The Tgf Beta Family
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Tgf Beta Family
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Author : Rik Derynck
language : en
Publisher:
Release Date : 2017-04-30
Tgf Beta Family written by Rik Derynck and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-04-30 with Science categories.
"Members of the transforming growth factor β (TGFβ) family, which include activins and bone morphogenetic proteins (BMPs), are essential intercellular signaling molecules that control of cell proliferation and embryonic development. This book provides a comprehensive view of the different members of the TGFβ family and their receptors, as well as their roles in normal physiology and development and pathological conditions such as cancer"--
The Tgf Beta Family
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Author : Rik Derynck
language : en
Publisher: CSHL Press
Release Date : 2008
The Tgf Beta Family written by Rik Derynck and has been published by CSHL Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with Transforming growth factors-beta categories.
Transforming growth factor-[beta] (TGF-[beta]), identified nearly three decades ago, is a secreted polypeptide that functions in critical cell cycle processes, including cellular proliferation, differentiation, and development: It belongs to a large protein family that, in humans, contains 33 members, including activins, inhibins, bone morphogenetic proteins, growth and differentiation factors, and Mullerian inhibiting substance. This volume draws on the world's leading laboratories to comprehensively cover all aspects of the biology of TGF-[beta] and related factors. In addition to providing historical and background information, it describes the cell biology and signaling pathways of TGF-[beta] members in detail, including the roles of TGF-[beta] factors in the development and physiology of humans and model organisms. The last few chapters are devoted to the role of TGF-[beta] members in cancer and other diseases, as well as the possibilities for therapeutics based on knowledge of signaling pathways and macromolecular structures. It serves as a comprehensive reference work for both specialists and researchers less familiar with the field.
Clinical Applications Of Tgf Beta
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Author : Gregory R. Bock
language : en
Publisher: John Wiley & Sons
Release Date : 2008-04-30
Clinical Applications Of Tgf Beta written by Gregory R. Bock and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-04-30 with Science categories.
TGF-beta, originally identified as a transforming growth factor with similar properties, is now known to exist as a family of factors with similar properties. These factors promote cell proliferation in some tissue types or conditions and induce cell differentiation in others. Features the latest information on the TGF-beta family and its receptors. Describes correlations between TGF-beta and certain cancers, including glioblastomas. Also contains reports of preliminary investigations of clinical applications for TGF-beta in many diseases, including leukemia and its use to accelerate wound healing.
Complex Formation And Endocytosis Of Tgf Beta Family Receptors And Their Role In Signaling
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Author : Maya Mouler Rechtman
language : en
Publisher:
Release Date : 2006
Complex Formation And Endocytosis Of Tgf Beta Family Receptors And Their Role In Signaling written by Maya Mouler Rechtman and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with categories.
Innovative Medicine
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Author : Kazuwa Nakao
language : en
Publisher: Springer
Release Date : 2015-10-13
Innovative Medicine written by Kazuwa Nakao and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-10-13 with Science categories.
This book is devoted to innovative medicine, comprising the proceedings of the Uehara Memorial Foundation Symposium 2014. It remains extremely rare for the findings of basic research to be developed into clinical applications, and it takes a long time for the process to be achieved. The task of advancing the development of basic research into clinical reality lies with translational science, yet the field seems to struggle to find a way to move forward. To create innovative medical technology, many steps need to be taken: development and analysis of optimal animal models of human diseases, elucidation of genomic and epidemiological data, and establishment of “proof of concept”. There is also considerable demand for progress in drug research, new surgical procedures, and new clinical devices and equipment. While the original research target may be rare diseases, it is also important to apply those findings more broadly to common diseases. The book covers a wide range of topics and is organized into three complementary parts. The first part is basic research for innovative medicine, the second is translational research for innovative medicine, and the third is new technology for innovative medicine. This book helps to understand innovative medicine and to make progress in its realization.
Cell Growth Regulation By Tgf Beta Family Members Identification Of Novel Antagonists
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Author : Joanne Wing Yee Ho
language : en
Publisher:
Release Date : 2006
Cell Growth Regulation By Tgf Beta Family Members Identification Of Novel Antagonists written by Joanne Wing Yee Ho and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with categories.
"Together, our results indicate that GRK2 is a potent negative feed-back regulator of activin/TGFbeta signaling in a variety of cell types and has the capacity to block, in particular, activin/TGFbeta-induced p15 expression, leading to an inhibition of activin/TGFbeta induced growth arrest and apoptosis. Moreover, the use of GRK2 phospho-mutant R-Smads, with the capacity to inhibit endogenous R-Smad signaling, may provide insights into the development of novel antagonists to the activin/TGFbeta signaling." --
Encyclopedia Of Cancer
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Author : Manfred Schwab
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-09-23
Encyclopedia Of Cancer written by Manfred Schwab and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-09-23 with Medical categories.
This comprehensive encyclopedic reference provides rapid access to focused information on topics of cancer research for clinicians, research scientists and advanced students. Given the overwhelming success of the first edition, which appeared in 2001, and fast development in the different fields of cancer research, it has been decided to publish a second fully revised and expanded edition. With an A-Z format of over 7,000 entries, more than 1,000 contributing authors provide a complete reference to cancer. The merging of different basic and clinical scientific disciplines towards the common goal of fighting cancer makes such a comprehensive reference source all the more timely.
Smad Signal Transduction
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Author : Peter Dijke
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-05-10
Smad Signal Transduction written by Peter Dijke and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-05-10 with Science categories.
This is the first comprehensive book on Smad signal transduction. Forward looking reviews of Smads are provided in a series of 22 cutting-edge chapters. The book is written for an audience with basic understanding of molecular and cell biology. This volume provides an in-depth review of a rapidly developing field and extensive cross-references between chapters are provided.
Glioma Signaling
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Author : Jolanta Barańska
language : en
Publisher: Springer Nature
Release Date : 2020-02-07
Glioma Signaling written by Jolanta Barańska and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-02-07 with Medical categories.
Gliomas, developing in the brain from the transformed glial cells, are a very special kind of tumor, extremely refractory to conventional treatments. Therefore, for the development of new antitumor strategies, a better understanding of molecular mechanisms responsible for their biology, growth and invasion is still needed. This book is a reference on cellular signaling processes regulating gliomas physiology and invasiveness. The work is focused on the mechanism of nucleotide receptor activation by exogenous nucleotides and formation of complex signaling cascades induced by growth factors, cytokines and cannabinoids. The second edition of the book enriched in new chapters provides a framework explaining how signal transduction elements may modulate numerous genetic and epigenetic alterations, describes the role of local microenvironment in cellular growth, progression and invasion and, in the light of extensive new results, presents perspectives concerning potential targets for gliomas therapy.
Therapeutic Manipulation Of The Tgf Beta Family May Lead To Scar Free Healing In The Adult Dermis
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Author : Robert Choyce Humble
language : en
Publisher:
Release Date : 2006
Therapeutic Manipulation Of The Tgf Beta Family May Lead To Scar Free Healing In The Adult Dermis written by Robert Choyce Humble and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with categories.