The Vroman Effect
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The Vroman Effect
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Author : C. H. Bamford
language : en
Publisher: VSP
Release Date : 1992-12-01
The Vroman Effect written by C. H. Bamford and has been published by VSP this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992-12-01 with Science categories.
The development of specific antibodies as probes and detectors for adsorbed proteins by Dr. Leo Vroman and co-workers in the 1960s and 1970s confirmed his earlier observations and suspicions that blood protein adsorption involved a hierarchical series of collision, adsorption, and exchange processes. These observations and concepts were confirmed by other scientists and came to be known as 'the Vroman effect'. The core concept of the Vroman effect admits many approaches and over-reaches complex and not fully resolved questions of enzymology, transport phenomena, the statistical mechanics of protein conformation, longrange forces in liquids, and surface physics. This volume contains the presentations from the symposium which was held in honour of the 75th birhday of Dr. Leo Vroman, in Gouda, The Netherlands, and deals with various aspects of the Vroman effect.
The Vroman Effect In Separated Flows
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Author : Charles Andrew LeDuc
language : en
Publisher:
Release Date : 1995
The Vroman Effect In Separated Flows written by Charles Andrew LeDuc and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995 with categories.
The Vroman Effect
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Author : Seung-Yong Jung
language : en
Publisher:
Release Date : 2005
The Vroman Effect written by Seung-Yong Jung and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with categories.
Investigations of specific and nonspecific interactions of biomolecules at liquid/solid interfaces are presented. To investigate specific multivalent ligand-receptor interactions, bivalent antibodies and haptens bound to solid supported membrane were used as models for ligand-receptor coupling. Novel microfabrication strategies, which included spatially addressed bilayer arrays and heterogeneous microfluidic assays, in conjunction with total internal reflection microscopy, was employed to achieve this goal. These high throughput techniques allow thermodynamic data of binding interactions to be acquired with only a few microliters of analyte and superior signal to noise. The results yield both the first and second dissociation constant for bivalent IgG antibodies with membrane bound hapten molecules. Studies were conducted both as a function of hapten density and cholesterol content in the membrane. Another research area of this dissertation is the molecular level description of nonspecific adsorption and displacement of the model protein, fibrinogen, onto hydrophilic surfaces. Techniques such as atomic force microscopy, immunochemical assays, fluorescence microscopy, and vibrational sum frequency spectroscopy were employed to probe this system. The results demonstrate that the protein's [alpha]C domains play the critical role. When fibrinogen is adsorbed to a hydrophilic surface via these moieties, its displacement rate in the presence of human plasma is approximately 170 times faster than when these domains are not in direct surface contact. Even more significantly, spectroscopic studies show evidence for highly aligned Arg and Lys residues interacting with the negatively charged substrate only when the [alpha]C domains make direct surface contact. The interfacial ordering of these residues appears to be the hallmark of a weak and labile electrostatic attraction between the substrate and the adsorbed macromolecule.
Modern Aspects Of Protein Adsorption On Biomaterials
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Author : E Missirlis
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Modern Aspects Of Protein Adsorption On Biomaterials written by E Missirlis and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Technology & Engineering categories.
The present book relates to the scientific records of a workshop held in Patras, Greece, in June 1989, under the auspices and with financial support of the European Economic Communities (Concerted Action EUROBIOMAT - Hemocompatibility - of the Medical Research Programme, Project: 11.1.212). This concerted action promotes the collaboration on science and technology on the particular field of hemocompatible biomaterials: exchange of experts, scholarships and scientific workshops within the EC-member countries and COST countries such as Sweden, Finland, Turkey, Switzerland. The first part of this monography refers to the oral presentations of the par ticipants. The second part gives the book its unique character: the scientific discussion on updated aspects of protein adsorption of synthetic polymers in contact with blood. This second part is subdivided into nine chapters where specific topics were discussed freely, open-minded and even controversially. This book intends to elucidate recurrent questions concerning the initial event when blood contacts artificial surfaces. Young investigators will consider this book to be appropriate to get familiar with the scientific background and the most relevant techniques and methods.
Principles Of Biomedical Engineering Second Edition
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Author : Sundararajan Madihally
language : en
Publisher: Artech House
Release Date : 2019-12-31
Principles Of Biomedical Engineering Second Edition written by Sundararajan Madihally and has been published by Artech House this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-12-31 with Technology & Engineering categories.
This updated edition of an Artech House classic introduces readers to the importance of engineering in medicine. Bioelectrical phenomena, principles of mass and momentum transport to the analysis of physiological systems, the importance of mechanical analysis in biological tissues/ organs and biomaterial selection are discussed in detail. Readers learn about the concepts of using living cells in various therapeutics and diagnostics, compartmental modeling, and biomedical instrumentation. The book explores fluid mechanics, strength of materials, statics and dynamics, basic thermodynamics, electrical circuits, and material science. A significant number of numerical problems have been generated using data from recent literature and are given as examples as well as exercise problems. These problems provide an opportunity for comprehensive understanding of the basic concepts, cutting edge technologies and emerging challenges. Describing the role of engineering in medicine today, this comprehensive volume covers a wide range of the most important topics in this burgeoning field. Moreover, you find a thorough treatment of the concept of using living cells in various therapeutics and diagnostics. Structured as a complete text for students with some engineering background, the book also makes a valuable reference for professionals new to the bioengineering field. This authoritative textbook features numerous exercises and problems in each chapter to help ensure a solid understanding of the material.
Heart Replacement
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Author : Tetsuzo Akutsu
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-06-29
Heart Replacement written by Tetsuzo Akutsu and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-29 with Medical categories.
The 5th International Symposium on Artificial Heart and Assist Devices was held in Tokyo on January 26 - 27, 1995, bringing together leading researchers and specialists from all over the world. The proceedings of the symposium presents the newest ideas and approaches in the field, and will be of special interest and relevance to all who are concerned with artificial organs, cardiovascular surgery, organ transplantation, biomaterials, and related disciplines. Reflecting the content of the symposium, the major topics in this volume include biocompatible material development, clinical use of assist devices, completely implantable devices, and heart transplantation. These are presented in the two main divisions of the book: The first consists of eight lectures by leading researchers, world-renowned in the field of the artificial heart. The second comprises more than 50 papers on such subjects as biomaterials, research and development of ventricular assist systems and the total artificial heart, and their use as a bridge to heart transplantation. An additional, special feature of the book is the inclusion of descriptions of exhibitions at the symposium, with photographs of all artificial heart devices and systems displayed by major laboratories and companies from around the world.
Plastics In Medical Devices For Cardiovascular Applications
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Author : Ajay Padsalgikar
language : en
Publisher: William Andrew
Release Date : 2017-02-01
Plastics In Medical Devices For Cardiovascular Applications written by Ajay Padsalgikar and has been published by William Andrew this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-02-01 with Technology & Engineering categories.
Plastics in Medical Devices for Cardiovascular Applications enables designers of new cardiovascular medical devices to make decisions about the kind of plastics that can go into the manufacture of their device by explaining the property requirements of various applications in this area, including artificial valves, lead insulation, balloons, vascular grafts, and more. Enables designers to improve device performance and remain compliant with regulations by selecting the best material for each application Presents a range of applications, including artificial valves, stents, and vascular grafts Explains which materials can be used for each application, and why each is appropriate, thus assisting in the design of better tools and processes
Protein Nanoparticle Interactions
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Author : Masoud Rahman
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-06-24
Protein Nanoparticle Interactions written by Masoud Rahman and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-24 with Science categories.
In recent years, the fabrication of nanomaterials and exploration of their properties have attracted the attention of various scientific disciplines such as biology, physics, chemistry, and engineering. Although nanoparticulate systems are of significant interest in various scientific and technological areas, there is little known about the safety of these nanoscale objects. It has now been established that the surfaces of nanoparticles are immediately covered by biomolecules (e.g. proteins, ions, and enzymes) upon their entrance into a biological medium. This interaction with the biological medium modulates the surface of the nanoparticles, conferring a “biological identity” to their surfaces (referred to as a “corona”), which determines the subsequent cellular/tissue responses. The new interface between the nanoparticles and the biological medium/proteins, called “bio-nano interface,” has been very rarely studied in detail to date, though the interest in this topic is rapidly growing. In this book, the importance of the physiochemical characteristics of nanoparticles for the properties of the protein corona is discussed in detail, followed by comprehensive descriptions of the methods for assessing the protein-nanoparticle interactions. The advantages and limitations of available corona evaluation methods (e.g. spectroscopy methods, mass spectrometry, nuclear magnetic resonance, electron microscopy, X-ray crystallography, and differential centrifugal sedimentation) are examined in detail, followed by a discussion of the possibilities for enhancing the current methods and a call for new techniques. Moreover, the advantages and disadvantages of protein-nanoparticle interaction phenomena are explored and discussed, with a focus on the biological impacts.
Improved Methods For Predicting Spectrum Loading Effects
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Author : J. B. Chang
language : en
Publisher:
Release Date : 1981
Improved Methods For Predicting Spectrum Loading Effects written by J. B. Chang and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1981 with Aerodynamic load categories.
This report presents the technical details of improved methods for predicting the load interaction effects on crack growth under flight spectrum loading developed in a research effort sponsored by the USAF. These include the cycle-by-cycle crack-growth prediction methods used in the detail design stage, the flight-by-flight crack-growth analysis method for individual aircraft tracking usage, and preliminary design trade-off studies.
Essential Biomaterials Science
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Author : David Williams
language : en
Publisher: Cambridge University Press
Release Date : 2014-07-17
Essential Biomaterials Science written by David Williams and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-07-17 with Medical categories.
This groundbreaking single-authored textbook equips students with everything they need to know to truly understand the hugely topical field of biomaterials science, including essential background on the clinical necessity of biomaterials, relevant concepts in biology and materials science, comprehensive and up-to-date coverage of all existing clinical and experimental biomaterials, and the fundamental principles of biocompatibility. It features extensive case studies interweaved with theory, from a wide range of clinical disciplines, equipping students with a practical understanding of the phenomena and mechanisms of biomaterials performance; a whole chapter dedicated to the biomaterials industry itself, including guidance on regulations, standards and guidelines, litigation, and ethical issues to prepare students for industry; informative glossaries of key terms, engaging end-of-chapter exercises, and up-to-date lists of recommended reading. Drawing on the author's 40 years' experience in biomaterials, this is an indispensible resource for students studying these lifesaving technological advances.
