Therapeutic Modulation Of Cytokines
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Therapeutic Modulation Of Cytokines
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Author : M. W. Bodmer
language : en
Publisher: CRC Press
Release Date : 1996-01-23
Therapeutic Modulation Of Cytokines written by M. W. Bodmer and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-01-23 with Medical categories.
Cytokines are peptide or protein cell-to-cell signaling molecules that play vital roles in normal cell and tissue homeostasis, as well as in responses to infectious agents. Because of their importance in virtually all forms of pathology, the pharmaceutical industry is devoting great effort to develop methods for the control of cytokine synthesis or action. This is the first volume to bring together experts from academia and the pharmaceutical industry to discuss problems and solutions in the therapeutic control of cytokines. An introductory section reviews the biology, physiology, and pathology of cytokines. Internationally recognized scientists then discuss the development of low molecular mass inhibitors, including inhibitors of cytokine convertases and oligonucleotide drugs. The potential use of natural inhibitors such as soluble receptors, interleukin-1 receptor antagonists, and anti-cytokine antibodies is detailed. This interesting book also covers intracellular signaling pathways induced by pro-inflammatory cytokines and the bio-modulatory activity of specific cytokines such as TGF-ß. Therapeutic Modulation of Cytokines will interest academic scientists in biochemistry, cell biology, pharmacology, and molecular biology and biological scientists in the pharmaceutical and biopharmaceutical industries.
Intracellular Cytokines And Their Therapeutic Modulation In Immunological Disorders
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Author : William Arthur Carrock Sewell
language : en
Publisher:
Release Date : 2000
Intracellular Cytokines And Their Therapeutic Modulation In Immunological Disorders written by William Arthur Carrock Sewell and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with categories.
Modulating Cytokines As Treatment For Autoimmune Diseases And Cancer
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Author : Erwan Mortier
language : en
Publisher: Frontiers Media SA
Release Date : 2020-12-11
Modulating Cytokines As Treatment For Autoimmune Diseases And Cancer written by Erwan Mortier and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-11 with Medical categories.
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Immune Modulating Agents
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Author : Thomas F. Kresina
language : en
Publisher: CRC Press
Release Date : 2020-10-28
Immune Modulating Agents written by Thomas F. Kresina and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-10-28 with Medical categories.
Discussing the systemic immune response in the contexts of health, disease, and therapy, this unique resource-the only broadly based book of its kind available on the subject-offers comprehensive examinations of the pathways and agents that affect the human immune response and provides state-of-the-art presentations on practical methods of immune modulation. Focuses on the immune response and modulation in infectious diseases, such as HIV, hepatitis, and parasitic infections and highlights immune modulating agents in gastrointestinal diseases, sepsis, cancer, and autoimmunity! Written by over 50 international authorities representing distinguished institutions in nine countries, Immune Modulating Agents introduces basic immunoregulatory mechanisms as homeostasis details cytokines, cellular and humoral immune responses, and hematopoiesis describes neuroendocrine - immune system interactions and the role of psychological stress on immune competence delineates factors that influence disease susceptibility, including nutrition covers drug delivery systems, gene therapy, organ transplantation, arthritis treatment, and vaccination strategies shows how to design clinical trials using immune modulating agents and more!
Clinical Applications Of Cytokines
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Author : Joost J. Oppenheim
language : en
Publisher: Oxford University Press, USA
Release Date : 1993
Clinical Applications Of Cytokines written by Joost J. Oppenheim and has been published by Oxford University Press, USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993 with Cytokines categories.
The driving force for research on cytokines has always been their clinical promise. Their biological properties suggested a key role in hematopoiesis, immunity, tumor genesis, hemostasis, vascularization, repair of connective tissues and integration of the immune system with the neuroendocrine system. Animal studies have shown that cytokines could be used as effective biotherapeutics with easily manageable and reversible toxicities. Clinical trials have confirmed these findings, culminating in the licensing of a number of the cytokines such as interferon alpha, interferon gamma, interleukin 2, erythropoietin, granulocyte colony stimulating factor, and granulocyte-macrophage colony stimulating factor. Many other cytokines are in clinical trials. This is the first comprehensive volume on the cytokines written primarily from a medical perspective. After presenting background information about the structure, production, assays and systemic effects of cytokines and their receptors, it is organized around diseases and organ systems. Infectious diseases, autoimmunity, immunodeficiency states, defective hematopoiesis, allergies, injury repair, cancer, vascular and skin diseases, and neurological disorders are all covered. This work reviews the role that cytokines play in the pathogenesis, diagnosis and therapy of each disease. The authors assess both the current state of the art and the potential for future applications.
Cytokines And Autoimmune Diseases
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Author : Vijay K. Kuchroo
language : en
Publisher: Springer Science & Business Media
Release Date : 2001-11-09
Cytokines And Autoimmune Diseases written by Vijay K. Kuchroo and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-11-09 with Medical categories.
Leading researchers synthesize scattered experimental data to help develop an intimate understanding of how cytokines and chemokines are involved in the pathogenesis of autoimmune diseases. The many chapters offer critical reviews the basic mechanisms controlling cytokine induction and regulation, as well as the resulting production of proinflammatory and anti-inflammatory cytokines, the former of which induces organ-specific autoimmune diseases. From the vantage of these insights, they address the role of cytokines in a wide variety of autoimmune diseases, uvetis, encephalomyelitis, multiple sclerosis, human type 1 diabetes, rheumatoid arthritis, SLE, and myasthenia gravis. Authoritative and state-of-the-art, Cytokines and Autoimmune Disease highlights the enormous therapeutic potential of cytokine modulation in the treatment of autoimmune disease.
Cytokines And Pain
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Author : L.R. Watkins
language : en
Publisher: Springer
Release Date : 2013-03-08
Cytokines And Pain written by L.R. Watkins and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-08 with Medical categories.
Within the past few years, it has become recognized that the immune system communicates to the brain. Substances released from activated immune cells (cytokines) stimulate peripheral nerves, thereby signaling the brain and spinal cord that infection/inflammation has occurred. Additionally, peripheral infection/inflammation leads to de novo synthesis and release of cytokines within the brain and spinal cord. Thus, cytokines effect neural activation both peripherally and centrally. Through this communication pathway, cytokines such as interleukin-1, interleukin-6 and tumor necrosis factor markedly alter brain function, physiology and behavior. One important but underrecognized aspect of this communication is the dramatic impact that immune activation has on pain modulation. The purpose of this book is to examine, for the first time, immune-to-brain communication from the viewpoint of its effect on pain processing. It is aimed both at the basic scientist and health care providers, in order to clarify the major role that substances released by immune cells play in pain modulation. This book contains chapters contributed by all of the major laboratories focused on understanding how cytokines modulate pain. These chapters provide a unique vantage point from which to examine this question, as the summarized work ranges from evolutionary approaches across diverse species, to the basics of the immune response, to the effect of cytokines on peripheral and central nervous system sites, to therapeutic potential in humans.
Cytokines In Severe Sepsis And Septic Shock
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Author : H. Redl
language : en
Publisher: Springer Science & Business Media
Release Date : 1998-11
Cytokines In Severe Sepsis And Septic Shock written by H. Redl and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998-11 with Health & Fitness categories.
This book deals with the central role of cytokines in the generalized inflammatory response of the host as the consequence of severe infection/endotoxin action. International specialists cover several aspects in 20 chapters starting with the agents responsible (endotoxin, superantigens) and recognition during cytokine induction. Further chapters deal with the signal transduction cascade, its modulation due to sex or genetic polymorphism, and the possibilities and problems in detection (including surrogate markers). Major targets of actions are covered in the chapters on coagulation-/fibrinolysis, adherence molecules, vasoactive factors, apoptosis and metabolism. As not all actions of cytokines are beneficial, several chapters deal with the prevention of induction, modulation of the cytokine generation or scavenging cytokines including gene therapy approaches. Models are necessary for obtaining pathophysiological information and for testing therapeutic approaches, and thus all chapters deal with experimental models as well as clinical trials. The reasons why these have failed so far are the subject of the final chapter.
Therapeutic Strategies For Modulating The Inflammatory Diseases
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Author : B.M. Weichman
language : en
Publisher: Springer Science & Business Media
Release Date : 1997-11-18
Therapeutic Strategies For Modulating The Inflammatory Diseases written by B.M. Weichman and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-11-18 with Medical categories.
The Eighth International Conference of the Inflammation Research Association was held on October 27 to 31, 1996 at Hershey Lodge and Convention Center in Hershey, Pennsylvania. As have others in this series, the conference focused on understanding the molecular mechanisms involved in acute and chronic inflammatory reactions as well as on therapeutic approaches to treating inflammatory diseases. One outstanding symposium focused on new drugs and was de signed as a forum for the dissemination of early clinical results on new anti-inflammatory agents. Other symposia spotlighted exciting advances being made in defining intracellular signaling path ways and the potential for future therapeutics that target cytokines and costimulatory pathways. This conference was characterized by a high level of participation by attendees, who represent both the academic and industrial sectors. It was gratifying to note that a large proportion of the attending scientists presented their latest findings during workshops, poster discussions, and pos ter se.ssions. This volume covers many of the highlights of the Eighth International Conference and should become a valuable resource for scientists involved in inflammation research and drug discovery.
Cytokines Roles And Therapeutic Implications
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Author : Erik Krueger
language : en
Publisher:
Release Date : 2021-02-16
Cytokines Roles And Therapeutic Implications written by Erik Krueger and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-02-16 with categories.
Cytokines are commonly referred to as the "language of intercellular interaction" since they send signals and commands to the cells to perform certain functions. In this compilation, the authors discuss how cytokines have demonstrated different patterns of production and interaction with other cytokines; therefore, cytokines can be considered as diagnostical markers and possible targets for therapeutic measures.The authors illuminate the role of cytokines in different physiological circumstances affecting the onset, development and resolution of inflammation associated with inflammatory bowel disease.The administration of cytokines as therapeutics has proven potential in the treatment of cancer and infectious and non-infectious disease. The authors discuss cytokine profiles and their signaling in the autoimmune disease Guillain-Barre syndrome, and the potential of using this specific information for developing new therapeutic strategies.The concluding study focuses on malignant breast cancer, the most common cancer in women worldwide. In recent decades, many advances have occurred in understanding the role of cytokines in this cancer, with several studies on new diagnostic and prognostic markers and their applications as a target in treatment.