthase Characterization And Functional Analysis
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Author :
language : en
Publisher: Academic Press
Release Date : 1996-09-18
Nitric Oxide Synthase Characterization And Functional Analysis written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-09-18 with Science categories.
Although the function of nitric oxide in a regulatory capacity in the central and peripheral nervous system is widely recognized, the full scope of its actions and its interrelationships with other classes of regulatory molecules is just beginning to be comprehended. This volume contains a number of sophisticated and advanced methods essential for exploring the activity of nitric oxide in the brain. It will be a valuable tool for the established investigator and for those just entering the field. Comprehensive protocols included for detection of NO and related compounds by chemical, immunohistochemical, and in situ hybridization techniques Newly developed methods for the purification of neuronal and endothelial NO synthase, production of monoclonal antibodies to NO synthase, molecular cloning and expression of NO synthesis, and control of NO synthase gene expression Assessment of NO-mediated functions in neurons, central nervous system, cerebral circulation, synaptic transmission, and vascular tone Calcium imaging by confocal microscopy, evaluation of the effect of NO on iron metabolism, and detection of heme oxygenase-1 and -2 message level and distribution
Nitric Oxide And The Central Nervous System
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Author : Eleonora Dzoljic
language : en
Publisher:
Release Date : 1998
Nitric Oxide And The Central Nervous System written by Eleonora Dzoljic and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with categories.
Nitric Oxide In The Central Nervous System Of The Gastropod Melibe Leonina And Its Role In Modulation Of Swimming
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Author : James M. Newcomb
language : en
Publisher:
Release Date : 2001
Nitric Oxide In The Central Nervous System Of The Gastropod Melibe Leonina And Its Role In Modulation Of Swimming written by James M. Newcomb and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001 with categories.