The Role Of Non Coding Rnas In Vascular Damage In Hypertension And Ckd
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The Role Of Non Coding Rnas In Vascular Damage In Hypertension And Ckd
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Author : Kugeng Huo
language : en
Publisher:
Release Date : 2018
The Role Of Non Coding Rnas In Vascular Damage In Hypertension And Ckd written by Kugeng Huo and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with categories.
"Hypertension and chronic kidney disease (CKD) are two of the most prevalent global health concerns that account for millions of deaths per year. They are both associated with vascular damage that is characterized by vascular remodeling and stiffening, as well as endothelial dysfunction, which contribute to further development of the disease and lead to end organ damage. MicroRNAs (miRNAs) are important non-coding RNA regulators of gene expression that cause translational repression and transcript degradation upon binding to their target mRNAs. miRNAs have been demonstrated to be associated with hypertension and CKD, and play a critical role in vascular cell development and function. However, their role in vascular damage is still poorly studied. We hypothesized that vascular and circulating miRNAs are dysregulated in hypertension and CKD; the dysregulation of vascular miRNAs is a key driving force of pathological gene expression changes that contribute to vascular damage; key dysregulated vascular miRNAs are potential therapeutic targets and key dysregulated circulating miRNAs are potential biomarkers for vascular damage in hypertension and CKD. The thesis contains 3 studies testing our hypotheses.In the first study, we profiled miRNAs using RNA sequencing in mesenteric arteries of mice infused or not with angiotensin (Ang) II for 7 or 14 days. We observed that both 7-day and 14-day Ang II infusion induced blood pressure (BP) elevation, oxidative stress and vascular stiffening, whereas only 14-day Ang II-infusion caused endothelial dysfunction and vascular remodeling. Using a candidate approach, we have identified miR-431-5p and its target Ets Homologous Factor (Ehf) as key regulators in Ang II-induced hypertension and vascular damage. miR-431-5p and Ehf were up- and down-regulated by 14-day Ang II-infusion, respectively, and were both correlated with BP. We demonstrated that miR-431-5p targets EHF in human aortic vascular smooth muscle cells, where EHF down-regulates collagen type I alpha 1 chain (Col1a1), and miR-382-5p. Intravenous injection of miR-431-5p inhibitors down-regulated miR-431-5p, Col1a1 and miR-382-5p, and up-regulated Ehf in mesenteric arteries, delayed BP elevation and reduced vascular damage in mice infused with Ang II for 14 days.In the second study, we profiled miRNAs as above but this time in small arteries dissected from subcutaneous gluteal biopsies performed in normotensive, hypertensive and CKD subjects to identify differentially expressed vascular miRNAs. Combined with the data from the first study, we found a common miRNA, miR-145-3p, that was down-regulated in both 7-day Ang II-infused mice and CKD patients. Whether miR-145-3p mediates vascular damage in Ang II-induced hypertension model and CKD remains to be elucidated.In the third study, we profiled circulating miRNAs from plasma of the same cohort of normotensive hypertensive and CKD subjects as in the second study. We identified and validated 4 differentially expressed miRNAs, let-7g-5p, miR-26a-5p, miR-191-5p and let-7b-5p, among which let-7g-5p was correlated with estimated glomerular filtration rate. We also found a correlation between circulating let-7g-5p and genes that were differentially expressed in small arteries of CKD patients.To summarize, miR-431-5p and its target Ehf are potential important regulators in the pathophysiology of vascular damage in hypertension, and may serve as novel therapeutic targets in the clinic. miR-145-3p may play a role in the development of Ang II-induced and CKD-associated vascular injury. Let-7g-5p has potential clinical value to serve as a biomarker for vascular damage in CKD." --
The Role Of Non Coding Rnas In The Pathophysiology Of Kidney Disease
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Author : Malte Kölling
language : en
Publisher:
Release Date : 2021
The Role Of Non Coding Rnas In The Pathophysiology Of Kidney Disease written by Malte Kölling and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021 with categories.
Biomarkers In Cardiovascular Disease
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Author : Vijay Nambi
language : en
Publisher: Elsevier Health Sciences
Release Date : 2018-11-27
Biomarkers In Cardiovascular Disease written by Vijay Nambi and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-11-27 with Medical categories.
Get a quick, expert overview of the ways in which biomarkers can be used to assess and guide the management of cardiovascular disease in the clinical setting. This concise, clinically-focused resource by Dr. Vijay Nambi consolidates today’s available information on this rapidly changing topic into one convenient resource, making it an ideal, easy-to-digest reference for cardiology practitioners, fellows, and residents. Covers lab standards and statistical interpretation of biomarkers with a clinical focus. Discusses relevant conditions such as hypertension and diabetes as key markers of injury and prognosis. Includes current information on biomarkers to assess and guide the management of heart failure, acute coronary syndrome, chest pain, shortness of breath, and more. Concludes the book with a timely chapter on how biomarkers may guide cardiologists in the future.
Biomarkers Of Renal Diseases
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Author : Joaquín García-Estañ
language : en
Publisher: MDPI
Release Date : 2021-01-19
Biomarkers Of Renal Diseases written by Joaquín García-Estañ and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-01-19 with Medical categories.
This book provides important and updated information on current research devoted to urinary biomarkers. Urinary biomarkers are characteristics that can be objectively measured and evaluated as indicators of normal biological or pathogenic processes of pharmacological responses to therapeutic intervention.
Pediatric Hypertension
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Author : Joseph Flynn
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-06-26
Pediatric Hypertension written by Joseph Flynn and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-26 with Medical categories.
The field of pediatric hypertension has undergone important changes in the time since the second edition of Pediatric Hypertension published. Much new information on hypertension in the young has become available. Previous chapters have been fully revised and new chapters have been added to cover important topics of recent interest such as consensus recommendations, the prevalence of hypertension in the young due to the obesity epidemic, studies of antihypertensive agents, and ambulatory blood pressure monitoring. Pediatric Hypertension, Third Edition is a comprehensive volume featuring 38 chapters covering the breadth of the current knowledge. It is divided into four sections: Regulation of Blood Pressure in Children; Assessment of Blood Pressure in Children: Measurement, Normative Data, Epidemiology; and Hypertension in Children: Predictors, Risk Factors, and Special Populations; Evaluation and Management of Pediatric Hypertension. Filled with the most up-to-date information, Pediatric Hypertension, Third Edition is an invaluable resource for clinicians and researchers interested in childhood hypertension.
Entering The Rna Wonderland Opportunities And Challenges For Rna Therapeutics In The Cardiovascular System
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Author : Anna Zampetaki
language : en
Publisher: Frontiers Media SA
Release Date : 2020-07-22
Entering The Rna Wonderland Opportunities And Challenges For Rna Therapeutics In The Cardiovascular System written by Anna Zampetaki and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-22 with categories.
Non Coding Rnas In Cardiovascular Diseases
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Author : Junjie Xiao
language : en
Publisher: Springer
Release Date : 2021-04-28
Non Coding Rnas In Cardiovascular Diseases written by Junjie Xiao and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-04-28 with Science categories.
This book presents the latest research on non-coding RNAs in cardiovascular disease, a major cause of death worldwide. Non-coding RNAs play a significant role in development, proliferation, differentiation and apoptosis. Since altered non-coding RNA expression is often associated with various diseases, their potential use in diagnostics, prognostics and therapeutics is an important current area of study. The book consists of six parts: 1) An overview of non-coding RNAs and cardiovascular system, 2) Bioinformatics and interactions, 3) Non-coding RNA regulation in cardiovascular system, 4) Non-coding RNAs and cardiovascular diseases, 5) Potential biomarkers and therapeutic implications, 6) Future prospects. It is particularly useful for researchers and students in the field of non-coding RNA and cardiovascular biology, as well as for cardiologists, pharmacologists and physiologists.
Renal Fibrosis Mechanisms And Therapies
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Author : Bi-Cheng Liu
language : en
Publisher: Springer
Release Date : 2019-08-09
Renal Fibrosis Mechanisms And Therapies written by Bi-Cheng Liu and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-08-09 with Science categories.
This book systemically presents the latest research on renal fibrosis, covering all the major topics in the field, including the possible mechanisms, biomarkers, and strategies for prevention and treatment of chronic kidney disease (CKD). Due to its high prevalence, CKD represents a huge global economic and social burden. Irrespective of the initial causes, CKD progresses to end stage kidney disease (ESKD) due to renal fibrosis, which is characterized by glomerulosclerosis, tubule atrophy and atresia, and the excessive accumulation of extracellular matrix (ECM) in the kidney. Unfortunately, an estimated 1%-2% of the adult population living with CKD will need renal replacement therapy at some point as a result of ESKD. As such, strategies for preventing or slowing CKD progression to ESKD are of utmost importance, and studies aiming to understand the mechanisms of renal fibrosis have been the focus of intensive research. Recently, novel insights into the pathophysiological processes have furthered our understanding of the pathogenesis of renal fibrosis, and more importantly, promoted studies on the early diagnosis and treatment of CKD. This book draws lessons from the extensive, state-of-the-art research in this field, elaborating the new theories and new techniques to offer readers a detailed and comprehensive understanding of renal fibrosis and as well as inspiration for future research directions.
New Insights Into Extracellular Vesicles In Cardiovascular Disease Molecular Basis Diagnosis And Therapy
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Author : Xiaoheng Liu
language : en
Publisher: Frontiers Media SA
Release Date : 2022-10-06
New Insights Into Extracellular Vesicles In Cardiovascular Disease Molecular Basis Diagnosis And Therapy written by Xiaoheng Liu and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-10-06 with Science categories.
Chronic Inflammation And Pharmacological Interventions In Cardiovascular Diseases
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Author : Xianwei Wang
language : en
Publisher: Frontiers Media SA
Release Date : 2022-10-06
Chronic Inflammation And Pharmacological Interventions In Cardiovascular Diseases written by Xianwei Wang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-10-06 with Science categories.