The Ubiquitin System
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The Ubiquitin System
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Author : Milton J. Schlesinger
language : en
Publisher: Cold Spring Harbor Laboratory Press
Release Date : 1988
The Ubiquitin System written by Milton J. Schlesinger and has been published by Cold Spring Harbor Laboratory Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1988 with Science categories.
The Ubiquitin System In Health And Disease
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Author : Stefan Jentsch
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-11-14
The Ubiquitin System In Health And Disease written by Stefan Jentsch and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-11-14 with Medical categories.
The ubiquitin system plays an essential role in numerous cellular processes by controlling protein stability and function. An understanding of the mechanisms governing these processes is likely to allow the identification of novel targets for pharmacological intervention. This work covers the developments in this field.
The Ubiquitin System In Health And Disease 2009
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Author :
language : en
Publisher:
Release Date :
The Ubiquitin System In Health And Disease 2009 written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.
The Ubiquitin Proteasome Proteolytic System
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Author : Aaron J. Ciechanover
language : en
Publisher: World Scientific
Release Date : 2002
The Ubiquitin Proteasome Proteolytic System written by Aaron J. Ciechanover and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Science categories.
Ubiquitin-proteasome-dependent proteolysis is central to an incredible multitude of processes in all eukaryotes, including the cell cycle, cell growth and differentiation, embryogenesis, apoptosis, signal transduction, DNA repair, regulation of transcription and DNA replication, transmembrane transport, endocytosis, stress responses, antigen presentation and other aspects of the immune response, the functions of the nervous system including circadian rhythms, axon guidance and acquisition of memory.This book tells the story of the ubiquitin system as we currently know it: from the regulation of basic cellular processes to quality control and the pathogenetic mechanisms of disease, from X-ray crystallography of the 26S proteasome to the interaction between substrates and their ligases, to the development of mechanism-based drugs, and to target-specific aberrant processes.
The Ubiquitin Proteasome System
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Author : R. J. Mayer
language : en
Publisher: Portland Press, London
Release Date : 2005
The Ubiquitin Proteasome System written by R. J. Mayer and has been published by Portland Press, London this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with Medical categories.
The importance of the ubiquitin-proteasome system in cellular homoeostasis was emphasized by the award of the 2004 Nobel Prize in Chemistry to the discoverers of ubiquitin as a cofactor for intracellular non-lysosomal proteolysis. This volume focuses on many different aspects of the role of the ubiquitin system in intracellular proteolysis.
The Ubiquitin System As A Determinantof Mitochondrial Function And Morphology
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Author : Guillaume P. Leboucher
language : en
Publisher:
Release Date : 2010
The Ubiquitin System As A Determinantof Mitochondrial Function And Morphology written by Guillaume P. Leboucher and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with categories.
The Proteasome Ubiquitin Protein Degradation Pathway
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Author : Peter Zwickl
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
The Proteasome Ubiquitin Protein Degradation Pathway written by Peter Zwickl and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
This volume gives an overview of pro tea some-mediated protein degradation and the regulatory role of the ubiquitin system in cellular proteolysis. The first chapter describes the molecular evolution of the proteasome and its associated activators, i. e. , the 20S core, the base and the lid of the 19S cap, and the 11 S regulator. The ensuing chapter gives an overview of the structure and assembly of the 20S proteasome and the regulation of the archaeal proteasome by PAN. The third contribution summarizes our knowledge on the eukaryotic 26S proteasome and its regulation by the 19S regu lator, followed by a chapter devoted to the llS regulator, which elucidates the structural basis for the 11 S-mediated activation of the 20S proteasome. The fifth chapter reviews in detail the role of the proteasome in the immune response. The subsequent chapter of the natural substrates of the gives a comprehensive description proteasome and their recognition by the enzymes of the ubiqui tination machinery. The penultimate chapter rounds up the in formation on intracellular distribution of proteasomes in yeast and mammalian cells, while the last contribution highlights proteasome inhibitors, tools which proved to be very valuable for dissecting the cellular roles of the proteasome and which might turn out to be of pharmacological importance.
Development Of A Reverse Split Ubiquitin System To Characterize Protein Protein Interactions
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Author : Fatih Sahin
language : en
Publisher: GRIN Verlag
Release Date : 2019-06-17
Development Of A Reverse Split Ubiquitin System To Characterize Protein Protein Interactions written by Fatih Sahin and has been published by GRIN Verlag this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-06-17 with Science categories.
Bachelor Thesis from the year 2018 in the subject Chemistry - Bio-chemistry, grade: 2,0, University of Frankfurt (Main), language: English, abstract: An important topic in research is the study of interactions between proteins. Therefore, many strategies have been developed to better understand these interactions. One method is the yeast two-hybrid system. The glo-1(QL) gene encodes a Rab GTPase and is localized in lysosomal organelles. Several effector proteins have been found for the glo-1 gene. One of them is C35B1.2a. Using the yeast two-hybrid system, the interaction between GLO-1(QL) and C35B1.2a should be shown. In addition, the expression rate of the interaction partners should be documented by promoter exchange. However, this system is not suitable for all proteins. For this reason, the reverse split ubiquitin system was developed. A yeast-two-hybrid system-based method to study protein-protein interactions (PPI) of membrane proteins. In this case, the ubiquitin is cleaved into an N-terminal domain (Nub) and C-terminal (Cub) domain, each domain being fused to a protein. The C-terminal domain additionally consists of an arginine and subsequent reporter gene. If there is an interaction of the two fusion proteins, this is recognized by so-called ubiquitin-specific proteases (USPs) and cut the ubiquitin apart. Subsequently, the reporter gene is degraded due to the arginine. In this study, the interaction could not be demonstrated because no clones grew on selective plates. Even by the replacement of the promoters no growth could be found. To optimize the interaction, the split ubiquitin system should be further refined.
Relationship Between The Ubiquitin System And Mitochondria
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Author : Nurit Livnat-Levanon
language : en
Publisher:
Release Date : 2011
Relationship Between The Ubiquitin System And Mitochondria written by Nurit Livnat-Levanon and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with categories.
Molecular Genetics Of The Ubiquitin System The Ubiquitin Fusion Proteins And Proteolytic Targeting Mechanisms
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Author : Bonnie Bartel
language : en
Publisher:
Release Date : 1990
Molecular Genetics Of The Ubiquitin System The Ubiquitin Fusion Proteins And Proteolytic Targeting Mechanisms written by Bonnie Bartel and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1990 with categories.